• 대한한방내과학회지
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• 제41권3호
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• pp.326-338
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• 2020

Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease that causes disorientation, mood swings, problems with language, and difficulty remembering recent events. Acetylcholinesterase inhibitors (AchEIs) and memantine have been used to slow the course of the disease, but they can neither modify its progression nor prevent disease onset. Previous studies have suggested that Kami-guibi-tang (KGT) could be beneficial for supporting cognitive function in AD patients, but few clinical trials have been published. This pilot study aimed to evaluate the effect of KGT in improving cognitive function in AD patients. Methods: The study will be a randomized, placebo-controlled, double-blind, single-center trial conducted using subjects diagnosed with mild AD by neurologists. Study subjects will be randomly assigned to either a treatment or control group. The treatment group will receive KGT granules for 24 weeks, while the control group will receive placebo granules. AchEI administration will be maintained in both groups during the entirety of the study. Subjects will be assessed using the following exams: the Seoul Neuropsychologic Screening Battery (SNSB) for cognitive function; brain magnetic resonance imaging (MRI) for brain metabolite, neurotransmitter, and cerebral blood flow (CBF) measurements; the Korean version of Quality of Life-Alzheimer's Disease (KQol-AD) for quality of life; the Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI) for neurobehavioral symptoms; blood tests for amyloid and tau proteins and general blood parameters; and electrocardiography (ECG) before and after taking the medication. Discussion: Our findings will provide insight into the feasibility of large-scale trials to consolidate evidence for the efficacy of KGT for dementia treatment. Registration ID in CRIS: KCT0002904 (Clinical Research Information Service of the Republic of Korea).

• 한국인터넷방송통신학회논문지
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• 제22권4호
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• pp.41-48
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• 2022

본 연구는 5G가 안정화되어 갈수록 많은 양의 트래픽이 건물 내 발생할 것으로 예상됨에 따라, 건물 내 5G 품질향상을 위해 지향성이 향상된 인빌딩용 안테나를 설계한 연구이다. 야기 안테나 전파 지향원리인 안테나 소자 전진 배열방식을 응용한 것이 아니라, 기지국용 안테나에 적용된 수직 배열 방식의 안테나 설계 방안을 제시한 것이고, 실험을 통해 안테나 지향성이 증가함을 확인하였다. 실험 결과에 따르면, 안테나와의 이격거리가 10m 이내에서는 지향성이 크게 증가하지 않았지만, 10m 이상 이격된 거리에서는 지향성이 약 3dB 가량 증가한 것으로 나타났으며, 빌딩 내 무선환경이 외부 환경과 달리 내부 구조물의 구조, 콘크리트, 유리와 같은 자재, 폐쇄된 공간, 벽면 등 다양한 변수가 존재하는 점을 고려하였을 때, 지향성이 향상된 안테나는 향후 빌딩 내 5G 품질개선의 폭을 넓힐 수 있고, 건물 내에서도 안정적인 통신 서비스를 유지시킬 수 있을 것으로 기대된다.

• 지능정보연구
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• 제18권4호
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• pp.43-57
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• 2012

제조업에 있어서 판매 후 서비스 건수와 내용 등은 향후 서비스 제공을 위한 자원배분의 효율성 증진과 서비스 품질 향상을 위해서도 매우 중요한 정보이다. 따라서 기업들은 향후 발생하는 판매 후 서비스에 대해 정확히 예측하고 그에 따라 적절히 대처하는 능력을 확보할 필요성이 제조업을 중심으로 증가하고 있다. 그러나 실제로 이들 기업들이 활용하고 있는 서비스 수요예측 방법들은 전통적인 통계적인 예측기법이거나, 시뮬레이션을 기반한 기법들이다. 예를 들면, 전통적인 통계적인 예측기법으로는 회귀분석(regression analysis)의 경우, 다양한 제품모델에 대한 판매 후 서비스 발생 패턴이 선형적인 관계가 매우 적음에도 불구하고 선형으로 가정하여 추정한다는 점과 적정한 회귀식을 가정하여야 되며, 이러한 가정이 실제 경영환경에서는 매우 어렵다는 점 등이 기존의 예측기법들의 한계점으로 지적되고 있다. 본 연구에서는 디지털 TV 모델을 생산 판매 하는 A사의 사례연구를 통하여 최근 인공지능연구에서 각광을 받고 있는 사례기반추론(case-based reasoning; CBR) 기법을 활용한 서비스 수요예측 프레임워크를 제안하고자 한다. 또한, 사례기반추론에서 핵심적인 역할 중 하나인 유사 사례추출 방법에 있어서 가장 일반적인 nearest-neighbor 방법 이외의 유사 사례추출 방법을 제안하고자 한다. 특히, 본 연구에서 제안하는 유사 사례추출 방법은 인공신경망(artificial neural network)을 활용한 자기조직화지도(Self-Organizing Maps : SOM) 군집화 기법을 활용한 유사 사례추출 방식으로 이를 활용한 서비스 수요예측 프레임워크에 구현하고, 실제 기업의 판매 후 서비스 데이터를 활용하여 본 연구에서 제안하는 서비스 수요 예측 프레임워크의 유효성을 실증적으로 검증하고자 한다.

• 한국병원경영학회지
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• 제17권4호
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• pp.87-115
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• 2012

This research classified hospital specialization strategy types through cluster analysis, analyzed fitness of hospital specialization strategy types for external environment or organizational structure, and examined relation between hospital specialization strategy types and organizational performance. This research surveyed 1,437 hospitals which have more than 30 patient's bed and practice national health service in Korea. Specifically, this research divided into two part : external fit - analysis of relation between external environment and specialization strategy, internal fit-analysis of relation between organizational structure factors and specialization strategy. also, as the organizational performance for achieving specialization strategic purpose, not only the productivity, efficiency, profit but also the medical quality was considered. In case of external fit, many hospitals chose integration type if there are a lot of competitive hospitals and regional population. Particularly, if there are many competitive hospitals, concentration type is chosen. In contrast, if there are many doctors in the region, differentiation type is chosen. In case of internal fit, according to organization type and patient's bed number, hospitals chose different types. If it is a general hospital and has a few bed number, generalization or concentration type is chosen. Tertiary hospital or the hospital with many patient's bed chose differentiation type. According to the number of specialists, if there are a few specialists, generalization or concentration type is chosen. If there are many specialists, differentiation type has high fitness for the hospital. In relation to strategy types and organizational performance, differentiation type has best result. Differentiation type has a good result in 7 items out of 11.

• 대한한의학회지
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• 제30권4호
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• pp.28-36
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• 2009

Objectives: Fatigue is a prevalent symptom encompassing both acute and chronic manifestations. Most fatigue symptoms can be cured by taking a rest or removing underlying causes. However, chronic fatigue is frequently problematic due to its duration and effect on quality of life. There are no particularly effective therapies for chronic fatigue of unknown causes, and patients in Korea usually visit an Oriental clinic. This study aimed to analyze the current status of treatments and patients with chronic fatigue, and then map out of a strategy for development of generalized-treatments for chronic fatigue in Oriental Medicine. Methods: Clinical information related to chronic fatigue was selected from various different databases such as PubMed, KoreaMed, KStudy, DBPIA, OIM, and KOMS. Also, to understand current tendency of medical examination and treatment related with chronic fatigue, we requested Health Insurance Review & Assessment Service for clinical datum from 2003 to 2007. Results: The medical fees of National Health Insurance related with fatigue show an explosive year-on-year increase. On the other hand, it has been decreasing annually in the western medical fields. To take charge of clinical fields related with chronic fatigue by Oriental Medicine, we should make a unified diagnostic system. Then, we should also make standard evaluation tools and develop herbal drugs according to this unified diagnostic system. Conclusions: Fatigue-related symptoms will be a main target of Oriental medicine in the future. We expect that various studies related with chronic fatigue will be undertaken hereafter.

• Journal of Nutrition and Health
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• 제36권2호
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• pp.223-230
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• 2003

사업체급식소와 HACCP 적용효과를 평가하기 위해 대구지역 특정 위탁급식소의 급식종사자 21명을 대상으로 2회에 걸친 HACCP 교육과 수시 현장지도를 통하여 HACCP을 적용한 후 미생물적 품질, 조리 및 배식온도와 소요시간을 측정하였다. 미생물 검사를 위한 음식물의 채취는 비가열조리식품, 가열후처리식품, 가열조리식품의 세 가지 조리 공정별로 CCP를 정하고 CCP별로 검수단계, 전처리단계, 조리단계, 배식단계에서 각각 취하였다. 미생물검사는 표준 평판균수와 대장균군수를 측정하였다. HACCP 적용 전에 비해 적용 후, 조리 및 배식단계에서 급식종사자들이 식품내부온도를 74$^{\circ}C$ 이상으로 유지하고, 위험온도대인 5~6$0^{\circ}C$ 에 보관하는 것을 피함으로써 가열조리식품에서 미생물적 품질은 향상되었으며, 조리기구의 미생물적 품질도 HACCP 적용 후 향상되었다. 그러나 HACCP 적용 후에도 비가열 조리식품과 가열후처리식품에서의 미생물적 품질은 기준에 적합할 만큼 향상되지 않았다. 비가열조리식품과 가열후처리식품은 검수단계에서의 식재료 및 양념류의 철저한 품질 검사부터 배식단계의 배식온도까지 세심한 주의가 요구되며, 조리종사자의 개인위생과 조리기구의 교차오염도 신경을 써야 한다. 그러므로 식품안전성이 보장된 급식을 위해서는 단체급식소의 조리종사자를 대상으로 하는 HACCP 교육을 통하여 HACCP을 적용할 뿐 아니라 식품제조업체에서의 HACCP 적용 또한 절실히 필요한 것으로 사료된다.

• Structural Engineering and Mechanics
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• 제44권5호
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• pp.633-647
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• 2012

Applying Information Technology (IT) in practical engineering has become one of the most important issues in the past few decades, especially on internal solitary wave, intelligent robot interaction, artificial intelligence, fuzzy Lyapunov, tension leg platform (TLP), consumer and service quality. Other than affecting the traditional teaching mode or increasing the inter-relation with users, IT can also be connected with the current society by collecting the latest information from the internet. It is apparently a fashion-catching-up technology. Therefore, the learning of how to use IT facilities is becoming one of engineers' skills nowadays. In addition to studying how well engineers learn to operate IT facilities and apply them into teaching, how engineers' general capacity of information effects the results of learning IT are also discussed. This research introduces the "Combined TAM and TPB mode," to understand the situation of engineers using IT facilities.

• 대한한의학원전학회지
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• 제21권2호
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• pp.173-191
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• 2008

The Chuna(推拿) in Korea has been developed since 1990's. Korean Chuna which is the only one manual therapy done by medical doctor is riched by absorbing other nation's manual therapy like Chinese Tuina(中國推拿) and Chiropractic therapy of U.S.A. So, We find that Korean Chuna's peculiarity and development by comparing Chinese Tuina, Chiropractic of U.S.A and Japanese manual therapy which influenced establishment of Korean Chuna. We compared each manual therapy's history, development, diagnosis, correction and treatment of human body, frequently contacting disease and medical service of the present state. Korean Chuna has absorbed other nation's manual therapy and advantage of preserving muscle-skeleton and spinal disorder disease. But, for more prosperity, it needs union of various conception and diagnosis and more research and application to more various disease, for example in internal medicine, gynecology or pediatry and founding system as regular academic work inside the college the possibility which objection and it will practice more completeness. And as one of specialty apprentice doctor subject inside the hospital, the possibility of raising a quality improvement of study and research environment.

• 한국환경농학회지
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• 제27권4호
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• pp.456-459
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• 2008

Quality of rice grain changes during dry storage with internal physiological changes and external injury by organism. Storage rice changes by condition with respiration via variable temperature, hydrolysis enzyme reaction, lipid peroxidation occurs with change of palatability. During dry storage, physiological change with protein variation pattern was examined by image analysis on proteomic technology. Analysis revealed that protein activity had no change store at room temperature and store at $40^{\circ}C$, but decreased store at $60^{\circ}C$. Analysis of variable hydrophobic protein pattern revealed that protein activity of beta-tubulin, protein disulfide isomerase, vacuolar ATPase b subunit, globulin was not significantly decreased all dry and store condition. However, heat shock protein 70, and glutathione transferase was significantly decreased when rice dried at $60^{\circ}C$ compared with room temperature and $40^{\circ}C$ dry condition.

• Structural Engineering and Mechanics
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• 제53권6호
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• pp.1083-1104
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• 2015

This paper provides the results of an experimental investigation into the flexural behavior of continuous two-span unbonded post-tensioned high strength concrete (HSC) beams, strengthened by end-anchored CFRP laminates of different configurations in the hogging region. Implementing two different configurations of end-anchorage systems consisting of steel plates and bolts and carefully monitoring the development of strains throughout the load history using sufficiently large number of strain gauges, the response of beams including the observed crack propagations, beam deflection, modes of failure, capacity enhancement at service and ultimate and the amount of moment redistribution are measured, presented and discussed. The study is appropriate in the sense that it covers the more commonly occurring two span beams instead of the simply supported beams investigated by others. The experiments reconfirmed the finding of others that proper installation of composite strengthening system is most important in the quality of the bond which is essential for the internal transfer of forces. It was also found that for the tested two span continuous beams, the capacity enhancement is more pronounced at the serviceability level than the ultimate. This is an important finding as the design of these beams is mostly governed by the serviceability limit state signifying the appropriateness of the suggested strengthening method. The paper provides quantitative data on the amount of this capacity enhancement.