• Structural Monitoring and Maintenance
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• v.2 no.1
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• pp.49-64
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• 2015

This paper presents a method for assessing the risk of wave run-up and overtopping of existing coastal defences and for analysing the probability of failure of the structures under future hydraulic conditions. The recent UK climate projections are employed in the investigations of the influence of changing environments on the long-term performance of sea defences. In order to reduce the risk of wave run-up and overtopping caused by rising sea level and to maintain the present-day allowances for wave run-up height and overtopping discharge, the future necessary increase in crest level of existing structures is investigated. Various critical failure mechanisms are considered for reliability analysis, i.e., erosion of crest by wave overtopping, failure of seaside revetment, and internal erosions within earth sea dykes. The time-dependent reliability of sea dykes is analysed to give probability of failure with time. The results for an example earth dyke section show that the necessary increase in crest level is approximately double of sea level rise to maintain the current allowances. The probability of failure for various failure modes of the earth dyke has a significant increase with time under future hydraulic conditions.

• Journal of Ocean Engineering and Technology
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• v.16 no.4
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• pp.7-12
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• 2002

This study is aimed to find the scouring mechanism at the toe of rubble mound structures. To investigate the characteristics of scouring in front of the structure, experiments were performed with regular waves in a 2-D flume. The results of this study are as follows. 1) It can be said the characteristics of incident wave causes rolling and sliding of armour block. The difference of wave pressure on the slope, internal flow as well as settlement of armour block due to the weight cause scouring. 2) It is observed that scouring depth at the toe increased when wave height or period increased. The location of ultimate scouring and deposition depth moved seaward when wave period increased. 3) The failure of rubble mound structure was caused by waves or scouring. Failure by erosion increased with high waves and long waves. 4) Using surf-similarity parameter including characteristics of incident waves and structure, scouring and deposition pattern were found and their limit was formulated.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.90-95
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• 2003

Fracture behaviors of pipes with local wall thinning are very important for the integrity of nuclear power plant. In pipes of energy plants, sometimes, the local wall thinning may result from severe erosion-corrosion (E/C) damage. However, the effects of local wall thinning on strength and fracture behaviors of piping system were not well studied. In this paper, the monotonic bending tests were performed of full-scale welded and unwelded carbon steel pipes with local wall thinning. A monotonic bending load was applied to straight pipe specimens by four-point loading at ambient temperature without internal pressure. The observed failure modes were divided into four types; ovalization, crack initiation/growth after ovalization, local buckling and crack initiation/growth after local buckling. Also, the strengths of welded and unwelded piping system with local wall thinning were evaluated.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.1249-1253
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• 2007

제방은 제내지에 거주하는 인간의 재산과 삶을 방어하고, 홍수를 제어하는 가장 기본적인 수공구조물이다. 제방파괴 원인은 월류, 활동, 침식, 그리고 침투 등으로 분류되어 질 수 있다. 특히 간극수압에 의해 발생하는 침투는 제방 내부침식(internal erosion) 및 파이핑(piping) 등을 야기함으로서 제방파괴를 유도한다. 침투에 의한 제방파괴는 월류나 침식에 의한 제방파괴 유형보다 상대적으로 적으나, 다른 제방파괴 원인을 더욱 활성화 시키는 인자로 작용한다. 도시하천의 경우 높은 치수안전도를 적용하여 제방을 축조함에 따라 월류에 의한 붕괴보다 강우와 하천수의 복합요인에 의한 침투파괴가 중요한 문제로 대두되고 있다. 본 연구에서는 침투와 활동에 대한 안전성을 확보할 수 있는 침투보강기법인 단면확대기법에 대한 적용성 및 유의사항을 수치모의를 통해 검토하였다. 제방 비탈면 경사를 1:2 확대할 경우, 침투유속이 70 %정도 감소되는 것을 확인하였다. 그러나 단면확대기법은 홍수시 통수능과 제내지의 부지 확보 문제 등을 고려하여 적용하여야 하며, 도시하천에서 단면확대기법을 적용하는 데는 일정부분 한계를 가질 것으로 판단된다.

• Journal of Veterinary Clinics
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• v.12 no.1
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• pp.853-860
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• 1995

Two cases of guttural pouch mycosis in race horses were observed for clinical and pathological aspects of the disease to investigate etiology and pathogenesis of dysphagia and epistaxis of the horse. In case 1 showing prolonged dysphagic sign a diphtheritic membrane was confined to the guttural pouch involved with neuritis of the glossopharyngeal nerve due to fungal penetration. The other horse showing fatal recurrent epistaxis had lesion of mycetoma invading the internal carotid artery to provoke erosion of the artery. An Aspergillosis sp. was isolated from the guttural pouches of the two horses and identified as A nidulans.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2010.11a
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• pp.257-260
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• 2010

The purpose of this paper is to introduce a method to predict the case thermal insulation charred and erosion thickness as a function of the exposure time to combustion gases and in solid rocket motors. The sizing of the insulator requires a good estimation of the thermal and mechanical loads at the wall. The method is particularly suitable for internal insulation areas subjected to high radiative, convective heat fluxes and $Al_2O_3$ slag pool. The mathematical approach and lab-scale experiment were intentionally simplified in order to obtain some simple and rapid relationships particularly useful for trade-off studies and thermal insulation preliminary design. The method was utilized to compute the charred and erosion thicknesses of the insulation on the aft chamber domes. A comparison between theoretical and experimental insulator char thicknesses of the motor insulation is reported, indicating the applicability of the predictive method employed.

• Journal of Veterinary Clinics
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• v.26 no.4
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• pp.340-343
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• 2009

A 3-year-old, intact female Poong-san dog was presented with a 4-month history of erosive, erythematous dermatitis unresponsive to systemic antibiotics and glucocorticoids. Crust, erosion, and alopecia were noted on the ear pinnae, bridge of nose, and forelimb. Cytological evaluation of intact pustules showed isolated free-floating rounded acantholytic keratinocytes admixed with non-degenerated neutrophils and eosinophils. Results of histopathologic examination revealed the intra-epidermal pustules with predominant neutrophils, less eosinophils, and isolated and clustered acantholytic cells. A diagnosis of pemphigus foliaceus (PF) was made based on the history, clinical, cytological and histopathological results. The skin lesions had improved after systemic cyclosporine therapy. This case report demonstrates that cyclosporine, an immunosuppressive agent, can be used in the management of PF in dogs.

• IMMUNE NETWORK
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• v.15 no.3
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• pp.135-141
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• 2015

Dysfunction of gut immune regulation is involved in mucosal damage in inflammatory bowel disease (IBD). However, there is still no efficacious immune-regulator for the treatment of IBD. Alloferon is a novel immune-modulatory peptide that was originally isolated from infected insects. It shows anti-inflammatory effects by the regulation of cytokine production by immune cells and their activities. Therefore, we investigated the effect of alloferon in a mouse model of colitis using dextran sulfate sodium (DSS). Colitis was induced by administration of DSS in drinking water for 7 consecutive days. It was confirmed by the presence of weight loss, diarrhea, hematochezia, and colon contraction. Alloferon was injected 4 days after DSS administration. We found that alloferon improved the pathogenesis of IBD based on the reduced disease activity index (DAI) and colon contraction. Edema, epithelial erosion, and immune cell infiltration were found in mice administered DSS, but the phenomena were reduced following alloferon treatment. The plasma level of IL-6, a classical pro-inflammatory cytokine in colitis, was also decreased by alloferon. Moreover, alloferon inhibited the TNF-${\alpha}$-induced degradation and phosphorylation of $I{\kappa}B$ in Colo205 colon cancer cells. Taken together, these results show that alloferon has anti-inflammatory effects and attenuates DSS-induced colitis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.3
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• pp.639-644
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• 2009

The aim of this study was carried out to investigate the protective effect of Rhizoma Dioscoreae on the gastric mucosal lesions induced by alcohol in rats. Experimental groups were treated by oral infusion with Rhizoma Dioscoreae extract at the dose of 0.03465 g/ml(OA-RD1 group), 0.0693 g/ml(OA-RD2 group), and 0.1386 g/ml(OA-RD3 group), while D.W group was administrated with the distilled water and control group did not pretreated. Experimental groups pretreated for 14 days, and given orally 1 ml of 75% alcohol two times(30min interval). The animals were killed 1hr 30min after alcohol treatment, and measured rats body weight, absolute stomach weight, relative stomach weight, SOD activity, glutathione peroxidase(GPx) activity, observed gastric mucosal lesions. The body weight was unremarkable changed. In once as dose intake group's absolute stomach weight was increased and In once as dose intake group, twice as dose intake group's relative stomach weight was increased. SOD activity, glutathione peroxidase activity in twice as dose intake group is remarkably increased. Light microscopy Observations of congestion, hemorrhage, and erosion in gastric mucosal lesions were shown severely in control group than OA-RD1, OA-RD2, OA-RD3. These results suggest that the proposed gastroprotective effect may involve activation of antioxidant effect. And Twice as dose is especially effective.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.1
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• pp.8-17
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• 2003

Fracture behaviors of pipes with local wall thinning are very important for the integrity of nuclear Power Plant. In Pipes of energy Plants, sometimes, the local wall thinning may result from severe erosion-corrosion (E/C) damage. However, the effects of local wall thinning on strength and fracture behaviors of piping system were not well studied. In this paper, the monotonic bending tests were performed of full-scale carbon steel pipes with local wall thinning. A monotonic bending load was applied to straight pipe specimens by four-point loading at ambient temperature without internal pressure. From the tests, fracture behaviors and fracture strength of locally thinned pipe were manifested systematically. The observed failure modes were divided into four types; ovalization. crack initiation/growth after ovalization, local buckling and crack initiation/growth after local buckling. Also, the strength and the allowable limit of piping system with local wall thinning were evaluated.