Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Therapeutic Effect of Cyclosporine Administration in a Dog with Pemphigus Foliaceus

풍산견에서 발생한 낙엽성 천포창의 사이클로스포린 적용의 치료적 효과 증례

  • Kim, Jung-Hyun (Department of Veterinary Internal Medicine and Konkuk University) ;
  • Sur, Jung-Hyang (Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University) ;
  • Park, Chul (Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis) ;
  • Yoo, Jong-Hyun (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases, Konkuk University) ;
  • Kim, Ha-Jung (Department of Veterinary Internal Medicine and Konkuk University) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine and Konkuk University)
  • 김정현 (건국대학교 수의과대학 수의 내과학) ;
  • 서정향 (건국대학교 수의과대학 수의 병리학) ;
  • 박철 (캘리포니아주립대(데이비스)) ;
  • 유종현 (BK21 동물 질병 진단 및 치료 전문 수의인력 양성 사업단) ;
  • 김하정 (건국대학교 수의과대학 수의 내과학) ;
  • 박희명 (건국대학교 수의과대학 수의 내과학)
  • Published : 2009.08.31
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Abstract

A 3-year-old, intact female Poong-san dog was presented with a 4-month history of erosive, erythematous dermatitis unresponsive to systemic antibiotics and glucocorticoids. Crust, erosion, and alopecia were noted on the ear pinnae, bridge of nose, and forelimb. Cytological evaluation of intact pustules showed isolated free-floating rounded acantholytic keratinocytes admixed with non-degenerated neutrophils and eosinophils. Results of histopathologic examination revealed the intra-epidermal pustules with predominant neutrophils, less eosinophils, and isolated and clustered acantholytic cells. A diagnosis of pemphigus foliaceus (PF) was made based on the history, clinical, cytological and histopathological results. The skin lesions had improved after systemic cyclosporine therapy. This case report demonstrates that cyclosporine, an immunosuppressive agent, can be used in the management of PF in dogs.

3살령의 중성화 하지 않은 암컷 풍산개가 4개월 동안의 전신 항생제와 글루코 코르티코이드 치료에 반응하지 않는 미란성의 발적을 동반한 피부염을 주증상으로 내원하였다. 신체검사상 귀끝, 콧잔등과 앞다리에서 가피, 미란, 탈모가 관찰되었으며, 농포의 세포학적 검사에서 원형의 극세포해리성 각질세포들이 비퇴행성의 호중구, 호산구와 함께 관찰되었다. 조직병리학적 검사 결과, 표피내 농포에는 다수의 호중구, 소수의 호산구와 고립되거나 군집되어있는 해리성 극세포가 포함되어 있었다. 본 환자는 병력, 임상증상, 세포학적, 조직병리학적 검사를 통해 낙엽성 천포창으로 진단되었으며, 피부병변은 사이클로스포린의 경구 투약으로 개선되었다. 이 증례는 면역 억제제인 사이클로스포린의 단독 사용으로 개에서의 낙엽성 천포창을 치료 관리 할 수 있다는 것을 입증하였다.

Keywords

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