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Therapeutic Effect of Cyclosporine Administration in a Dog with Pemphigus Foliaceus  

Kim, Jung-Hyun (Department of Veterinary Internal Medicine and Konkuk University)
Sur, Jung-Hyang (Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University)
Park, Chul (Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis)
Yoo, Jong-Hyun (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases, Konkuk University)
Kim, Ha-Jung (Department of Veterinary Internal Medicine and Konkuk University)
Park, Hee-Myung (Department of Veterinary Internal Medicine and Konkuk University)
Publication Information
Journal of Veterinary Clinics / v.26, no.4, 2009 , pp. 340-343 More about this Journal
Abstract
A 3-year-old, intact female Poong-san dog was presented with a 4-month history of erosive, erythematous dermatitis unresponsive to systemic antibiotics and glucocorticoids. Crust, erosion, and alopecia were noted on the ear pinnae, bridge of nose, and forelimb. Cytological evaluation of intact pustules showed isolated free-floating rounded acantholytic keratinocytes admixed with non-degenerated neutrophils and eosinophils. Results of histopathologic examination revealed the intra-epidermal pustules with predominant neutrophils, less eosinophils, and isolated and clustered acantholytic cells. A diagnosis of pemphigus foliaceus (PF) was made based on the history, clinical, cytological and histopathological results. The skin lesions had improved after systemic cyclosporine therapy. This case report demonstrates that cyclosporine, an immunosuppressive agent, can be used in the management of PF in dogs.
Keywords
cyclosporine; dog; pemphigus foliaceus;
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