• Title/Summary/Keyword: interim analysis

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Comparative evaluation of the fitness of anterior and posterior interim crowns fabricated by additive manufacturing (적층가공 방식으로 제작한 전치와 구치 임시보철물의 적합도 비교)

  • Park, Young-Dae;Kang, Wol
    • Journal of Technologic Dentistry
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    • v.43 no.4
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    • pp.153-159
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    • 2021
  • Purpose: The purpose of this study was to assess the fitness of anterior and posterior interim crowns fabricated by three different additive manufacturing technologies. Methods: The working model was digitized, and single crowns (maxillary right central incisor and maxillary right first molar) were designed using computer-aided design software (DentalCad 2.2; exocad). On each abutment, interim crowns (n=60) were fabricated using three types of additive manufacturing technologies. Then, the abutment appearance and internal scan data of the interim crown was obtained using an intraoral scanner. The fitness of the interim crowns were evaluated by using the superimposition of the three-dimensional scan data (Geomagic Control X; 3D Systems). The one-way analysis of variance and Tukey posterior test were used to compare the results among groups (α=0.05). Results: A significant difference was found in the fitness of the interim crowns according to the type of additive manufacturing technology (p<0.05). The posterior interim crown showed smaller root mean square value than the anterior interim crown. Conclusion: Since the fitness of the posterior interim crown produced by three types of additive manufacturing technology were all within clinically acceptable range (<120 ㎛), it can be sufficiently used for the fabrication of interim crowns.

A new consideration for the heat transfer coefficient and an analysis of the thermal stress of the high-interim pressure turbine casing model (열전달계수에 대한 새로운 고찰 및 고-중압 터빈 케이싱 모형의 열응력 해석)

  • Um, Dall-Sun
    • Proceedings of the KSME Conference
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    • 2004.11a
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    • pp.425-429
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    • 2004
  • In real design of the high & interim pressure turbine casing, it is one of the important things to figure out its thermal strain exactly. In this paper, with the establishment of the new concept for the heat transfer coefficient of steam that is one of the factors in analysis of the thermal stress for turbine casing, an analysis was done for one of the high & interim pressure turbine casings in operating domestically. The sensitivity analysis of the heat transfer coefficient of steam to the thermal strain of the turbine casing was done with a 2-D simple model. The analysis was also done with switching of the material properties of the turbine casing and resulted in that the thermal strain of the turbine casing was not so sensitive to the heat transfer coefficient of steam. On the basis of this, 3-D analysis of the thermal strain for the high and interim pressure turbine casing was done.

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Determinants of The Level of Information Distribution on Financial Statement

  • Van Thi Hong NGUYEN;Anh Phuong PHAM
    • Journal of Distribution Science
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    • v.21 no.6
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    • pp.91-97
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    • 2023
  • Purpose: Interim financial statements provide timely and qualified financial information for users. Hence, the importance of the interim financial statement is increasingly noticeable among information users. This research studies determinants of interim financial statements disclosure in Vietnamese-listed enterprises. Research design, data and methodology: The sample is 55 enterprises listed in VNIndex and is in the list of Forbes top 100 largest companies in 2020. Data was collected from interim financial statements for four years, from 2018 to 2021. GMM is used in this study. Results: The regression analysis results show that reporting lag has a positive impact on the level of information distribution of interim financial reporting; companies audited by BIG4 tend to have a higher level of information disclosure. The higher the return on assets, the more disclosure is made; the larger the company size, the greater the disclosure level. Owner equity structure and Leverage do not affect the disclosure level of interim financial reporting. Conclusions: The information disclosure level on the interim financial statement should be improved to increase transparency. In addition to continuing to encourage these companies to provide more information voluntarily, government authorities should have effective regulations to require sufficient information disclosure from other listed companies.

Wear of 3D printed and CAD/CAM milled interim resin materials after chewing simulation

  • Myagmar, Gerelmaa;Lee, Jae-Hyun;Ahn, Jin-Soo;Yeo, In-Sung Luke;Yoon, Hyung-In;Han, Jung-Suk
    • The Journal of Advanced Prosthodontics
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    • v.13 no.3
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    • pp.144-151
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    • 2021
  • PURPOSE. The purpose of this in vitro study was to investigate the wear resistance and surface roughness of three interim resin materials, which were subjected to chewing simulation. MATERIALS AND METHODS. Three interim resin materials were evaluated: (1) three-dimensional (3D) printed (digital light processing type), (2) computer-aided design and computer-aided manufacturing (CAD/CAM) milled, and (3) conventional polymethyl methacrylate interim resin materials. A total of 48 substrate specimens were prepared. The specimens were divided into two subgroups and subjected to 30,000 or 60,000 cycles of chewing simulation (n = 8). The wear volume loss and surface roughness of the materials were compared. Statistical analysis was performed using one-way analysis of variance and Tukey's post-hoc test (α=.05). RESULTS. The mean ± standard deviation values of wear volume loss (in mm3) against the metal abrader after 60,000 cycles were 0.10 ± 0.01 for the 3D printed resin, 0.21 ± 0.02 for the milled resin, and 0.44 ± 0.01 for the conventional resin. Statistically significant differences among volume losses were found in the order of 3D printed, milled, and conventional interim materials (P<.001). After 60,000 cycles of simulated chewing, the mean surface roughness (Ra; ㎛) values for 3D printed, milled, and conventional materials were 0.59 ± 0.06, 1.27 ± 0.49, and 1.64 ± 0.44, respectively. A significant difference was found in the Ra value between 3D printed and conventional materials (P=.01). CONCLUSION. The interim restorative materials for additive and subtractive manufacturing digital technologies exhibited less wear volume loss than the conventional interim resin. The 3D printed interim restorative material showed a smoother surface than the conventional interim material after simulated chewing.

The Necessity of Independent Data Monitoring Committee in Domestic Clinical Trials (현재 국내임상시험에서 독립적 자료모니터링위원회의 필요성)

  • Kang, Seung-Ho
    • The Korean Journal of Applied Statistics
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    • v.22 no.2
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    • pp.317-327
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    • 2009
  • In adaptive designs important components of clinical trials may be changed based on the results of interim analysis. Several international guidelines point out that such interim analysis should be performed by independent experts who do not participate in clinical trials when adaptive designs are used in therapeutic confirmatory clinical trials, and if not, it may cause bias. The international guidelines recommend the establishment of independent data monitoring committee for conducting interim analysis independently.

A Study on Spatial Characteristics of Post-Disaster Interim Housing - Focusing on Asian Precedents of Natural Disasters - (재난 이후 임시주거의 공간특성 연구 - 아시아지역에서 발생한 자연재난을 중심으로 -)

  • Kim, sara;Nam, Kyung-Sook
    • Korean Institute of Interior Design Journal
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    • v.24 no.5
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    • pp.108-116
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    • 2015
  • This study intends to research the spatial characteristics of Asian interim housing that accommodates sufferers pro tempore after disasters. The scope of this research covers the interim spaces used for housing people after natural disasters that occurred in Asia for the past fifteen years. Within this scope, literature review was conducted as the basis to derive the characteristics and environmental elements of interim housing, which provided the criteria to compare and evaluate cases of interim housing along with characteristic elements required of interim housing found in previous studies. According to literature review, interim housing can be classified by life-span, region, economy, climate, type, number of household, square measure, residential cost, structure/material, and service life. Within the scope of the present research, literature review showed a total of twenty-eight cases of interim housing in fifteen countries revealing a high rate of disaster occurrence in the subtropic and tropic climate of Southeast Asia. A great percentage of interim housing was used for long-term stay of over a year. The structure of interim housing varied from lightweight steel, wooden, masonry, membrane, to traditional structure and the type were divided into temporary shelter, transitional housing, temporary housing, and permanent housing. Followed by literature review, the characteristics required of post-disaster interim housing were analyzed based on previous research and case studies. The characteristics of interim housing can be divided into environmental, technological, and socio-cultural ones. Sub-characterical items according to such division include amenity, health, surroundings, structure, convenience, eco-friendliness, safety, communication, and locality. As a result of evaluation, most items met the required characteristics of interim housing, while technological characteristics such as structure and convenience varied with the types of interim housing and appeared even unnecessary in some cases. According to analysis, amenity is maintained through the structural and material characteristics of interim housing and is also facilitated by increasing number of infrastructure such as educational, sanitary, and convenience facilities provided by the governmental and organizational bodies. It is expected that this study will be utilized as preliminary data for follow-up studies that improve the environment of post-disaster interim housing suitable for domestic circumstances in environmental, technological, and socio-cultural respects.

Modelling of the fire impact on CONSTOR RBMK-1500 cask thermal behavior in the open interim storage site

  • Robertas Poskas;Kestutis Rackaitis;Povilas Poskas;Hussam Jouhara
    • Nuclear Engineering and Technology
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    • v.55 no.7
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    • pp.2604-2612
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    • 2023
  • Spent nuclear fuel and long-lived radioactive waste must be carefully handled before disposing them off to a geological repository. After the pre-storage period in water pools, spent nuclear fuel is stored in casks, which are widely used for interim storage. Interim storage in casks is very important part in the whole cycle of nuclear energy generation. This paper presents the results of the numerical study that was performed to evaluate the thermal behavior of a metal-concrete CONSTOR RBMK-1500 cask loaded with spent nuclear fuel and placed in an open type interim storage facility which is under fire conditions (steady-state, fire, post-fire). The modelling was performed using the ANSYS Fluent code. Also, a local sensitivity analysis of thermal parameters on temperature variation was performed. The analysis demonstrated that the maximum increase in the fuel load temperatures is about 10 ℃ and 8 ℃ for 30 min 800 ℃ and 60 min 600 ℃ fires respectively. Therefore, during the fire and the post-fire periods, the fuel load temperatures did not exceed the 300 ℃ limiting temperature set for an RBMK SNF cladding for long-term storage. This ensures that fire accident does not cause overheating of fuel rods in a cask.

The Revision Guideline of Interim Measures of Protection under UNCITRAL Model Law on International Commercial Arbitration (UNCITRAL 모델중재법상 임시적 보호처분의 개정방향)

  • Lee Kang-Bin
    • Journal of Arbitration Studies
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    • v.14 no.2
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    • pp.73-106
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    • 2004
  • The UNCITRAL Arbitration Working Group began its deliberations on the topic of interim measures of protection at its thirty-second session (Vienna, 21-30 March 2000), when the Working Group expressed general support for a legal regime governing enforcement of interim measures of protection ordered by the arbitral tribunal. Also the Working Group took a preliminary analysis of whether there was a need for a uniform rule on court-ordered interim measures of protection in support of arbitration. The Working Group agreed, at its thirty-third session (Vienna, 20 November-1 December 2000), that the proposed new article to the UNCITRAL Model Law on International Commercial Arbitration on enforcement of interim measures of protection (tentatively numbered article 17 bis) should include an obligation on courts to enforce interim measures if prescribed conditions were met. At its thirty-fourth session (New York, 21 May-1 Jun 2001), in addition to continuing its review of draft article 17 bis, the Working Group proceeded to consider a text revising article 17 of the UNCITRAL Model Law, which defined the scope of an arbitral tribunal's power to order interim measures and included an additional provision on the granting of interim measures on an ex parte basis. Discussions in relation to revised drafts of article 17 and 17 bis of the UNCITRAL Model Law have continued at the fortieth session ( New York, 23-27 February 2004). Article 17 of the UNCITRAL Model Law provides that the arbitral tribunal may order any party to take such interim measure of protection as the arbitral tribunal may consider necessary in respect to the subject matter of the dispute. However it may be noted that the article does not deal with enforcement of such measures.

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Evaluating the accuracy (trueness and precision) of interim crowns manufactured using digital light processing according to post-curing time: An in vitro study

  • Lee, Beom-Il;You, Seung-Gyu;You, Seung-Min;Kim, Dong-Yeon;Kim, Ji-Hwan
    • The Journal of Advanced Prosthodontics
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    • v.13 no.2
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    • pp.89-99
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    • 2021
  • PURPOSE. This study aimed to compare the accuracy (trueness and precision) of interim crowns fabricated using DLP (digital light processing) according to post-curing time. MATERIALS AND METHODS. A virtual stone study die of the upper right first molar was created using a dental laboratory scanner. After designing interim crowns on the virtual study die and saving them as Standard Triangulated Language files, 30 interim crowns were fabricated using a DLP-type 3D printer. Additively manufactured interim crowns were post-cured using three different time conditions-10-minute post-curing interim crown (10-MPCI), 20-minute post-curing interim crown (20-MPCI), and 30-minute post-curing interim crown (30-MPCI) (n = 10 per group). The scan data of the external and intaglio surfaces were overlapped with reference crown data, and trueness was measured using the best-fit alignment method. In the external and intaglio surface groups (n = 45 per group), precision was measured using a combination formula exclusive to scan data (10C2). Significant differences in accuracy (trueness and precision) data were analyzed using the Kruskal-Wallis H test, and post hoc analysis was performed using the Mann-Whitney U test with Bonferroni correction (α=.05). RESULTS. In the 10-MPCI, 20-MPCI, and 30-MPCI groups, there was a statistically significant difference in the accuracy of the external and intaglio surfaces (P<.05). On the external and intaglio surfaces, the root mean square (RMS) values of trueness and precision were the lowest in the 10-MPCI group. CONCLUSION. Interim crowns with 10-minute post-curing showed high accuracy.

Monitoring of Clinical Trials: Issues and Recammendations

  • Fleming Thomas R.;Demets David L.
    • 대한예방의학회:학술대회논문집
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    • 1994.02b
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    • pp.270-284
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    • 1994
  • Interim analyses of randomized trials enable investigators to make more efficient use of limited research resources and to satisfy ethical requirements that a regimen be discontinued as soon as it has been established to have an inferior efficacy/toxicity profile. Unfortunately. the integrity and credibility of these trials can be compromised if inappropriate procedures are used in monitoring interim data. 'In this paper we discuss how group sequential designs provide useful guidelines that enable one to satisfy the valid objectives of interim monitoring while avoiding undesirable consequences, and we consider how flexible one can be in the way such designs are implemented. We also provide motivation for the role of data-monitoring committees in preserving study integrity and credibility in either government- or industry-sponsored trials. In our view. these committees should have multidisciplinary representation and membership limited to individuals free of apparent significant conflict of interest, and ideally should be the only individuals to whom the data analysis center provides interim results on relative efficacy of treatment regimens. Finally. we discuss some important practical issues such as estimation following group sequential testing, anal ysis of secondary outcomes after using a group sequential design applied to a primary outcome, early stopping of negative trials. and the role of administrative analyses.

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