• Proceedings of the Korea Society for Simulation Conference
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• 1998.03a
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• pp.74-77
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• 1998

This paper presents a real design and implementation of an intelligent client-server equipment controller in computer-integrated manufacturing systems. An automated manufacturing process is commonly controlled by a number of PLC (Programmable Logic Controllers), which are attached to various equipments. A manufacturing cell consists of a set of equipments or workstation, which are also controlled by equipment or cell controller. We propose an intelligent equipment controller which has two function: one is to request (collect) an important information from each equipment and the other is to send the collected equipment information to the upper level controller (shop floor controller). Two-phase approaches are considered for the development of equipment client-server controller. The first events are generated virtually using computer simulation. Using the virtually generated activities, operating software of equipment server is developed. The second phase is to embed the virtually developed software (controller) into a real manufacturing system. The proposed methodology might be a novel design and implementation of a virtual simulator, which could be used for developing an intelligent equipment server.

• Development and Reproduction
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• v.22 no.3
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• pp.225-234
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• 2018

A new embryonic cell line (OFEC-17FEN) derived from olive flounder Paralichthys olivaceus was developed. OFEC-17FEN cells were subcultured for <30 passages over ~200 days. OFEC-17FEN cells had a doubling time of 114.34 h and modal diploid chromosome number was 48. The pluripotency genes POU5f1 and NANOG were expressed in OFEC-17FEN cells. However, the lack of several pluripotency-related genes expression indicates that OFEC-17FEN cells are not stem cells. OFEC-17FEN cells transfected with plasmid pEGFP-c1 exhibited a strong green fluorescent signal at 48 h after transfection. Accordingly, OFEC-17FEN cells may be useful for both basic research and biotechnological application.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.4
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• pp.805-815
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• 1994

The development of automatic production systems has a trend toward Computer Integrated Manufacturing System(CIMS) in recent years. In hardware configuration, CIMS are composed of intelligent CAD/CAM work stations, multifunction CNC machining centers including material handling systems. The DNC systems present the key element of automation hierarchy in a FMS. A DNC system is one which connects a number of numerically-controlled machines to a common memory in a digital computer for part program storage with provision for on-demand distribution of part program data to machines using communication in hierarchical structure of central computer, control computer and cell controller. This paper describes the development of Behind-the-Tape-Reader(BTR) type DNC system using CYBER 180-830 as a central computer and IBM PC-386 cell control computer and NC lathe with FANUC 5T NC controller. In this system, the connection between central computer and cell control computer is done via RS-232C serial interface board, and the connection between cell control computer and FANUC 5T controller is done via parallel interface board. The software consists of two module, central computer communication module for NC program downloading and status uploading, NC machine running module for NC operating.

• Journal of Photoscience
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• v.9 no.2
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• pp.258-260
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• 2002

We investigated the interaction of serotonin and galanin (GA) by a double immunostaining method in the Japanese quail. Serotonin-immunoreactive (IR) cells were located in the paraventricular organ (PVO) and infundibular nucleus (IF). The number of the cells under short-day photoperiod (SD) was less in the dark phase than in the light phase. GA-IR cells were found in the PVO, IF and median eminence. The number of GA-IR cells in SD was significantly greater than that in long-day photoperiod (LD). Numerous GA- IR varicose fibers ran along serotonin- IR cell bodies and nerve fibers in the PVO and IF of the same sections. Very few serotonin-IR fibers ran along GA-IR cell bodies and GA-IR nerve fibers in the ventral part of the IF. The present results suggest that the possibility of functional interaction takes place between serotonin- and GA- IR neurons in the PVO and IF.

• The Plant Pathology Journal
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• v.24 no.4
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• pp.407-416
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• 2008

Studies were conducted to determine the effects of temperature, solute potential and carbon source on the mycelial growth, sclerotia development, and apothecium production of an isolate of Sclerotinia sclerotiorum. Mycelial growth rate was greatest at $25^{\circ}C$ on potato dextrose agar (PDA) medium amended with up to 2% NaCl (${\psi}s{\leq}1.91\;MPa$) and thereafter, growth rate declined. The least number of sclerotia were produced at $20^{\circ}C$on both PDA and malt extract agar (MEA) amended with 8% NaCl (${\psi}s=6.62\;MPa$). With increasing temperature and decreasing solute potential the number and size of sclerotia were significantly reduced. The combined effect of temperature, solute potential and carbon source on sclerotia production were highly significant and had an impact on the development of the rind layer cells of sclerotia. These cells lacked a transparent cell wall which was surrounded by a compact melanized layer, and some of these cells appeared to be devoid of cell contents or were totally vacuolated. The survival of the sclerotia with increase in salinity and temperature appeared to affect melanization and the nature of the rind cells. The observations of this study re-enforces the need for an integrated disease management to control S. sclerotiorum.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.6 no.6
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• pp.1522-1545
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• 2012

Call admission control (CAC) plays an important role in mobile cellular network to guarantee the quality of service (QoS). In this paper, a dynamic hybrid CAC scheme with integrated cutoff priority and handoff queue for mobile cellular network is proposed and some performance metrics are derived. The unique characteristic of the proposed CAC scheme is that it can support any number of service types and that the cutoff thresholds for handoff calls are dynamically adjusted according to the number of service types and service priority index. Moreover, timeouts of handoff calls in queues are also considered in our scheme. By modeling the proposed CAC scheme with a one-dimensional Markov chain (1DMC), some performance metrics are derived, which include new call blocking probability ($P_{nb}$), forced termination probability (PF), average queue length, average waiting time in queue, offered traffic utilization, wireless channel utilization and system performance which is defined as the ratio of channel utilization to Grade of Service (GoS) cost function. In order to validate the correctness of the derived analytical performance metrics, simulation is performed. It is shown that simulation results match closely with the derived analytic results in terms of $P_{nb}$ and PF. And then, to show the advantage of 1DMC modeling for the performance analysis of our proposed CAC scheme, the computing complexity of multi-dimensional Markov chain (MDMC) modeling in performance analysis is analyzed in detail. It is indicated that state-space cardinality, which reflects the computing complexity of MDMC, increases exponentially with the number of service types and total channels in a cell. However, the state-space cardinality of our 1DMC model for performance analysis is unrelated to the number of service types and is determined by total number of channels and queue capacity of the highest priority service in a cell. At last, the performance comparison between our CAC scheme and Mahmoud ASH's scheme is carried out. The results show that our CAC scheme performs well to some extend.

• IEMEK Journal of Embedded Systems and Applications
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• v.11 no.2
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• pp.97-105
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• 2016

Microcontrollers (MCUs) for endpoint smart sensor devices of internet-of-thing (IoT) are being implemented as system-on-chip (SoC) with on-chip instruction flash memory, in which user firmware is embedded. MCUs directly fetch binary code-based instructions through bit-line sense amplifier (S/A) integrated with on-chip flash memory. The S/A compares bit cell current with reference current to identify which data are programmed. The S/A in reading '0' (erased) cell data consumes a large sink current, which is greater than off-current for '1' (programmed) cell data. The main motivation of our approach is to reduce the number of accesses of erased cells by binary code level transformation. This paper proposes a built-in write/read path architecture using binary code inversion method based on hot-spot region detection of instruction code access to reduce sensing current in S/A. From the profiling result of instruction access patterns, hot-spot region of an original compiled binary code is conditionally inverted with the proposed bit-inversion techniques. The de-inversion hardware only consumes small logic current instead of analog sink current in S/A and it is integrated with the conventional S/A to restore original binary instructions. The proposed techniques are applied to the fully-custom designed MCU with ARM Cortex-M0$^{TM}$ using 0.18um Magnachip Flash-embedded CMOS process and the benefits in terms of power consumption reduction are evaluated for Dhrystone$^{TM}$ benchmark. The profiling environment of instruction code executions is implemented by extending commercial ARM KEIL$^{TM}$ MDK (MCU Development Kit) with our custom-designed access analyzer.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.7A
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• pp.964-972
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• 1999

In this paper, we proposed a simulation model to which apply the AAL 2 (AAL type 2) between BSC and MSC in the cellular mobile communication systems. We suggested the frame structure of processing the packets of short length and the scheme which multiplex to one or more ATM cell. Also, we analyzed the performance of the APR, transmission delay, and channel transmission efficiency used in the packetized voice traffic and the low bit-rate data traffic such as fax. From the simulation results, the maximum number of users are 47 users without using AAL 2 multiplexing, but the maximum number of users are 70 (Non-Overlapping scheme) users, 110 (Overlapping scheme) users, respectively. Thus, we knew that the Overlapping scheme is more efficient than the Non-Overlapping scheme. Finally, we showed that the optimum transmission buffer size is 4 ATM cells in the cellular communication systems with the bandwidth of 2 Mbps.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.8A
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• pp.1160-1168
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• 2000

This paper presents a real-time integrated traffic management (RITM) scheme that can effectively manage variable bit rate (VBR) and available bit rate (ABR) traffics having unpredictable characteristics in asynchronous transfer mode (ATM) networks. An unique feature of this scheme is that it has a special ATM cell control block which makes it possible to monitor bursty traffics in real-time so that the delay incurred to measure cell arrival rate is minimized. Additionally, the proposed scheme intends to dynamically reassign the leftover network resources to VBR/ABR connections without any deterioration in quality of service (QoS) of the existing connections. The RITM scheme has been verified to reliably monitor incoming traffics and to efficiently manage network resources by computer simulations. The capability of managing the incoming ATM traffics in real-time helps determine an optimal acceptable number of user connections for a given network condition. We can use this value as a threshold to protect the network from being congested and to find out a cost-effective buffer design method.

• Biomolecules & Therapeutics
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• v.19 no.1
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• pp.1-8
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• 2011

G-protein coupled receptors (GPCRs) constitute an important class of drug targets and are involved in every aspect of human physiology including sleep regulation, blood pressure, mood, food intake, perception of pain, control of cancer growth, and immune response. Radiometric assays have been the classic method used during the search for potential therapeutics acting at various GPCRs for most GPCR-based drug discovery research programs. An increasing number of diverse small molecules, together with novel GPCR targets identified from genomics efforts, necessitates the use of high-throughput assays with a good sensitivity and specificity. Currently, a wide array of high-throughput tools for research on GPCRs is available and can be used to study receptor-ligand interaction, receptor driven functional response, receptor-receptor interaction,and receptor internalization. Many of the assay technologies are based on luminescence or fluorescence and can be easily applied in cell based models to reduce gaps between in vitro and in vivo studies for drug discovery processes. Especially, cell based models for GPCR can be efficiently employed to deconvolute the integrated information concerning the ligand-receptor-function axis obtained from label-free detection technology. This review covers various platform technologies used for the research of GPCRs, concentrating on the principal, non-radiometric homogeneous assay technologies. As current technology is rapidly advancing, the combination of probe chemistry, optical instruments, and GPCR biology will provide us with many new technologies to apply in the future.