| 1 |
Vilardaga, J. P., Nikolaev, V. O., Lorenz, K., Ferrandon, S., Zhuang,
Z. and Lohse, M. J. (2008) Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling.
Nat. Chem. Biol. 4, 126-131.
DOI
|
| 2 |
Waldhoer, M., Fong, J., Jones, R. M., Lunzer, M. M., Sharma, S. K.,
Kostenis, E., Portoghese, P. S. and Whistler, J. L. (2005) A heterodimer-selective agonist shows in vivo relevance of G proteincoupled
receptor dimers. Proc. Natl. Acad. Sci. USA. 102, 9050-9055.
DOI
|
| 3 |
Wang, H. B., Guan, J. S., Bao, L. and Zhang, X. (2008) Distinct subcellular
distribution of delta-opioid receptor fused with various tags in
PC12 cells. Neurochem. Res. 33, 2028-2034.
DOI
|
| 4 |
Wu, S. and Liu, B. (2005). Application of scintillation proximity assay in
drug discovery. Bio. Drugs 19, 383-392.
|
| 5 |
Xie, Z., Bhushan, R. G., Daniels, D. J. and Portoghese, P. S. (2005) Interaction
of bivalent ligand KDN21 with heterodimeric delta-kappa
opioid receptors in human embryonic kidney 293 cells. Mol. Pharmacol.
68, 1079-1086.
DOI
|
| 6 |
Zhao, X., Jones, A., Olson, K. R., Peng, K., Wehrman, T., Park, A.,
Mallari, R., Nebalasca, D., Young, S. W. and Xiao, S. H. (2008)
A homogeneous enzyme fragment complementation-based beta-arrestin
translocation assay for high-throughput screening of G-protein-coupled receptors. J. Biomol. Screen 13, 737-747.
DOI
|
| 7 |
Soriano, A., Ventura, R., Molero, A., Hoen, R., Casado, V., Cortes, A.,
Fanelli, F., Albericio, F., Lluis, C., Franco, R. and Royo, M. (2009)
Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist
bivalent ligands as pharmacological tools to detect A2A-D2 receptor
heteromers. J. Med. Chem. 52, 5590-5602.
DOI
|
| 8 |
Stables, J., Green, A., Marshall, F., Fraser, N., Knight, E., Sautel, M.,
Milligan, G., Lee, M. and Rees, S. (1997) A bioluminescent assay
for agonist activity at potentially any G-protein-coupled receptor.
Anal. Biochem. 252, 115-126.
DOI
|
| 9 |
Tamayama, T., Maemura, K., Kanbara, K., Hayasaki, H., Yabumoto, Y.,
Yuasa, M. and Watanabe, M. (2005) Expression of GABA(A) and
GABA(B) receptors in rat growth plate chondrocytes: activation of
the GABA receptors promotes proliferation of mouse chondrogenic
ATDC5 cells. Mol. Cell Biochem. 273, 117-126.
DOI
|
| 10 |
Tabata, T., Araishi, K., Hashimoto, K., Hashimotodani, Y., van der Putten,
H., Bettler, B. and Kano, M. (2004) Ca2+ activity at GABAB receptors
constitutively promotes metabotropic glutamate signaling
in the absence of GABA. Proc. Natl. Acad. Sci. USA. 101, 16952-16957.
DOI
|
| 11 |
Toms, N. J. and Roberts, P. J. (1999) Group 1 mGlu receptors elevate
[Ca2+]i in rat cultured cortical type 2 astrocytes: [Ca2+]i synergy
with adenosine A1 receptors. Neuropharmacology 38, 1511-1517.
DOI
|
| 12 |
Verdonk, E., Johnson, K., McGuinness, R., Leung, G., Chen, Y. W.,
Tang, H. R., Michelotti, J. M. and Liu, V. F. (2006) Cellular dielectric
spectroscopy: a label-free comprehensive platform for functional
evaluation of endogenous receptors. Assay Drug Dev. Technol. 4,
609-619.
DOI
|
| 13 |
Vidi, P. A. and Watts, V. J. (2009) Fluorescent and bioluminescent protein-fragment complementation assays in the study of G protein-coupled
receptor oligomerization and signaling. Mol. Pharmacol.
75, 733-739.
DOI
|
| 14 |
Rink, T. J. (1990) Receptor-mediated calcium entry. FEBS Lett. 268,
381-385.
DOI
|
| 15 |
Rives, M. L., Vol, C., Fukazawa, Y., Tinel, N., Trinquet, E., Ayoub, M.
A., Shigemoto, R., Pin, J. P. and Prezeau, L. (2009) Crosstalk
between GABAB and mGlu1a receptors reveals new insight into
GPCR signal integration. EMBO J. 28, 2195-2208.
DOI
|
| 16 |
Rozenfeld, R. and Devi, L. A. (2010) Receptor heteromerization and
drug discovery. Trends Pharmacol. Sci. 31, 124-130.
DOI
|
| 17 |
Shenoy, S. K. and Lefkowitz, R. J. (2003) Multifaceted roles of beta-arrestins
in the regulation of seven-membrane-spanning receptor
traffi cking and signalling. Biochem. J. 375, 503-515.
DOI
|
| 18 |
Rubenstein, K. (2008). GPCRs: Dawn of a new era? Insight Pharma. Reports., Needham.
|
| 19 |
Sanger, G. J., Westaway, S. M., Barnes, A. A., Macpherson, D. T., Muir,
A. I., Jarvie, E. M., Bolton, V. N., Cellek, S., Naslund, E., Hellstrom,
P. M., Borman, R. A., Unsworth, W. P., Matthews, K. L. and Lee, K.
(2009) GSK962040: a small molecule, selective motilin receptor
agonist, effective as a stimulant of human and rabbit gastrointestinal
motility. Neurogastroenterol. Motil. 21, 657-664, e630-651.
DOI
|
| 20 |
Schroder, R., Janssen, N., Schmidt, J., Kebig, A., Merten, N., Hennen,
S., Muller, A., Blattermann, S., Mohr-Andra, M., Zahn, S., Wenzel,
J., Smith, N. J., Gomeza, J., Drewke, C., Milligan, G., Mohr, K. and
Kostenis, E. (2010) Deconvolution of complex G protein-coupled
receptor signaling in live cells using dynamic mass redistribution
measurements. Nat. Biotechnol. 28, 943-949.
DOI
|
| 21 |
Small, K. M., Schwarb, M. R., Glinka, C., Theiss, C. T., Brown, K. M.,
Seman, C. A. and Liggett, S. B. (2006) Alpha2A- and alpha2C-adrenergic
receptors form homo- and heterodimers: the heterodimeric
state impairs agonist-promoted GRK phosphorylation and
beta-arrestin recruitment. Biochemistry 45, 4760-4767.
DOI
|
| 22 |
Maurel, D., Comps-Agrar, L., Brock, C., Rives, M. L., Bourrier, E., Ayoub,
M. A., Bazin, H., Tinel, N., Durroux, T., Prezeau, L., Trinquet,
E. and Pin, J. P. (2008) Cell-surface protein-protein interaction
analysis with time-resolved FRET and snap-tag technologies: application
to GPCR oligomerization. Nat. Methods 5, 561-567.
DOI
|
| 23 |
Maurel, D., Kniazeff, J., Mathis, G., Trinquet, E., Pin, J. P. and Ansanay,
H. (2004) Cell surface detection of membrane protein interaction
with homogeneous time-resolved fl uorescence resonance energy
transfer technology. Anal. Biochem. 329, 253-262.
DOI
|
| 24 |
Perry, S. J. and Lefkowitz, R. J. (2002) Arresting developments in heptahelical
receptor signaling and regulation. Trends Cell Biol. 12,
130-138.
DOI
|
| 25 |
McGrath, J. C., Arribas, S. and Daly, C. J. (1996) Fluorescent ligands
for the study of receptors [published erratum appears in Trends
Pharmacol Sci 1997 May;18(5):181]. Trends Pharmacol. Sci. 17,
393-399.
DOI
|
| 26 |
McGuinness, D., Malikzay, A., Visconti, R., Lin, K., Bayne, M., Monsma,
F. and Lunn, C. A. (2009) Characterizing cannabinoid CB2 receptor
ligands using DiscoveRx PathHunter beta-arrestin assay. J.
Biomol. Screen 14, 49-58.
|
| 27 |
Oakley, R. H., Hudson, C. C., Cruickshank, R. D., Meyers, D. M.,
Payne, R. E. Jr., Rhem, S. M. and Loomis, C. R. (2002) The cellular
distribution of fl uorescently labeled arrestins provides a robust,
sensitive, and universal assay for screening G protein-coupled receptors. Assay Drug Dev. Technol. 1, 21-30.
DOI
|
| 28 |
Peters, M. F., Knappenberger, K. S., Wilkins, D., Sygowski, L. A.,
Lazor, L. A., Liu, J. and Scott, C. W. (2007) Evaluation of cellular
dielectric spectroscopy, a whole-cell, label-free technology for drug
discovery on Gi-coupled GPCRs. J. Biomol. Screen 12, 312-319.
DOI
|
| 29 |
Pinilla, C., Appel, J. R., Borras, E. and Houghten, R. A. (2003) Advances
in the use of synthetic combinatorial chemistry: mixture-based
libraries. Nat. Med 9, 118-122.
DOI
|
| 30 |
Le Poul, E., Hisada, S., Mizuguchi, Y., Dupriez, V. J., Burgeon, E. and
Detheux, M. (2002) Adaptation of aequorin functional assay to high
throughput screening. J. Biomol. Screen. 7, 57-65.
DOI
|
| 31 |
Lee, S., Kim, G. D., Park, W. K., Cho, H., Lee, B. H., Yoo, S. E. and
Jae Yang, K. (2006) Development of a time-resolved fl uorometric
assay for the high throughput screening of melanin concentrating
hormone receptor antagonists. J. Pharmacol. Toxicol. Methods. 53,
242-247.
DOI
|
| 32 |
Lohse, M. J., Benovic, J. L., Codina, J., Caron, M. G. and Lefkowitz,
R. J. (1990). beta-Arrestin: a protein that regulates beta-adrenergic
receptor function. Science 248, 1547-1550.
DOI
|
| 33 |
Lefkowitz, R. J. (2004) Historical review: a brief history and personal
retrospective of seven-transmembrane receptors. Trends Pharmacol.
Sci. 25, 413-422.
DOI
|
| 34 |
Lin, F. T., Miller, W. E., Luttrell, L. M. and Lefkowitz, R. J. (1999) Feedback
regulation of beta-arrestin1 function by extracellular signal-regulated
kinases. J. Biol. Chem. 274, 15971-15974.
DOI
|
| 35 |
Liu, J., Gallagher, M., Horlick, R. A., Robbins, A. K. and Webb, M. L.
(1998) A time resolved fluorometric assay for galanin receptors. J.
Biomol. Screen 3, 19-27.
DOI
|
| 36 |
Luttrell, L. M. and Lefkowitz, R. J. (2002) The role of beta-arrestins
in the termination and transduction of G-protein-coupled receptor
signals. J. Cell. Sci. 115, 455-465.
|
| 37 |
Maeda, A., Nishimura, S., Kameda, K., Imagawa, T., Shigekawa, M.
and Barsoumian, E. L. (1996) Generation of cell transfectants expressing
cardiac calcium ion channel and calcium indicator protein
aequorin. Anal. Biochem. 242, 31-39.
DOI
|
| 38 |
Marcellino, D., Ferre, S., Casado, V., Cortes, A., Le Foll, B., Mazzola,
C., Drago, F., Saur, O., Stark, H., Soriano, A., Barnes, C., Goldberg,
S. R., Lluis, C., Fuxe, K. and Franco, R. (2008) Identifi cation
of dopamine D1-D3 receptor heteromers. Indications for a role
of synergistic D1-D3 receptor interactions in the striatum. J. Biol.
Chem. 283, 26016-26025.
DOI
|
| 39 |
Handl, H. L. and Gillies, R. J. (2005) Lanthanide-based luminescent
assays for ligand-receptor interactions. Life Sci. 77, 361-371.
DOI
|
| 40 |
Handl, H. L., Vagner, J., Yamamura, H. I., Hruby, V. J. and Gillies, R.
J. (2004) Lanthanide-based time-resolved fl uorescence of in cyto
ligand-receptor interactions. Anal. Biochem. 330, 242-250.
DOI
|
| 41 |
Hirono, M., Yoshioka, T. and Konishi, S. (2001) GABA(B) receptor activation
enhances mGluR-mediated responses at cerebellar excitatory
synapses. Nat. Neurosci. 4, 1207-1216.
|
| 42 |
Handl, H. L., Vagner, J., Yamamura, H. I., Hruby, V. J. and Gillies, R.
J. (2005) Development of a lanthanide-based assay for detection
of receptor-ligand interactions at the delta-opioid receptor. Anal.
Biochem. 343, 299-307.
DOI
|
| 43 |
Hedley, L., Phagoo, S. B. and James, I. F. (1996) Measurement of intracellular
calcium in cell populations loaded with aequorin: neurokinin-1 responses in U373MG cells. Anal. Biochem. 236, 270-274.
DOI
|
| 44 |
Hemmila, I. I. (1999) LANCEtrade mark: Homogeneous Assay Platform
for HTS. J. Biomol. Screen. 4, 303-308.
DOI
|
| 45 |
Inglese, J., Samama, P., Patel, S., Burbaum, J., Stroke, I. L. and Appell,
K. C. (1998) Chemokine receptor-ligand interactions measured using
time-resolved fluorescence. Biochemistry 37, 2372-2377.
DOI
|
| 46 |
Jalink, K. and Moolenaar, W. H. (2010) G protein-coupled receptors:
the inside story. Bioessays 32, 13-16.
DOI
|
| 47 |
Jansson, C. C., Pohjanoksa, K., Lang, J., Wurster, S., Savola, J. M.
and Scheinin, M. (1999) Alpha2-adrenoceptor agonists stimulate
high-affi nity GTPase activity in a receptor subtype-selective manner.
Eur. J. Pharmacol. 374, 137-146.
DOI
|
| 48 |
Kamikubo, Y., Tabata, T., Kakizawa, S., Kawakami, D., Watanabe, M.,
Ogura, A., Iino, M. and Kano, M. (2007) Postsynaptic GABAB receptor
signalling enhances LTD in mouse cerebellar Purkinje cells.
J. Physiol. 585, 549-563.
DOI
|
| 49 |
Franco, R., Casado, V., Cortes, A., Mallol, J., Ciruela, F., Ferre, S.,
Lluis, C. and Canela, E. I. (2008) G-protein-coupled receptor heteromers:
function and ligand pharmacology. Br. J. Pharmacol.
153(Suppl 1), S90-98.
DOI
|
| 50 |
Gagne, A., Banks, P. and Hurt, S. D. (2002) Use of fl uorescence polarization
detection for the measurement of fl uopeptidet binding to G
protein-coupled receptors. J. Recept. Signal. Transduct. Res. 22,
333-343.
DOI
|
| 51 |
Gainetdinov, R. R., Premont, R. T., Bohn, L. M., Lefkowitz, R. J. and
Caron, M. G. (2004) Desensitization of G protein-coupled receptors
and neuronal functions. Annu. Rev. Neurosci. 27, 107-144.
DOI
|
| 52 |
Gao, X., Hsu, C. K., Heinz, L. J., Morin, J., Shi, Y., Shukla, N. K., Smiley,
D. L., Xu, J., Zhong, B. and Slieker, L. J. (2004) Europiumlabeled
melanin-concentrating hormone analogues: ligands for
measuring binding to melanin-concentrating hormone receptors 1
and 2. Anal. Biochem. 328, 187-195.
DOI
|
| 53 |
Glickman, J. F., Schmid, A. and Ferrand, S. (2008) Scintillation proximity
assays in high-throughput screening. Assay. Drug. Dev. Technol.
6, 433-455.
DOI
|
| 54 |
Gonzalez-Maeso, J., Ang, R. L., Yuen, T., Chan, P., Weisstaub, N. V.,
Lopez-Gimenez, J. F., Zhou, M., Okawa, Y., Callado, L. F., Milligan,
G., Gingrich, J. A., Filizola, M., Meana, J. J. and Sealfon, S.
C. (2008) Identifi cation of a serotonin/glutamate receptor complex
implicated in psychosis. Nature 452, 93-97.
DOI
|
| 55 |
Hamdan, F. F., Percherancier, Y., Breton, B. and Bouvier, M. (2006)
Monitoring protein-protein interactions in living cells by bioluminescence
resonance energy transfer (BRET). Curr Protoc Neurosci.
Chapter 5, Unit 5. 23, John Wiley & Sons, Somerset.
|
| 56 |
Hampton, S. L. and Kinnaird, A. I. (2010) Genetic interventions in
mammalian cells; applications and uses in high-throughput screening
and drug discovery. Cell Biol. Toxicol. 26, 43-55.
DOI
|
| 57 |
Dodgson, K., Gedge, L., Murray, D. C. and Coldwell, M. (2009) A
100K well screen for a muscarinic receptor using the Epic labelfree
system--a refl ection on the benefi ts of the label-free approach
to screening seven-transmembrane receptors. J. Recept. Signal.
Transduct. Res. 29, 163-172.
DOI
|
| 58 |
Fan, F., Binkowski, B. F., Butler, B. L., Stecha, P. F., Lewis, M. K. and
Wood, K. V. (2008) Novel genetically encoded biosensors using
firefly luciferase. ACS Chem. Biol. 3, 346-351.
DOI
|
| 59 |
Dupriez, V. J., Maes, K., Le Poul, E., Burgeon, E. and Detheux, M.
(2002) Aequorin-based functional assays for G-protein-coupled receptors,
ion channels, and tyrosine kinase receptors. Receptors
Channels 8, 319-330.
DOI
|
| 60 |
Eapen, M. S., Sodhi, R., Balakrishnan, G., Dastidar, S., Ray, A. and
Vijayakrishnan, L. (2010) Evaluation of nonradioactive cell-free
cAMP assays for measuring in vitro phosphodiesterase activity.
Pharmacology 85, 280-285.
DOI
|
| 61 |
Ferre, S., Baler, R., Bouvier, M., Caron, M. G., Devi, L. A., Durroux,
T., Fuxe, K., George, S. R., Javitch, J. A., Lohse, M. J., Mackie,
K., Milligan, G., Pfl eger, K. D., Pin, J. P., Volkow, N. D., Waldhoer,
M., Woods, A. S. and Franco, R. (2009) Building a new conceptual
framework for receptor heteromers. Nat. Chem. Biol. 5, 131-134.
DOI
|
| 62 |
Ferre, S., Karcz-Kubicha, M., Hope, B. T., Popoli, P., Burgueno, J.,
Gutierrez, M. A., Casado, V., Fuxe, K., Goldberg, S. R., Lluis, C.,
Franco, R. and Ciruela, F. (2002) Synergistic interaction between
adenosine A2A and glutamate mGlu5 receptors: implications for
striatal neuronal function. Proc. Natl. Acad. Sci. USA. 99, 11940-11945.
DOI
|
| 63 |
Ferre, S., Navarro, G., Casado, V., Cortes, A., Mallol, J., Canela, E.
I., Lluis, C. and Franco, R. (2010) G protein-coupled receptor heteromers
as new targets for drug development. Prog. Mol. Biol.
Transl. Sci. 91, 41-52.
DOI
|
| 64 |
Fiorentini, C., Busi, C., Gorruso, E., Gotti, C., Spano, P. and Missale,
C. (2008) Reciprocal regulation of dopamine D1 and D3 receptor
function and traffi cking by heterodimerization. Mol. Pharmacol. 74,
59-69.
DOI
|
| 65 |
Calebiro, D., Nikolaev, V. O., Persani, L. and Lohse, M. J. (2010) Signaling
by internalized G-protein-coupled receptors. Trends. Pharmacol.
Sci. 31, 221-228.
DOI
|
| 66 |
Daly, C. J. and McGrath, J. C. (2003) Fluorescent ligands, antibodies,
and proteins for the study of receptors. Pharmacol. Ther. 100,
101-118.
DOI
|
| 67 |
Chen, X. P., Yang, W., Fan, Y., Luo, J. S., Hong, K., Wang, Z., Yan, J.
F., Chen, X., Lu, J. X., Benovic, J. L. and Zhou, N. M. (2010) Structural
determinants in the second intracellular loop of the human
cannabinoid CB1 receptor mediate selective coupling to G(s) and
G(i). Br. J. Pharmacol. 161, 1817-1834.
DOI
|
| 68 |
Cheng, Z., Tu, C., Rodriguez, L., Chen, T. H., Dvorak, M. M., Margeta,
M., Gassmann, M., Bettler, B., Shoback, D. and Chang, W. (2007)
Type B gamma-aminobutyric acid receptors modulate the function
of the extracellular Ca2+-sensing receptor and cell differentiation in
murine growth plate chondrocytes. Endocrinology 148, 4984-4992.
DOI
|
| 69 |
Ciruela, F., Escriche, M., Burgueno, J., Angulo, E., Casado, V., Soloviev,
M. M., Canela, E. I., Mallol, J., Chan, W. Y., Lluis, C., McIlhinney,
R. A. and Franco, R. (2001) Metabotropic glutamate 1alpha
and adenosine A1 receptors assemble into functionally interacting
complexes. J. Biol. Chem. 276, 18345-18351.
DOI
|
| 70 |
Daniels, D. J., Lenard, N. R., Etienne, C. L., Law, P. Y., Roerig, S. C.
and Portoghese, P. S. (2005) Opioid-induced tolerance and dependence
in mice is modulated by the distance between pharmacophores
in a bivalent ligand series. Proc. Natl. Acad. Sci. USA 102,
19208-19213.
DOI
|
| 71 |
Decaillot, F. M., Rozenfeld, R., Gupta, A. and Devi, L. A. (2008) Cell
surface targeting of mu-delta opioid receptor heterodimers by
RTP4. Proc. Natl. Acad. Sci. USA 105, 16045-16050.
DOI
|
| 72 |
Albizu, L., Cottet, M., Kralikova, M., Stoev, S., Seyer, R., Brabet, I.,
Roux, T., Bazin, H., Bourrier, E., Lamarque, L., Breton, C., Rives,
M. L., Newman, A., Javitch, J., Trinquet, E., Manning, M., Pin, J. P.,
Mouillac, B. and Durroux, T. (2010) Time-resolved FRET between
GPCR ligands reveals oligomers in native tissues. Nat. Chem. Biol.
6, 587-594.
DOI
|
| 73 |
Bhushan, R. G., Sharma, S. K., Xie, Z., Daniels, D. J. and Portoghese,
P. S. (2004) A bivalent ligand (KDN-21) reveals spinal delta and
kappa opioid receptors are organized as heterodimers that give
rise to delta(1) and kappa(2) phenotypes. Selective targeting of
delta-kappa heterodimers. J. Med. Chem. 47, 2969-2972.
DOI
|
| 74 |
Alfaras-Melainis, K., Gomes, I., Rozenfeld, R., Zachariou, V. and Devi,
L. (2009) Modulation of opioid receptor function by protein-protein
interactions. Front Biosci. 14, 3594-3607.
|
| 75 |
Auld, D. S., Thorne, N., Maguire, W. F. and Inglese, J. (2009) Mechanism
of PTC124 activity in cell-based luciferase assays of nonsense
codon suppression. Proc. Natl. Acad. Sci. USA. 106, 3585-3590.
DOI
|
| 76 |
Berridge, M. J. (1993) Inositol trisphosphate and calcium signalling.
Nature 361, 315-325.
DOI
|
| 77 |
Bovolenta, S., Foti, M., Lohmer, S. and Corazza, S. (2007) Development
of a Ca(2+)-activated photoprotein, Photina, and its application
to high-throughput screening. J. Biomol. Screen 12, 694-704.
DOI
|
| 78 |
Branchek, T. A., Smith, K. E., Gerald, C. and Walker, M. W. (2000)
Galanin receptor subtypes. Trends Pharmacol. Sci. 21, 109-117.
DOI
|
| 79 |
Burbaum, J. J. and Sigal, N. H. (1997) New technologies for high-throughput
screening. Curr. Opin. Chem. Biol. 1, 72-78.
DOI
|
| 80 |
Cabello, N., Gandia, J., Bertarelli, D. C., Watanabe, M., Lluis, C.,
Franco, R., Ferre, S., Lujan, R. and Ciruela, F. (2009) Metabotropic
glutamate type 5, dopamine D2 and adenosine A2a receptors form
higher-order oligomers in living cells. J. Neurochem. 109, 1497-1507.
DOI
|
| 81 |
AbdAlla, S., Lother, H., el Massiery, A. and Quitterer, U. (2001) Increased
AT (1) receptor heterodimers in preeclampsia mediate
enhanced angiotensin II responsiveness. Nat. Med. 7, 1003-1009.
DOI
|
webmaster
