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Toxic Optic Neuropathy Caused by Chlorfenapyr Poisoning (클로르페나피르 음독 후 발생한 독성 시신경병증 1예)

  • Park, Su Jin;Jung, Jae Uk;Kang, Yong Koo;Chun, Bo Young;Son, Byeong Jae
    • Journal of The Korean Ophthalmological Society
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    • v.59 no.11
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    • pp.1097-1102
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    • 2018
  • Purpose: To report a case of toxic optic neuropathy caused by chlorfenapyr ingestion accompanied by central nervous system involvement. Case summary: A 44-year-old female visited our clinic complaining of reduced visual acuity in both eyes for 7 days. She had ingested a mouthful of chlorfenapyr for a suicide attempt 2 weeks prior to the visit. Gastric lavage was performed immediately after ingestion at the other hospital. Her best-corrected visual acuity was finger count 30 cm in the right eye and hand motion in the left eye. Both pupils were dilated by 5.0 mm and the response to light was sluggish in both eyes. A relative afferent pupillary defect was detected in her left eye. Funduscopy revealed optic disc swelling in both eyes. Magnetic resonance imaging of the brain showed a symmetric hyper-intense signal in the white matter tract including the internal capsule, corpus callosum, middle cerebellar peduncle, and brainstem. The patient was diagnosed with toxic optic neuropathy induced by chlorfenapyr ingestion, and underwent high-dose intravenous corticosteroid pulse therapy. Three days later, the best-corrected visual acuity was no light perception in both eyes. Three months later, optic atrophy was observed in both eyes. Optical coherence tomography revealed a reduction in the thicknesses of the retinal nerve fiber layer and ganglion cell and inner plexiform layer in the macular area. Conclusions: Ingestion of even a small amount of chlorfenapyr can cause severe optic nerve damage through the latent period, despite prompt lavage and high-dose steroid treatment.

Histology and Histochemistry of the Male and Female Reproductive System of the Sesarmid Crab Muradium Tetragonum

  • Pothiappan Kumarasamy;Viswambaram Ganapiriya;Kannayiram Muthukumaravel;Manickam Sasipriya;Bharathi Santhanabharathi;Mohamed Saiyad Musthafa;Marckasagayam Priyadharshini
    • Journal of Integrative Natural Science
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    • v.16 no.1
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    • pp.13-31
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    • 2023
  • The sesarmid crab Muradium tetragonum, inhabiting the mangrove, are considered as a key consumer of litter and thereby play an important role in the detritus food chain and energy flow in the mangrove ecosystem. The present investigation was carried out with objectives to enlighten the reproductive system of Muradium tetragonum through histological and histochemical studies. Histological organization of the testis of M. tetragonum revealed that each testis has a lobular structure consisting of several testicular lobules arranged around the collecting duct. Histology of the deferens of M. tetragonum revealed it to be composed of three-layer of tissues along the entire length:the outer connective tissue, the middle muscular and the inner epithelial layer. Based on the histological architecture these three regions are recognized as proximal vas deferens (PVD), middle vas deferens (MVD) and distal vas deferens (DVD). Histological characteristics of the ovary of M. tetragonum during different phases of ovarian development were studied. Based on the colour changes of the ovary and diameter of the oocytes five stages of ovarian development can be pronounced. Histochemical analysis of the male reproductive tissues of M. tetragonum signifies the secretion of a different biomolecule by specifying their origin in the reproductive tissue and their possible transformation into spermatophores. In the female reproductive tissues, histochemical evaluation envisaged the secretory products during different stages of ovarian development The secretory substances of the spermatheca expound on the significance of its secretion in dehiscing the spermatophore wall and in nourishing as well as protecting the spermatozoa.

Changes of superoxide dismutase and glutathione peroxidase in light damaged rat retina

  • Kaidzu, Sachiko;Tanito, Masaki;Takanashi, Taiji;Ohira, Akihiro
    • Journal of Photoscience
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    • v.9 no.2
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    • pp.430-432
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    • 2002
  • The changes in expression of copper-zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn-SOD) and glutathione peroxidase (GPX) in light-damaged rat retinas were examined. Sprague-Dawley rats (male, 6-weeks-old) were maintained on a cyclic photoperiod (12 hours light and 12 hours darkness) for 2 weeks. The illumination intensity during the light period was 80 lux. To induce light damage to the retina, a high-intensity illumination (3000-lux) was applied to the animals for 24 hours. After light exposure, the animals were returned to cyclic lighting. Eyes were enucleated 12 and 24 hours after light exposure started or 1,3, and 7 days after light exposure ended. Eyes were fixed and embedded in paraffin wax. Tissues were cut into 4${\mu}{\textrm}{m}$-thick sections. Sections were immunostained using antibody against CuZn-SOD, Mn-SOD, GPX and 8-hydroxy-deoxyguanocine (8-OHdG) as oxidative stress marker. 8-OHdG was observed in the outer nuclear layer (ONL) and retinal pigment epithelium (RPE) during light exposure. In light-damaged retinas CuZn-SOD labeling was up regulated in the ONL and RPE. Mn-SOD labeling was up regulated in rod inner segments (RIS) during light exposure and that in the RPE was up regulated after exposure. GPX labeling was observed in rod outer segments (ROS) during light exposure. GPX labeling was also observed in the RPE during and after light exposure. All three enzymes were observed in the outer retina, which suffered light damage, but occurred in defferent layers except within the RPE, in which case all three were expressed. These enzymes may play complementary roles as protective factors in light-damaged retinas.

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A study on the Creep Behavieo of Rene 80 Superalloy (Rene 80초내열 합금의 크리프 거동에 관한 연구)

  • Han, Seong-Ho;Lee, Gi-Ryong;Jo, Chang-Yong;Kim, In-Bae;Kim, Hak-Min
    • Korean Journal of Materials Research
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    • v.3 no.6
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    • pp.575-584
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    • 1993
  • The effects of atmosphere on the creep rupture properties of Ni-base superalloy Ren6 80 were investigated. Creep rupture tests were performed at $760^{\circ}C$, 657MPa and 982%, 157MPa under Ar gas atmospheres. Creep rupture mode and rupture properties (rupture life and elongation) were similar in two different atmospheres under the condition of $760^{\circ}C$, 657MPa. However, the results at $982^{\circ}C$, 157MPa showed different creep rupture mode and life between air and Ar gas atmospheres. In air, it was shown that creep cracks were initiated at surface-exposed grain boundaries and propagated along grain boundaries. In Ar gas atmosphere, the cracks were initiated at inner grain boundaries and coalesced to surface cracks which cause cup-and-cone type fracture. Due to protective oxide layer formation, air test showed longer rupture life than Ar test.

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Characterization of Aerosol Concentration during Severe Asian Dust Period at Busan, Korea in 20 March 2010 (2010년 3월 20일 부산지역에 발생한 극심한 황사의 에어로솔 농도 분포 특성)

  • Jung, Woon-Seon;Park, Sung-Hwa;Lee, Dong-In;Kang, Deok-Du;Kim, Dongchul
    • Journal of Environmental Science International
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    • v.23 no.2
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    • pp.275-289
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    • 2014
  • Asian dust (or yellow sand) occurring mainly in spring in East Asia is affected by the distribution of weather systems. This study was performed to investigate the characteristics of suspended particulate for Asian dust at Busan, Korea in 20 March 2010, which was one of the extreme case for the last 10 years. There was used the data of weather chart, satellite, automatic weather system (AWS), $PM_{10}$, laser particle counter (LPC), and backward trajectories model. In synoptically, the high pressure was located in the northwestern part and low pressure was located in the northeastern part of Korea. The strong westerly winds from surface to upper layer makes it possible to move air masses rapidly. Air masses passing through Gobi Desert in Mongolia and Inner Mongolia plateau covered the entire Korean peninsula. As the results of aerosol analysis, $PM_{10}$ concentration at Gudeok mountain in Busan was recorded $2,344{\mu}g/m^3$ in 2300 LST 20 March 2010 and their concentration was markedly increased at coarse mode particle. In surface condition, westerly wind about 3 ~ 5 m/s was dominant and small particles of $0.3{\sim}0.5{\mu}m$ were distributed on the whole. In heavy metal components analysis, the elements from the land was predominated.

Comparison of Organic Carbon Composition in Profile by Using Solid 13C CPNMR Spectroscopy in Volcanic Ash Soil

  • Sonn, Yeon Kyu;Kang, Seong Soo;Ha, Sang Keun;Kim, Yoo Hak;Lee, Chang Hoon
    • Korean Journal of Soil Science and Fertilizer
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    • v.46 no.5
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    • pp.391-398
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    • 2013
  • Soil organic carbon (SOC) has the potential to promote the soil quality for sustainability and mitigation of global warming. There is little information on organic carbon composition despite of having resistance of carbon degradation in soil. In this study, to understand the effect of volcanic ash on organic carbon composition and quantity in soil, we investigated characteristics of volcanic soil and compared organic carbon composition of soil and humic extract by using $^{13}C$-CPMAS-NMR spectra under soil profiles of Namweon series in Jeju. SOC contents of inner soil profiles were 134.8, 101.3, and 27.4 g C $kg^{-1}$ at the layer of depth 10-20, 70-80 and 90-100 cm, respectively. These layers were significantly different to soil pH, oxalate Al contents, and soil moisture contents. Alkyl C/O-alkyl C ratio in soil was higher than that of humic extracts, which was decreased below soil depth. Aromaticity of soil and humic extract was ranged from 29-38 and 24-32%, which was highest at the humic extract of 70-80 cm in soil depth. These results indicate that the changes of SOC in volcanic ash soil resulted from alteration of organic composition by pyrolysis and stability of organic carbon by allophane in volcanic ash soil.

Observed Long-term Water Content Change in Concrete Track Roadbed by Rainfall (콘크리트궤도노반에서의 강우량에 따른 장기 함수비 변화)

  • Choi, Chanyong;Kim, Hunki;Yang, Sangbeom;Eum, KiYoung
    • Journal of the Korean Geosynthetics Society
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    • v.14 no.4
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    • pp.35-43
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    • 2015
  • In this study, it was performed in characteristics of settlement of roadbed materials with variation of water content using cylinder model device. The ratio of settlement ($R_e$) of subgrade soils in the initial water content were about 2.08, whereas it was increased about 4.06 which resulted in increase two times in the initial water content. Also, it was monitoring long-term to measure variation of the field water contents at concrete track using rainfall measuring sensors. The water content at directly underneath of concrete track rarely seems to affect the variation of water content, but it was increased by about 4% than intial water content with 20 mm/hr rainfall index at slope section. As for the result from the field date, it was determined that the water content of the inner subgrade layer was rarely affect caused by more than 20 mm/h rainfall index during if good drainage system at concrete track properly maintained.

Design of Electromagnetic Band Gap Structure for Global Navigation Satellite Service (Global-Navigation Satellite Service를 위한 Electromagnetic Band Gap 구조체 설계)

  • Chung, Ki-Hyun;Jang, Young-Jin;Yeo, Sung-Dae;Jung, Chang-Won;Kim, Seong-Kweon
    • The Journal of the Korea institute of electronic communication sciences
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    • v.10 no.1
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    • pp.27-32
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    • 2015
  • In this paper, a mushroom typed electromagnetic band gap (EBG) structure to be inserted in the printed circuit board (PCB) inner layer in order to stabilize the PCB power line is proposed for global-navigation satellite service (GNSS). In designing the proposed EBG structure, the target stop-bandwidth was designed from 1.55GHz to 1.81GHz including GNSS and mobile communication-related frequency bandwidth. In this bandwidth, the insertion loss(S21) was observed below about -40dB. From the simulation results, it is expected that the stabilization of power delivery network (PDN) structure in the PCB circuit design should be improved and the effective correspondence to EMI will be helpful.

Development of Schizogenous and Lysigenous Aerenchyma in Rice Root

  • Kang, Si-Yong;Wada, Tomikichi;Choi, Kwan-Sam
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.43 no.2
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    • pp.77-82
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    • 1998
  • Aerenchyma development in rice (Oryza sativa L.) roots is quite important for adaptation to waterlogged or reduced soil conditions. Anatomical observations were carried out to clarify the development of schizogenous and lysigenous aerenchyma in elongating crown roots of rice. The crown roots of 3rd and 4th phytomer were taken from rice plants of the 8th leaf stage grown by hydroponic culture. The schizogenous intercellular spaces in the cortex of crown root tip were observed using a light microscope with semi ultra-thin sections and the lysigenous aerenchyma in mature tissue of crown root were observed using a cryo scanning electron microscope (cryo-SEM) with freezing fracture method. The schizogenous intercellular spaces in the root tip exist obviously in the middle portion of cortical cell layers close to the root-root cap junction, but not in root cap, stele and outer cell layers of cortex. The air spaces were formed at the junction of four neighbouring cells of inner cortex in the transverse sections, and between longitudinal cell layer connected along the root axis. Although many of those spaces were filled with liquid, some spaces seem to exist as air spaces. The lysigenous aerenchyma in the cortex, which hardly filled with liquid, emerged at 3-4 cm segment from the root tip and increased toward the basal region of root axis. The developing process of lysigenous aerenchyma was primarily separation of a radial row of cells caused by the shrinking and collapsing of cortical cells and then formation of septa along the radial cell rows by the fusion of cell wall with each other. These results suggest that the schizogenous and lysigenous aerenchyma playa role as a passage for the movement of oxygen into the root tip region where oxygen is required for respiration.

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Geoacoustic Model at the SSDP-105 Long-core Site of the Ulsan Coastal Area, the East Sea (동해 울산 연안해역 SSDP-105 심부코어 지점의 지음향 모델)

  • Ryang, Woo-Hun;Lee, Gwang-Soo;Hahn, Jooyoung
    • Journal of the Korean earth science society
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    • v.39 no.2
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    • pp.154-163
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    • 2018
  • Geoacoustic model comprises physical and acoustic properties of submarine bottom layers influencing sound transmission through sea water and underwater. This study suggested for the first time that we made a geoacoustic model of long-coring bottom layers at the SSDP-105 drilling site of the Ulsan coastal area, which is located in the southwestern inner shelf of the East Sea. The geoacoustic model of 52 m depth below seafloor with three-layer geoacoustic units was reconstructed in the coastal sedimentary strata at 79 m in water depth. The geoacoustic model was based on the data of a deep-drilled sediment core of SSDP-105 and sparker seismic profiles in the study area. For actual modeling, the geoacoustic property values of the models were compensated to in situ depth values below the sea floor using the Hamilton modeling method. We suggest that the geoacoustic model be used for geoacoustic and underwater acoustic experiments of mid- and low-frequency reflecting on the deep bottom layers in the Ulsan coastal area of the East Sea.