• Journal of the Institute of Electronics Engineers of Korea SP
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• v.48 no.1
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• pp.1-7
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• 2011

In this paper, we propose the digital image enhancement method including local tone reproduction and preservation of the hue. In recent studies, an integrated multi-scale retinex (IMSR) has produced great naturalness in the resulting images through enhancement of visibility in dark area in input images. However, most methods, including IMSR, work in RGB color spaces. As such, this produces hue distortion from the perspective of the human visual system, that is, hue distortion in CIELAB color space. Accordingly, this paper proposes an tone reproduction and enhancement of saturation method in a device-independent color space, CIELAB, to preserve the hue and obtain a high contrast and naturalness. First, to achieve the desired objectives, the IMSR is then applied to only the $L^*$ values in CIELAB color space, normalization, and simple mapping function, thereby preserving the balance of the color components and enhancement of visibility. Then, saturation adjustment is performed by applying the ratio of the chroma variation at the sRGB gamut boundary according to the corrected luminance. In experiments, the proposed method is shown to improve the visibility in dark shadows and bright regions in the resulting images and reduce any color distortion then preference test are performed.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.49 no.1
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• pp.73-80
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• 2012

Recent research efforts have focused on combining high dynamic range imaging with super-resolution reconstruction to enhance both the intensity range and resolution of images. The processes developed to date start with a set of multiple-exposure input images with low dynamic range (LDR) and low resolution (LR), and require several procedural steps: conversion from LDR to HDR, SR reconstruction, and tone mapping. Input images captured with irregular exposure steps have an impact on the quality of the output images from this process. In this paper, we present a simplified framework to replace the separate procedures of previous methods that is also robust to different sets of input images. The proposed method first calculates weight maps to determine the best visible parts of the input images. The weight maps are then applied directly to SR reconstruction, and the best visible parts for the dark and highlighted areas of each input image are preserved without LDR-to-HDR conversion, resulting in high dynamic range. A new luminance control factor (LCF) is used during SR reconstruction to adjust the luminance of input images captured during irregular exposure steps and ensure acceptable luminance of the resulting output images. Experimental results show that the proposed method produces SR images of HDR quality with luminance compensation.

• Bulletin of the Korean Chemical Society
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• v.30 no.5
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• pp.1152-1156
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• 2009

Silent information regulator 2 (Sir2) or sirtuins are NAD(+)-dependent deacetylases, which hydrolyze the acetyllysine residues. In mammals, sirtuins are classified into seven different classes (SIRT1-7). SIRT1 was reported to be involved in age related disorders like obesity, metabolic syndrome, type II diabetes mellitus and Parkinson’s disease. Activation of SIRT1 is one of the promising approaches to treat these age related diseases. In this study, we have used HipHop module of CATALYST to identify a series of pharmacophore models to screen SIRT1 enhancing molecules. Three molecules from Sirtris Pharmaceuticals were selected as training set and 607 sirtuin activator molecules were used as test set. Five different hypotheses were developed and then validated using the training set and the test set. The results showed that the best pharmacophore model has four features, ring aromatic, positive ionization and two hydrogen-bond acceptors. The best hypothesis from our study, Hypo2, screened high number of active molecules from the test set. Thus, we suggest that this four feature pharmacophore model could be helpful to screen novel SIRT1 activator molecules. Hypo2-virtual screening against Maybridge database reveals seven molecules, which contains all the critical features. Moreover, two new scaffolds were identified from this study. These scaffolds may be a potent lead for the SIRT1 activation.

• The KIPS Transactions:PartA
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• v.11A no.6
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• pp.459-468
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• 2004

Sharing XML trees on mobile devices has become more and more popular. Optimistic replication of XML trees for mobile devices raises the need for reconciliation of concurrently modified data. Especially for reconciling the modified tree structures, we have to compare trees by node mapping which takes O($n^2$) time. Also, using semantic based conflict resolving policy is often discussed in the literature. In this research, we focused on an efficient reconciliation method for mobile environments, using edit scripts of XML data sent from each device. To get a simple model for mobile devices, we use the XML list data sharing model, which allows inserting/deleting subtrees only for the repetitive parts of the tree, based on the document type. Also, we use keys for repetitive part subtrees, keys are unique between nodes with a same parent. This model not only guarantees that the edit action always results a valid tree but also allows a linear time reconciliation algorithm due to key based list reconciliation. The algorithm proposed in this paper takes linear time to the length of edit scripts, if we can assume that there is no insertion key conflict. Since the previous methods take a linear time to the size of the tree, the proposed method is expected to provide a more efficient reconciliation model in the mobile environment.

• The KIPS Transactions:PartD
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• v.8D no.5
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• pp.507-512
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• 2001

Feature-based similarity has become an important research issue in multimedia database systems. The features of multimedia data are useful for discriminating between multimedia objects. the performance of conventional multidimensional data structures tends to deteriorate as the number of dimensions of feature vectors increase. The $R^{*}-Tree$ is the most successful variant of the R-Tree. In this paper, we propose a SOM-based $R^{*}-Tree$ as a new indexing method for high-dimensional feature vectors. The SOM-based $R^{*}-Tree$ combines SOM and $R^{*}-Tree$ to achieve search performance more scalable to high-dimensionalties. Self-Organizingf Maps (SOMs) provide mapping from high-dimensional feature vectors onto a two-dimensional space. The map is called a topological feature map, and preserves the mutual relationships (similarity) in the feature spaces of input data, clustering mutually similar feature vectors in neighboring nodes. Each node of the topological feature map holds a codebook vector. We experimentally compare the retrieval time cost of a SOM-based $R^{*}-Tree$ with of an SOM and $R^{*}-Tree$ using color feature vectors extracted from 40,000 images. The results show that the SOM-based $R^{*}-Tree$ outperform both the SOM and $R^{*}-Tree$ due to reduction of the number of nodes to build $R^{*}-Tree$ and retrieval time cost.

• The KIPS Transactions:PartD
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• v.17D no.2
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• pp.129-146
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• 2010

Nowadays, XML has been favored by many companies internally and externally as a means of sharing and distributing data. there are many researches and systems for modeling and storing XML documents by an object-oriented method as for the method of saving and managing web-based multimedia document more easily. The representative tool for the object-oriented modeling of XML documents is UML (Unified Modeling Language). UML at the beginning was used as the integrated methodology for software development, but now it is used more frequently as the modeling language of various objects. Currently, UML supports various diagrams for object-oriented analysis and design like class diagram and is widely used as a tool of creating various database schema and object-oriented codes from them. This paper proposes an Efficinet Query Modelling of XML-GL using the UML class diagram and OCL for searching XML document which its application scope is widely extended due to the increased use of WWW and its flexible and open nature. In order to accomplish this, we propose the modeling rules and algorithm that map XML-GL. which has the modeling function for XML document and DTD and the graphical query function about that. In order to describe precisely about the constraint of model component, it is defined by OCL (Object Constraint Language). By using proposed technique creates a query for the XML document of holding various properties of object-oriented model by modeling the XML-GL query from XML document, XML DTD, and XML query while using the class diagram of UML. By converting, saving and managing XML document visually into the object-oriented graphic data model, user can prepare the base that can express the search and query on XML document intuitively and visually. As compared to existing XML-based query languages, it has various object-oriented characteristics and uses the UML notation that is widely used as object modeling tool. Hence, user can construct graphical and intuitive queries on XML-based web document without learning a new query language. By using the same modeling tool, UML class diagram on XML document content, query syntax and semantics, it allows consistently performing all the processes such as searching and saving XML document from/to object-oriented database.

• The KIPS Transactions:PartD
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• v.16D no.6
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• pp.851-858
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• 2009

Mobbing is not restricted to problem of young people but the bigger recent problem occurs in workspaces. According to reports of ILO and domestic case mobbing in the workplace is increasing more and more numerically from 9.1%('03) to 30.7%('08). These mobbing brings personal and social losses. The proposed algorithm makes it possible to grasp not only current mobbing victims but also potential mobbing victims through user profile and contribute to efficient personnel management. This paper extracts user profile related to mobbing, in a way of selecting seven factors and fifty attributes that are related to this matter. Next, expressing extracting factors as '1' if they are related me or not '0'. And apply similarity function to attributes summation included in factors to calculate similarity between the users. Third, calculate optimizing weight choosing factors included attributes by applying neural network algorithm of SPSS Clementine and through this summation Mobbing-Value(MV) can be calculated . Finally by mapping MV of online social network users to G2 mobbing propensity classification model(4 Groups; Ideal Group of the online social network, Bullies, Aggressive victims, Victims) which is designed in this paper, can grasp mobbing propensity of users, which will contribute to efficient personnel management.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.42 no.3 s.303
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• pp.39-52
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• 2005

In this paper, a registration method is presented to register partial 3D point clouds, acquired from a multi-view camera, for 3D reconstruction of an indoor environment. In general, conventional registration methods require a high computational complexity and much time for registration. Moreover, these methods are not robust for 3D point cloud which has comparatively low precision. To overcome these drawbacks, a projection-based registration method is proposed. First, depth images are refined based on temporal property by excluding 3D points with a large variation, and spatial property by filling up holes referring neighboring 3D points. Second, 3D point clouds acquired from two views are projected onto the same image plane, and two-step integer mapping is applied to enable modified KLT (Kanade-Lucas-Tomasi) to find correspondences. Then, fine registration is carried out through minimizing distance errors based on adaptive search range. Finally, we calculate a final color referring colors of corresponding points and reconstruct an indoor environment by applying the above procedure to consecutive scenes. The proposed method not only reduces computational complexity by searching for correspondences on a 2D image plane, but also enables effective registration even for 3D points which have low precision. Furthermore, only a few color and depth images are needed to reconstruct an indoor environment.

• IMMUNE NETWORK
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• v.7 no.3
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• pp.149-157
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• 2007

Background: The microsatellites within human leukocyte antigen (HLA) region show considerable polymorphism and strong linkage disequilibrium (LD) with HLA alleles. These microsatellites have been used for genetic analysis including disease mapping to understand susceptibility to autoimmune and infectious diseases. Also, use of microsatellites has recently been proposed as an approach for identifying non-HLA markers within the HLA region that could function as transplantation determinants and for the selection of potential donors for transplantation. Methods: To analyse the frequency of five microsatellites in the Korean population, genotyping for polymorphisms at five microsatellites markers (BAT2, MIB, DQCAR, D6S105 and TNFd) within HLA region was performed on 143 healthy Korean controls. Results: The most frequent genotype shown in healthy Korean controls were BAT2 8 (153 bp, 42.7%), MIB 1 (326 bp, 40.6%), DQCAR 3 (188 bp, 38.5%), D6S105 7 (126 bp, 58.0%) and TNFd 3 (128 bp, 58.0%). And common two-loci haplotypes were found as MIB 1-HLA-B*62 (HF: 10.6%), MIB 6-HLA-B*44 (HF: 7.8%), DQCAR 3-HLA-DRB1*13 (HF: 8.5%), TNFd 5-HLA-B*62 (HF: 7.8%) and D6S105 7-HLA-A*02 (HF: 16.2%). Conclusion: These data might provide useful information on the microsatellites markers with HLA region in Korean population and be helpful in further defining the clinical impact of these microsatellites.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.40
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• pp.16.1-16.5
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• 2018

Background: Proliferative verrucous leukoplakia (PVL) is an oral potentially malignant disorder, characterized by multifocal expression, progressive clinical evolution, and a high rate of malignant transformation. Evidence-based information regarding optimal PVL management is lacking, due to the paucity of data. The present report describes a case of PVL associated with HPV-16 infection and epithelial dysplasia treated by diode laser surgery, and the outcome of disease clinical remission over a 2-year follow-up period. Case report: A 61-year-old Caucasian male with oral verrucous hyperkeratosis presented for diagnosis. The lesions were localized on the maxillary gingiva and palatal alveolar ridge. Multiple biopsy specimens have been taken by mapping the keratotic lesion area. Microscopic examination was compatible with a diagnosis of PVL with focal mild dysplasia, localized in the right maxillary gingiva. Polymerase chain reaction (PCR) was done for human papillomavirus (HPV) detection which revealed presence of HPV DNA, and the genotype revealed HPV 16 in the sample. The PVL in the right gingival area was treated on an outpatient basis by excision with a diode laser. This approach resulted in good clinical response and decreased morbidity over a 2-year follow-up period. Conclusions: This case illustrates the benefit of a conservative approach by diode laser treatment than wide surgical excision for management of the PVL lesions associated with mild dysplasia and HPV-16 infection.