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Distributions of HLA Microsatellite Markers and the Linkage Disequilibria between HLA and Microsatellites in Koreans  

Jang, Jung-Pil (Department of Microbiology, College of Medicine, The Catholic University of Korea)
Choi, Eun-Jeong (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea)
Yoon, Ho-Yeul (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea)
Choi, Hee-Baeg (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea)
Kim, Hee-Je (Catholic Hematopoietic Stem Cell Transplantation Center, College of Medicine, The Catholic University of Korea)
Cho, Byung-Sik (Catholic Hematopoietic Stem Cell Transplantation Center, College of Medicine, The Catholic University of Korea)
Min, Woo-Sung (Catholic Hematopoietic Stem Cell Transplantation Center, College of Medicine, The Catholic University of Korea)
Lee, Jong-Wook (Catholic Hematopoietic Stem Cell Transplantation Center, College of Medicine, The Catholic University of Korea)
Kim, Chun-Choo (Catholic Hematopoietic Stem Cell Transplantation Center, College of Medicine, The Catholic University of Korea)
Kim, Tai-Gyu (Department of Microbiology, College of Medicine, The Catholic University of Korea)
Publication Information
IMMUNE NETWORK / v.7, no.3, 2007 , pp. 149-157 More about this Journal
Abstract
Background: The microsatellites within human leukocyte antigen (HLA) region show considerable polymorphism and strong linkage disequilibrium (LD) with HLA alleles. These microsatellites have been used for genetic analysis including disease mapping to understand susceptibility to autoimmune and infectious diseases. Also, use of microsatellites has recently been proposed as an approach for identifying non-HLA markers within the HLA region that could function as transplantation determinants and for the selection of potential donors for transplantation. Methods: To analyse the frequency of five microsatellites in the Korean population, genotyping for polymorphisms at five microsatellites markers (BAT2, MIB, DQCAR, D6S105 and TNFd) within HLA region was performed on 143 healthy Korean controls. Results: The most frequent genotype shown in healthy Korean controls were BAT2 8 (153 bp, 42.7%), MIB 1 (326 bp, 40.6%), DQCAR 3 (188 bp, 38.5%), D6S105 7 (126 bp, 58.0%) and TNFd 3 (128 bp, 58.0%). And common two-loci haplotypes were found as MIB 1-HLA-B*62 (HF: 10.6%), MIB 6-HLA-B*44 (HF: 7.8%), DQCAR 3-HLA-DRB1*13 (HF: 8.5%), TNFd 5-HLA-B*62 (HF: 7.8%) and D6S105 7-HLA-A*02 (HF: 16.2%). Conclusion: These data might provide useful information on the microsatellites markers with HLA region in Korean population and be helpful in further defining the clinical impact of these microsatellites.
Keywords
Linkage disequilibria; Microsatellite; Human leukocyte antigen (HLA); Graft-versus-host- disease (GVHD);
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