• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7838-7843
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• 2015

In this study, metformin hydrochloride for first choice of type 2 diabetes patient is administered relatively high dose, 1000 to 2000 mg orally once a day, and had very high water solubility, so it make difficult to swallow tablet to requires high amount of sustained release agent. To overcome these challenges, we used novel metformin salts had relatively low water solubility to minimize sustaining excipient for small size of dosage form. six novel metformin salts were synthesized by making metformin free form under reaction with NaOH and adding acid salts. we confirmed metformin stearate had the lowest water solubility and showed half drug release in dissolution study at 12hour. In conclusion, novel metformin salts had low water solubility can be used to reduce the size of sustained metformin tablet for improving patient compliance.

• Journal of the Korea Institute of Military Science and Technology
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• v.20 no.4
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• pp.491-496
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• 2017

The hydrogen($H_2$) is promising energy carrier of renewable energy in the microgrid system such as small village and military base due to its high energy density, pure emission and convenient transportation. $H_2$ can be generated by photocatalytic water splitting, gasification of biomass and water electrolysis driven by solar cell or wind turbine. Solid oxide electrolysis cells(SOECs) are the most efficient way to mass production due to high operating temperature improving the electrode kinetics and reducing the electrolyte resistance. The SOECs are consist of nickel-yttria stabilized zirconia(NiO-YSZ) fuel electrode / YSZ electrolyte / lanthanum strontium manganite-YSZ(LSM-YSZ) air electrode due to similarity to Solid Oxide Fuel Cells(SOFCs). The Ni-YSZ most widely used fuel electrode shows several problems at SOEC mode such as degradation of the fuel electrode because of Ni particle's redox reaction and agglomeration. Therefore Ni-YSZ need to be replaced to an alternative fuel electrode material. In this study, We studied on the Double perovskite $PrBrMnO_{5+{\delta}}$(PBMO) due to its high electric conductivity, catalytic activity and electrochemical stability. PBMO was impregnated into the scaffold electrolyte $La_{0.8}Sr_{0.2}Ga_{0.85}Mg_{0.15}O_{3-{\delta}}$(LSGM) to be synthesized at low temperature for avoiding secondary phase generated when it exposed to high temperature. The Half cell test was conducted at SOECs and SOFCs modes.

• Journal of Fashion Business
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• v.12 no.3
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• pp.87-98
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• 2008

The purposes of this study are to measure physiological reactions of human body according to the scalp treatment, a popularized service in beauty care industry and propose efficient ways of scalp treatment. To meet the goals, total 30 applicants without any medical history(5 males and 5 females in 20's, 30's and 40's respectively) were informed on the purpose of experiment hereof and were investigated and received a 30-minute scalp treatment, which combines standardized scalp treatment massage technique proposed by KAT and ITF with another massage technique operated in the beauty salon run by the author of this paper. 5ml of blood samples were taken from each subject before and after the scalp treatment respectively and the blood sample was divided into 3 different tubes for analysis: 1) 2 ml for blood cell analysis, 2) 2ml for enzyme activity measurement, 3) 1ml for hormone level reading. In order to determine effects of scalp treatment on ALP, GOT, GPT, ${\gamma}-GTP$, WBC, RBC, Hb, Hct, Platelet, MCV, MCH and MCHC, all collected data were used for measuring respective levels of these blood substances by means of enzyme reaction measurement, enzyme activity measurement and automated hematology analyzer. Then, all measured data were analyzed through paired t-test using SPSS WIN 11.5. As a result, the scalp treatment is associated with improving hepatic function, facilitating blood circulation and helping blood coagulation and hemostasis in a effective way. Therefore, it would be necessary to conduct further studies on this subject related to anemia in the future.

• Journal of Korea Multimedia Society
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• v.12 no.8
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• pp.1128-1141
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• 2009

Graphical expressions are continuously improving, spurred by the astonishing growth of the game technology industry. Despite such improvements, users are still demanding a more natural gaming environment and true reflections of human emotions. In real life, people can read a person's moods from facial color and expression. Hence, interactive facial colors in game characters provide a deeper level of reality. In this paper we propose a facial color adaptive technique, which is a combination of an emotional model based on human emotion theory, emotional expression pattern using colors of animation contents, and emotional reaction speed function based on human personality theory, as opposed to past methods that expressed emotion through blood flow, pulse, or skin temperature. Experiments show this of expression of the Facial Color Model based on facial color adoptive technique and expression of the animation contents is effective in conveying character emotions. Moreover, the proposed Facial Color Adaptive Technique can be applied not only to 2D games, but to 3D games as well.

• Journal of the Korean Applied Science and Technology
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• v.31 no.3
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• pp.345-351
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• 2014

Dinitramide ($N(NO_2)_2$) salts are one of plausible oxidizing agents for a high efficient propellant. Guanidine dinitramide (GDN) is an organic salt improving its stability against moisture, so that enables massive production and long term storage. Several types of GDN (GDN-1,2,3,4,5) were synthesized using some types of starting materials such as guanidine acetate, chloride, carbonate, nitrate and sulfate. As a result of the experimental work, synthesized GDN from the carbonate salt appeared fairly pure relatively higher yield (99%) than the other samples. The absorption wave length of all prepared GDNs by FTIR were found at 3452, 3402, 3354, 3278, 3208, 1642, 1570, 1492, 1416, 1337, 1179 and $1000cm^{-1}$. DSC analysis found a thermal phase change at $130^{\circ}C$, and indicated exothermic reaction at about $150^{\circ}C$ to $160^{\circ}C$.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.5
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• pp.288-294
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• 2019

Gardenia jasminoides is an herbal medicine that treats obesity and dampness-phlegm. This study aimed to investigate the efficacy of Gardenia jasminoides on insulin resistance induced by Non-alcoholic fatty liver disease (NAFLD). 8-week-old C57BL/6 male mice were divided into three groups: control group (Ctrl), high-fat diet group (HFF), and high fat diet with Gardenia jasminoides extract administration group (GJT). Each 10 mice was allocated to each group (a total of 30 mice). All mice were allowed to eat fat-rich diet freely throughout the experiment. To examine the effect of Gardenia jasminoides, we observed weight changes, lipid blot distributions, PPAR-${\gamma}$, p-IkB, p-JNK in liver tissue, total cholesterol, and glucose levels in serum. Comparing of body weight measurements between 3 groups, in the GJT group, weight gain was significantly suppressed compared to the HFF group. The distribution of lipid blots and positive reaction of PPAR-${\gamma}$ were significantly lower in GJT group. The expression levels of p-$I{\kappa}B$ and p-JNK that plays critical roles in the development of insulin resistance were significantly decreased by GJ treatment. Total cholesterol and glucose levels in serum were also significantly lower in GJT group. Gardenia jasminoides has the effect of improving non - alcoholic fatty liver induced insulin resistance through the regulation of lipid metabolism.

• Journal of the Korean Recycled Construction Resources Institute
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• v.9 no.4
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• pp.460-468
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• 2021

Owing to the production of conventional concrete/cement, the climate crises is increasing and is mainly caused greenhouse gas (GHG) emission into the environment by industrial process. To reduce the emission of GHG, and excessive consumption of energy, research on geopolymer binder is increasing as it is environmentally friendly compared to the conventional binders such as Portland cement. The research on improving the strength and durability of geopolymer cement becomes one of the trending researches. Generally, the strength and durability of geopolymer binders are improved by altering alkaline solution & its concentration, the precursor materials and curing temperature & time, which significantly influence the chemical composition and microstructure of geopolymer to which the strength and durability of geopolymers relies. This paper included the detailed discussion on the factors affecting the mechanical properties and durability of geopolymer binder and the influence of reaction mechanism on the strength and durability of geopolymer is also discussed in this paper.

• Journal of the Korean Recycled Construction Resources Institute
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• v.9 no.4
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• pp.521-528
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• 2021

The high-density fiber composite manufacturing method by the extrusion molding method has the characteristic that continuous production is possible, and the product is molded through a mold forming a specific cross-section. OPC is used as a defect material, an appropriate amount of SiO₂ is supplied for CaO reaction activity, and high density and high strength are expressed through steam and autoclave curing. However, due to the use of organic reinforcing fibers, the flame duration exceeds the regulations during the non-combustible performance test, making it difficult to secure performance. In this study, the product was produced by mixing alkali-resistant organic fiber and fly ash having voids as a binder by replacing the existing polypropylene fiber. appeared to be possible.

• Environmental Engineering Research
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• v.23 no.4
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• pp.383-389
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• 2018

Microbial fuel cell (MFC) is an innovative environmental and energy system that converts organic wastewater into electrical energy. For practical implementation of MFC as a wastewater treatment process, a number of limitations need to be overcome. Improving cathodic performance is one of major challenges, and introduction of a current collector can be an easy and practical solution. In this study, three types of current collectors made of stainless steel (SS) were tested in a single-chamber cubic MFC. The three current collectors had different contact areas to the cathode (P $1.0cm^2$; PC $4.3cm^2$; PM $6.5cm^2$) and increasing the contacting area enhanced the power and current generations and coulombic and energy recoveries by mainly decreasing cathodic charge transfer impedance. Application of the SS mesh to the cathode (PM) improved maximum power density, optimum current density and maximum current density by 8.8%, 3.6% and 6.7%, respectively, comparing with P of no SS mesh. The SS mesh decreased cathodic polarization resistance by up to 16%, and cathodic charge transfer impedance by up to 39%, possibly because the SS mesh enhanced electron transport and oxygen reduction reaction. However, application of the SS mesh had little effect on ohmic impedance.

• Journal of Ginseng Research
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• v.43 no.1
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• pp.135-142
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• 2019

Background: Panax ginseng Meyer, known as Korean Red Ginseng (KRG), is one of the important age-old traditional herbs used in boosting libido and improving male fertility. In this study, the effects of Rg3-enriched KRG extract (KGC04P) on heat stress-induced testicular damage in experimental rats was evaluated. Methods: Male rats (Sprague-Dawley) were divided into four groups (n = 10): normal control (NC), heat-stressed control (HC), heat-stressed plus KGC04P-100 mg/kg (HK100), and heat-stressed plus KGC04P-200 mg/kg (HK200) groups. Starting 1 week prior to heat stress, animals were administered orally with KGC04P (100 and 200 mg/kg) mixed with a regular pellet diet and continued for 25 weeks. Heat stress was induced to HC, HK100, and HK200 groups by intermittently exposing the animals to high temperatures ($32{\pm}1^{\circ}C$, 2 h/day). After 6 months, animals were euthanized under general anesthesia with carbon dioxide and evaluated for various parameters in serum and testicular tissue by using Western blotting, biochemical kits, and reverse transcription-polymerase chain reaction. Results: Significant (p < 0.05) alterations in several parameters, such as body/organ weight, sperm kinematics, and lipid metabolism marker levels, in the serum and testis of rats were observed. Further, the expression of testicular antioxidant enzymes, inflammatory cytokines, sex hormonal receptors, and spermatogenesis-related genes were also affected significantly (p < 0.05) in the heat-stressed group. However, KGC04P prevented the heat stress-induced changes in rats significantly (p < 0.05) at both concentrations. Conclusion: KGC04P attenuated heat stress-induced testicular damage by a multifunctional approach and can be developed as an excellent therapeutic agent for hyperthermia-mediated male infertility.