• Natural Product Sciences
• /
• 제11권3호
• /
• pp.183-187
• /
• 2005

The objective of the present study was to determine the possible immune-enhancing effects of a substance extracted from a submerged culture of Lentinus edodes with rice bran (SLRB). According to the results obtained by measuring the in vitro macrophage activity of the exo-biopolymer from SLRB, it appears to exhibit activity similar to that of LPS, and this activity seems to occur in a dose-dependent manner. According to the results obtained by measuring splenocyte proliferation, the exo-biopolymer appears to induce an increase in proliferation of approximately 1.4-fold compared to the control group. We measured the proliferation of bone marrow cells in order to evaluate gut immunity and, according to our results, proliferation was increased to 109% that of the control group, and was similar to that associated with LPS. In order to characterize the enhancement of immunological activity in vivo, we orally administered the exo-biopolymer (25, 50, 250 mg/kg bw) to C3H/He mice, and then measured the macrophage activity, determining that the activity was higher than that of the controls at concentrations of 50 and 250 mg/kg. Therefore, the exo-biopolymer from SLRB can be considered to be a useful a BRM agent, as it clearly allows some protection against immunological diseases.

• Journal of Microbiology and Biotechnology
• /
• 제28권3호
• /
• pp.349-356
• /
• 2018

Asterias amurensis is a marine organism that causes damage to the fishing industry worldwide; however, it has been considered a promising source of functional components. The present study aimed to investigate the immune-enhancing effects of fatty acids from three organs of A. amurensis on murine macrophages (RAW 264.7 cells). A. amurensis fatty acids boosted production of immune-associated factors such as nitric oxide (NO) and prostaglandin E2 in RAW 264.7 cells. A. amurensis fatty acids also enhanced the expression of critical immune-associated genes, including iNOS, $TNF-{\alpha}$, $IL-1{\beta}$, and IL-6, as well as COX-2. Western blotting showed that A. amurensis fatty acids stimulated the $NF-{\kappa}B$ and MAPK pathways by phosphorylation of $NF-{\kappa}B$ p-65, p38, ERK1/2, and JNK. A. amurensis fatty acids from different tissues resulted in different levels of $NF-{\kappa}B$ and MAPK phosphorylation in RAW 264.7 cells. The results increase our understanding of how A. amurensis fatty acids boost immunity in a physiological system, as a potential functional material.

• 대한수의학회지
• /
• 제34권2호
• /
• pp.275-286
• /
• 1994

Plasma protein which has been known as one of nonspecific immunostimulators was added to feedstuff to examine its effect on the enhancement of cellular immune response in porcine immune system. A total of 40 piglets, 20 male and 20 female each, were fed for 30 days with or without plasma protein. The peripheral blood were collected and analyzed for the investigation of leukocyte subpopulations and their activities by using a panel of monoclonal antibodies specific to porcine leukocyte differentiation antigens and flow cytometry. The results obtained as follows. 1. Total weight gain, daily feed intake and feed conversion rate for 10 days were significantly improved to 56%, 20% and 22% in the piglets fed plasma protein, respectively. 2. A significant increase in N (null or non T/non B) cells was also noticed. Leukocyte proportion from piglets fed plasma protein was 20.2-24.7%, otherwise that from piglets fed without plasma protein was 12.3-13.4%, respectively. 3. A significant increase in the proportion of B cells and cells expressing poCD1 was not found in piglets fed plasma protein. 4. Reaction with monoclonal antibodies specific to adhesion molecules, poCD11a, poCD11b, poCD44 and poCD45A and poCD45B, has shown that leukocyte subpopulation from piglets fed plasma protein did not significantly higher than that from piglets fed without plasma protein. 5. Total proportion of granulocytes and monocytes was about 50% in both group and the proportion after treated with Hypaque/Ficoll was 2.7% and 5.8% in each group, respectively.

• Journal of Animal Science and Technology
• /
• 제64권3호
• /
• pp.409-431
• /
• 2022

Various insects have emerged as novel feed resources due to their economical, eco-friendly, and nutritive characteristics. Fish, poultry, and pigs are livestock that can feed on insects. The digestibility of insect-containing meals were presented by the species, life stage, nutritional component, and processing methods. Several studies have shown a reduced apparent digestibility coefficient (ADC) when insects were supplied as a replacement for commercial meals related to chitin. Although the expression of chitinase mRNA was present in several livestock, indigestible components in insects, such as chitin or fiber, could be a reason for the reduced ADC. However, various components can positively affect livestock health. Although the bio-functional properties of these components have been verified in vitro, they show positive health-promoting effects owing to their functional expression when directly applied to animal diets. Changes in the intestinal microbiota of animals, enhancement of immunity, and enhancement of antibacterial activity were confirmed as positive effects that can be obtained through insect diets. However, there are some issues with the safety of insects as feed. To increase the utility of insects as feed, microbial hazards, chemical hazards, and allergens should be regulated. The European Union, North America, East Asia, Australia, and Nigeria have established regulations regarding insect feed, which could enhance the utility of insects as novel feed resources for the future.

• 생명과학회지
• /
• 제28권5호
• /
• pp.621-626
• /
• 2018

최근 의공학과 의학기술의 발달로 인간의 수명이 늘어나고 있으며, 이제는 수명에 대한 관심보다는 건강한 노후에 대한 관심에 초점을 맞추어 항노화 산업과 의과학 및 스포츠 과학이 발달하고 있다. 노화의 자연스런운 과정동안 노인들은 면역기능과 생리학적인 기능이 소실되고, 제2형 당뇨병, 고혈압, 골다공증, 골관절염, 심혈관 질환 및 인지감소 등을 경험하게 된다 하지만 규칙적인 운동을 참여할 때 건강한 노후를 맞이할 수 있다. 하지만 이제까지 노인들에게 규칙적인 운동활동의 참여가 건강체력, 정신건강, 인지기능 및 면역력의 변화를 확인하는 연구가 부족한 것으로 여겨진다. 따라서 본 연구는 노인에게서 일상생활도 관리 및 규칙적인 운동활동의 참여가 건강한 노후와 면역력유지에 미치는 효과를 분석하고자 한다. 본 연구를 수행하기 위하여 최근 20여년간 국내,외 이 분야에서 수행된 최신 연구결과들은 펍메드 데이터 베이스를 활용하여 비교 및 분석하고자 한다. 본 연구결과 레저활동을 포함하는 규칙적인 운동활동은 노인의 근육량과 골밀도를 증진시키고, 아울러 당뇨병, 고혈압, 동맥경화, 관절염 등과 같은 성인병을 예방하며, 아울러 인지기능 증가에 따른 치매의 예방과 치료 뿐만 아니라 면역력의 증진을 통한 만성질환과 암의 예방에도 필수적인 것으로 사료된다. 특히 노인에게는 요가나 필라테스를 기반으로 하는 수행하기 쉬운 운동이 좋으며, 흥미있고 자주 할 수 있는 운동이 권장된다. 체력이 전반적으로 약하기 때문에 무리한 운동은 오히려 심혈관계의 부담, 항상성의 교란, 및 면역저하를 동반할 수 있으므로, 레저스포츠 활동, 근력운동을 포함하는 저항운동, 및 일상생활도 증가를 통한 체력증진, 충분한 휴식, 최적의 영양관리가 필요하며 추후 건강한 노인에 최적화된 스포츠 장비, 영양소 섭취와 스포츠 음료 등의 계발에 관한 연구가 이루어져야 할 것이다.

• Journal of Photoscience
• /
• 제9권2호
• /
• pp.530-533
• /
• 2002

We present a case of The Miller Fisher Syndrome (MFS), showing a remission during a recently developed noninvasive therapy. Two weeks after an appearance of cough and fever, a 35 years old Japanese male developed diplopia, ataxia and numbness of his fingers and toes. He was diagnosed as MFS, and a fixed dose of prednisolone acetate (60mg/day) was administered for 3 months, but little improvement was observed. In addition to this administration, we tried 20 minutes of Photic Feedback (PFB) treatment daily for 40 days. The PFB system detects brain waves from the subject's forehead, and extracts alpha waves by the band-pass filter with a center frequency set at 10.0Hz. It also simultaneously modulates the augmentation of a red light-emitting diode, corresponding with the amplitudes of the extracted alpha waves. In this treatment, this adjusted photic stimulation was given to the subject's closed eyes, resulting in the effective alpha enhancement by photic driving response. The numbness increased during each of PFB treatment, but the symptoms started to improve gradually after 10 days. Other symptoms disappeared after 40 days. CD20 levels increased with this treatment. This case suggests that the PFB treatment may speed the natural remission of MFS. This treatment may be worth considering in patients who suffer polyneuropathy.

• 한국수정란이식학회지
• /
• 제33권3호
• /
• pp.159-168
• /
• 2018

Bovine colostrum is necessary for newborn calves to survive, grow and receive immunity from their mother. Cows in Korea produce about 35kg of colostrum, 4Kg of which is fed to the calf, and the rest is discarded. The bovine colostrum causes the harmful side effects to human, such as allergies and digestive problems; so, it is prohibited by law to consume colostrum itself as a food. However, many scientific research data have suggested that components in the colostrum can improve human health and has the ability to help treat diseases. In line with the trend of food and pharmacy industries using natural product materials, which attract positive attention, recently, some ingredients in colostrum have been used in the production of food supplements, and it has been used in its raw form in some cosmetics. This review introduces the active ingredients and physiologically active substances contained in bovine colostrum, summarizes the efficacy of physiological enhancement of the colostrum, which has been proven by scientific methods to date, and also suggests the possibility of industrial applications of colostrum as an animal-derived natural material.

• 한국통신학회논문지
• /
• 제36권8C호
• /
• pp.516-521
• /
• 2011

이 논문에서는 심각한 다중경로 페이딩 왜곡과 충격성 잡음을 극복하기 위해 결정궤환 구조를 갖추고 오차의 영확률을 최대화하는 비선형 알고리듬(MZEP-DF)를 제안하였다. 제안된 MZEP-DF 알고리듬은 충격성 잡음에 강인성을 보였고 궤환구조 영역에서 잔여 심볼간 간섭을 제거하는 능력을 보였다. 기존 LMS 알고리듬이 정상상태 오차 전력에 대해 -3 dB 이하로 수렴하지 못했던 심각한 다중경로 페이딩과 충격성 잡음 환경에 대해 제안한 알고리듬은 선형 MZEP 알고리듬과 비교하였을 때, 10 dB 이상 성능향상을 보였다.

• 한국임상수의학회지
• /
• 제15권2호
• /
• pp.352-357
• /
• 1998

Effects of chicken egg white derivatives (EWD and EF-203) on the changes of blood cells and the neutrophil phagocytic activity were examined in the rats. Rats were administered orally with either EWD (200 mg/kg) or EF-203 (200 mg/kg) for 3 days. Thereafter, the changes of blood cell values (RBC, WBC, platelets, PCV, differential count of neutrophils) and the phagocytic activity of neutrophils were evaluated for 7 days. The numbers of WBC and the differential count of neutrophils of rats administered with either EWD or EF-203 were significantly increased (p

• 대한의생명과학회지
• /
• 제17권1호
• /
• pp.79-84
• /
• 2011

Photodynamic therapy consists of a photosensitizer, suitable light source and oxygen. The excitation of the photosensitizer at a cancer mass results in oxidation which would ultimately reduce the mass via apoptosis. Millimeter wave (MMW) therapy has also been known to be effective on cancer cell mass reduction, human cell regeneration and immunity enhancement among the Russian clinicians and scientists. In the present study, the two modalities were combined to achieve synergistic effects while reducing the administration dosage of the photosensitizer, photogem, thus minimizing the side effects. The CT-26 adenocarcinoma cell mass was implanted on mice and the tumors were exposed to a simple MMW irradiation or a combined treatment of MMW and PDT. The treatments continued for 4 weeks and the size of the tumor was measured continuously. The significant therapeutic result of MMW was not found during 4 weeks, preferably more cancer recurrence possibility after MMW irradiation was observed. The results of this study suggest that the combination of MMW irradiation and photodynamic treatment should not be recommended. The result of the MMW treatment alone, however, displayed suppressive effect on cancer cell proliferation for both in vitro and in vivo. The results of the present study suggest that the millimeter wave therapy deserves a further study.