• 전자통신동향분석
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• 제37권1호
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• pp.63-72
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• 2022

Recently, blockchain has been attracting attention as a high-reliability technology in various fields. However, the Proof-of-Work-based distributed consensus algorithm applied to representative blockchains, such as Bitcoin and Ethereum, has limitations in applications to various industries owing to its excessive resource consumption and performance limitations. To overcome these limitations, various distributed consensus algorithms have appeared, and recently, hybrid distributed consensus algorithms that use two or more consensus algorithms to achieve decentralization and scalability have emerged. This paper introduces the technological trends of the latest high-performance distributed consensus algorithms by analyzing representative hybrid distributed consensus algorithms.

• ETRI Journal
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• 제43권2호
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• pp.357-370
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• 2021

The evolution of blockchain-based systems has enabled researchers to develop nextgeneration e-voting systems. However, the classical consensus method of blockchain, that is, Proof-of-Work, as implemented in Bitcoin, has a significant impact on energy consumption and compromises the scalability, efficiency, and latency of the system. In this paper, we propose a hybrid consensus model (PSC-Bchain) composed of Proof of Credibility and Proof of Stake that work mutually to address the aforementioned problems to secure e-voting systems. Smart contracts are used to provide a trustworthy public bulletin board and a secure computing environment to ensure the accuracy of the ballot outcome. We combine a sharding mechanism with the PSC-Bchain hybrid approach to emphasize security, thus enhancing the scalability and performance of the blockchain-based e-voting system. Furthermore, we compare and discuss the execution of attacks on the classical blockchain and our proposed hybrid blockchain, and analyze the security. Our experiments yielded new observations on the overall security, performance, and scalability of blockchain-based e-voting systems.

• 한국국방경영분석학회지
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• 제33권1호
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• pp.1-18
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• 2007

본 연구의 목적은 비교항목들의 척도가 서로 상이하고 측정치를 산정하기 곤란한 대안들의 의사결정시 대안 비교를 과학적으로 할 수 있는 지식기반 대안분석모델(KAAM)을 제안하는 것이다. KAAM은 기존의 방법인 Saaty, Delphi/Shang, Consensus, SAW 기법을 근간으로 하는 하이브리드 방식으로 구성되고 엑셀기반으로 구현하였다. 또한, 무기체계 획득사업의 사전분석 단계에서 최적 획득방안을 선정하는 실증적 사례를 적용함으로서 KAAM의 유용성을 확인하였다.

• 경영정보학연구
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• 제21권3호
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• pp.27-47
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• 2019

본 연구의 목적은 방한 외국인을 위한 블록체인 기반 결제시스템에 대한 소비자 수용의도를 규명하여 거래 편의성을 높이는 결제플랫폼 개발의 방향성을 제시하는 것이다. 이를 위해 블록체인의 특성으로 보안성, 신뢰성, 기능성을 도출 했다. 도출된 특성을 토대로 제안된 모델의 구조적 검증을 통해 소비자들의 측면에서 블록체인 기술수용에 영향을 미치는 요인을 확인하였다. 통합기술수용이론을 적용하여 성과기대, 노력기대, 사회적 영향, 촉진 조건, 인지된 혜택과 수용의도 간의 인과관계, 개인의 혁신성과 블록체인 인지수준에 따른 조절효과를 검증하였다. 개인의 혁신성과 블록체인 기술 인지수준에 따른 수용의도 차이에서도 혁신성향이 강하고 전반적인 기술에 대한 인지상태가 높은 집단이 블록체인 시스템을 기반으로 제시된 블록체인 수용의도에 더 많은 인과관계를 보여주었다. 또한, 블록체인 수용의도에 직접적인 영향을 미치는 요인은 기대되는 편익(성과기대), 이 서비스를 사용하기 위해 필요한 기술적 기반구조(촉진조건), 소비자 입장에서의 인지된 혜택(보안 및 신뢰, 기능성) 등 4가지 기제이다. 새로운 기술의 용이성(노력기대)과 기술을 도입할 때 주변 환경의 영향(사회적 영향)은 수용의도에 유의미한 영향을 미치지 못했다.

• Genomics & Informatics
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• 제16권4호
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• pp.29.1-29.5
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• 2018

Hybrid capture-based targeted sequencing is being used increasingly for genomic variant profiling in tumor patients. Unique molecular index (UMI) technology has recently been developed and helps to increase the accuracy of variant calling by minimizing polymerase chain reaction biases and sequencing errors. However, UMI-adopted targeted sequencing data analysis is slightly different from the methods for other types of omics data, and its pipeline for variant calling is still being optimized in various study groups for their own purposes. Due to this provincial usage of tools, our group built an analysis pipeline for global application to many studies of targeted sequencing generated with different methods. First, we generated hybrid capture-based data using genomic DNA extracted from tumor tissues of colorectal cancer patients. Sequencing libraries were prepared and pooled together, and an 8-plexed capture library was processed to the enrichment step before 150-bp paired-end sequencing with Illumina HiSeq series. For the analysis, we evaluated several published tools. We focused mainly on the compatibility of the input and output of each tool. Finally, our laboratory built an analysis pipeline specialized for UMI-adopted data. Through this pipeline, we were able to estimate even on-target rates and filtered consensus reads for more accurate variant calling. These results suggest the potential of our analysis pipeline in the precise examination of the quality and efficiency of conducted experiments.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제20권3호
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• pp.178-185
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• 2017

Purpose: To evaluate the outcomes of a hybrid prophylactic strategy to prevent cytomegalovirus (CMV) disease in pediatric liver transplantation (LT) patients. Methods: CMV DNAemia was regularly monitored by quantitative nucleic acid amplification test (QNAT) and was quantified in all children. CMV infection and disease were defined according to the International Consensus Guidelines. The hybrid strategy against CMV infection consisted of universal 3-week prophylaxis and preemptive treatment of intravenous ganciclovir regardless of the recipient's serostatus. Results: A total of 143 children who underwent living donor LT were managed using the hybrid strategy. The overall incidence of CMV infection by QNAT was 48.3% (n=69/143). The highest CMV DNAemia positivity was observed in 49.2% (n=60/122) of children in the D+/R+ group, followed by 46.7% (n=7/15) in the D+/R- group. CMV disease was noted in 26.1% (n=18/69) patients. Forty-three (62.3%) children had undergone preemptive therapy consisting of intravenous ganciclovir. No symptomatic patients developed tissue-invasive disease, resulting in no CMV-associated mortality. Conclusion: The incidence of CMV infection was high in pediatric LT patients despite the hybrid strategy. However, tissue-invasive disease in pediatric LT did not occur.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 제4회 추계심포지움
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• pp.55-64
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• 1996

mouse chromesome2에 있는 agouti locus는 정상적으로는 털색깔을 조절하는 gene이다. mouse agouti gene은 최근에 cloning 되었고 131 amino acid peptide와 consensus signal peptide를 encode한다고 보고되었다. 이 논문에서 interspecies-DNA hybridization approach를 이용하여 mouse agouti gene의 human homologue를 cloning 하였다. Sequence analysis 결과, 이는 mouse gene에 85% 유사하였고 consensus signal peptide sequence 를 포함하는 132 amino acid를 coding하였다. somatic-cell hybrid mapping pannel과 Fluorescence-in-situ hybridization에 의한 chromosomal mapping을 한 결과, agouti gene은 MODY (maturity onset diabetes of the young), myeloid leukemia locus 등이 위치한 human chromosome 20q 11.2에 mapping 되었다. 성인 tissue로부터 추출한 RNA를 이용한 발현연구에 의하면 human agouti gene은 adipose tissue와 teatis에 발현되었다.

• 한국방사선학회논문지
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• 제16권5호
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• pp.649-660
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• 2022

1959년도 Satomura가 분광 도플러 초음파를 이용하여 시간변화에 따른 적혈구의 속도를 표현하였고 Kato가 혈류의 방향을 알 수 있는 제로베이스 선(Zerobase line)을 정의하면서 혈류의 방향을 알 수 있게 되었다. 이는 현재 폭넓게 사용하고 있는 삼상파 (Triphasic), 이상파(Biphasic), 단상파(Monophasic) 분류의 기초가 되었다. 하지만 위와 같은 분류는 임상 환경에서 사용 의미와 시점에 사용자들에게 혼란을 주는 한계가 있었고 이와 같은 결과로 미국의 혈관의학회(Society for Vascular Medicine, SVM)와 혈관초음파학회(Society for Vascular Ultrasound, SVU)가 구성한 공동 위원회에서 도플러 파형 해석 합의문(Consensus document)을 선언하였다. 본 연구에서는 이 합의문을 고찰하고 국내 혈관 초음파 임상 현장에서 사용될 수 있는 명명법과 수식어를 제언하고자 하였다. SVM과 SVU가 구성한 공동 위원회에서는 동맥 삼상파(Triphasic waveform)와 이상파(Biphasic waveform)의 해석의 모호함을 이유로 사용을 지양하고 다상파(Multiphasic waveform)로 사용하길 권고 하였다. 또한 임상 환경에서 항상 해석의 문제가 되었던 단상파이면서 고저항성 파형인 하이브리드 형태 파형을 중저항성 파형(Intermediate resistive)으로 명명하기로 합의하였다. 또한 판독의사와 초음파사간에 의사소통의 효율성을 높이기 위해 파형 해석을 주 설명어(Main descriptor)와 수식어(Modifier)로 분류하였고 다양하게 사용하던 동의어들을 통일하여 하나의 명명법으로 사용하도록 권고하였다. 본 문헌 고찰을 통해 임상에서 혈관 초음파 검사 직무를 수행하는 방사선사들에게 정확한 동맥 분광 도플러 파형 해석과 합의된 명명법을 제공하여 국민보건향상에 이바지할 수 있는 기초자료로 활용되기를 기대한다.

• 복식
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• 제54권2호
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• pp.53-65
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• 2004

As the contemporary public consensus prefers individuality to classical things, they have gotten sick of the universality and pursue fashion anew. As a result the new concept of artistic value delivers a shock to ordinary and traditional images. The bizarreness culture of fashion contains two extremes, horror and humor. which make people uneasy but amused by sensuous descriptions. Bizarre things captivate the audience regardless of the violent stimuli. The conversion of aesthetic consciousness is brought accordingly by horror and humor. In this paper, It is discussed that the concept of history of bizarreness and the social effect from its phenomena in current fashion are expressed through the two methods above. The bizarreness phenomena in current fashion is shown as a new hybrid type which has been recreated and came out of the internet. This phenomena has caused abnormal results and ironically mixed products, what was once directness, violence and disgust, are on the other hand enjoyment and amusement. A widening field, the bizarreness phenomenon, as an important implication in which can completely change the current trend, will be on track as a crucial concept representing contemporary cultures.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2018년도 춘계학술대회 및 임시총회
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• pp.22-22
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• 2018

Fungal genome sequencing and assembly have been trivial in these days. Genome analysis relies on high quality of gene prediction and annotation. Automatic fungal genome annotation pipeline is essential for handling genomic sequence data accumulated exponentially. However, building an automatic annotation procedure for fungal genomes is not an easy task. FunGAP (Fungal Genome Annotation Pipeline) is developed for precise and accurate prediction of gene models from any fungal genome assembly. To make high-quality gene models, this pipeline employs multiple gene prediction programs encompassing ab initio, evidence-, and homology-based evaluation. FunGAP aims to evaluate all predicted genes by filtering gene models. To make a successful filtering guide for removal of false-positive genes, we used a scoring function that seeks for a consensus by estimating each gene model based on homology to the known proteins or domains. FunGAP is freely available for non-commercial users at the GitHub site (https://github.com/CompSynBioLab-KoreaUniv/FunGAP).