• Genomics & Informatics
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• v.21 no.1
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• pp.5.1-5.13
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• 2023

Neisseria gonorrhoeae is a Gram-negative aerobic diplococcus bacterium that primarily causes sexually transmitted infections through direct human sexual contact. It is a major public health threat due to its impact on reproductive health, the widespread presence of antimicrobial resistance, and the lack of a vaccine. In this study, we used a bioinformatics approach and performed subtractive genomic methods to identify potential drug targets against the core proteome of N. gonorrhoeae (12 strains). In total, 12,300 protein sequences were retrieved, and paralogous proteins were removed using CD-HIT. The remaining sequences were analyzed for non-homology against the human proteome and gut microbiota, and screened for broad-spectrum analysis, druggability, and anti-target analysis. The proteins were also characterized for unique interactions between the host and pathogen through metabolic pathway analysis. Based on the subtractive genomic approach and subcellular localization, we identified one cytoplasmic protein, 2Fe-2S iron-sulfur cluster binding domain-containing protein (NGFG RS03485), as a potential drug target. This protein could be further exploited for drug development to create new medications and therapeutic agents for the treatment of N. gonorrhoeae infections.

• Asian Journal of Innovation and Policy
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• v.12 no.2
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• pp.261-267
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• 2023

In the paper of 'Natural Selection Favors AIs over Humans,' Dan Hendrycks applies principles of Darwinian evolution to forecast potential trajectories of AI development. He proposes that competitive pressures within corporate and military realms could lead to AI replacing human roles and exhibiting self-interested behaviors. However, such claims carry the risk of oversimplifying the complex issues of competition and natural selection without clear criteria for judging whether AI is selfish or altruistic, necessitating a more in-depth analysis and critique. Other studies, such as ''The Threat of AI and Our Response: The AI Charter of Ethics in South Korea,' offer diverse opinions on the natural selection of artificial intelligence, examining major threats that may arise from AI, including AI's value judgment and malicious use, and emphasizing the need for immediate discussions on social solutions. Such contemplation is not merely a technical issue but also significant from an ethical standpoint, requiring thoughtful consideration of how the development of AI harmonizes with human welfare and values. It is also essential to emphasize the importance of cooperation between artificial intelligence and humans. Hendrycks's work, while speculative, is supported by historical observations of inevitable evolution given the right conditions, and it prompts deep contemplation of these issues, setting the stage for future research focused on AI safety, regulation, and ethical considerations.

• Journal of Animal Science and Technology
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• v.66 no.2
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• pp.266-278
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• 2024

Antibiotic resistance (AR) is a complex, multifaceted global health issue that poses a serious threat to livestock, humans, and the surrounding environment. It entails several elements and numerous potential transmission routes and vehicles that contribute to its development and spread, making it a challenging issue to address. AR is regarded as an One Health issue, as it has been found that livestock, human, and environmental components, all three domains are interconnected, opening up channels for transmission of antibiotic resistant bacteria (ARB). AR has turned out to be a critical problem mainly because of the overuse and misuse of antibiotics, with the anticipation of 10 million annual AR-associated deaths by 2050. The fact that infectious diseases induced by ARB are no longer treatable with antibiotics foreshadows an uncertain future in the context of health care. Hence, the One Health approach should be emphasized to reduce the impact of AR on livestock, humans, and the environment, ensuring the longevity of the efficacy of both current and prospective antibiotics.

• Journal of Korean Society of Disaster and Security
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• v.9 no.1
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• pp.25-32
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• 2016

Technical development have broaden human activity ranges and make human possible to defend the disasters which was undependable in the past. However, human's space activity brought a new kind of disaster to human. In the past, natural space objects was the only concern from the space, like the asteroid fallen on Chelyabinsk, Russia. But, nowadays, by the increasing number of the man-made space objects, these space kind of threat have diversified and become very real. So, nationwide safety strategy should be established to protect the people. In this paper, we suggest three points to make the decision for establishing the strategy based on the AHP analysis results.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.5
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• pp.240-248
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• 2020

Over the past 20 years, brain science has developed rapidly thanks to new technologies such as functional magnetic resonance imaging (fMRI), leading to more accurate knowledge of human nature and behavioral changes. This knowledge is also actively applied in the field of management. This research aimed to gain insights into how neuroscience can be incorporated into management through the case of Midas IT Co. This construction software company has a separate organization with the purpose of studying brain science, and it makes and implements human resource management policies based on brain science. The founder Lee Hyung-woo has a humanist management philosophy, and the company's brain science research supports that philosophy. The case study method was adopted as the research method, and procedures such as interviews and direct observation, participation observation, and document information were carried out. The company's human resource management system can be explained by a brain science model called "SCARF", which combines various neuroscience discoveries. As this model suggests, the company has improved the trust and satisfaction of its members by reducing threat of status and by increasing certainty, autonomy, relationship, and fairness in the workplace, resulting in the creation of a platform for creativity, integrity, and high performance.

• Journal of the Korea Convergence Society
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• v.7 no.4
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• pp.33-38
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• 2016

DDoS attack has been continuously utilized that caused the excessively large amount of traffic that network bandwidth or server was unable to deal with paralyzing the service. Most of the people regard NTP as the biggest cause of DDoS. However, according to recently executed DDoS attack, there have been many SSDP attack in the use of amplified technique. According to characteristics of SSDP, there is no connection for making a forgery of source IP address and amplified resources feasible. Therefore, it is frequently used for attack. Especially, as it is mostly used as a protocol for causing DDoS attack on IoT devices that constitute smart home including a wireless router, media server, webcam, smart TV, and network printer. Hereupon, it is anticipated for servers of attacks to gradually increase. This might cause a serious threat to major information of human lives, major government bodies, and company system as well as on IoT devices. This study is intended to identify DDoS attack techniques in the use of weakness of SSDP protocol occurring in IoT devices and attacking scenario and counter-measures on them.

• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.4
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• pp.881-895
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• 2012

Micro-robots are utilized as useful tools in diagnosis and treatment of various human diseases. At present, lots of countries are developing and making many micro-robots. Government of S. Korea are trying to push ahead with the plan as technology policy, for the same reason. So this study examined about micro-robot technology development and trend of S. Korea, by using the method of SWOT(Strength-Weakness-Opportunity-Threat) analysis. As a result, the future policy for micro-robot of S. Korea is to further spur the development of new micro-robot technology and more improvement of the technology level of micro-robots registered by patent as 'micro-robot of bacterium base for lesion treatment' and 'micro-robot moved by compressive fluid'. Finally, It was already confirmed as high level, technology of 'micro-robot of bacterium base for lesion treatment' and 'micro-robot moved by compressive fluid' invented at S. Korea.

• Journal of Applied Biological Chemistry
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• v.59 no.1
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• pp.83-90
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• 2016

The aim of the present study was to evaluate the degree of metal contamination of the Turag River water and its suitability for irrigation. Twenty water samples were analyzed for physicochemical parameters and metals viz., calcium, magnesium, potassium (K), sodium, copper (Cu), zinc (Zn), iron (Fe), manganese (Mn), lead (Pb), cadmium (Cd), chromium (Cr), and nickel (Ni). All water samples were slightly alkaline to alkaline. Regarding electrical conductivity (EC), all samples were suitable for crop in soils with moderate permeability and leaching. Water samples were medium salinity and low alkalinity hazard classes. In terms of total dissolved solids (TDS), all samples were classified as freshwater. As per sodium adsorption ratio (SAR) and soluble sodium percentage (SSP), all samples were classified as excellent. No residual sodium carbonate (RSC) was detected in any of the samples, indicating suitability for irrigation; and all samples were considered very hard. Cr and Mn contents in all samples were above FAO guideline values and, therefore, these metals were considered toxic. Zn, Cu, Pb, Cd, and Ni concentrations were below acceptable limit for irrigation and do not pose a threat to soil environment. Significant relationships were found between EC and TDS, SAR and SSP, SAR and RSC, and SSP and RSC. The combinations of ions such as K-Zn, K-Fe, K-Cu, K-Mn, K-Pb, Zn-Fe, Zn-Cu, Zn-Mn, Fe-Mn, Cu-Mn, Cu-Pb and Mn-Pb exhibited significant correlation. This study revealed that Turag River water samples are contaminated with Cr and Mn. This fact should not be ignored because water contamination by metals may pose a threat to human health through food chain.

• Journal of Navigation and Port Research
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• v.36 no.1
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• pp.9-14
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• 2012

Maritime security incidents by pirates and by terrorists increase, but maritime incidents investigation models are limited to figure out the maritime security incidents. This paper provides the analysis model for maritime security incidents. To develop this analysis model, this categorizes five threat factors, the ship, the cargo type, port system, human factor, information flow system, makes the risk assessment matrix to quantify the risk related to threat factors and classifies four priority categories of risk assessment matrix. Also, this model makes from the frameworks which include a variety of security initiatives implementing in stakeholder levels like international organizations, individual governments, shipping companies, and the ship. Therefore, this paper develops the Analysis for Maritime Security Management model based on various security initiatives responding to the stakeholder levels of maritime security management and top-bottom/bottom-up decision trees, and shows the validity through verifying the real maritime security incident of M/V Petro Ranger.

• Environmental Engineering Research
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• v.24 no.1
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• pp.1-16
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• 2019

N-nitrosodimethylamine (NDMA) is a typical nitrogen disinfection by-product, which has posed a potential threat to human health during drinking water disinfection. Because of the well-known effects of mutagenesis, carcinogenesis and teratogenesis, the high detection rate in water engineering systems (such as coagulation, membrane filtration and biological systems), and difficulty to remove, it has received wide concern in the field of water engineering systems. The NDMA is a low molecular weight hydrophilic organic substance, which is difficult to remove. Also, the mechanism for NDMA formation is also recognized to be complex, and many steps still needed to be further evaluated. Therefore, the mechanistic knowledge on NDMA formation potential and their removal processes is of particularly interest. Few papers summarize the occurrence and control of NDMA in water engineering systems. It is for this reason that the content of this paper is particularly important for us to understand and control the amount of NDMA thus reducing the threat of disinfection by-products to drinking water. Four parts including the mechanisms for the NDMA formation potential, the factors affecting the NDMA formation potential, the technologies for removal of NDMA are summarized. Finally, some definite suggestions are given.