• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2001년도 추계학술대회논문집 II
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• pp.597-602
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• 2001

The structure of the human body has a limit to absorb the high-level-impact that occurs in shoulder-fired system. In other to solve this problem, short recoil system is applied to shoulder-fired system, and is verified experimentally, and then is performed analysis of parameters sensitivity, optimization of main part. According to the results, we developed A fundamental basis for buffering structure modeling that is operated by high level input in shoulder-fired system

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2015년도 추계학술발표대회
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• pp.1585-1588
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• 2015

본 논문은 human visual system(HVS)에 따른 주파수 민감도와 공간에서 다양한 특성들을 구현하기 위한 신호처리 방법을 개발하였다. 인간의 눈은 주파수 성분에 따라 민감도가 다르며 초점에서 멀수록 인지 가능한 해상도가 떨어진다. 주파수 민감도를 구현하기 위해서 본 논문은 영상 신호의 에너지 스펙트럼 모양이 contrast sensitivity function(CSF)의 모양이 되도록 하여 영상 신호의 에너지를 증가시켰으며 신호 방향에 적응적인 multiband energy scaling 방법을 개발하였다. 기존의 시스템에서 능률만을 향상시키는 기존의 분석 모델과 비교하면 개발한 방법은 HVS에 좀 더 적절하고 선호되게 영상 신호를 처리할 수 있다.

• Journal of information and communication convergence engineering
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• 제20권3호
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• pp.153-159
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• 2022

Plain radiographic analysis is the initial imaging modality for suspected small bowel obstruction. Among the many features that affect the diagnosis of small bowel obstruction (SBO), the presence of gas-filled or fluid-filled small bowel loops is the most salient feature that can be automatized by computer vision algorithms. In this study, we compare three frequently applied pixel-clustering algorithms for extracting gas-filled areas without human intervention. In a comparison involving 40 suspected SBO cases, the Possibilistic C-Means and Fuzzy C-Means algorithms exhibited initialization-sensitivity problems and difficulties coping with low intensity contrast, achieving low 72.5% and 85% success rates in extraction. The Adaptive Resonance Theory 2 algorithm is the most suitable algorithm for gas-filled region detection, achieving a 100% success rate on 40 tested images, largely owing to its dynamic control of the number of clusters.

• 센서학회지
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• 제31권5호
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• pp.293-300
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• 2022

Flexible, wearable, and implantable electronic sensors have started to gain popularity in improving the quality of life of sick and healthy people, shifting the future paradigm with high sensitivity. However, conventional technologies with a limited lifespan occasionally limit their continued usage, resulting in a high cost. In addition, traditional battery technologies with a short lifespan frequently limit operation, resulting in a substantial challenge to their growth. Subsequently, utilizing human biomechanical energy is extensively preferred motion for biologically integrated, self-powered, functioning devices. Ideally suited for this purpose are piezoelectric energy harvesters. To convert mechanical energy into electrical energy, devices must be mechanically flexible and stretchable to implant or attach to the highly deformable tissues of the body. A systematic analysis of piezoelectric nanogenerators (PENGs) for personalized healthcare is provided in this article. This article briefly overviews PENGs as self-powered sensor devices for energy harvesting, sensing, physiological motion, and healthcare.

• 대한의용생체공학회:의공학회지
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• 제43권5호
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• pp.331-340
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• 2022

Early afterdepolarization (EAD), a significant cause of fatal ventricular arrhythmias including Torsade de Pointes (TdP) in long QT syndromes, is a depolarizing afterpotential at the plateau or repolarization phase in action potential (AP) profile early before completing one pace. AP duration prolongation is related to EAD but is not necessarily accounted for EAD. Several computational studies suggested EAD can form from an abnormality in the late plateau and/or repolarization phase of AP shape. In this sense, we hypothesized the slope during repolarization has the characteristics to predict TdP risk, mainly focusing on the maximum slope during repolarization (dVm/dt_{max_repol}). This study aimed to predict the sensitivity of dVm/dt_{max_repol} to ion channel conductances as a TdP risk metric through a population simulation considering multiple effects of simultaneous reduction in six ion channel conductances of g_NaL, g_Kr, g_Ks, g_to, g_K1, and g_CaL. Additionally, we verified the availability of dVm/dt_{max_repol} for TdP risk prediction through the correlation analysis with qNet, the representative TdP metric. We performed the population simulations based on the methodology of Gemmel et al. using the human ventricular myocyte model of Dutta et al. Among the sixion channel conductances, dVm/dt_{max_repol} and qNet responded most sensitively to the change in g_Kr, followed by g_NaL. Furthermore, dVm/dt_{max_repol} showed a statistically significant high negative correlation with qNet. The dVm/dt_{max_repol} values were significantly different according to three TdP risk levels of high, intermediate, and low by qNet (p<0.001). In conclusion, we suggested dVm/dt_{max_repol} as a new biomarker metric for TdP risk assessment.

• Geomechanics and Engineering
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• 제31권5호
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• pp.453-460
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• 2022

It is essential for geotechnical engineers to conduct studies and make predictions about the stability of slopes, since collapse of a slope may result in catastrophic events. The Gaussian process regression (GPR) approach was carried out for the purpose of predicting the factor of safety (FOS) of the slopes in the study that was presented here. The model makes use of a total of 327 slope cases from Iran, each of which has a unique combination of geometric and shear strength parameters that were analyzed by PLAXIS software in order to determine their FOS. The K-fold (K = 5) technique of cross-validation (CV) was used in order to conduct an analysis of the accuracy of the models' predictions. In conclusion, the GPR model showed excellent ability in the prediction of FOS of slope stability, with an R² value of 0.8355, RMSE value of 0.1372, and MAPE value of 6.6389%, respectively. According to the results of the sensitivity analysis, the characteristics (friction angle) and (unit weight) are, in descending order, the most effective, the next most effective, and the least effective parameters for determining slope stability.

• Nuclear Engineering and Technology
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• 제23권2호
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• pp.174-182
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• 1991

안전계통의 이용불능도 및 최적시험주기 평가에 있어서 주기적인 시험과 관련된 인간실수의 영향을 고려하였다. 시험 및 보수와 관련된 인간실수는 건전한 계통이 시험 후 잘못된 상태에 놓이게 될 가능성과(Type A인간실수)건전하지 못한 계통이 시험시 감지되지 못할 가능성(Type B인간실수)이다. 계통이용불능도 및 최적시험주기에 미치는 인간실수의 영향을 결정하기 위하여 안전계통의 이용불능도를 계산하기 위한 사상수목모델이 개발되었다. 또한 안전주입계통의 신뢰도 분석을 통하여 계통전체에 미치는 영향을 평가하였다. 다양한 민감도 분석 결과, (1) 계통이용불능도는 인간실수의 확률이 커질수록 증가하며 Type A인간실수의 영향이 훨씬 크다. (2) 최적시험주기 는 Type A 인간실수가 커 질수록 약간 증가하나, Type B 인간실수가 커 질수록 감소한다. (3) 안전주입펌프의 시험주기를 고정시키면 안전주입계통의 이용불능도는 Type A인간실수가 커질수록 크게 증가하나 Type B 인간실수가 커지더라도 약간 증가한다. 따라서 인간실수의 영향을 고려 할 때 계통의 이용불능도를 일정 수준으로 유지하기 위해서는 시험주기(최적시험주기가 아님 )를 줄여야 한다. 그리고 시험 및 보수시 Type A 인간실수는 계통의 이용불능도에 미치는 영향이 크므로, 특히 TyPe A 인간실수를 줄이기 위한 노력이 필요하다.

• Korean Chemical Engineering Research
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• 제58권1호
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• pp.106-112
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• 2020

Analyzing vitamin D levels is important for monitoring health conditions because vitamin D deficiency is associated with various diseases such as rickets, osteomalacia, cardiovascular disorders and some cancers. However, vitamin D concentration in the blood is very low with optimal level of 75 nmol/L, making quantitative analysis difficult. The objective of this study was to develop a highly sensitive analysis method for vitamin D using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS). 25-hydroxyvitamin D (25(OH)D), which has been used as an indicator of vitamin D metabolites in human biofluids was chemically derivatized using a secosteroid signal enhancing tag (SecoSET) with powerful dienophile and permanent positive charge. The SecoSET-derivatized 25(OH)D provided good linearity (R² > 0.99) and sensitivity (limit of quantitation: 11.3 fmol). Chemical derivatization of deuterated 25-hydroxyvitamin D₃ (d₆-25(OH)D3) with SecoSET enabled absolute quantitative analysis using MALDI-MS. The highly sensitive method could be successfully applied into monitoring of quantitative changes of bioactive vitamin D metabolites after treatment with ketoconazole to inhibit 1α-hydroxylase reaction related to vitamin D metabolism in human breast cancer cells. Taken together, we developed a MALDI-MS-based platform that could quantitatively analyze vitamin D metabolites from cell products, blood and other biofluids. This platform may be applied to monitor various diseases associated with vitamin D deficiency such as rickets, osteomalacia and breast cancer.

• Bulletin of the Korean Chemical Society
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• 제35권4호
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• pp.1159-1164
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• 2014

A simple, highly sensitive and selective method based on the rhodamine B-covered gold nanoparticle with dual-readout (colorimetric and fluorometric) detection for $\small{L}$-cysteine is proposed. A mechanism is that citrate-stabilized AuNPs were modified with RB by electrostatic interaction, which enables the nanometal surface energy transfer (NSET) from the RB to the AuNPs, quenching the fluorescence. In the presence of $\small{L}$-cysteine, it was used as a competitor in the NSET by the strongly Au-S bonding to release RB from the Au surface and recover the fluorescence, and the red-to-purple color change quickly, which was monitored simply by the naked eye. Under the optimum conditions, the detection limit is as low as 10 nM. The method possessed the advantages of simplicity, rapidity and sensitivity at the same time. The method was also successfully applied to the determination of $\small{L}$-cysteine in human urine samples, and the results were satisfying.

• Journal of Biosystems Engineering
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• 제30권6호통권113호
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• pp.333-339
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• 2005

The pesticide is raising public interest in the world, because it causes damage to an environmental pollution and the human health remaining agricultural products and an ecosystem, in spite of the advantages. Particularly, each country restricts the residual pesticide and induces observance about the safety and usage standard so that they can control the amount of pesticide used and defend the safety of agricultural products. The habitual practice for the analysis of the residual pesticide depends on GC (gas chromatography), HPLC (high performance liquid chromatography) and GC/MS (gas chromatography/mass spectroscopy), which triturate the fixed quantity of samples, abstract and purify as a suitable organic solvent. These methods have the highly efficient in aspects of sensitivity and accuracy. On the other hand, they need the high cost, time consuming, much effort, expensive equipment and the skillful management. Carbofuran is highly toxic by inhalation and ingestion and moderately toxic by dermal absorption. As with other carbamate compounds, it is metabolized in the liver and eventually excreted in the urine. The half-life of carbofuran on crops is about 4 days when applied to roots, and longer than 4 days if applied to the leaves. This research was conducted to develop immunoassay for detecting carbofuran residue quickly on the basis of surface plasmon resonance and to evaluate the measurement sensitivity. Gold chip used was CM5 spreaded dextran on the surface. An applied antibody to Immunoassay was GST (glutathione-s-transferase). The association and the dissociation time were 176 second and 215 second between GST and carbofuran. The total analysis time using surface plasmon resonance was 13 minutes including regeneration time, on the other hand HPLC and GC/MS was 2 hours usually. The minimum detection limit of a permissible amount for carbofuran in the country is 0.1 ppm. The immunoassay method using surface plasmon resonance was 0.002 ppm.