• BMB Reports
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• 제57권5호
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• pp.207-215
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• 2024

The gut microbiota, an intricate community of bacteria residing in the gastrointestinal system, assumes a pivotal role in various physiological processes. Beyond its function in food breakdown and nutrient absorption, gut microbiota exerts a profound influence on immune and metabolic modulation by producing diverse gut microbiota-generated metabolites (GMGMs). These small molecules hold potential to impact host health via multiple pathways, which exhibit remarkable diversity, and have gained increasing attention in recent studies. Here, we elucidate the intricate implications and significant impacts of four specific metabolites, Urolithin A (UA), equol, Trimethylamine N-oxide (TMAO), and imidazole propionate, in shaping human health. Meanwhile, we also look into the advanced research on GMGMs, which demonstrate promising curative effects and hold great potential for further clinical therapies. Notably, the emergence of positive outcomes from clinical trials involving GMGMs, typified by UA, emphasizes their promising prospects in the pursuit of improved health and longevity. Collectively, the multifaceted impacts of GMGMs present intriguing avenues for future research and therapeutic interventions.

• 생명과학회지
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• 제21권5호
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• pp.693-699
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• 2011

Spermidine은 spermine의 전구체로 역할을 하는 putrescine로부터 합성되는 polycation의 한 형태이다. 최근에 spermidine는 수명연장에 중요한 역할을 하는 하나의 polyamine으로 알려져 있다. Hydroxyl radical, superoxide 및 hydrogen peroxide와 같은 활성산소(ROS)는 노화뿐만 아니라 다양한 병원성 과정에서 관여한다고 보고되고 있다. DPPH radical, $H_2O_2$ 및 hydroxyl radical에 대한 spermidine의 소거활성과 산화적 스트레스와 관련된 DNA oxidation에 대한 보호 효과가 in-vitro에서 평가되었다. Spermidine은 500 ${\mu}M$ 이상에서 DPPH radical와 $H_2O_2$에 대한 소거 효과를 보여주었다. 특히 활성산소종 중에서 spermidine는 hydroxyl radical에 대한 효과가 탁월하였다. 뿐만 아니라, spermidine는 500 ${\mu}M$에서 DNA oxidation에 대해서도 뚜렷한 보호 효과를 나타내었다. 더욱이 사람피부섬유아세포에서 superoxide dismutase와 같은 항산화 관련 단백질의 발현이 대조군과 비교시 spermidine 존재 하에 증가하였다. 이상의 결과로부터 spermidine은 암, 노화 및 염증을 포함하는 활성산소와 관련 있는 질병들을 예방하기 위한 항산화제로 이용될 수 있을 것이다.

• 기본간호학회지
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• 제5권2호
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• pp.237-256
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• 1998

Death and dying of human being is a comprehensive system, and death orientation, the subjective meaning related to every component of the death system is developed throughout life. This study was designed and carried out to identify, describe and classify the orientations of Korean adult towards the death system. In an attempt to measure the subjective meaning of death and dying, unstructured Q-methodology was used. The 65 Q-statements developed by Kim(1994), used by Kim(1994) and Park(1996) were adopted as Q-population and 39 Q-statements were selected by the three researchers for Q-items for this study. Thirty-three P-samples were sampled from P-population of literate Korean men and women, 35 and 55 years of age, lived in urban Korea for the last 10 years. Sortings of the 39 Q-items according to the level of personal agreement, and a forced normal distribution into the 9 levels were carried out by the P-samples. The Z-scores of the Q-sort data were computed, and the principal components factor analysis by PC-QUANL Program were carried out. The demographic, socio-cultural and health-related attributes of the P-samples were descriptively analysed. Eight types of death orientation were identified ; Type I ; 'naturalist'. Six P-samples. Death is a natural phenomena, to be accepted as it is and to follow its natural course. Prefer to be informed of all facts and possibilities concernig the course of dying and death to occur to self. Type II ; 'life-after-life negator'. Three P-samples. Time and process of death is the destiny of each person. Death means 'darkness' and 'end to every thing, the absolute end'. Yet, wish physical integrity at the dying and after death. Type III ; 'life-after-life believer'. Six P-samples. Men are travellers passing by this life bound to the life-after-life. Priority concerns are on the activities to prepare self for the eternal life ahead. Disregard premature and sudden death. Type IV ; 'here-now believer' Five P-samples. Positive regard to the cremation of the body and donation of the organs on death. Regard religious and customary post-motem rituals meaningless. Negate life-after life. Type V; 'believer of rituals'. Five P-samples. Death being accepted as a part of, a natural end to, and destiny of human life. Concerned to ensure a dignified end to personal life and dignified post-mortem rituals. Type VI ; 'Realist'(derived from Type I). Two P-samples. Life and death as universal reality. The abrupt death at golden age at the peak of happiness is favored to avoid inevitable physical and mental distress of self and the family. Agreed to the cremation of the body. Disregard rituals. Type VII : 'Fatalist' (derived from Type II). Five P-samples. Not favored, yet, all man are destined to death, the inevitable end of all living beings. To ensure dignified end by personal consummation, information on one's dying and imminent death are to be shared. Type VIII ; 'reality avoider'(derived from Type III). One P-sample. Negative to longevity, artificial prolongation of, meaningless and distressful life. Highly positive to postmortem organ donation.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2007년도 정기학술발표대회 논문집
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• pp.331-336
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• 2007

건축물 관리의 중요성이 건설 산업에서 크게 부각되고 건축물의 수명연장과 효율적인 건설 프로젝트 관리에 대해 많은 관심이 집중되고 있다. 현재는 기존의 건물의 유지관리를 위한 연구가 많이 진행 되어지고 있으며 현재 기존 논문들은 건설 프로젝트 과정 중 일부 부분에 집중하여 관리 방안들을 제시 하고 있다. 본 논문은 기획, 설계, 조달, 시공, 운전${\cdot}$유지관리 등 여러 단계를 걸쳐 이루어지는 건설 프로젝트의 전 과정에서 RFID/USN을 이용하는 관리 방안을 제안하고자 한다. 먼저, 건설 프로젝트에서 일반 적으로 이루어지는 프로세스를 분석하고 RFID/USN 적용 가능한 범위를 분석한다. 각 단계로 보면 기획, 설계 단계에서 사용 범위, 위치 및 방법 등을 결정하고 조달 단게에 장비, 인력, 자재등의 조달 계획을 수립하고 시공 단계에서 실시간 진도, 인력 및 안전, 자재, 장비 관리 등을 실시하고 운전${\cdot}$유지관리 단계에서는 이미 설치된 센서 태그와 무선 센서 네트워크를 통하여 실시간 건축물을 관리 한다. 본 논문에 의해 건설프로젝트에서 효율적인 프로젝트 진행과 관리에 도움을 주고 건축무리 완공된 후에도 유지관리의 편의성을 제시하고자 한다.

• 대순사상논총
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• 제45집
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• pp.37-67
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• 2023

이 논문은 『문창효경(文昌孝經)』과 『정명충효전서(淨明忠孝全書)』에 나타난 충효관을 중심으로 하여 도교가 지향하는 충효관을 살펴보고자 한 것이다. 한대(漢代) 이후 유학이 지배 이데올로기로 작동한 이후 효 관념은 국가와 사회를 이끌어가는 대표적인 덕목으로서 황제에서부터 한 개인에 이르기까지 모두 해당하였다. 도교에서도 충효를 강조하는 것은 마찬가지였다. 도교의 종파에 따라 효 그 자체를 중시하는 경우도 있고 효를 충과 함께 중시하는 경우도 있다. 특히 도교를 '세속에서의 인간관계망에서 요구되는 바람직한 행동거지를 잊어버리고 삶을 살아가면서 맞닥트리는 다양한 사물과의 관계를 끊는 것[絶世遺物]'으로 규정하는 것을 비판하면서 충과 효를 강조하는 '정명충효도(淨明忠孝道)'의 효도관 및 충효관은 유가의 충효관의 영향 관계를 보여주면서 동시에 도교의 효도관과 충효관을 보여준다. 도교가 지향하는 가장 근본적인 것은 불로장생하는 신선 되기 혹은 우화등선(羽化登仙)을 추구하는 것이다. 그런데 이 같은 신선이 되기 위한 전제조건으로 충효(忠孝), 화순(和順), 인신(仁信)을 행할 것을 요구한다. 충효, 화순, 인신을 강조하는 것은 유가와 동일하다. 하지만 그것을 통해 신선 되기를 추구하고자 하는 것은 유가에서 신선을 부정하는 것과 차별화된 사유에 속한다. 특히 정명충효도에서는 '절세유물'로 이해되는 도교관을 거부함과 동시에 충효를 통한 제가(齊家)와 치국(治國)은 물론 모든 만물에까지 충효의 이념과 실천을 강조하고 있다. 본 논문에서 유가의 효도관과 대비하여 본 도교 효도관의 특징은 세가지로 정리할 수 있다. 하나는 도교가 추구하는 장수(長壽)하면서 성선(成仙)하는 것을 효와 매우 밀접하게 관련짓는다는 것이다. 이런 점은 장수성선(長壽成仙) 신앙을 가미해 유가의 효도관을 개조하고 제고시킨 점이 있다. 다른 하나는 도교의 효도관에는 천인감응(天人感應)의 사상이 농후하다는 점이다. 효행을 하면 천지신명과 감응한다는 도리를 강조하면서 동시에 불효하고 불충한 경우 하늘로부터 재앙을 받는다는 사유를 제시한다. 마지막으로 친소(親疏)의 구별을 하지 않고 부모부터 천지 만물에 이르기까지 효도를 실천해야 한다는 것이다.

• 생명과학회지
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• 제28권8호
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• pp.931-937
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• 2018

뇌공등에 함유되어있는 트립톨라이드는 뛰어난 항염증, 항산화 효능을 가지고 있음이 보고되었다. 예쁜꼬마선충을 이용한 이전 연구에서 트립톨라이드의 섭취가 개체의 항스트레스 효능을 높이고, 수명을 연장시킴이 밝혀졌다. 본 연구에서는 트립톨라이드에 의한 수명연장에 관여하는 세포 내 기전과 트립톨라이드가 노화관련 질환인 당뇨병과 알츠하이머병에 미치는 영향을 평가하였다. 트립톨라이드는 인슐린/IGF-1-like 신호전달 저하에 의한 수명연장 돌연변이인 age-1과 미토콘드리아 전자 전달계 저하에 의한 수명연장 돌연변이인 clk-1의 수명을 유의적으로 증가시킨 반면, 식이제한 유도 돌연변이인 eat-2의 수명에는 유의적인 변화를 유도하지 못했다. 또한 박테리아 희석을 이용한 식이제한에 의해 연장된 수명을 추가적으로 더 연장시키지 못했다. 트립톨라이드 섭취는 고농도의 당 섭취에 의한 체내 독성과 사람 아밀로이드 베타 형질전환 유전자로 인한 체내 독성을 유의적으로 저하시켰다. 이러한 결과들은 트립톨라이드에 의한 수명연장이 식이제한에 의한 수명연장 기전과 중복되며, 트립톨라이드가 노화관련 질환을 저해하는 효능이 있음을 보여준다. 따라서, 트립톨라이드는 식이제한 효능을 대체할 수 있는 식의약품 개발에 활용될 수 있다.

• 대한약침학회지
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• 제20권2호
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• pp.107-111
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• 2017

Objectives: Radiation is one of the most important sources of free radical (such as reactive oxygen species) production, which plays an essential role in the etiology of over hundred diseases. The aim of the study was to investigate some immune parameters and hematological indices in healthy workers of the Radiology Department, University Hospital of Mashhad, Iran. Methods: The study was performed on 50 healthy workers: 30 radiology staff as the case group and 20 laboratory workers as the control group. The radiation dose received by the radiology staff participating in the study was less than the annual maximum permissible level, 50 millisievert. Hematological parameters, lymphocyte proliferation and cytokine production were studied in both groups. Results: Among healthy radiology workers, the hematological indices did not differ statistically; however, their proliferation indices and $IFN-{\gamma}$ levels showed significant increases in parallel with decreases in the IL-4 levels as compared to controls. The immune system of workers exposed to low-dose ionizing radiation was found to be shifted from a Type 2 to a Type 1 response to promote cellular immunity. Conclusion: Based on our data, exposure to low-dose ionizing radiation may decrease the prevalence, frequency, and recurrence of various cancers and infectious diseases because of an increase in Th1-cell-based response, thus leading to more protection of the human body against tumor cells and foreign agents and possibly increased longevity. However, due to high rate of fluoroscopy use for interventional radiology, we suggest continuing research projects on radiation protection and hazards to prevent irreversible damage. As a recommendation, in future studies, radiology staff with a weakened immunity due to high radiation exposure should be considered as good choices to be treated using acupuncture techniques because acupuncture has been demonstrated to enhance the function and the number of immune cells.

• 한국실내디자인학회논문집
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• 제12호
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• pp.57-66
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• 1997

This study was carried out to find out some similarities and differences of the ornamental technique and motifs in folk furniture between Denmark and Korea which had quite different background of development of folk furniture as one of a cross-cultural study. Furniture made and used in the 18th and 19th century was investigated in order to eliminate the influence of internationalism in the design area in the 20th century. This study was fulfilled by many study trips all over the districts in Denmark to identify Danish folk furniture as well as literature study. Study trips to folk museums. Insa-dong, Janghanpyung furniture market were done for Korean folk furniture. Characteristics of ornament in Danish folk furniture were as followings; Main materials of the Danish folk furniture were conifers, especially pine tree, as pine was very common and easy to get from their surroundings. The most popular and unique types of decoration in Danish folk furniture was painting. Colors used in painted furniture were very bright and vivid. This might be a reaction to the long and dark winter of Scandinavian countries. Motifs used in Danish folk furniture had been chosen to reflect their surroundings. Flowers, six-angular stars, animals, human figures and Biblical motifs were popular sources of decoration for Danish folk furniture. Characteristics of Korean folk furniture were as followings; Main materials of Korean folk furniture were broad-leaved trees as well as conifers, because of their beautiful wood grain. The Korean ways of decoration were different from Danish ones. The method of painting with bright from Danish ones. The method of painting with bright colors was hardly ever used in Korea, except only in lacquering. The most popular decoration method for Korean folk furniture was revealing the natural wood grain with transparent vegetable oil finish, instead of painting. Metal ornament was unique to Korean folk furniture. therefore a lot of metal ornaments were attached on the furniture. Motifs used in Korean folk furniture were more like symbolic than Danish ones. Korean people tried to express their longings and norms through the motifs, such as longevity, prosperity, good luck, and many sons, etc. Therefore, it was natural for Korean motifs to have special symbolic meanings.

• 대한한방내과학회지
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• 제19권1호
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• pp.524-552
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• 1998

Purgation therapy has played an important role as a influential remedy from the begining of the Chinese medicine. Especially purgation therapy is raised as the effective remedy on the acute infectious disease in the book of 'Treatise on Febrile Disease'. But It was inclined to cold-nature and available only in the excess syndrome. Nevertheless it is evident that the book has showed an example of this therapy. During the middle age, purgation therapy is classified into several subtype; hydrogogue therapy, laxation with lubricants, purgation with cold-natured drugs and purgation with warm-natured drugs. Comparing with the ancient times, it must be a progression. It was investigated earnestly by a school leaded by Zhang Congzheng. They were not restricted to several diseases, but applied it to the wide range of diseases. They thought as following. 'One is ill from pathogenic factor so that you should eliminate it from the human body'. Hence, they frequently used three major remedies such as diaphoresis, emesis and purgation. In this process, purgation therapy had showed eye-opening progress. But opposition to it was not little. Li Gao was a representative man on the opposite side. He expressed a critical opinion and placed great importance on the genuine energy, the natural healing force. Under his influence, a large number of doctors evaded purgation and put it under taboo. On account of these trend, purgation therapy had took a backward step and retrograded. Therefore cathartics such as Rhei Radix et Rhizoma, Rharbitidis Semen, cold drugs such as Gypsum Fibrosum, etc. had been excluded for preservation of the genuine energy, and came about an obnoxious custom to value only 'tonity deficiency', or 'warm and tonify'. As it had came into fashion to approach most disease from the point of view, purgation therapy was merely fall into a remedy of constipation. After the eighteenth century purgation therapy encountered the new period of rivival. It was introduced by them who strived for the study of Epidemics to the new current of thought, so called '增水行舟'. It was because 온병 was apt to dissipate one's Yin fluid. Therefore purgation therapy of this period was characterized by establishing nourishment Yin and body fluid with or without use of timely purgation of accumulation of heat. From the time of Zhang Congzheng, it was accomplished by Lee Je-ma to the most epoch-making change. He caused an improvement in the use of purgation therapy by regarding innate constitutional contradiction as importance than representing clinical symptoms. He warned that existing remedies that depend only upon symptoms and signs, not upon individual characteristics including constitutional features didn't bring round to but kill them. And he understood all the pathologic processes in his constitutional theory, investigated specific drugs on four constitution, made indications of each prescriptions clear. For giving to differentiation of constition before differentiation of syndrom, his new slant on the pathologic phenomena overcome the limitations of 변증시치, and revaluate purgation therapy from remedy impaire the genuine energy to that restore it by recover the balance between the internal organ. It is the product of him to fundamentally upset the cause to be in disregard of purgation therapy.

• 응용통계연구
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• 제29권1호
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• pp.41-59
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• 2016

지속적인 사망률 개선으로 인한 평균 수명연장은 인구 고령화의 주요인이며 연금 공급자의 재정건전성에 심각한 영향을 미치는 원인으로 지목되기에 정확한 미래 사망률의 예측은 현 시점에서 선행되어야할 중요한 과제다. 본 연구는 미래 사망률을 예측하는 대표적인 확률적 사망률 모형인 Lee-Carter 모형을 사용하여 과거 생명표로 산출한 왜도를 기반으로 미래 사망률 지수를 간접적으로 예측하는 왜도예측방식을 제시한다. 기존의 Lee-Carter 모형을 이용한 사망률 예측방식은 사망률 지수를 추정하고 미래값을 직접 예측함으로써 미래 사망률이 지나치게 개선되는 현상을 보이며, 이를 바탕으로 산출된 연금액과 지급기간 추정 등 연금 공급자의 리스크 관리에 영향을 미친다. 본 연구는 기존 예측 방식의 사망률 예측 결과와 제시한 왜도 예측 방식의 사망률 예측 결과를 비교함으로써 기존 사망률 예측 방식의 문제점을 지적한다. 분석결과 왜도 예측을 통한 Lee-Carter 모형의 사망률 예측은 기존 방식보다 사망률 개선효과를 더 적게 반영하며 장수리스크를 덜 왜곡한다는 데 의의가 있다고 할 수 있다. 하지만 기존 방식 간 차이를 감안하여 적정한 미래 사망률 수준을 찾기 위해 임의로 부여한 가중치에 대해 향후 검토가 필요할 것으로 보인다.