• Proceedings of the Safety Management and Science Conference
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• 2013.11a
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• pp.231-241
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• 2013

In recent years, accident induced by human error is increasing in the chemical plant. Human error analysis of the chemical plant was conducted on the basis of past accident. Some company called by A for the basis of a chemical accident. Factor analysis of human errors was separated in plant operation and work. Agency's work of occupational safety & health was classified into four types. It is based on the work before, during work, recovery work, and discontinue work. It was still separated work of human error by analysis and then was derived factor and issue. The human error factor and priority for accident prevention in the chemical plant is presented.

• Journal of the Ergonomics Society of Korea
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• v.30 no.1
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• pp.127-135
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• 2011

The nuclear power plants and chemical industries are trying to find human error to prevent occupational injury. The ratio of occupational injury is higher than the other industries in shipbuilding industry. It is known that the most important reason is human error. Recently, the shipbuilding industries interest in human error to prevent occupational injury. This paper outlines four approaches of human error identification used in shipbuilding industry such as survey of occupational injury, root cause analysis, risk assessment, and performance shaping factors. Finally, this paper proposes the interventions of ergonomics for preventing the human errors.

• Proceedings of the KSR Conference
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• 2006.11b
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• pp.1529-1535
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• 2006

Human error is one of the major contributors to the railway accidents or incidents. In order to develop an effective countermeasure to remove or reduce human errors, a systematic analysis should be preferentially performed to identify their causes, characteristics, and types of human error induced in accidents or incidents. This paper introduces a case study for human error analysis of the railway accidents and incidents. For the case study, more than 1,000 domestic railway accidents or incidents that happened during the year of 2004 have been investigated and a detailed error analysis was performed on the selected 90 cases, which were obviously caused by human error. This paper presents a classification structure for human error analysis, and summarizes the analysis results such as causes of the events, error modes and types, related worker, and task type.

• Journal of Microbiology and Biotechnology
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• v.23 no.5
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• pp.689-698
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• 2013

The production and characterization of an active recombinant N-acetylgalactosamine-6-sulfate sulfatase (GALNS) in Escherichia coli BL21(DE3) has been previously reported. In this study, the effect of the signal peptide (SP), inducer concentration, process scale, and operational mode (batch and semi-continuous) on GALNS production were evaluated. When native SP was presented, higher enzyme activity levels were observed in both soluble and inclusion bodies fractions, and its removal had a significant impact on enzyme activation. At shake scale, the optimal IPTG concentrations were 0.5 and 1.5 mM for the strains with and without SP, respectively, whereas at bench scale, the highest enzyme activities were observed with 1.5 mM IPTG for both strains. Noteworthy, enzyme activity in the culture media was only detected when SP was presented and the culture was carried out under semi-continuous mode. We showed for the first time that the mechanism that in prokaryotes recognizes the SP to mediate sulfatase activation can also recognize a eukaryotic SP, favoring the activation of the enzyme, and could also favor the secretion of the recombinant protein. These results offer significant information for scaling-up the production of human sulfatases in E. coli.

• Journal of the Korea Safety Management & Science
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• v.10 no.4
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• pp.65-72
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• 2008

The Manchester Driver Behavior Questionnaire (DBQ) is the most commonly used frameworks for investigating the relationship between self-reported driving behavior and accident involvement. After Reason et al. introduced DBQ, there were many studies replicating the research of Reason et al. in many countries. There was, however, no study replication of the Reason's research in Korea. The aim of this study is to replicate the distinction among errors, lapses and violations, and to evaluate the relationship of these behaviors with road traffic accidents on Korean drivers. 223 Korean drivers completed the Korean version of original DBQ with questions regarding background information, such as age, gender, annual mileage and accident involvement. Participants answered self-assessment questions, also. Factor analysis revealed three factors like Reason et al. The three factors were dangerous errors, violations and relatively harmless errors.

• Proceedings of the ESK Conference
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• 1996.10a
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• pp.125-140
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• 1996

Human Factors Engineering(HFE) program should be developed from the early stage of the design process for Nuclear Power Plant. The HFE program is conducted in accordance with the guidance in the Standard Review Plan(SRP) NUREG 0800, Chapter 18. The major purpose of this program is to reduce the incidence of human error during the operating life of the plants. A comprehensive human factors program is prepared by KOPEC to assure that key elements of human factors involvement are not inadvertently overlooked and the early, complete, and continuing inclusion of HFE in the design process. This paper is to introduce engineering steps of the HF activities to verify that the HF involvements on man-machine interface are adequate to support safe and efficient operation of nuclear power plant. If systems are developed without sufficient consideration on the HFE in the design, such systems may cost a high price due to the malfunction of the plant induced by the human errors.

• Genomics & Informatics
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• v.12 no.4
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• pp.136-144
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• 2014

Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. Recent experimental findings have shed light on the links between different genome architectures and CNV mutagenesis. In this review, we summarize various genomic features and discuss their contributions to CNV formation. Genomic repeats, including both low-copy and high-copy repeats, play important roles in CNV instability, which was initially known as DNA recombination events. Furthermore, it has been found that human genomic repeats can also induce DNA replication errors and consequently result in CNV mutations. Some recent studies showed that DNA replication timing, which reflects the high-order information of genomic organization, is involved in human CNV mutations. Our review highlights that genome architecture, from DNA sequence to high-order genomic organization, is an important molecular factor in CNV mutagenesis and human genomic instability.

• Journal of the Ergonomics Society of Korea
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• v.20 no.2
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• pp.1-28
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• 2001

This paper deals with the selection of the important Influencing Factors (IFs) under accident management situations in nuclear power plants for use in the assessment of human errors. In order to achieve this goal, we collected two types of IF taxonomies, one is the full set IF list mainly developed for human error analysis. and the other is the IFs for human reliability analysis (HRA) in probabilistic safety assessment (PSA). Five sets of IF taxonomy among the full set IF list and ten sets of IF taxonomy among HRA methodologies were collected in the study. From the review and analysis of BRA IFs, we could obtain some insights for the selection of HRA IFs. By considering the situational characteristics of the accident management domain, candidate IFs are chosen. Finally, those IFs are structured hierarchically to be appropriate for the use in the assessment of human error under accident management situation. Three nuclear accidents such as TMI. Chernobyl and JCO were analysed to validate the proposed taxonomy.

• Journal of the Ergonomics Society of Korea
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• v.30 no.1
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• pp.87-98
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• 2011

In this study, we investigated and identified criterial human factors(errors), most of which lead to terrible ship accidents such as collisions, sinking, fire and explosions resulting both in human lives and physical damages to ships as well as surrounding environments. To this end, we went through the accident reports of 413 cases over 2005~2009 period and classified the human factors into 6 major factors with 19 sub ones which were constructed in hierarchical order. The relative importance of major factors was calculated and among others the lack of awareness turned out to be the most important factor with the weight of 0.391. The contributions of the results in the research are two fold: it will help (i) identify the root causes of ship accidents and prevent further potential ship related incidents, (ii) analyze the degree of the risk associated with the ship accidents, when risk analysis is performed.

• Proceedings of the KSR Conference
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• 2006.11b
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• pp.1082-1087
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• 2006

Human factors still plays a significant role in railway accidents. The accidents often resulted from multiple causes of hardware failures and human errors. So to ensure the safety of railway operations, human error should be effectively prevented and managed. Among several factors influencing human performance, task load (or task complexity) is well known as a major contributor to human error. In order to reduce the potential of human error, a systematic analysis should be undertaken to evaluate task load and to reduce it by modifying task process and/or education&training. In this paper, we proposed a systematic framework for railway industry to perform task analysis and to evaluate task load, and applied it to KTX operational tasks. According to the application study, we identified 14 generic task types of KTX operation. And also this paper shows the quantitative task load of those generic tasks which were analyzed by NASA-TLX method.