• Archives of Pharmacal Research
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• v.22 no.1
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• pp.18-24
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• 1999

Various flavonoid derivatives were previously reported to possess the inhibitory activity on cyclooxygenase/lipoxygenase. And these properties of flavonoids might contribute to their anti-inflammatory activity in vivo. In this study, several polyhydroxylated/methoxylated flavonoid derivatives such as oroxylin A. wogonin, skullcapflavone II, tectorigenin and iristectorigenin A were isolated from the medicinal plants. these compounds were evaluated fro their inhibitory effects on cyclooxygenase/lipoxygenase from the homogenate of human platelets in vitro. It was found that isoflavones including daidzein and tectorigenin possessed the inhibitory activity on cycloooxygenase, although the potency of inhibition was far less than that of indomethacin. In addition, oroxylin A, baicalein and wogonin inhibited 12-lipoxygenase activity without affecting cyclooxygenase, which suggested that 5,6,7- or 5,7,8-trisubstitutions of A-ring of flavone gave favorable results. The IC50 values of oroxylin A and NDGA against 12-lipoxygenase were found to be 100 and 1.5 uM, respectively.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2000.05a
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• pp.416-417
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• 2000

Chitin, a poly $\beta$-(1longrightarrow14)-N-acetyl-D-glucosamine, is best known as a cell wall component of fungi and as a skeletal materials of invertebrates. Chitosan is derived from chitin by deacetylation in the presence of alkali. Chitosan has been developed as new physiological materials since it possesses antibacterial activity, hypocholesterolemic activity and antihypertensive action. However, the actions of chitosan in vivo still remain ambiguous as the physiological functional properties because most animal intestines, especially the human gastrointestinal tract, do not possess enzyme such as chitosanase which directly degrade the $\beta$-glucosidic linkage in chitosan, and consequently the unbroken polymers may be poorly absorbed into the human intestine. Therefore, recent studies as chitosan have attracted interest for chitosan oligosaccharides, because the oligosaccharides process not only water-soluble property but also versatile functional properties such as antitumor activity, immune-enhancing effects, enhancement of protective effects against infection with some pathogens in mice and antimicrobial activity (Kingsnorth et al., 1983, Mori et al., 1997). (omitted)

• Bulletin of the Korean Chemical Society
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• v.32 no.10
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• pp.3566-3570
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• 2011

A series of 2,4,6-tripyridyl pyridines were synthesized, and evaluated for their antitumor cytotoxicity, topoisomerase I and II inhibitory activity. From the eighteen prepared compounds, compounds 10-12 have shown better or similar cytotoxicity against several human cancer cell lines as compared to 2,2':6',2"-terpyridine and doxorubicin. Especially, compound 10 exhibited the most potent cytotoxicity better than positive controls. Structure-activity relationship study indicated that 2,2':6',2"-terpyridine skeleton has an important role in displaying significant cytotoxicity against several human cancer cell lines.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1629-1635
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• 2006

The migration of vascular smooth muscle cells (VSMC) and the production of matrix metallopreteinases-9 (MMP-9) may play a key role in the development of atherosclerosis. In this study, we have more extensively investigated the inhibitory effect of UR on MMP-9 activity and TNF-${\alpha}$ induced human aortic smooth muscle cells (HASMC) migration. The result from gelatin zymography showed that UR inhibited MMP-9 activity in a dose-dependent manner (IC50 = 55 g/ml). In addition, UR strongly inhibited the migration of HASMC induced by TNF-treatment (IC50 = 125 g/ml), although it has very low cytotoxic effect on HASMC (IC50 > 500 g/ml). These results suggest that UR is a potential anti-atherosclerotic agent through inhibition of MMP-9 activity and VSMC migration.

• Annual Conference of KIPS
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• 2019.05a
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• pp.542-544
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• 2019

Changes in a person's health affect one's lifestyle and work activities. According to the World Health Organization (WHO), abnormal activity is growing faster in people aged 60 or more than any other age group in almost every country. This trend steadily continues and expected to increase further in the near future. Abnormal activity put these people at high risk of expected incidents since most of these people live alone. Human abnormal activity analysis is a challenging, useful and interesting problem among the researchers and its particularly crucial task in life and health care areas. In this paper, we discuss the problem of abnormal activities of old people lives alone at home. We propose Convolutional Neural Network (CNN) based model to detect the abnormal behaviors of elderlies by utilizing six simulated action data from daily life actions.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.2
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• pp.800-816
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• 2018

In recent years, video surveillance research has been able to recognize various behaviors of pedestrians and analyze the overall situation of objects by combining image analysis technology and deep learning method. Human Activity Recognition (HAR), which is important issue in video surveillance research, is a field to detect abnormal behavior of pedestrians in CCTV environment. In order to recognize human behavior, it is necessary to detect the human in the image and to estimate the pose from the detected human. In this paper, we propose a novel approach for 2D Human Pose Estimation based on object detection using RGB-D information. By adding depth information to the RGB information that has some limitation in detecting object due to lack of topological information, we can improve the detecting accuracy. Subsequently, the rescaled region of the detected object is applied to ConVol.utional Pose Machines (CPM) which is a sequential prediction structure based on ConVol.utional Neural Network. We utilize CPM to generate belief maps to predict the positions of keypoint representing human body parts and to estimate human pose by detecting 14 key body points. From the experimental results, we can prove that the proposed method detects target objects robustly in occlusion. It is also possible to perform 2D human pose estimation by providing an accurately detected region as an input of the CPM. As for the future work, we will estimate the 3D human pose by mapping the 2D coordinate information on the body part onto the 3D space. Consequently, we can provide useful human behavior information in the research of HAR.

• Proceedings of the Zoological Society Korea Conference
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• 2005.08a
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• pp.18-18
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• 2005

• Proceedings of the Korean Nutrition Society Conference
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• 2003.10a
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• pp.72-72
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• 2003

• 한국생활과학회:학술대회논문집
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• 2009.05a
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• pp.173-174
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• 2009

• Korean Journal of Human Ecology
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• v.8 no.1
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• pp.95-107
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• 1999

Difficulties in the measuring home food production activities obstructs development of home production activity related studies. For solving such problems, this study intended to develope a home food production frequency scale. The data were collected from 219 housewives in Taejon. Validity, reliability, correlation, and multiple regression analysis were used to test home food production frequency scale. The scale's validity and reliability were reveled considerable potential for its use to ascertain relationships between home food production activity and other family variables.