• 대한수의학회지
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• 제56권3호
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• pp.197-200
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• 2016

A one-year-old, 3.25 kg intact male Chinchilla cat presented with acute right hind limb paralysis. Diagnostic imaging studies found cardiomegaly with interstitial lung pattern, abnormal mitral valve leaflets without maximum opening at the end of the ventricular diastole and during atrial systole and severe mitral inflow obstruction. Based on these findings and its young age, the case was diagnosed as congenital mitral valve stenosis. Treatment was directed to stabilize clinical conditions related to heart failure, to prevent further formation of thrombus and to relieve pain associated with thromboembolism. After one month of therapy, hind limb motor function was fully recovered.

• 한국임상수의학회지
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• 제25권1호
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• pp.23-26
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• 2008

2일간의 구토와 침울을 동반한 후지마비를 주증상으로 내원한 2년령의 암칫 터키 앙고라 고양이에서 약한 대퇴 동맥 맥박, 후지의 청색증이 관찰되었으나 흉부 청진, 흉부 방사선, 심초음파 상에서 이상소견을 보이지 않았으며 복부 초음파상에서 복부 대동맥내의 색전으로 판단되는 고에코성 물질이 확인되었다. 대동맥 혈전의 원인이 될 수 있는 다양한 진단 검사를 시행한 결과, 특발성 안장 색전혈전증으로 진단하였다. Heparin sodium, aspirin 및 diltiazem으로 4주간 치료하였으나 양쪽 후지의 병변은 진행적이고 비가역적으로 괴사되어 대퇴부를 절단한 결과, 30개월 이상 임상적으로 건강한 생활을 하고 있다.

• 한국임상수의학회지
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• 제34권4호
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• pp.275-278
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• 2017

An 8-year old female Korean Short Hair cat with a history of paralysis of both hind limbs less than 1 hour before admission was referred. On physical examination, the left hind limb was cold and there was no pulsation or mobility. On abdominal ultrasound examination, a thrombus 8 mm in length was found at the aortic bifurcation. The patient was diagnosed with hypertrophic cardiomyopathy (HCM) and cardiogenic pulmonary edema through radiologic evaluation and echocardiography. A tissue plasminogen activator (tPA) was applied intravenously using an accelerated dosing protocol (1 mg administered intravenously [IV] bolus, 2.5 mg IV over 30 min, 1.5 mg IV over 1 h) to treat the feline arterial thromboembolism. Within 12 h after administration of tPA, pulsation and mobility of both hind limbs were normal, without any noticeable complications. Clopidogrel was prescribed to prevent additional thrombus formation, and pimobendan, benazepril, and furosemide were prescribed for administration at home. The patient was discharged and survived 377 days.

• Anatomy and Cell Biology
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• 제51권4호
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• pp.292-298
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• 2018

Experimental autoimmune encephalomyelitis (EAE) is a T-cell-mediated autoimmune central nervous system disease characterized by inflammation with oxidative stress. The aim of this study was to evaluate an anti-inflammatory effect of Ishige okamurae on EAE-induced paralysis in rats. An ethanolic extract of I. okamurae significantly delayed the first onset and reduced the duration and severity of hind-limb paralysis. The neuropathological and immunohistochemical findings in the spinal cord were in agreement with these clinical results. T-cell proliferation assay revealed that the ethyl-acetate fraction of I. okamurae suppressed the proliferation of myelin basic protein reactive T cells from EAE affected rats. Flow cytometric analysis showed $TCR{\alpha}{\beta}^+$ T cells was significantly reduced in the spleen of EAE rats with I. okamurae treatment with concurrent decrease of inflammatory mediators including tumor necrosis $factor-{\alpha}$ and cyclooxygenase-2. Collectively, it is postulated that I. okamurae ameliorates EAE paralysis with suppression of T-cell proliferation as well as decrease of pro-inflammatory mediators as far as rat EAE is concerned.

• Journal of Microbiology and Biotechnology
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• 제16권10호
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• pp.1570-1576
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• 2006

An encephalomyocarditis virus (EMCV-CBNU) was isolated from an aborted swine fetus in October 2005. To investigate the genetic origin and virulence of the EMCV-CBNU strain, we determined the complete sequence of the virus and tested its virulence in mice. Genetic characterization revealed that the RNA genome was composed of 7,713 nucleotides with a single open reading frame (2,292 amino acids), coding 12 proteins. The EMCV-CBNU had the shortest poly(C) tract, consisting of 10 C's ($C_{10}$), compared with all the other EMCV strains reported in GenBank. Amino acid and phylogenetic analyses showed that EMCV-CBNU had the highest genetic identity with strain 2887A (99.7%), which was originally isolated from a fetus in a pig breeding farm that had a history of reproductive failure. Because rodents are the natural host of EMCV, we investigated the virulence of EMCV-CBNU in mice. Surprisingly, all mice inoculated with more than $1{\times}10^2\;TCID_{50}/0.1ml$ of EMCV-CBNU showed symptoms of hind limb paralysis and eventually died during 3 and 8 days postinoculation (DPI). Furthermore, when we inoculated the virus into pregnant mice, all dams and their fetuses died in 6 DPI. This is the first report on a full genomic analysis of swine EMCV in Korea, which exhibits high virulence in mice.

• 한국어병학회지
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• 제22권1호
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• pp.67-73
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• 2009

양식산 복어에서는 tetrodotoxin(TTX)가 존재하지 않는다고 일반적으로 생각되고 있다. 본 연구에서는 실제로 양식산 황복(Takifugu obscurus)에는 TTX가 존재하지 않는지 확인하기 위해 생쥐를 이용한 bioassay로 여러 장기를 동시에 분석하였다. 자연산에서는 동물이 치사하는 수준의 독력을 함유한 시료가 있었으며 정소>간장>장>근육>피부의 순으로 독력이 확인되었다.양식산 시료에서는 TTX의 미량존재로 추정되는 졸림, 행동둔화, 후지마비 등의 증상이 나타났지만 치사동물은 발견되지 않았다. 이 결과는 양식 산 황복에서 TTX가 매우 낮은 농도로 존재할가능성을 제시하지만 기기분석법을 이용한 정확한 정량이 필요하다고 판단된다.