• Journal of Ginseng Research
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• v.41 no.2
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• pp.201-208
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• 2017

Background: Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. Methods: VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative-hypnotic (pentobarbital-induced sleeping test), anti-stress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects. Results: VGE treatment increased the spontaneous locomotor activity, enhanced the endurance to stress, reduced the anxiety-like behavior, and ameliorated the scopolamine-induced memory impairments in mice. In addition, VGE treatment did not alter the motor balance and coordination of mice and did not potentiate pentobarbital-induced sleep, indicating that VGE has no sedative-hypnotic effects. The effects of VGE were comparable to those of the Korean Red Ginseng extract. Conclusion: VG, like other ginseng products, has significant and potentially useful psychopharmacological effects. This includes, but is not limited to, psychomotor stimulation, anxiolytic, antistress, and memory enhancing effects.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.9
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• pp.997-1002
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• 2012

With the increasing demand for lightweight materials to reduce fuel consumption, especially in the transportation industry, magnesium alloys are being widely studied. However, there are several limitations to the large-scale application of magnesium alloys in a structure because of their low formability and strong anisotropy. In order to take into account both the strong anisotropy and tension-compression asymmetry of AZ31 sheet alloy, the Cazacu-Plunkett-Barlat yield criterion (Cazacu, 2006) was adopted in material modeling. The variation of the anisotropic coefficients that describe the yield surface evolution of AZ31 is optimized using an interpolation function based on specific calibration results. It generates continuous yield surfaces, which makes it possible to describe different hardening rates in tension and compression as well as the tension-compression asymmetry of magnesium alloys. The performance of the CPB06 yield criterion for simulating an axial crushing test was tested and compared with that of the Hill (1948) yield criterion.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.3
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• pp.775-787
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• 1996

An optimization procedure is proposed for the design of cylindrically laminated composite shell having midplane symmetry and subjected to axial force, torsion and internal pressure. Tsai-Wu and Tsai-Hill failure criteria are taken as objective functions. The stacking sequence represents the design variable. The optimal design formulation based on state space method is adopted and solution proccedure is described with the emphasis on the method of calculations of the design sensitivities. A gradient projection algorithm is employed for the optimization process. Numerical results are presented for the several test problems.

• Wind and Structures
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• v.12 no.3
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• pp.219-237
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• 2009

This study examines the accuracy of large-eddy simulation (LES) to simulate the flow around a large irregular sloping complex terrain. Typically, real built up environments are surrounded by complex terrain geometries with many features. The complex terrain surrounding The Hong Kong University of Science and Technology campus was modelled and the flow over an uphill slope was simulated. The simulated results, including mean velocity profiles and turbulence intensities, were compared with the flow characteristics measured in a wind tunnel model test. Given the size of the domain and the corresponding constraints on the resolution of the simulation, the mean velocity components within the boundary layer flow, especially in the stream-wise direction were found to be reasonably well replicated by the LES. The turbulence intensity values were found to differ from the wind tunnel results in the building recirculation zones, mostly due to the constraints placed on spatial and temporal resolutions. Based on the validated mean velocity profile results, the flow-structure interactions around these buildings and the surrounding terrain were examined.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.310-310
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• 2017

'Gawaji 1', an early maturing and low amylose content rice variety adaptable to double cropping system with barley as later winter crop., was developed by the crop breeding team of Crop Research Division, GARES, Hwaseong, Korea in 2016. 'Gawaji 1' was derived from a cross between 'Baegjinju' and 'Sangmibyeo' in 2004. This variety had heading date of August 4 in Gyeonggi Province. It had a semi-elect plant type and resistance to lodging with strong culm. Its culm length was 67 cm. This variety had 15 tillers per hill and 104 spikelets per panicle. It was medium grain variety showing 1,000 grain weight of brown rice of 19.3g. Its protein contents of milled rice was 8.2% which was lower than 'Baegjinju'. Its milling ratio was 75.5% which was higher than 'Baegjinju'. The yield of milled rice was 5.0 MT/ha under the ordinary culture of the local adaptability test in 3 areas of Gyeonggi Province for three years. 'Gawaji1' is highly adaptable to Gyeonggi Province, especially to northern region of Han River.

• Transactions of the Korean Society of Automotive Engineers
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• v.19 no.5
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• pp.7-13
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• 2011

The climate change due to the increased consumption with fossil fuel and rise of the oil price have been serious global issues. Automobile industry consumes 30% of the oil every year and causes air pollution and global warming by the exhaust emissions and carbon dioxide ($CO_2$). The demand of two-wheeled vehicle increases every year due to the parking and traffic problem caused by the increased automobiles in the urban area. Approximately 50,000,000 two-wheeled vehicles were produced in 2008. The development and sales of the hybrid two-wheeled vehicle industry become active due to its increased market demands. In this paper, the change of the motor and battery efficiency, driving distance, hill climbing ability with the change of the motor capacity was analyzed. Simulation of the peculiarities in urban driving schedule(World-wide Motorcycle Test Cycle(WMTC), Manhattan driving schedule), constant speed(10 km/h, 35 km/h) of small electronic two-wheeled vehicle was also carried out. Through the simulation result, appropriate capacities of the motor and battery for urban driving was acquired.

• Korean Journal of Veterinary Service
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• v.31 no.1
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• pp.79-86
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• 2008

In this study two stage investigation was used for seroprevalence of Neospora caninum in cattle between January, 2005 and November, 2007; first stage was to examine positiveness of the farms selected randomly, second was to test all individual cow in positive farms. A total of 850 sera were collected from 170 farms for the first stage, and positive rate of farm and head were 23.5% (40/170farms) and 7.5% (64/850heads), respectively. Seroprevalence of Holstein cattle was much higher than that of Hanwoo. In second stage positive rate of cow was 18.9% (246/1,303head), but seroprevalence of farm was very variable (1 - 90.5%). It was supposed that 3 farms with high positive rate had some risk factors to be infected; raising dogs in the same farm, location of hill-side where is easy to contact with wild animals.

• The Journal of Advanced Prosthodontics
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• v.14 no.4
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• pp.236-249
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• 2022

PURPOSE. The present study compared the accuracy between digital and conventional implant impressions. MATERIALS AND METHODS. The experimental models were divided into six groups depending on the implant location and the scanning span. Digital impressions were captured using the intraoral optical scanner TRIOS (3Shape, Copenhagen, Denmark). Conventional impressions were taken with the monophase impression material based on addition-cured silicones, Honigum-Mono (DMG, Hamburg, Germany). A high-precision laboratory scanner D900 (3Shape, Copenhagen, Denmark) was used to obtain digital data of resin models and stone casts. Surface tessellation language (STL) datasets from scanner were imported into the analysis software Geomagic Qualify 14 (3D Systems, Rock Hill, SC, USA), and scan body deviations were determined through two-dimensional and three-dimensional analyses. Each scan body was measured five times. The Sidak t test was used to analyze the experimental data. RESULTS. Implant position and scanning distance affected the impression accuracy. For a unilateral arch implant and the mandible models with two implants, no significant difference was observed in the accuracy between the digital and conventional implant impressions on scan bodies; however, the corresponding differences for trans-arch implants and mandible with six implants were extremely significant (P<.001). CONCLUSION. For short-span scanning, the accuracy of digital and conventional implant impressions did not differ significantly. For long-span scanning, the precision of digital impressions was significantly inferior to that of the traditional impressions.

• The Korean Journal of Financial Management
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• v.22 no.1
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• pp.119-146
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• 2005

This study applies extreme value theory to get extreme value-VAR for Korean Stock market and showed the usefulness of the approach. Block maxima model and POT model were used as extreme value models and tested which model was more appropriate through back testing. It was shown that the block maxima model was unstable as the variation of the estimate was very large depending on the confidence level and the magnitude of the estimates depended largely on the block size. This shows that block maxima model was not appropriate for Korean Stock market. On the other hand POT model was relatively stable even though extreme value VAR depended on the selection of the critical value. Back test also showed VAR showed a better result than delta VAR above 97.5% confidence level. POT model performs better the higher the confidence level, which suggests that POT model is useful as a risk management tool especially for VAR estimates with a confidence level higher than 99%. This study picks up the right tail and left tail of the return distribution and estimates the EVT-VAR for each, which reflects the asymmetry of the return distribution of the Korean Stock market.

• YAKHAK HOEJI
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• v.39 no.2
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• pp.153-160
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• 1995

Receptor binding study was carried out as an in vitro assay to test the anti-ulcer effect for newly synthesized test compounds(IY-80843 and IY-80845) which were reported to have a strong anti-secretory effect in Shay-ligated rats. The histamine H$_{2}$-receptor fraction was prepared from the membranes of the isolated gastric glands in guinea pigs and $^{3}$H-cimetidine was used as a radioligand. The binding of $^{3}$H-cimetidine to the membranes of the isolated gastric glands was found to be time dependent, saturable and confined to a single population of binding sites with $K_{D}$ value of 0.13$\pm$0.03 $\mu{M}$ and B$_{max}$ value of 52.5$\pm$1.5 pmol/mg. From the competition experiments, both IY-80843 and IY-80845 were shown to have a strong blocking effect against binding of $^{3}$H-cimetidine to the histamine H$_{2}$-receptor. The IC$_{50}$, Ki, and Hill coefficient(nH) values for IY-80843 were 0.18$\pm$0.02 $\mu{M}$, 0.16$\pm$0.02 $\mu{M}$, and 0.97$\pm$0.15, respectively and those values for IY-80845 were 0.27$\pm$0.02 $\mu{M}$, 0.24$\pm$0.02 $\mu{M}$, and 0.82$\pm$0.13, respectively. The results demonstrated that the blocking effects of IY-80843 and IY-80845 were 7 and 5 times stronger than that of cimetidine, respectively. Therefore, the newly synthesized compounds, IY-80843 and IY-80845, appeared to be the highly potent competitive inhibitors of histamine on the H$_{2}$-receptor.