• Communications for Statistical Applications and Methods
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• v.28 no.5
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• pp.411-424
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• 2021

Inference following two-stage adaptive designs (also known as two-stage randomization designs) with survival endpoints usually focuses on estimating and comparing survival distributions for the different treatment strategies. The aim is to identify the treatment strategy(ies) that leads to better survival of the patients. The objectives of this study were to assess the performance three commonly cited methods for estimating survival distributions in two-stage randomization designs. We review three non-parametric methods for estimating survival distributions in two-stage adaptive designs and compare their performance using simulation studies. The simulation studies show that the method based on the marginal mean model is badly affected by high censoring rates and response rate. The other two methods which are natural extensions of the Nelson-Aalen estimator and the Kaplan-Meier estimator have similar performance. These two methods yield survival estimates which have less bias and more precise than the marginal mean model even in cases of small sample sizes. The weighted versions of the Nelson-Aalen and the Kaplan-Meier estimators are less affected by high censoring rates and low response rates. The bias of the method based on the marginal mean model increases rapidly with increase in censoring rate compared to the other two methods. We apply the three methods to a leukemia clinical trial dataset and also compare the results.

• JSTS:Journal of Semiconductor Technology and Science
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• v.5 no.4
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• pp.255-261
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• 2005

With the advent of sub-90nm technologies, the system-on-chip (SoC) and system-in-package (SiP) are becoming the trend in delivering low-cost, low-power, and small-form-factor consumer electronic systems running at multiple GHz. The shortened transistor channel length reduces the transistor switching cycles to the range of several picoseconds, yet the time-of-flights of the critical on-chip and off-chip interconnects are in the range of 10 picoseconds for 1.5mm-long wires and 100 picoseconds for 15mm-long wires. Designers realize the bottleneck today often lies at chip-to-chip interconnects and the industry needs a good model to compute the inductance in these parts of circuits. In this paper we propose a new method for extracting accurate equivalent inductance circuit models for SPICE-level circuit simulations of system-on-chip (SoC) and system-in-package (SiP) designs. In our method, geometrical meshes are created and numerical methods are used to find the solutions for the electromagnetic fields over the fine meshes. In this way, multiple-GHz SoC and SiP designers can use accurate inductance modeling and interconnect optimization to achieve high yields.

• JSTS:Journal of Semiconductor Technology and Science
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• v.12 no.2
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• pp.139-149
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• 2012

A 3D stacked IC is made by multiple dies (possibly) with heterogeneous process technologies. Therefore, die-to-die variation in 2D chips renders on-package variation (OPV) in a 3D chip. In spite of the different variation effect in 3D chips, generally, 3D die stacking can produce high yield due to the smaller individual die area and the averaging effect of variation on data path. However, 3D clock network can experience unintended huge clock skew due to the different clock propagation routes on multiple stacked dies. In this paper, we analyze the on-package variation effect on 3D clock networks and show the necessity of a post silicon management method such as body biasing technique for the OPV induced 3D clock skew control in 3D stacked IC designs. Then, we present a parametric yield improvement method to mitigate the OPV induced 3D clock skew.

• Journal of Microbiology and Biotechnology
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• v.19 no.4
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• pp.378-386
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• 2009

A sequential optimization strategy, based on statistical experimental designs, is employed to enhance the production of alkaline protease by a Bacillus pseudofirmus local isolate. To screen the bioprocess parameters significantly influencing the alkaline protease activity, a 2-level Plackett-Burman design was applied. Among 15 variables tested, the pH, peptone, and incubation time were selected based on their high positive significant effect on the protease activity. A near-optimum medium formulation was then obtained that increased the protease yield by more than 5-fold. Thereafter, the response surface methodology(RSM) was adopted to acquire the best process conditions among the selected variables, where a 3-level Box-Behnken design was utilized to create a polynomial quadratic model correlating the relationship between the three variables and the protease activity. The optimal combination of the major medium constituents for alkaline protease production, evaluated using the nonlinear optimization algorithm of EXCEL-Solver, was as follows: pH of 9.5, 2% peptone, and incubation time of 60 h. The predicted optimum alkaline protease activity was 3,213 U/ml/min, which was 6.4 times the activity with the basal medium.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.05a
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• pp.303-306
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• 2003

To reduce the storage space of spent fuels used at the atomic power plants all over the world, the uranium elements contained in the spent fuels is being extracted and effectively stored. For this, the spent fuel are oxidized and deoxidized. In this study, it is produced conceptual design specification about the spent fuel management technology research and test facilities have been produced. The first considered processes in the facilities is the metal conversion furnace in the dry environment. Since this process is operates at the high temperature range, we have to consider heat-resisting designs for the device. For the heat-resisting designs, we have surveyed and analyzed technical references for material properties. Also, we have determined the temperature distribution condition of the device based on experimental results. We have calculated thermal stress and strain of each devices by the commercial analysis software, I-DEAS. By using the results, we have analyzed design configurations of the point at issue by thermal effects, and suggested alternative design configurations. It is experimented for inspecting confidence rate of heat strain. Based on these results, necessary design specifications for heat-resisting design have been produced.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.33 no.2
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• pp.109-113
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• 2020

A power device is a component used as a switch or rectifier in power electronics to control high voltages. Consequently, power devices are used to improve the efficiency of electric-vehicle (EV) chargers, new energy generators, welders, and switched-mode power supplies (SMPS). Power device designs, which require high voltage, high efficiency, and high reliability, are typically based on MOSFET (metal-oxide-semiconductor field-effect transistor) and IGBT (insulated-gate bipolar transistor) structures. As a unipolar device, a MOSFET has the advantage of relatively fast switching and low tail current at turn-off compared to IGBT-based devices, which are built on bipolar structures. A superjunction structure adds a p-base region to allow a higher yield voltage due to lower R_DS (on) and field dispersion than previous p-base components, significantly reducing the total gate charge. To verify the basic characteristics of the superjunction, we worked with a planar type MOSFET and Synopsys' process simulation T-CAD tool. A basic structure of the superjunction MOSFET was produced and its changing electrical characteristics, tested under a number of environmental variables, were analyzed.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.3
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• pp.447-456
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• 2021

Methods for predicting the ultimate/buckling strength of ship structures have been extensively improved in terms of design formulas and analytical solutions. In recent years, the design strategy of ships and offshore structures has tended to emphasize lighter builds and improve operational safety. Therefore, the corresponding geometrical changes in design necessitate the use of high-tensile steel and thin plates. However, the existing design formulas were mainly developed for thick plates and mild steels. Therefore, the calculation methods require appropriate modification for new designs beased on high-tensile steel and thin plates. In this study, a modified formula was developed to predict the ultimate strength of thin steel plates subjected to compressive and shear loads. Based on the numerical results, the effects of the yield stress, slenderness ratio, and loading condition on the buckling/ultimate strength of steel plates were examined, and a newly modified double-beta parameter formula was developed. The results were used to derive and modify existing closed-form expressions and empirical formulas to predict the ultimate strength of thin-walled steel structures.

• Computers and Concrete
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• v.33 no.4
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• pp.385-398
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• 2024

As concrete dominates the construction industry, alternatives to traditionally used steel reinforcement are being sought. This study explored the suitability of carbon fiber-reinforced polymer (CFRP) as a substitute within rigid frames, focusing on its impact on section ductility and overall structural durability against seismic events. However, current design guidelines address quasi-static loads, leaving a gap for dynamic or extreme circumstances. Our approach included multiscale simulations, parametric study, and energy dissipation analyses, drawing upon a unique adaptation of modified compression field theory. In our efforts to optimize macro and microparameters to improve yield strength, manage brittleness, and govern failure modes, we also recognized the potential of CFRP's high corrosion resistance. This characteristic of CFRP could significantly reduce the frequency of required repairs, thereby contributing to enhanced durability of the structures. The research reveals that CFRP's durability and seismic resistance are attributed to plastic joints within compressed fibers. Notably, CFRP can impart ductility to structural designs, effectively balancing its inherent brittleness, particularly when integrated with quasi-brittle materials. This research challenges the notion that designing bendable components with carbon fiber reinforcement is impractical. It shows that creating ductile bending components with CFRP in concrete is feasible despite the material's brittleness. This funding overturns conventional assumptions and opens new avenues for using CFRP in structural applications where ductility and resilience are crucial.

• Journal of Korean Society of Steel Construction
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• v.15 no.2
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• pp.117-124
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• 2003

Wind-induced motions, like acceleration for instance, often influence designs for high-rise buildings. As a consequence, correct assessment of natural frequency becomes important. The empirical expressions used to quantify this parameter at the design phase tend to yield values that are significantly different from each other. This paper is concerned with the natural periods of steel buildings. It describes the vibration measurement methods that were employed for testing buildings. This paper will also present reliable methods of assessing the natural period from ambient vibration tests. Data from measurements on 21 buildings in Seoul were provided while 21 buildings were tested by ambient vibration measurements to obtain the natural periods. While regression formulas of natural periods for steel-frarried tall buildings were suggested,the obtained formula was compared with the empirical expressions of structural standards and the Eigen-value analysis.

• Journal of the Korean Institute of Educational Facilities
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• v.11 no.5
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• pp.14-23
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• 2004

Building-integrated photovoltaic(BIPV) systems can operate as a multi-functional building components, which generates electricity and serves as part of building envelope. It can be regarded as a new architectural elements, adding to the building's aesthetics. Besides of these benefits, the application of PV systems into school buildings tends to play an important role in energy education to students. In this context, this study aims to analyse the applicability of PV systems into school buildings. For an existing school building, four types of BIPV designs were developed; rooftops, wall-attached, wall-mounted with angle, and sunshading device. Based on energy modeling of those BIPV systems, the whole 60.1kWp rated PV installation is expected to yield about 65.6MWh of electricity, that is about 50% more than the annual electricity consumption of the school, 44MWh. It was also found that the applicability of the PV systems into the school building was very high, and the rooftop systems with the optimized angle was the most efficient in energy production, followed by sunshading, wall-mounted with angle and wall-attached. It concludes that school buildings have a reasonable potential to apply PV systems in the aspects of building elements and electricity production.