• 제목/요약/키워드: hereditary

검색결과 510건 처리시간 0.024초

자발성 혈흉으로 내원하여 진단된 유전출혈모세혈관확장증 1예 (A Case of Hereditary Hemorrhagic Telangiectasia Diagnosed through Spontaneous Hemothorax)

  • 김종환;박일환;권우철;김영주;정순희;이선녕;이석정;이지호;정세현;정예령;김상하
    • Tuberculosis and Respiratory Diseases
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    • 제72권1호
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    • pp.50-54
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    • 2012
  • Hereditary hemorrhagic telangiectasia (HHT, Osler-Weber-Rendu disease) is a rare autosomal dominant disease characterized by heterogenous multisystemic dysplasia of the vascular tissue. Prevalence of HHT is 1 in 5,000~8,000. HHT commonly presents with recurrent epistaxis, but may have more serious consequences if visceral vascular beds are involved. Approximately 30~50% of HHT cases also present with pulmonary arteriovenous malformation (PAVM). Spontaneous hemothorax is less common, and PAVM is one of the causes leading to hemothorax. Our case involved an 18-year-old female who had suddenly developed right chest pain. The reason for chest pain was due to right spontaneous hemothorax accompanied by PAVM in the right middle lobe. The patient was additionally diagnosed with HHT upon examination of her family history, specifically through her mother's symptom that included recurrent epistaxis and mucosal telangiectasia.

Factors associated with the decision to undergo risk-reducing salpingo-oophorectomy among women at high risk for hereditary breast and ovarian cancer: a systematic review

  • Park, Sun-young;Kim, Youlim;Kim, Sue
    • 여성건강간호학회지
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    • 제26권4호
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    • pp.285-299
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    • 2020
  • Purpose: This systematic review aims to identify factors associated with risk-reducing salpingo-oophorectomy (RRSO), including the uptake rate and decision timing, among women at high risk for hereditary breast and ovarian cancer (HBOC). Methods: We found 4,935 relevant studies using MEDLINE, Embase, CINAHL, and PsycINFO on July 6, 2020. Two authors screened the articles and extracted data. Twenty-four studies met the inclusion criteria. Quality assessment of articles was conducted using the Risk of Bias for Nonrandomized Studies tool. Results: Five types of factors were identified (demographic factors, clinical factors, family history of cancer, psychological factors, and objective cancer risk). The specific significant factors were older age, having child(ren), being a BRCA1/2 carrier, mastectomy history, perceived risk for ovarian cancer, and perceived advantages of RRSO, whereas objective cancer risk was not significant. The uptake rate of RRSO was 23.4% to 87.2% (mean, 45.2%) among high-risk women for HBOC. The mean time to decide whether to undergo RRSO after BRCA testing was 4 to 34 months. Conclusion: RRSO decisions are affected by demographic, clinical, and psychological factors, rather than objective cancer risk. Nonetheless, women seeking RRSO should be offered information about objective cancer risk. Even though decision-making for RRSO is a complex and multifaceted process, the psychosocial factors that may influence decisions have not been comprehensively examined, including family attitudes toward RRSO, cultural norms, social values, and health care providers' attitudes.

III급 부정교합에서 두개안면 형태와 지문의 유전성향 분석 (Analysis of the hereditary factor in craniofacial morphology and fingerprints in Class III malocclusion)

  • 오태경;백형선
    • 대한치과교정학회지
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    • 제34권4호
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    • pp.279-287
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    • 2004
  • 성장기 부정교합 환자의 치료시 다양한 악안면 성장은 치료성패의 중요한 요소이다. 따라서 치료를 시작하기 전에 안면성 장을 예측하는 것은 매우 중요하다. 본 연구는 III급 부정 교합을 보이 는 아동에서 성장을 예측할 수 있는 방법들 중의 하나로 두부방사선 계측사진 분석을 통해 유전적 요소의 관련여부를 알아보고자 50가족에서 부모자식간의 악안면 형태의 상관관계를 통계학적으로 분석하였다. 또한 자식과 부모간의 지문의 형태적 연관성을 조사하고 부모자식간의 악안면 형태와 지문의 형태적 연관성과의 유전적 상관관계를 조사하여 다음과 같은 결론을 얻었다. 1 부모자식간의 악안면 형태에서 치성관계보다는 악골관계에서 더 유전성향이 높았으며 아버지가 어머니에 비해 자식의 악골관계에 더 영향을 주었다. 2. 자식의 지문 형태는 아버지보다는 어머니와의 연관성이 더 높게 나타났다. 3. 부모와 자식간의 지문과 악안면 형태에서 유전적 상관관계가 있었으며(P<0.05-0.01), 딸보다는 아들에게서 연관성이 더 높게 나타났다.

국내 임상 의사의 유전성 유방암에 대한 지식도 (Physicians' Knowledge about Hereditary Breast Cancer in South Korea)

  • 최경숙;태영숙;소양숙;이우숙;허명행;강미영;손성이;이미희;이영란;최인순;장은실;김성재;전명희
    • 한국간호교육학회지
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    • 제13권1호
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    • pp.105-113
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    • 2007
  • Background: Cancer genetics have gained public attention dramatically. Everyday physicians and nurses use the knowledge of cancer genetics in their practices. Despite the importance of the knowledge of the health care providers on cancer genetics, there is a paucity of literature investigating the levels of knowledge about cancer genetics among health care providers. Purpose: This study aimed to describe the Korean physicians' current knowledge level about hereditary breast and ovarian cancer (HBOC). Method: This nation-wide survey used a 15-item questionnaire which is modified from the Breast Cancer Genetic Counseling Knowledge Questionnaire originally developed by Erblich et al.(2005). One hundred and forty-four physicians participated in this survey from October 1, 2006 to March 31, 2007. Result: Physicians' knowledge level about hereditary breast cancer was 11.94 (S.D=2.46). Physicians with short-term careers (less than one year), the position of Intern, or who were involved in breast or ovarian cancer care demonstrated the highest knowledge about HBOC. Conclusion: Genetic courses in medical education seemed to contribute to the high level of physicians' genetic knowledge. Also, nursing discipline needs to incorporate genetics or genetic counseling courses into the formal educational curriculum in order to deliver up to date cancer care services which are sensitive to ever-changing cancer genetic information.

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직선형 도파관의 유전체와의 상호작용 연구 (Position Introduction Research with Hereditary body of Formation Waveguide)

  • 김원섭
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2009년도 제40회 하계학술대회
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    • pp.1477_1478
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    • 2009
  • 마이크로파는 통신과 플라즈마 가열등 많은 분야에서 이용되어져 왔다. 본 연구에서는 대 전력 마이크로파를 발생시키는 발생기의 하나로서 체렌코프 상호작용에 대하여 후진파발진기를 연구하였으며 현재 고출력화, 고주파수를 목적으로 하여 연구하였다.

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Notes on correct modules

  • Lee, Dong-Soo;Park, Chul-Hwan
    • 대한수학회논문집
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    • 제11권2호
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    • pp.295-301
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    • 1996
  • In this paper we will define correct module and strongly correct module. We can have some basic results about those modules. And we will show that M is a graded correct R-module if and only if $M_e$ is a correct $R_e$-module.

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