• 대한한의학원전학회지
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• 제30권4호
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• pp.69-82
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• 2017

Objective : This study was conducted to infer the effect of superficies-resolveing herbs by analyzing effect terms which have extracted and refined, based on four temperatures and five tastes. Method : Firstly, temperatures, tastes and effect terms were extracted from the 27 kinds of superficies-resolving herbs written in Herbology. Then, each effect terms was divided into single meaning term and refined as typical term, using the inclusive effect terms I established. After that, herbs were grouped by tastes and found the effect terms which are mentioned most frequently. And it could be supposed to be classified into each herb's new effects based on the relationship between properties and those effect terms. It is also inferred into new tastes from some herbs by analysing the representative effects group of each taste and finding which other tastes can be related to each herb's effect. Result & Conclusion : All the superficies-resolving herbs can have wind-dispelling effect and superficies-resolving effect, except Bulpleuri Radix. This herb is able to has just the wind-dispelling effect. And it's more appropriate to categorize Bulpleuri Radix to heat-clearing herb group than superficies-resolving herb group, considering its several, distinctly cold characteristics. Some effects are concentrated to wind-cold-dispersing herb group and others to wind-heat-dispersing herb group. Each tastes has its own representative effect group. And, according to its tastes' representative effect, some of herbs are reasonable to get new effect term. With not so feasible reason, 4 kinds of herbs are supposed to contain all of hot, bitter, and sweet tastes. Also It's needed to study much deeper whether Perillae Herba, Zingiberis Rhizoma Crudus and Elsholtziae Herba are belong to superficies-resolving herb group or to interior-warming or damp-dissolving aromatic herb group.

• 혜화의학회지
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• 제20권1호
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• pp.11-23
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• 2011

Systemic Lupus Erythematosus(SLE) is an autoimmune disease invading the skin, joint, kidney, intestinal membrane, neurosystem and other organs. SLE is an autoimmune disease characterized by immune dysregulation resulting in the production of antinuclear antibodies(ANA), generation of circulating immune complexes, and activation of the complement system. In Korean medicine, lupus can be classified as acute arthritis, reddish butterfly erythema, asthenic disease, edema and so on. The cause and procedure of the diseases are flourishing noxious heat, excessive fire due to deficiency of yin, blood stasis due to stagnation of qi, internal movement of the liver-wind, congenital deficiency, exhausted vital-qi, which are treated by clearing away heat and cooling the blood, nourshing yin and extinguishing fire, treating flatulence and activating blood circulation, nourishing the blood to expel wind, invigorating the liver and kidney, invigorating qi and replenishing the blood. To experimentally examine the influence of Insam-Buja-Tang (Ginseng & Aconiti Extract, IBT) on the outbreak and development of lupus, lupus induce MRL/MpJ-Faslpr lupus-prone mice model was used. As IBT was orally administrated to a lupus model mouse, various tests such as the weight, urine protein, renal function, Lymph cell test of the spleen, Cytokine expression, histopathological analysis of kideny were performed to see the influence on the kidney and whether it work effectively on the immune function. The main purpose of this study is to evaluate the effect of IBT on MRL/MpJ-Faslpr lupus-prone mice model. The effect of IBT on MRL/MpJ-Faslpr lupus-prone mice that can have autoimmune disease similar to SLE in human was evaluated after IBT per oral in the present study.

• 대한한방내과학회지
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• 제15권2호
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• pp.148-162
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• 1994

A Literature study was done for identifying the effects of Bloodletting on C.V.A. The major results of the study were as follows. 1. The frequency of points of Bloodletting on C.V.A. were in order Twelve well point, Ship son, Gold SalivaJade Fluid, Paekoe, Chungchung, Sugu, Sosang, Taechu, Wijung, Kwanchung, etc. 2. The frequency of meridians of Bloodletting on C.V.A. were in order Extra-point, Tongmaek-kyong, Su-gworum-Shimpo-Kyong, Susoyang-Samcho-Kyong, Sutaeum-Pye-Kyong, Choktaeyang-Panggwang-Kyong. ete. 3. The frequency of the site of points of Bloodletting on C.V.A. were in order four extremities, face, neck and head, etc. 4. The effects of Bloodletting on C.V.A. is clear away heat and alleviate pain, therapy for waking up a patient from unconsciousness, dredge the meridian passage, expel wind-evil and promote blood circulation, emergency treatment for collapse, etc, 5. The effects of Bloodletting on the early stage of C.V.A. were wake up the patient from unconsciousness by clearing away the heat and The effects of Bloodletting on sequence of C.V.A. were dredge the meridian passage, 6. The frequency of points and meridians of Bloodletting on Hemiplegia were in order Twelve well point, Kyonjong, Extra-point, Chok soyang-Tam-Kyong, etc. 7. The frequency of points and meridians of Bloodletting on Aphasia were in order Gold Saliva Jade Fluid, Amun, Extra-point, Tongmaek-Kyong, etc. 8. The frequency of points and meridians of Bloodletting on Quadriplegia were in order Ship son, Twelve well point, Koktaek, Wijung, Extra-point, Chok soyang-Tam-Kyong, etc. 9, The frequency of points and meridians of Bloodletting on Vertigo were in order Four Gods Cleverness, Tuyu. Chanjuk, Paekoe, Taeyang, Extra-point, Yang-Kyong, etc. 10. The frequency of points and meridians of Bloodletting on Headache were in order Taeyang, Paekoe, Taechu, Extra-point, Tongmaek-Kyong, Yang-Kyong, etc. 11. The points and meridians of Bloodletting on Bells palsy were Chichang, Hyopko in Yangmyong-Kyong.

• 대한약침학회지
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• 제15권2호
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• pp.7-10
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• 2012

Objectives: The root of Lithospermum erythrorhizon Sieb. et Zucc. (Lithospermi Radix, LR) is a kind of heat clearing and blood cooling medicinal herbs. It can clear away heat and cool the blood, reduce toxins and disperse maculae. LR has long been used as efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis. Methods: In the present study, we investigate anti-allergic and anti-inflammatory effects of LR by using the 1-fluoro-2, 4- dinitrofluorobenzene (DNFB)-induced contact dermatitis mouse model. Results: Topical application of 10 mg/mL of LR effectively inhibited skin lesions induced by repeated paintings with DNFB. Topical application of LR also inhibited hyperplasia, edema, spongiosis and infiltrations of mononuclear cells. In addition, production levels of total immunoglobulin and IgG1 in serum were decreased by using LR in vivo. Conclusions: These data suggest that LR acts as an antiinflammatory agent, improving skin lesions in CD mice.

• Journal of Acupuncture Research
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• 제32권2호
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• pp.35-57
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• 2015

Objectives : The purpose of this study is to analyze literature on oriental medicine to investigate the pathology, acupuncture, and moxibustion therapy applicable to alopecia Methods : We searched for the causes of alopecia in the bibliographic data from 41 sources of literature and the acupunctural treatments for alopecia in the bibliographic data from 49 sources of Chinese and Korean literature and from the journals of the acupunctural treatments for alopecia which have been published since 2000. Results : 1. The main causes of alopecia are blood deficiency, blood heat, static blood, depletion of kidney's water, wind excess, seven emotional damage, dietary damage, etc. 2. The acupuncture points frequently used are $GV_{20}$, $GB_{20}$, $ST_{36}$, $SP_6$, $SP_{10}$, $BL_{17}$, $BL_{18}$, $BL_{23}$, $GV_{23}$, $GV_{14}$, $CV_6$, $ST_8$, $KI_3$, $LR_3$, $HT_7$, $LI_{11}$, EX-$HN_1$, and ouch point. 3. New acupuncture therapies, including herbal acupuncture therapy, ear acupuncture therapy, dermal needle therapy, needle-embedding therapy and scalp acupuncture therapy are frequently used to treat alopecia. Conclusions : The acupuncture points frequently used for treating alopecia have characteristics such as tonifying blood, tonifying the liver and kidney, extinguishing wind, activating blood, clearing heat and draining dampness, so they are highly associated with the causes and the mechanisms of alopecia.

• 대한한방내과학회지
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• 제22권3호
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• pp.453-458
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• 2001

Guillain-Barre syndrome, or acute inflammatory demyelinating Polyradiculoneuropathy, is frequently accompanied by cardiac and autonomic dysfunction. We report a patient who had tachycardia, orthostatic hypotension, hypertension, pronounced blood pressure fluctuations, abnormal sweating, constipation and urinary frequency as well as qudriparesis. We thought that the GBS was incurred by Damp-Heat, used Heat-Clearing and Dampness-Transforming decoction(Chongjoo-tang) in the early stage. In the later stage, fortifying the Spleen and Boosting Qi plus Supplementing the Kidney decoction(Palmultang+chongawon) was used to remove low back pain and boost recovery. The patient reached the nadir 14 days after onset. He became bed-bound and autonomic dysfunction was very severe. From 3rd week, abnormalities of autonomic function and paresis impoved gradually and he could walk above 5m without walker or equivalent support at the 5th week after onset.

• 동의생리병리학회지
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• 제22권1호
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• pp.32-50
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• 2008

This study is concerned with examining the causes and symptoms of Woman various diseases and clearing up the situations of pulses and their treatment. Woman various diseases are said to be various kinds of diseases including the disorder of menstruation and genitals except pregnancy and postpartum diseases. The main contents are the penetration of heat into worm, the discharge of much blood, stomachache, and the postpartum cyst diseases. Among them, the nature of the diseases which often occur in the gynecology, such as the menstrual diseases and stomachache, were described comparatively in detail. The reason why heat penetrates into the worm is that the external germs come into it under its weakness. To treat it, heat should be removed and lumping blood should be sent out of body. Especially only after whether the disease is serious or not is examined, and just after the process of the disease is examined, the lumping blood can be eliminated. The ways to cure it by sweating a patient too much, getting him or her to vomit, or forcing him or her to be urinated too much, should be avoided. The disorder of menstruation, as the disease which most often occur among the diseases of gynecology, includes menstrual irregularity and blood discharge, and non-menstruation. Among them, non-menstruation and blood discharge are comparatively often discussed. When they are treated, lumping blood and cold energy should be cured well through getting rid of the lumping blood and making the blood vessel flow well. The difficult urination after childbirth, which comes from the weak urinary cist, makes symptoms such as the stuffy chest, the difficulty of lying down, and breathing with his or her back something. To urinate better, the ability of the urinary cist should be supplemented and improved. The principle of the treatment for Woman various diseases is to examine the situation of the pulse closely, then set up the way to treat it, and prescribe a patient. In this study, besides the treatment of Chinese herb medicine, the medicine for washing genitals and the medicine placed in the worm were used to cure Woman various diseases. This treatment is the beginning of the surgical treatment in the gynecology.

• 한방안이비인후피부과학회지
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• 제16권2호
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• pp.1-45
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• 2003

We get the conclusion this following through bibliographic consideration about the cause of disease, disease mechanisms and remedy, prescription of tuberculosis of the cervical lymphic node. 1. The tuberculosis of the cervical Iymphic node is named the linear lump of scrofula(마도라력), the scrofula around neck(반사력), the wide-spread scrofula(류주력), the papule like lotus seed(련자력), the scrofula(라력), the subcutaneous nodes(結核), the scrofula due to disorder of Gi(기력) and the scrofula due to accumulation of phlegm(담력) according to the criterion of regions of disease, causes, rounding parts and shapes. 2. The cause of the tuberculosis of the cervical lymphic node are the stagnation of liver Gi(肝氣鬱結), the accumulation of phlegm and the stagnation of Gi(痰凝氣滯), the deficiency of vital essence of the liver and kidney(肝腎陰虛), the wind-heat of liver, gallbladder and triple warmer(肝膽三焦風熱), the dry-fire(燥火), the dryness of blood(血燥), the unwholesome diet(飮食不潔), the abundance of diet(食味之厚), the stagnation of Gi(鬱氣之積), the exhaustion syndrome(虛勞), the excessive thought(思慮過多), the toxin of wind-heat(風熱毒) and the germ of subcutaneous nodes(結核菌). 3. Symptoms of the tuberculosis of the cervical lymphic node are swelling slowly in comparison in the early days of occurrence, and are not pain, not itch, not heat, not other special symptoms. But in some cases, tuberculosis of the cervical lymphic node are quickly swelling in the early days of occurrence, and the fever and pain appear, The pyosis is accompanied with the fever and the pain at first generally, and then removing the pus from abscess is dissolved the fever and the pain in the majority of cases and representative of the general exhaustion syndrome. 4, The remedy of tuberculosis of the cervical Iymphic node is the early days, clearing the liver and relieves constraint(疏肝解鬱), phlegm and dissolving accumulation(化痰散結) the middle days, pus draining and toxin expelIing(托裏透膿) the latter days, replenish the kidney and strengthen the spleen(滋腎健脾). 5. The medication to treat the tuberculosis of the cervical lymphic node are the 益氣養榮湯(lkgiyangyoungtang)(14th), the 夏枯草散(Hagochosan)(10th) and et cetra in regular sequence. 6. The herb to treat the tuberculosis of the cervical Iymphic node are the 連翹(FRUCTUS FORSYTHlAE)(59th), the 甘草(RADIX GLYCYRRHIZAE)(51th), the 當歸(RADIX ANGELICAE GlGANTIS)(47th), the 黃芩(RADlXSCUTELLARIAE)(40th), the 夏枯草(SPICA PRUNELLAE)(23th) in regular sequence.

• 한방안이비인후피부과학회지
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• 제21권2호
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• pp.28-38
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• 2008

In traditional oriental medicine, Gentianae Radix has been used clinically for clearing away 'heat', removing dampness and purging fire in the liver and gall bladder. However, there has been a lack of studies regarding the effects of Gentianae Radix on the immunological activities. The present study was conducted to evaluate the effect of Gentianae Radix on the regulatory effects of cytokines and nitric oxide(NO) for the immunological activities in Raw 264.7 cells. After the treatment of Gentianae Radix MeOH extract, cell viability was measured by MTT assay, and NO production was monitored by measuring the nitrite content in culture medium. The expression of COX-2 and iNOS was determined by immunoblot analysis, and the content of levels of cytokines in media was analyzed by ELISA kit. Results provided evidence that Gentianae Radix inhibited the production of nitrite and nitrate (NO), inducible nitric oxide synthase (iNOS), $interleukin-l{\beta}$ $(IL-l{\beta})$ and IL-6, and the activation of phospholylation of inhibitor ${\kappa}B{\alpha}$ ($p-I {\kappa}B{\alpha}$) in Raw 264.7 cells activated with lipopolysaccharide (LPS). These findings suggest that Gentianae Radix can make anti-inflammatory effect, which may playa role in adjunctive therapy.

• 동의생리병리학회지
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• 제32권3호
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• pp.149-156
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• 2018

Traditional medicines (TM) in Korea, China, and Japan share most of the theories and therapeutic tools, but there are also differences due to their unique histories and cultures. Here, we aim to identify the differences in the utilization of TM theory between three countries by analyzing herb usage data in terms of the related traditional theories. Herb usage data of each country was collected from "Investigation of Korean medicine use and herbal medicine consumption survey" (Korea), "Analytical report on circulation of key Chinese medicinal materials" (China), and "Survey report on raw material crude drug usage" (Japan). Fifty five herbs with sixty features belonging to five theoretical categories (four properties, five tastes, targeting meridians, treatment strategies, and herbal parts) were selected and analyzed. Weight Sum Model (WSM) and Network-Based Group Features (NBGF) were used to compare the theoretical characteristics of TM between three countries. For the statistical evaluation, we developed and applied Herb Set Enrichment Analysis (HSEA) for WSM and NBGF results. HSEA for WSM results revealed the kidney meridian were targeted more in Korea than Japan, while the spleen meridian were targeted more in Japan than Korea. Herbs with sour taste were used more in Japan than China. HSEA for NBGF results found that NBGF including warm, neutral, sweet, and tonifying features were more dominant in Korea and than Japan, while NBGF including cold, bitter, heat-clearing features were more dominant in Japan than the others. These results suggest that TM in Korea, China, and Japan have unique aspects of practice patterns and theoretical utilization.