Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
권호 표지

Study of Insam-Buja-Tang (IBT) on MRL/MpJ-Faslpr lupus-prone mice

루푸스 동물 모델에서 인삼부자탕(人蔘附子湯)이 미치는 영향

  • Kim, Kyoung-Shin (Department of Physiology, Colleage of Oriental Medicine, Daejeon University) ;
  • Moon, Sung-Sikm (Department of Physiology, Colleage of Oriental Medicine, Daejeon University) ;
  • Kim, Byoung-Soo (Department of Physiology, Colleage of Oriental Medicine, Daejeon University) ;
  • Kang, Jung-Soo (Department of Physiology, Colleage of Oriental Medicine, Daejeon University)
  • 김경신 (대전대학교 한의과대학 생리학교실) ;
  • 문성식 (대전대학교 한의과대학 생리학교실) ;
  • 김병수 (대전대학교 한의과대학 생리학교실) ;
  • 강정수 (대전대학교 한의과대학 생리학교실)
  • Received : 2011.07.12
  • Accepted : 2011.08.01
  • Published : 2011.08.20
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Abstract

Systemic Lupus Erythematosus(SLE) is an autoimmune disease invading the skin, joint, kidney, intestinal membrane, neurosystem and other organs. SLE is an autoimmune disease characterized by immune dysregulation resulting in the production of antinuclear antibodies(ANA), generation of circulating immune complexes, and activation of the complement system. In Korean medicine, lupus can be classified as acute arthritis, reddish butterfly erythema, asthenic disease, edema and so on. The cause and procedure of the diseases are flourishing noxious heat, excessive fire due to deficiency of yin, blood stasis due to stagnation of qi, internal movement of the liver-wind, congenital deficiency, exhausted vital-qi, which are treated by clearing away heat and cooling the blood, nourshing yin and extinguishing fire, treating flatulence and activating blood circulation, nourishing the blood to expel wind, invigorating the liver and kidney, invigorating qi and replenishing the blood. To experimentally examine the influence of Insam-Buja-Tang (Ginseng & Aconiti Extract, IBT) on the outbreak and development of lupus, lupus induce MRL/MpJ-Faslpr lupus-prone mice model was used. As IBT was orally administrated to a lupus model mouse, various tests such as the weight, urine protein, renal function, Lymph cell test of the spleen, Cytokine expression, histopathological analysis of kideny were performed to see the influence on the kidney and whether it work effectively on the immune function. The main purpose of this study is to evaluate the effect of IBT on MRL/MpJ-Faslpr lupus-prone mice model. The effect of IBT on MRL/MpJ-Faslpr lupus-prone mice that can have autoimmune disease similar to SLE in human was evaluated after IBT per oral in the present study.

Keywords

References

  1. 양용석 外. 면역혈청학. 서울, 라이프사이언스, p.367, 2004.
  2. Kurtt J. Lssebacher. Harrison's 내과학. 서울, 정담, pp.1771-1776, 1997.
  3. 이수곤 역. Pathophysiology로 이해하는 내과학. 서울, 정담, pp.42-46, 2002.
  4. 전국 의과대학 임상교수 편. Color Atlas 임상의학. 서울, 한우리, pp.13-15, 2000.
  5. 김형섭. 내과학(5권. 감염.류마티스.알러지). 서울, 고려의학, pp.267-277, 2003.
  6. Ward MM, Pyun E, Studenski S: Causes of death in systemic lupus erythematosus. Long-term followup of an inception cohort. Arthritisi Rheum, 38(10):1492-9, 1995. https://doi.org/10.1002/art.1780381016
  7. Pettersson T, Pukkala E, Teppo L, Friman C: Increased risk of cancer in patients with systemic lupus erythematosus, Ann Rheum Dis, 51(4):437-9, 1992. https://doi.org/10.1136/ard.51.4.437
  8. Kotzin BL. Systemic lupus erythematosus. Cell 85:303-6, 1996. https://doi.org/10.1016/S0092-8674(00)81108-3
  9. Cohen JJ, Duke RC, Fadok VA, Sellins KS. Apoptosis and programmed cell death in immunity. Annu RevImmunol 10:267-93, 1992.
  10. 沈丕安. 紅斑狼瘡 中醫臨床硏究. 北京, 人民衛生出版社, pp.4-10, 50, 1999.
  11. 전국한의과대학 본초학교실. 본초학. 서울, 영림사, pp.322, 531-532, 1991.
  12. M. H. Park, et al., Tubulointerstitial disease in lupus nephritis: Relationship to immune deposits, interstitial inflammation, glomerular changes, renal function, and prognosis, Nephron 44:310, 1986.
  13. 이연태. 최신면역학. 서울, 집문당, pp. 398-399, 1989.
  14. 박성환. 전신성 홍반성 루푸스 환자의 신장 질환. 류마티스 건강학회지 Vol.3, No.2, 231-239, 1996.
  15. Vivette D. D'Agati, Agnes B. Fogo, Jan A. Bruijn, J. Charles Jennette, Pathologic Classification of focal Segmental Glomerulosclerosis: A working Proposal, American journal of kidney diseases, 43(2):368-382, 2004. https://doi.org/10.1053/j.ajkd.2003.10.024
  16. Trauth BC, Klas C, Peters AM, Matzku S, Moller P, Falk W, et al. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301-5, 1989. https://doi.org/10.1126/science.2787530
  17. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen thatmediates apoptosis. Nature 356:314-7, 1992. https://doi.org/10.1038/356314a0
  18. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969-76, 1994. https://doi.org/10.1016/0092-8674(94)90375-1
  19. Drappa J, Vaishnaw AK, Sullivan KE, Chu JL, Elkon KB. Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J Med 335:1643-9, 1996. https://doi.org/10.1056/NEJM199611283352204
  20. Vaishnaw AK, Toubi E, Ohsako S, Drappa J, Buys S, Estrada J, et al. The spectrum of apoptotic defects and clinical manifestations, including systemic lupus erythematosus, in humans with CD95 (Fas/ APO-1)mutations. Arthritis Rheum 42:1833- 42, 1999. https://doi.org/10.1002/1529-0131(199909)42:9<1833::AID-ANR7>3.0.CO;2-Q
  21. Lorenz HM, Grunke M, Hieronymus T, Herrmann M, Kuhnel A, Manger B, et al. In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum 40:306-17, 1997. https://doi.org/10.1002/art.1780400216
  22. 李曉宇, 中醫藥治療紅斑性狼瘡, 陜西中醫學院學報, 11(3):28-29, 1998.
  23. 姜泉, 系統性紅斑狼瘡中醫辨證分型與血淸免疫指標的關係, 中國中醫藥信息雜誌, 2(10):17, 1995.
  24. 周楚漢 等, 中醫辨證分型治療系統性紅斑狼 瘡118例療效分析, 中西醫結合雜誌, 10(2):108-109, 1990.
  25. 孫年樣, 淸熱化瘀治療狼瘡性腎炎100例, 江蘇中醫, 17(12):16, 1996.
  26. 余其珷 等, 靑蒿琥酯治療紅斑狼瘡56例, 中華皮膚科雜誌, 30(1):51-52, 1997.
  27. 憑樹芳 等, 雷公藤對女性SLE性激素水平的影響, 中華皮膚科雜誌, 22(1):3, 1989.
  28. 張國强 等, 丹蔘對狼瘡性腎炎成縴維細胞增殖, 凋亡及G-myc蛋白表達的影響, 中國中西醫結合雜誌, 17(8):473, 1997.
  29. 정현아 외, 전신성홍반성낭창에 대한 문헌적 고찰, 大韓眼耳鼻咽喉皮膚科學會誌, 15(1):356-83, 2002.
  30. 이석우 외, 전신성홍반성낭창의 東醫病理 및 治法에 관한 고찰, 대한한의학회지, 16(1):51-70, 1995.
  31. 안창석 외, 전신성홍반성낭창(SLE)환자 1례에 대한 증례보고, 대한약침학회지, 3(2):245-55, 2000.
  32. 催勳燮, 滋腎活血湯이 全身性紅斑性狼瘡 동물모델에 미치는 影響, 대전대학교 한의학대학원 박사학위논문, 2005.
  33. 金起鳳.周德瑛, 中醫皮膚科學, 北京, 中國醫藥科技出版社, pp.260-268, 2000.
  34. 徐宜厚, 皮膚病中醫診療學, 北京, 人民衛生出版社, pp.150-151, 1997.
  35. 陳以平, 腎病的變證與辨病治療, 北京, 人民衛生出版社, pp.125-130, 1997.
  36. 김덕곤 外. 동의소아과학. 서울, 정담사, 2002, pp. 611-614.