Browse > Article
http://dx.doi.org/10.3831/KPI.2012.15.2.007

Effect of Lithospermi Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice  

Kim, Han-Na (Division of Pharmacology, Pusan National University School of Korean Medicine)
Kim, Mi-Young (Division of Pharmacology, Pusan National University School of Korean Medicine)
Choi, Chan-Hun (Department of Pathology, College of Oriental Medicine, Dongshin University College of Korean Medicine)
Kim, Byung-Joo (Division of Pharmacology, Pusan National University School of Korean Medicine)
Kim, Kyung-Yoon (Department of Physical Theraphy, Dongshin University College of Health and Welfare)
Kim, Gye-Yeop (Department of Physical Theraphy, Dongshin University College of Health and Welfare)
Jeong, Hyun-Woo (Department of Pathology, College of Oriental Medicine, Dongshin University College of Korean Medicine)
Kim, Hyung-Woo (Division of Pharmacology, Pusan National University School of Korean Medicine)
Publication Information
Journal of Pharmacopuncture / v.15, no.2, 2012 , pp. 7-10 More about this Journal
Abstract
Objectives: The root of Lithospermum erythrorhizon Sieb. et Zucc. (Lithospermi Radix, LR) is a kind of heat clearing and blood cooling medicinal herbs. It can clear away heat and cool the blood, reduce toxins and disperse maculae. LR has long been used as efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis. Methods: In the present study, we investigate anti-allergic and anti-inflammatory effects of LR by using the 1-fluoro-2, 4- dinitrofluorobenzene (DNFB)-induced contact dermatitis mouse model. Results: Topical application of 10 mg/mL of LR effectively inhibited skin lesions induced by repeated paintings with DNFB. Topical application of LR also inhibited hyperplasia, edema, spongiosis and infiltrations of mononuclear cells. In addition, production levels of total immunoglobulin and IgG1 in serum were decreased by using LR in vivo. Conclusions: These data suggest that LR acts as an antiinflammatory agent, improving skin lesions in CD mice.
Keywords
Lithospermi Radix; dinitrofluorobenzene; contact dermatitis; anti-allergic;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Kyogoku K, Terayama H, Tachi Y, Suzuki T, Komatsu, M. [Studies on the constituents of Shikon. II: Comparison of contents, constituents, and antibacterial effect of fat soluble fraction between Nanshikon and Koshikon]. Shoyakugaku Zasshi. 1973;27(1):31-6. [In Japanese]
2 Guo XP, Zhang XY, Zhang SD. [Clinical trial on the effects of Shikonin mixture on later stage lung cancer]. Zhong Xi Yi Jie He Za Zhi. 1991;11(10):598-9. [In Chinese]
3 Niwano Y, Nishizawa M, Kohno M. Shikonin, an active principle of the medicinal plant Lithospermum erythrorhizon, is a potent scavenger of peroxyradicals in cigarette smoke. In recent progress in medicinal plants. Houston: Studium Press LLC; 2007. p.203-14.
4 Weng XC, Xiang GQ, Jiang AL, Liu YP, Wu LL, Dong XW, et al. Antioxidant properties of components extracted from puccoon (Lithospermum erythrorhizon Sieb. et Zucc.). Food Chemistry. 2000;69(2):143-6.   DOI   ScienceOn
5 Boerrigter GH, Bril H, Scheper RJ. Hapten-specific antibodies in allergic contact dermatitis in the guinea pig. Int Arch Allergy Appl Immunol. 1988;85(4):385-91.   DOI
6 Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Kohler A, et al. Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity. 2011;34(6):973-84.   DOI
7 Chen X, Yang L, Zhang N, Turpin JA, Buckheit RW, Osterling C, et al. Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2003;47(9):2810-6.   DOI
8 Kim SH, Lee JY, Kim DG. Effects of Mori Folium, Arctii Fructus, Lithospermum Erythrorhizon on the anti-allergic response. J Kyung Hee Univ Med Cent. 2005;21(1):71-9.
9 Grabbe S, Schwarz T. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today. 1998;19(1):37-44.   DOI   ScienceOn
10 Broide DH. Molecular and cellular mechanisms of allergic disease. J Allergy Clin Immunol. 2001;108(2 Suppl):S65-71.   DOI   ScienceOn
11 Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol. 2006;126(12):2565-75.   DOI   ScienceOn
12 Machado-Pinto J, McCalmont TH, Golitz LE. Eosinophilic and neutrophilic spongiosis: clues to the diagnosis of immunobullous diseases and other inflammatory disorders. Semin Cutan Med Surg. 1996;15(4):308-16.   DOI   ScienceOn
13 Saint-Mezard P, Rosieres A, Krasteva M, Berard F, Dubois B, Kaiserlian D, et al. Allergic contact dermatitis. Eur J Dermatol. 2004;14(5):284-95.
14 Cohen D, Heidary N. Treatment of irritant and allergic contact dermatitis. Dermatol Ther. 2004;17(4):334-40.   DOI   ScienceOn
15 Wen MC, Wei CH, Hu ZQ, Srivastava K, Ko J, Xi ST, et al. Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. J Allergy Clin Immunol. 2005;116(3):517-24.   DOI   ScienceOn
16 Ju JH, Cho HH, Lee YS. Progress on phytochemical and atopic dermatitis-related study of the root of Lithospermum erythrorhizon. Kor J Pharmacogn. 2010;41(2):73-88.