• 한국임상약학회지
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• 제31권4호
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• pp.311-323
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• 2021

Objective: The disabled are in a blind spot for obtaining information on drugs, and the pharmacies' counseling on drug use is centered on non-disabled people. Few studies have investigated the current statuses of drug use by type of disability. The purpose of this study is to understand the drug use by type of disability and by life cycle of visually impaired and hearing impaired in Korea. Methods: The study participants consisted of 16 people with visually impairments, 12 people with hearing impairments. One in-depth interview was conducted per participant, and each interview was recorded and documented. Results: Common barriers against safe medication and medical service uses across disability types are 'lack of consideration and service for the disabled, limited access to medical facilities due to disability, limited access to information regarding medication use, psychological anxiety about drug use and side effects, and inconvenience regarding COVID-19 epidemic. The specific factors were 'difficulties in identifying proper medicines and following prescribed dosages' in the case of visually impaired, and 'problems with sign language interpretation system' for the hearing impaired. Conclusion: Disabled people are hindered from using medicines properly due to various factors. Based on the content derived from this study, it is necessary to eliminate the inhibition factors and devise specific measures for the safety of each type of disorder such as developing a method for medication counseling considering disabilities and establishing communication support systems.

• 한국병원경영학회지
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• 제27권2호
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• pp.34-43
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• 2022

Objective: Telemedicine service is gaining importance in remote military areas. This study aimed to explore the mediating effect of user satisfaction on the association between military telemedicine service's quality and customer loyalty. Methods: The research data comprised the results of a satisfaction survey on 1,116 military telemedicine satisfaction surveys conducted from November 1 to November 31, 2021. T-tests and ANOVA were analyzed to confirm the difference in satisfaction and loyalty according to the general characteristics of the study subjects. User satisfaction, customer loyalty, and mediating effects were analyzed using multiple linear regression analysis. Results: Among the study subjects, 458 were affiliated with the Army, 68 with the Navy, and 36 with the Air Force. Among the quality of telemedicine service, tangibility, reliability, and empathy affected user satisfaction while reliability and empathy affected customer loyalty. Since the standardized coefficient beta of empathy was 0.150 (P=0.018), it was confirmed that it significantly affected customer loyalty by mediating user satisfaction. Conclusion: The telemedicine service's quality affects users' satisfaction and customer loyalty. Moreover, there was the mediating effect of user satisfaction on the association between telemedicine service and customer loyalty. Therefore, the reliability and reliability of the current telemedicine service can be improved through the replacement of outdated equipment and performance improvement, expansion of medicines in telemedicine units, and improvement of medical services through periodic CS education to increase the customers' satisfaction and loyalty.

• BMB Reports
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• 제55권11호
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• pp.547-552
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• 2022

Sorafenib, originally identified as an inhibitor of multiple oncogenic kinases, induces ferroptosis in hepatocellular carcinoma (HCC) cells. Several pathways that mitigate sorafenib-induced ferroptosis confer drug resistance; thus strategies that enhance ferroptosis increase sorafenib efficacy. Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is upregulated in human HCC tissues and plays a role in cancer cell proliferation. The aim of this study was to determine whether inhibition of ERRγ with DN200434, an orally available inverse agonist, can overcome resistance to sorafenib through induction of ferroptosis. Sorafenib-resistant HCC cells were less sensitive to sorafenibinduced ferroptosis and showed significantly higher ERRγ levels than sorafenib-sensitive HCC cells. DN200434 induced lipid peroxidation and ferroptosis in sorafenib-resistant HCC cells. Mechanistically, DN200434 increased mitochondrial ROS generation by reducing glutathione/glutathione disulfide levels, which subsequently reduced mTOR activity and GPX4 levels. DN200434 induced amplification of the antitumor effects of sorafenib was confirmed in a tumor xenograft model. The present results indicate that DN200434 may be a novel therapeutic strategy to re-sensitize HCC cells to sorafenib.

• 대한예방한의학회지
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• 제26권2호
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• pp.1-9
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• 2022

Objectives : The purpose of this study is to identify priorities for the 4th Comprehensive Plan for Korean Medicine Development using Delphi and AHP techniques. Methods : This study uses Delphi-AHP method to first, select the target priority policy based on the policy content of the 4th Comprehensive Plan. In addition, two surveys on the priorities were conducted to reach consensus between experts. The main results of the first survey were also provided to experts participating in the second survey to help form expert consensus. Finally, the final policy priority was chosen based on the second survey result. Results : Survey results showed that of the 39 policies in the 4th Comprehensive Plan, "improve the accessibility of Korean medicines," was the most important goal. This was followed by "support for Korean medicine R&D from clinical research to industrialization," "provide foundation for a pilot project that provides customized medical services" and "strengthen the public medicine function of Korean medicine by expanding the its infrastructure in national and public hospitals." Conclusion : The results showed that capacity building of Korean medicine in primary care, improvement of the health insurance system, and research centered on industrialization are relatively more important goals, while the need to enhance global competitiveness was much less important. These key points can serve as a reference when formulating the 5th Comprehensive Plan for Korean Medicine Development in the future.

• Advances in environmental research
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• 제11권1호
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• pp.31-38
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• 2022

The current observational epidemiological study analyzed blood lead levels (BLLs) in occupationally exposed workers from Riyadh region, Saudi Arabia and correlated them with the alterations in the differential cell populations of the WBC panel (lymphocytes [Lym %], mixed [Mid %] cells, and neutrophils [Neu %]). In addition, we examined the effect of confounding factors and their relation to BLLs. BLLs were estimated using the LeadCare II analyzer and hematological parameters using the ADVIA 120 analyser. An inferential analysis was conducted to detect association between the observations and the subjects' clinical characateristics. A total of 132 male subjects were included in the final analyses. Based on CDC guidelines, the subjects were categorized as Group I (BLL <10 ㎍/dL; n=118) or Group II (BLL >10 ㎍/dL; n=14) with average BLLs of 4.4 ㎍/dL and 18.1 ㎍/dL, respectively (p <0.0001). The percentages of Mid cells (p <0.0001) and neutrophils (p=0.048), were significantly altered in subjects with High BLL. A regression analysis indicated that subjects > 50 years of age had significantly higher BLLs (53.2 ㎍/dL) than younger age sub-groups (p <0.0001). Age, education, and profession were significant predictors for lead toxicity. Pb exposure is a major public health issue in Saudi Arabia and calls for further investigations on the cellular and molecular effects on hematological system.

• 한국전자통신학회논문지
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• 제18권2호
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• pp.361-366
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• 2023

빅데이터의 분산 처리를 수행하기 위한 대표적인 프레임워크인 하둡은 클러스터 규모를 수천 개 이상의 노드까지 증가시켜서 병렬분산 처리 성능을 높일 수 있는 장점이 있다. 하지만 클러스터의 규모를 줄이는 것은 결함이 있거나 성능이 저하된 노드들을 영구적으로 퇴역시키는 수준에서 제한되어 있음에 따라 소규모 클러스터에서 여러 노드들을 유연하게 운용하기에는 한계가 있다. 본 논문에서는 하둡 클러스터에서 노드를 제거할 때 발생하는 문제점을 논의하고 분산 클러스터의 규모를 탄력적으로 관리하기 위한 동적 다운 스케일링 기법을 제안한다. 일시적 다운스케일을 목적으로 노드를 제거할 때 완전히 퇴역시키는 것이 아니라 일시적으로 해제하고 필요시 다시 연결할 수 있도록 함으로써 동적 다운 스케일링을 지원할 수 있도록 시스템과 인터페이스를 설계하고 구현하였다. 실험 결과 성능저하 없이 효과적으로 다운 스케일링을 수행하는 것을 검증하였다.

• 산업융합연구
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• 제21권3호
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• pp.117-127
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• 2023

본 연구는 코로나-19 범유행시 임산부의 생생한 경험을 현상학적 접근을 통해 탐구함으로 임산부의 스트레스 경험을 이해하기 위한 질적연구이다. 연구대상자는 COVID-19 범유행 기간 동안 임신한 임산부 12명을 대상자로 선정하여 심층면담하였다. 참여자의 인터뷰는 2022년 6월부터 10월까지 진행하였으며, Colaizzi (1978) 분석 방법을 사용하여 Taguette 프로그램을 통해 데이터를 분석하였다. 분석된 결과로는 경험의 범주가 4개의 주제와 12개의 하위 주제로 도출되었다. 주요 주제는 부정확한 정보로 인한 혼란, 무너진 산전관리, 통제된 삶으로 인한 스트레스, 적응해가는 몸과 마음으로 나타났다. 임산부의 건강을 위한 사회적 지원과 안정적인 의료시스템 구축이 전반적으로 이루어져야 할 필요가 있음이 확인되었다. 이를 뒷받침하기 위해서는 후속 연구들이 더 필요하다.

• Journal of Veterinary Science
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• 제25권1호
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• pp.13.1-13.9
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• 2024

Background: Foot-and-mouth disease (FMD) is a highly contagious viral disease in livestock that has tremendous economic impact nationally. After multiple FMD outbreaks, the South Korean government implemented a vaccination policy for efficient disease control. However, during active surveillance by quarantine authorities, pig farms have reported an insufficient antibody positivity rate to FMD. Objective: In this study, the spatial and temporal trends of insufficiency among pig farms were analyzed, and the effect of the number of government veterinary officers was explored as a potential preventive factor. Methods: Various data were acquired, including national-level surveillance data for antibody insufficiency from the Korea Animal Health Integrated System, the number of veterinary officers, and the number of local pig farms. Temporal and geographical descriptive analyses were conducted to overview spatial and temporal trends. Additionally, logistic regression models were employed to investigate the association between the number of officers per pig farm with antibody insufficiency. Spatial cluster analysis was conducted to detect spatial clusters. Results: The results showed that the incidence of insufficiency tended to decrease in recent years (odds ratio [OR], 0.803; 95% confidence interval [95% CIs], 0.721-0.893), and regions with a higher density of governmental veterinary officers (OR, 0.942; 95% CIs, 0.918-0.965) were associated with a lower incidence. Conclusions: This study implies that previously conducted national interventions would be effective, and the quality of government-provided veterinary care could play an important role in addressing the insufficient positivity rate of antibodies.

• 한국전자통신학회논문지
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• 제19권1호
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• pp.295-300
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• 2024

본 논문에서는 SNOMED CT 용어체계가 가지는 불완전성을 논의하고 이를 유지하는 방법으로 형제 노드 간 유사성을 평가하는 지표를 제안한다. SNOMED CT는 방대한 양의 의학용어를 포함하고 있으나 계층구조 내 컨셉의 누락 등 온톨로지의 불완전성 문제가 존재한다. 누락된 컨셉 발견을 위해 다수의 노드로 구성된 형제 노드 그룹 내에서의 노드 간 유사도 평가를 위한 지표를 제안하고 유사도가 낮은 그룹을 도출하였다. 2023년 3월 SNOMED CT 국제 배포판에 적용하여 형제 노드 그룹들의 유사도를 분석한 결과 임상적 발견 컨셉의 하위 컨셉들 중 2개 이상의 형제 노드를 가진 29,199개의 형제 노드 그룹의 평균 유사도는 0.81로 나타났다. 반면, 유사도가 가장 낮은 그룹은 중독 컨셉의 자식 컨셉으로 그 유사도는 0.0036으로 확인되었다.

• 치위생과학회지
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• 제3권1호
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• pp.33-38
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• 2003

이 연구는 면역계에 부정적인 영향을 미치는 질환들과 교정치료에 수반되는 치근흡수와의 관련성을 해명하기 위하여 시행되었다. 51명 교정환자(남자 25명, 여자 26명, 평균연령 $16.1{\pm}3.3$)의 기록과 이에 상응하는 51명 대조군(평균연령 $15.4{\pm}4.1$의 진료기록을 후향 검토하였다. 치료전 문진과 치료과정기록 분석 결과 천식과 앨러지 및 높은 심리적 스트레스를 가진 환자에서 치근흡수가 빈발하는 것으로 나타났다. 이전의 연구에서 천식이나 앨러지 및 고도의 심리적 스트레스는 면역체계의 변화 혹은 부정적 영향을 미침을 기술하고 있다. 파골세포와 파치세포의 전구 인자는 면역계의 주도니 세포군인 단핵구와 대식구 계열의 단핵세포로부터 유래되기 때문에, 이 연구 결과는 고도의 심리적 스트레스 상태에 있거나 천식과 앨러지를 가진 경우 또는 면역체계에 부정적 영향을 미칠 수 있는 전신 질환자에서 교정치료와 관련된 치근 흡수의 가능성이 높음을 시사한다.