• 한국가스학회지
• /
• 제26권5호
• /
• pp.41-48
• /
• 2022

2-Chloro-N-(Cyano-2-thienyl methyl) acetamide(CCTA)는 농약을 합성하는데 사용하는 중간체로써 상온 및 상압에서는 안정하지만 열축적 시 분해될 수 있다. 본 연구에서는 열중량분석기(TGA) 실험을 통해 온도에 따른 질량 변화 측정으로 분해거동을 확인하고, 시차주사열량계(DSC)를 이용하여 열분해특성을 평가하였다. CCTA는 약 91℃에서 발열 분해반응이 급격하게 발생하였으며, Kissinger method, Kissinger-Akahira- Sunose(KAS) method, Flynn-Wall-Ozawa(FWO) method를 이용한 활성화 에너지 계산 결과, 각각 162 kJ/mol, 140 kJ/mol, 139 kJ/mol 으로 나타났다. 활성화에너지를 이용하여 계산된 24시간 이내 최대발열속도에 도달하는 온도인 T_D24는 52~55 ℃로 평가되었다.

• The Journal of Korean Physical Therapy
• /
• 제35권1호
• /
• pp.13-18
• /
• 2023

Purpose: The purpose of this study was to investigate the effects of posterior oblique sling activation on the muscle activities of the gluteus maximus (GM), multifidus (MF), and biceps femoris (BF) during three different prone hip extension exercises in healthy male individuals. Methods: Twenty healthy subjects participated in this study. An electromyography device was used to measure the muscle activities of the GM, MF, and BF. Each subject was asked to perform three different prone hip extensions as follows: [1) Prone hip extension with knee flexion + hip abduction 30°; PHE1, 2) Prone hip extension with knee flexion + hip abduction 30° and shoulder abduction 125°; PHE2, 3) Prone hip extension with knee flexion + hip abduction 30° and shoulder abduction 125° with 1kg loading; PHE3, in random order. A one-way repeated measures analysis of the variance and a Bonferroni post hoc test were used to analyze the results. The statistical significance was set at α=0.01. Results: The muscle activity of the GM was significantly different between the three positions (P_adj<0.01). The muscle activity of the GM was significantly greater during PHE3 compared with PHE1 and PHE2 (P_adj<0.01). The BF muscle activity was significantly lower during PHE3 compared with PHE1 and PHE2 (P_adj< 0.01). There was no significant difference in the muscle activity of the MF (P_adj<0.01). The ratio of the muscle activity (ratio=GM/BF) during PHE3 was significantly greater compared to PHE1 and PHE2 (P_adj< 0.01). Conclusion: The GM activity and GM/BF ratio during the PHE3 exercise were significantly greater compared to that during PHE1 and PHE2. Therefore, the PHE3 exercise could be recommended as a selectively effective GM activation exercise while decreasing the muscle activity of the BF.

• Journal of Microbiology and Biotechnology
• /
• 제18권11호
• /
• pp.1755-1761
• /
• 2008

The present study revealed that Lrp, a leucine-responsive regulatory protein, is involved in the regulation of cadBA transcription through activation of $P_{cadBA}$. The influence of Lrp on $P_{cadBA}$ was mediated by CadC, and thereby, CadC was able to compensate for the lack of Lrp in the activation of $P_{cadBA}$. Western blot analyses and EMSA demonstrated that the cellular level of CadC was not significantly affected by Lrp, and that Lrp exerted its effect by directly binding to $P_{cadBA}$. These combined results suggested that CadC and Lrp function cooperatively to activate the $P_{cadBA}$ rather than sequentially in a regulatory cascade.

• Archives of Pharmacal Research
• /
• 제22권6호
• /
• pp.533-541
• /
• 1999

Many conventional anticancer drugs display relatively poor selectivity for neoplastic cells, in particular for solid tumors. Furthermore, expression or development of drug resistance, increased glutathione transferases as well as enhanced DNA repair decrease the efficacy of these drugs. Research efforts continue to overcome these problems by understanding these mechanisms and by developing more effective anticancer drugs. Cyclophosphamide is one of the most widely used alkylating anticancer agents. Because of its unique activation mechanism, numerous bioreversible prodrugs of phosphramide mustard, the active species of cyclophosphamide, have been investigated in an attempt to improve the therapeutic index. Solid tumors are particularly resistant to radiation and chemotherapy. There has been considerable interest in designing drugs selective for hypoxic environments prevalent in solid tumors. Much of the work had been centered on nitroheterocyclics that utilize nitroreductase enzyme systems for their activation. In this article, recent developments of anticancer prodrug design are described with a particular emphasis on exploitation of selective metabolic processes for their activation.

• 대한임상검사과학회지
• /
• 제42권1호
• /
• pp.46-54
• /
• 2010

Ceramide induces cell death in a variety of cell types however, the underlying molecular mechanisms related to renal epithelial cells remain unclear. The present study was undertaken to determine the role of extracellular signal-regulated protein kinase (ERK) in ceramide-induced cell death in renal epithelial cells. An established renal proximal tubular cell line of opossum kidney (OK) cells was used for this research. Ceramide induced apoptotic cell death in these cells. Western blot analysis showed that ceramide induced activation of ERK. The ERK activation and cell death induced by ceramide were prevented by the ERK inhibitor PD98059. Ceramide caused cytochrome C release from mitochondria into the cytosol as well as activation of caspase-3. Both effects were prevented by PD98059. The ceramide-induced cell death was also prevented by a caspase inhibitor. These results suggest that ceramide induces cell death through an ERK-dependent mitochondrial apoptotic pathway in OK cells.

• 한국주거학회:학술대회논문집
• /
• 한국주거학회 2005년도 추계학술대회 논문집
• /
• pp.379-382
• /
• 2005

The modern has been the aged society. It is also the result of the improvement of the whole living conditions such as the improvement of medical health and national income level. But, as nuclear family has been extended according to industrialization and urbanization, the consciousness of supporting the aged has been weakened. And the problems of old people such as poverty, disease and alienation has been raised. This study propose the three activation methods for paid elderly welfare house which will be another measures for solving the aged problems

• PNF and Movement
• /
• 제20권2호
• /
• pp.235-241
• /
• 2022

Purpose: The purpose of this study was to identify the effects of low intensity blood flow restriction training (LBFR) on the central nervous system of healthy adults. Methods: Ten healthy right-handed adults (eight males and two females, mean age of 28.6 ± 2.87 years) were selected as study subjects. Functional magnetic resonance imaging (fMRI) was conducted to measure brain activation (BA) following LBFR and non-LBFR. The primary motor area, premotor area, and supplementary motor area, which are closely related to exercise, were set as the regions of interest. Results: The BA recorded during the LBFR condition was 931.7 ± 302.44 voxel, and the BA recorded during the non-LBFR condition was 1,510.9 ± 353.47 voxel. Conclusion: BA was lower during LBFR than during non-LBFR.

• BMB Reports
• /
• 제48권3호
• /
• pp.166-171
• /
• 2015

We previously demonstrated that resveratrol and clofarabine elicited a marked cytotoxicity on malignant mesothelioma (MM) MSTO-211H cells but not on the corresponding normal mesothelial MeT-5A cells. Little is known of the possible molecules that could be used to predict preferential chemosensitivity on MSTO-211H cells. Resveratrol and clofarabine induced downregulation of Mcl-1 protein level in MSTO-211H cells. Treatment of cells with cycloheximide in the presence of proteasome inhibitor MG132 suggested that Mcl-1 protein levels were regulated at the post-translational step. The siRNA-based knockdown of Mcl-1 in MSTO-211H cells triggered more growth-inhibiting and apoptosis-inducing effects with the resultant cleavages of procaspase-3 and its substrate PARP, increased caspase-3/7 activity, and increased percentage of apoptotic propensities. However, the majority of the observed changes were not shown in MeT-5A cells. Collectively, these studies indicate that the preferential activation of caspase cascade in malignant cells might have important applications as a therapeutic target for MM.

• 한국환경보건학회지
• /
• 제28권3호
• /
• pp.64-71
• /
• 2002

Hair provides important information about the body's mineral status. Therefore, we have studied the trace elemental distribution in human hair under different inhalation and ingestion environment using neutron activation analysis (NAA). NAA is a powerful analytical method which can be used successfully to determine trace elements in environmental and biological materials. Total diet and six different herbal medicine were analysed to study ingestion environment. Airborne dust in foundry was analysed and compared with outdoor dust to study inhalation environment. Human hairs of common person, herbal medicine taker and foundry worker were analysed to estimate the trace elemental distribution of people under different inhalation and ingestion environment. Analytical results show that herbal medicines contain higher micronutrients such as Ca, Mg, Mn and Cu that total diet and airborne dust in foundry has high Cr. The concentration of Ca, Mg and Mn in hair of herbal medicine taker is two times higher than in hair of common person and Cr con-centration in hair of foundry worker is about three times higher than in hair of common person. These results show that NAA can be used importantly to monitor human health through biological and environmental samples.

• The Journal of Korean Physical Therapy
• /
• 제34권1호
• /
• pp.6-11
• /
• 2022

Purpose: This study investigated the muscle activity of the lower trapezius (LT) during three different shoulder flexion exercises. Methods: Twenty-three subjects between 20 and 25 years of age were enrolled. The subjects were asked to perform three different shoulder flexion exercises: 1) shoulder flexion in prone (SFP), 2) shoulder flexion in push-up with a swiss ball (SFPUS) and 3) shoulder flexion in a quadruped position with a swiss ball (SFQPS) in random order. The muscle activity of LT during each shoulder flexion exercise was measured by using surface electromyography. The muscle activity of LT was compared using one-way analysis of variance (ANOVA) and Bonferroni post hoc test among three different shoulder flexion exercises. The statistical significance level was set at α=0.01. Results: The muscle activity of LT was significantly different among three different shoulder flexion exercises (SFP, SFPUS, and SFQPS). The LT muscle activity with SFQPS exercise was greater than SFP and SFPUS exercises (p<0.01). There was no significant difference in LT muscle activity between SFP and SFPUS exercises (p>0.01). Conclusion: The LT muscle activity was greater during SFQPS than SFP and SFPUS. Therefore, SFQPS exercise can be recommended for selectively activation of LT muscle.