• Title/Summary/Keyword: health abnormality

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Report on Two Cases of Gilbert's Syndrome Found in the Process of Administering Herbs (단미 한약 복용중 발견한 Gilbert's syndrome 2예 임상고찰)

  • Lee, Jong Deok;Kim, Dong Woung
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.28 no.6
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    • pp.657-661
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    • 2014
  • Gilbert's syndrome is one that shows a benign course with intermittent unconjugate hyperbilirubinemia without any evidence of hepatobiliary tract disease or hemolysis. It is often found in a health examination or blood laboratory test by chance. In particular, patients who are taking drugs, including herbal medicine should be careful for their medication due to the possibility of associations with changes in liver function because of drug metabolism, sometimes they have to quit the use of the medication for a certain period and often they should get an additional test. Two male patients increased serum total bilirubin level without other systemic symptoms in screening test for clinical herb medicine pharmacokinetics study. Therefor they was diagnosed with suspected Gilbert's syndrome. They had been calory deprivation test with 24 hours fasting state. They also performed liver function test and ultrasonogram for evaluation of hepatobiliary tract disease. Total serum bilirubin was markedly increased, especially unconjugate bilirubin level higher over the two times than base line after they had been calory deprivation for 24 hours, They was not found another abnormality all laboratory results and physical examination. This study is a report on two cases of hyperbilirubinemia, diagnosed as Gilbert's syndrome, which were found in the process of a clinical pharmacokinetic study of a decoction of medicinal herbs.

Androgen in the Uterus: A Compensator of Estrogen and Progesterone

  • Cheon, Yong-Pil;Lee, Dong-Mok;Chun, Tea-Hoon;Lee, Ki-Ho;Choi, In-Ho
    • Development and Reproduction
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    • v.13 no.3
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    • pp.133-143
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    • 2009
  • Pivotal roles of steroid hormones in uterine endometrial function are well established from the mouse models carrying the null mutation of their receptors. Literally androgen belongs to male but interestingly it also detected in female. The fluctuations of androgen levels are observed during reproductive cycle and pregnancy, and the functional androgen receptor is expressed in reproductive organs including uterus. Using high throughput methodology, the downstream genes of androgen have been isolated and revealed correlations between other steroid hormones. In androgen-deficient mice, uterine responses to exogenous gonadotropins are impaired and the number of pups per litter is reduced dramatically. As expected androgen has important role in decidual differentiation through AR. It regulates specific gene network during those cellular responses. Recently we examined the effects of steroid hormonal complex containing high level of androgen. Interestingly, on the contrary to the androgen-alone administration, the hormonal complex did not disturb the decidual reaction and the pubs did not show any morphological abnormality. It is suspected that the complexity of communication between other steroid hormone and their receptors are the reasons. In summary, androgen exists in female blood and it suggests the importance of androgen in female reproduction. However, the complex interactions with other hormones are not fully understood compared with estrogen and progesterone. The further studies to evaluate the possible role of androgen are needed and important to provide the in vivo rational for the prevention of associated pregnancy complications and help human's health.

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A Study on Oriental Medical Factors of Teenagers' Menstrual Disorders Based on DSOM (한방진단시스템(DSOM)을 이용한 청소년 월경통, 월경량 이상의 한의학적 인자(因子) 연구)

  • Yim, Sun-Hee;Cho, Hye-Sook;Lee, In-Seon;Kim, Kyu-Kon
    • The Journal of Korean Obstetrics and Gynecology
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    • v.23 no.3
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    • pp.156-172
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    • 2010
  • Purpose: In Oriental medicine, menstruation is a significant index of women's health. Especially high school girls often have various menstrual problems. We think that students who have menstrual problem have some symptoms in relation to an etiological cause. So we had carried out this study to investigate association of DSOM scores and an abnormality of menstruation in oriental medicine. Methods: First we have 2137 high school girls answer to menstrual questionnaire that we made and DSOM, next investigated the pathogenic factor of DSOM which effect dysmenorrhea and menorrhagia using regression model. Logistic regression analysis indicate as follows. Results: 1. In comparison with dysmenorrhea, Qi depression(氣滯), blood stasis(血瘀), dampness (濕), phlegm(痰) is associated positively and liver(肝) negatively. The sensitivity is 64.3%, and the specificity is 75.1%. 2. In comparison with menorrhagia, Blood deficiency(血虛), Qi depression(氣滯), blood stasis(血瘀) is associated positively and liver(肝) negatively. The sensitivity is 53.9%, and the specificity is 76.1%. Conclusion: In this study, that has been carried out to organize the diagnosis of dysmenorrhea and menorrhagia in Oriental medicine, we can see that the disease factors of them were correlated with our Medical theory.

Effects of Polycyclic Aromatic Hydrocarbons (PAHs) on Early Development of Sea Urchin Anthocidaris crassispina (Polycyclic aromatic hydrocarbons (PAHs)가 보라성게 (Anthocidaris crassispina)의 초기발생에 미치는 영향)

  • Na Oh-Soo;Moon Sang-Hee;Lee Chi-Hoon;Park Chang-Beom;Kim Byung-Ho;Jin Young-Seok;Hur Sang-Woo;Kam Sang-Kyu;Lee Young-Don
    • Environmental Analysis Health and Toxicology
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    • v.20 no.1
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    • pp.57-65
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    • 2005
  • Effects of five polycyclic aromatic hydrocarbon (PAHs) constituents (naphthalene, fluorine, fluoranthene, benzo(a)pyrene, pyrene) on fertilization and early development of sea urchin egg, sperm and fertilized egg were investigated. The eggs, sperm and fertilized eggs were exposed to several concentrations of PAHs (1, 10, 100, 1000 and 10000㎍/L). The rate of fertilization and hatching decreased when the eggs and sperm were exposed to aqueous solution of PAHs. Also, Exposure of fertilized eggs with each PAHs did decrease survival and hatching rate. Concentration-dependent toxic effects on the rate of fertilization, hatching, survival and abnormality in A. crassispina were observed following exposure to PAHs (1, 10, 100, 1000 and 10000㎍/L). These data show that PAHs exposure decreased in fertilization success of sea urchin egg and sperm and producted abnormal embryo. It is plausible to suggest that PAHs had the potential to significantly reduce coastal recruitment of sea urchin.

Periodontal treatment of a Glanzmann's thrombasthenia patient : A case report (Glanzmann씨 혈소판무력증(Glanzmann's Thrombasthenia) 환자의 치주 치료 증례)

  • Lee, Hak-Churl;Han, Soo-Boo;Kim, Woo-Sung;Lee, Hye-Ja
    • Journal of Periodontal and Implant Science
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    • v.27 no.3
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    • pp.597-602
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    • 1997
  • Glanzmann's thrombasthenia is a Qualitative platelet disorder characterized by a deficiency in the platelet membrane glycoproteins IIb/IIIa. It belongs to a group of hereditary platelet disorders typified by normal platelet numbers and a prolonged bleeding time. The severity of bleeding does not correlate with the severity of the platelet glycoprotein IIb/IIIa a abnormality. The present case report describes the periodontal treatment of a patient with Glanzmann's thrombasthenia. A 30-year-old female with a history of Glanzmann's thrombasthenia was referred for gingival bleeding on tooth brushing and discomforts in #38 area. The periodontal finding revealed a diagnosis of localized slight adult periodontitis. Root planing and extraction of #38 was performed under 12 pack of platelets transfusion and digital compression was done for hemostasis. The gingival bleeding ceased within a day in maxilla and 2 days later in mandible. 42 pack of platelets was administered for 3 days of post-treatment and for iron-deficiency anemia 3 pack of RBCs was transfused 2 days later. 1 week later the inflammation in gingiva disappeared and gingival stippling appeared. The clinical result we got was good and in such a medically compromised patient it is an ability to maintain a proper oral hygiene that is essential both for oral and systemic health.

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Characterization of Plasma Carnitine Level in Obese Adolescent Korean Women

  • Yoo, Hye-Hyun;Yoon, Ho-Joo;Shin, Hye-Jung;Lee, Sang-Hyup;Yoon, Hye-Ran
    • Biomolecules & Therapeutics
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    • v.17 no.2
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    • pp.181-187
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    • 2009
  • Carnitine is known to be involved in lipid metabolism and affects body composition as well as energy metabolism of the whole body. Improvement of obesity by L-carnitine supplement suggests that obesity can be related with the abnormality of carnitine metabolism and therefore, plasma carnitine level in normal and obesity groups was investigated. For the characterization of plasma carnitine level in obese people, 60 plasma samples collected from Korean women subjects were analyzed using LC/MS and plasma fatty acid level was also determined using GC/MS. Additionally, several clinical chemical parameters including fasting glucose, cholesterol, AST, and ALT level were measured. All the data obtained were combined and pattern recognition analysis was carried out with the dataset. Obese group showed a different metabolic pattern compared with normal group. Plasma acylcarnitine level of the obese group was found to be $11.7{\mu}g/ml$, which was higher than that of normal group ($8.0{\mu}g/ml$). Statistically significant differences in plasma fatty acid level were not observed between the two groups. Other clinical parameters for the obese group were within normal ranges but AST and ALT levels were slightly elevated compared to normal group. The obese group showed elevated plasma acylcarnitine level.

Effect of Exogenous Insulin on The Metabolism of Normal Rat (인슐린 투여가 정상쥐의 대사에 미치는 영향)

  • 주진순
    • Journal of Nutrition and Health
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    • v.22 no.4
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    • pp.237-246
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    • 1989
  • The objective of this study was to determine the metabolic effect of exogenous insulin on Sprague-Dawley rats. In a short-term study, the rats were injected insulin and sacrificed at 0.50, 1, 1.5, 2, 4 and 6hr, respectively. Another group of the rats were injected long-acting insulin everyday and sacrificed at 0, 10, 20 and 30days, respectively. Levels of hemoglobin, hematocrit, plasma glucose, plasma protein, plasma albmin, plasma lipids, cholesterol were determined for each experimental group. Also microscopic observation of fat infiltration of liver and aorta performed. No significant abnormality was abserved either at the short-term or at the long-term insulin injection on normal rats.

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Evaluation of functional wireless sensor node based Ad-hoc network for indoor healthcare monitoring (실내 건강모니터링을 위한 Ad-hoc기반의 기능성 무선센서노드 평가)

  • Lee, Dae-Seok;Do, Kyeong-Hoon;Lee, Hun-Jae
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2009.05a
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    • pp.313-316
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    • 2009
  • A novel approach for electrocardiogram (ECG) analysis within a functional sensor node has been developed and evaluated. The main aim is to reduce data collision, traffic over loads and power consumption in healthcare applications of wireless sensor networks (WSN). The sensor node attached on the patient's bodysurface around the heart can perform ECG analysis based on a QRS detection algorithm to detect abnormal condition of the patient. Data transfer is activated only after detected abnormality in the ECG. This system can reduce packet loss during transmission by reducing traffic overload. In addition, it saves power supply energy leading to more reliable, cheap and user-friendly operation in the WSN based ubiquitous health monitoring.

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Decentralized Structural Diagnosis and Monitoring System for Ensemble Learning on Dynamic Characteristics (동특성 앙상블 학습 기반 구조물 진단 모니터링 분산처리 시스템)

  • Shin, Yoon-Soo;Min, Kyung-Won
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.34 no.4
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    • pp.183-189
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    • 2021
  • In recent years, active research has been devoted toward developing a monitoring system using ambient vibration data in order to quantitatively determine the deterioration occurring in a structure over a long period of time. This study developed a low-cost edge computing system that detects the abnormalities in structures by utilizing the dynamic characteristics acquired from the structure over the long term for ensemble learning. The system hardware consists of the Raspberry Pi, an accelerometer, an inclinometer, a GPS RTK module, and a LoRa communication module. The structural abnormality detection afforded by the ensemble learning using dynamic characteristics is verified using a laboratory-scale structure model vibration experiment. A real-time distributed processing algorithm with dynamic feature extraction based on the experiment is installed on the Raspberry Pi. Based on the stable operation of installed systems at the Community Service Center, Pohang-si, Korea, the validity of the developed system was verified on-site.

A Study On the Operating Room Nurses' Performances of Duties and Their Fatigue (수술실간호사의 직무수행과 피로에 관한 연구)

  • Park, Jeong Sook
    • Korean Journal of Occupational Health Nursing
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    • v.6 no.2
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    • pp.110-127
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    • 1997
  • The aim of this study is to present the basic datum for the promotion of effectiveness and improvement of nursery tasks, by grasping the situation of operating room nurses tasks and the degree of their fatigue. For these researches, 70 nurses out of the operating rooms of 3 university-affiliated hospitals-two in Seoul and one in Pusan, were chosen at random by a non-probability sampling method. These researches were done from April 14 to April 26 in 1997 by questionairing method. The questionaire was composed of 30 items, which asks the examinees of their physical, mental, and neurosensory symptoms, with 10 items respectively. The reliability of the research instrument was turned out very high with Cronbach's ${\alpha}=.9376$. The datum were electronically processed using Statistics Program for Social Sciences(SPSS). The analysis of datum in this study has a general character, in which the demosociological character and the special ex-officio character was calculated by frequency and percentage. The situation of tasks in operating rooms was calculated by frequency and percentage. The fatigue of operating room nurses was calculated by average and standard deviation. To compare the fatigue with regard to the character of operating room nurse's tasks, t-test and F-test(ANOVA) were used after the character of variations, and the variations at the level of P<.05 which might have some meaning was verified after the fact with Duncan's Multiple Range(DMR). The results of this research are as follows : 1) The nurses working in operating rooms show their fatigue in three fields-in Group I physical symptoms 3.28, in Group III neurosensory symptoms 2.85, and in Group II mental symptoms 2.73, which shows I Dominant type (general type). 2) They complain, in Group I they are "feeling the heavy legs," 3.28 and in Group II they "occasionally forget soon what to do," 3.09. and in Group III, they "feel lumbago," 3.47, which is the highest rate of the three. The highest rate results from the character of their tasks, in which they have to move rapidly the heavy appliances and do their jobs standing many hours, especially wearing heavy radiation protector. 3) As to transportation, subway using group feel the greatest fatigue, 3.18(F=4.315, P=.008). 4) As to department, nurses in the orthopedic's surgery part feel the greatest fatigue, 3.26(F=2.040, P=.050). 5) As to the change of physical symptoms, the group answering that they found physical abnormality after working in operating rooms show the greatest fatigue, 3.12(t=-3.13, P=.003). 6) At to the general circumstances, the group answering that they receive insufficient consideration on their physical abnormality in their department, show the greatest fatigue, 3.10(F=3.200, P=0.47). 7) As to the relation with superior officers, the group answering that their superior officer has an impetuous temperament, show great fatigue, 3.11(F=4.855, P=.011). 8) As to the time of feeling fatigue, the fatigue reaches the highest point 1~2 hours after operations, 3.04(F=2.703, P=.046). 9) When they feel fatigue after scrub nurse duties, they feel the greatest fatigue 2 hours after the duties, 3.09( F=2.841, P=.038). 10) As to the operation instruments, when they use complex instruments borrowing from the outside in addition to the basic instruments, their fatigue becomes the greatest, 3.09(F=7.831, P=.000). 11) As to the kind of operation, when they participate in orthopedic's surgery operations, they feel the greatest fatigue, 3.18(F=4.362, P=.000). With the above results, it is proved that the degree of operating room nurses' fatigue is considerably high. So it may be concluded that the measure for lessening the fatigue should be find immediately, not on the level of personal matters but on the level of hospital nursing administration.

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