• Biomolecules & Therapeutics
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• 제10권3호
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• pp.137-141
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• 2002

Taurine, amino acid, chemically known as 2-amino ethane sulphonic acid was discovered more than two hundred years ago from ox bile. it is widely distributed in both mammals and nonmammals. It is found in considerably high amount in hUl11an: a normal adult of 70 kgs contains about 70 grams of taurine. Taurine with this much concentration, is involved in almost all life processes. Its deficiency causes several abnormalities in major organs like brain, eye and heart. Taurine-bone interaction is latest addition to its long list of actions. In bone cells, taurine is also found in high concentration. Taurine is found to help in enhancing the bone tissue formation which is evidenced by increased matrix formation and collagen synthesis. Besides stimulating the bone tissue formation, it also inhibits the bone loss through inhibiting the bone resorption and osteoclast formation. Thus, taurine acts as a double agent. In addition to these two major actions of taurine in bone, it also has beneficial effect in wound healing mld bone repair. Taurine possess radioprotective properties, too. As it is a naturally available molecule, it can be used as a preventive agent. Taurine has a potential to replace bisphosphonates which are currently in use for the inhibition of bone loss but this needs in depth study. As taurine is involved in bone formation and inhibition of bone loss, a detailed study can make it a single marker of bone metabolism. All these taurine-bone interaction is a symbol of their deep involvement but still require further extension to make taurine as a choice for tile sound bone health.

• 한국건설순환자원학회논문집
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• 제4권4호
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• pp.463-469
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• 2016

본 연구에서는 팽창재-팽윤재-결정성장 촉진제로 구성된 자기치유 재료(SH-PO-0)와 칼슘이온 용출을 촉진하는 인산염계 혼화재(PO)를 첨가한 자기치유 재료(SH-PO-5, 15, 30)를 사용한 모르타르의 압축강도 및 투수성능을 평가하였다. SH-PO-0는 OPC 대비 28일 압축강도는 9% 감소하였지만, 투수량 감소비는 OPC 대비 현저히 낮아, 자기치유 재료의 유효성을 확인하였다. PO의 첨가량이 증가함에 따라 압축강도는 감소하고, 초기재령에서 투수성능은 개선되는 경향을 나타내었고, 적정 PO 치환율은 15% 수준이었다. SH-PO-15는 SH-PO-0 대비 28일 압축강도는 8% 이내에서 감소하였고, 초기 재령에서 투수성능이 더욱 개선되었으나, 장기재령까지 이어지지는 않았다. SEM-EDS분석에 의해 SH-PO-15의 칼슘 이온량이 더 많이 고정화되어 있음을 확인하였다.

• 동의생리병리학회지
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• 제25권5호
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• pp.887-893
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• 2011

The purpose of this study was to investigate the wound healing effects of Danggwieumja (DG), which is commonly used for skin inflammation, skin wound, skin pruritus, and chronic hives etc. The 1.5 cm ${\times}$ 1.5 cm full-thickness skin wound was induced to two groups, DG (n=16) and Saline (n=16) group. The DG extract and Saline were orally administrated daily for 15 days after skin wound induction. Then, the body weight of rats and the congestion indices were daily measured for 15 days after skin wound induction. The wound contractions and epithelizations were also measured. The wound contractions were daily measured for 15 days after wound induction and wound epithelizations were measured for 8 days from day 7 after wound induction. For evaluating angiogenesis, the immunoreactivities of vWF and VEGF protein were measured immunohistochemistrically on day 15. In results, although the percentage increases in mean body weight of rats in the DG and Saline groups hve no significant differences, DG extract decreased the time of wound healing and congestion around wound, and improved wound contraction and epithelization. The contraction percentage of DG group was significantly increased on day 5 (P<0.05) and day 7 (P<0.01) than that of Saline group. DG group showed significant increase of wound epithelization on day 7 (P<0.05) as compared to Saline group. Moreover, DG extract reduced the inflammation of skin dermis and promoted the growth of vascular vessels of dermis by accelerating vascular endothelial growth factor (VEGF) protein. These results suggest that DG has the beneficial effects on skin incision wound and can be the suitable wound healing agent for various surgical wounds.

• Archives of Plastic Surgery
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• 제35권2호
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• pp.121-126
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• 2008

Purpose: Poly-N-acetyl glucosamine(PGlcNAc) nanofiber-based materials, produced by a marine microalga, have been characterized as effective hemostatic and angiogenic agents. The similarity between PGlcNAc patch and the natural extracellular matrix allows it to support new healthy tissue growth in an injured area and to encourage fluid absorption. In this study, we hypothesized that a poly-N-acetyl glucosamine fiber patch(PGlcNAc patch) may enhance wound healing in the db/db mouse. Methods: PGlcNAc patches were applied on one square centimeter, full-thickness, skin wounds in the db/db mouse model. Wounds(n=15 per group) were dressed with a PGlcNAc nanofiber patch for 1 hour(1 h), 24 hours(24 h) or left untreated(NT). After the application time, patches were removed and wounds were allowed to heal spontaneously. The rate of wound closure was evaluated by digital analysis of unclosed wound area in course of time. At day 10, wounds(n=7 per group) were harvested and quantified with immunohistochemical markers of proliferation(Ki-67) and vascularization (platelet endothelial cell adhesion molecule, PECAM-1). Results: Wounds dressed with PGlcNAc patches for 1 hour closed faster than control wounds, reaching 90% closure in 16.6 days, nine days faster than untreated wounds. Granulation tissue showed higher levels of proliferation and vascularization following 1 h treatment than the 24 h and NT groups. In addition to its hemostatic properties, the PGlcNAc material also appears to accelerate wound closure in healing-impaired genetically diabetic mice. Conclusion: This material, with its combination of hemostatic and wound healing properties, has the potential to be effective agent for the treatment of complicated wounds.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 추계학술대회 논문집
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• pp.1668-1673
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• 2008

고분자 복합재 구조물의 경우 일반적으로 여러 층의 단층(laminar)이 적층된 구조로 이루어져 있으며, 모재균열, 층간분리 및 섬유파단과 같은 손상이 발생되어 파단에 이르게 된다. 자가손상 복구기법은 복합소재의 열경화성 수지 내에 손상복구액을 포함하고 있는 마이크로캡슐과 촉매를 투입하여 외부의 도움 없이 손상을 치료할 수 있는 방법으로, 소재의 디자인에 있어서 새로운 페러다임을 제공할 수 있는 것으로 현재 많은 연구가 진행되고 있다. 본 연구에서는 ENB(5-ethylidene-2-norbornene)와 DCPD(dicyclopentadiene)에 대하여 DMA(dynamic mechanical analysis)와 DSC(differential scanning calorimetry)를 이용하여 특성을 분석하였다. 또한 그들의 ROMP(ring-opening metathesis polymerization)반응과의 관계를 조사하였으며, ENB와 DCPD 블렌드에 대한 복구액으로서의 특성도 조사하였다. 본 연구실에서 합성된 두 가지 다른 종류의 ROMP 경화제에 대한 실제 자가손상복구에으로서의 적용상 특성도 연구하였다.

• Composites Research
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• 제17권4호
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• pp.40-46
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• 2004

본 연구에서는 single lap 전단시험을 통해 자가치료제와 촉매의 혼합비율 및 경화온도가 자가치료용 폴리머 복합재에 적용되는 자가치료제의 접착성능에 미치는 영향을 조사하였다. 자가치료세로는 DCPD (dicyclopentadiene), ENB(5-ethylidene-2-norbornene), DCPD와 ENB가 혼합된 경우를 고려하였으며 촉매로는 bis(riclohexylphosphine) benzyllidine rethenium (IV) dichloride Grubbs' catalyst를 사용하였다. 이때 DCPD에 대한 촉매의 혼합비율은 1.0wt%와 0.5wt%, ENB에 대한 촉매의 혼합비율은 0.lwt%, DCPD와 ENB의 혼합액에 대한 촉매의 혼합비율은 0.5wt%를 적용하였으며 경화온도는 $25^{\circ}C$, $60{\circ}C$, $80^{\circ}C$를 고려하였다. 연구결과에 따르면 DCPD의 경우 안정화된 접착강도를 얻기 위해서는 많은 양의 촉매와 긴 경화시간이 요구되었다 ENB의 경우는 DCPD의 경우에 비해 촉매의 혼합비율이 낮아도 빠른 경화반응을 얻을 수 있었지만 경화시간이 증가함에 따라 접착전단강도는 DCPD와는 달리 최대 값에 도달하였다가 점차 감소하면서 안정화되는 양상을 나타내었다. DCPD와 ENB의 혼합액 경우도 ENB와 유사한 경화거동을 나타내며 DCPD에 대한 ENB의 혼합비율이 높을 수록 경화반응이 빨라지는 양상을 얻을 수 있었다. 아울러 경화온도가 높을수록 집착전단강도는 증가되며 안정화된 평탄부에 도달하는 경화시간은 짧아짐을 알 수 있었다

• Archives of Plastic Surgery
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• 제41권5호
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• pp.466-471
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• 2014

Background Bleeding can be a problem in wound debridement. In search for an effective hemostatic agent, we experimented with a chitosan film combined with the recombinant human epidermal growth factor (rh-EGF), hypothesizing that it would achieve effective hemostasis and simultaneously enhance arterial healing. Methods Forty-eight Sprague-Dawley rats were used, and 96 puncture wounds were made. The wounds were divided into the following four groups: treated with sterile gauze, treated with gelatin sponge, treated with chitosan, and treated with chitosan combined with rh-EGF. Immediate hemostasis was evaluated, and arterial healing was observed histologically. Results Groups B, C, and D showed a significant rate of immediate hemostasis as compared to group A (P<0.05), but there were no significant differences among groups B, C, and D. Histologically, only group D showed good continuity of the vessel wall after 1 week. It was the only group to show smooth muscle cell nuclei of the vessel wall. Conclusions We observed that chitosan has an effective hemostatic potential and the mix of rh-EGF and chitosan does not interfere with chitosan's hemostatic capabilities. We also identified enhanced healing of vessel walls when rh-EGF was added to chitosan. Further research based on these positive findings is needed to evaluate the potential use of this combination on difficult wounds like chronic diabetic ulcerations.

• 한국임상수의학회지
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• 제23권1호
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• pp.55-60
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• 2006

Aucuba japonica has variable pharmacological effects such as hepatoprotective, choleretic, hemodynamic, antimicrobial, and anti-inflammatory activities. This study was performed to investigate the effects of Aucuba japonica extract on oral wound healing. Aucubin was extracted from Aucuba japonica, and injected on either side of buccal mucosa of male mice. Artificial full thickness wounds were made on the site with 1.5 mm biopsy punch under sterile technique. The specimens had taken on day 1, 3, and 5 with 4 mm biopsy punch. Light microscopic examination and quantitative histologic analysis were performed for reepithelization, inflammatory cell infiltration. Reepithelization of the aucubin (0.1%) group was earlier than the control group. And the number of inflammatory cells of the aucubin group was lesser than the control group. In view of the results so far achieved, the aucubin extracted from Aucuba japonica may be useful for oral wound healing and it can be applied as a topical agent on the oral wound. Further research should be performed on the mechanism of aucubin on oral wound healing and proper formulation for effective topical agents.

• 대한건축학회논문집:구조계
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• 제35권9호
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• pp.199-206
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• 2019

Experimental study on the durability characteristics to examine the feasibility of concrete with high water-tightness and self-healing performance to minimize maintenance of concrete for artificial ground is as follows. 1) When blending agent, swelling agents, and curing accelerator were added on the ternary system cement with blast-furnace slag fine particles and fly ash to give a self-healing property, higher blending strengths by 82% at design standard strength of 24MPa and by 74% at design strength of 30MPa, respectively could be obtained. 2) The permeability test for the specimens having high water-tightness and no shrinkage showed that the permeability was reduced at maximum of 98%. However, the permeability was decreased as the design strength was increased, showing the reduction rate of 87% at the design strength of 50MPa. 3) The depth of carbonation of blast-furnace slag and fly ash was increased in all the specimens compared with those of OPC only. However, as the material age was increased, carbonation penetration depth was decreased compared with the reference blend. 4) Compared with the reference blending using only OPC, the freeze-thaw resistance was higher in the case of blending with 40% of blast-furnace slag and 10% of fly ash at the design standard strength of 50MPa. In addition, the freeze-thaw resistance in general was superior in the design standard strength of 50MPa with the lower water-binder ratio (W/B) as compared with the design standard strength of 24MPa and 30MPa with the high water-binder ratios.

• 폴리머
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• 제39권1호
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• pp.56-63
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• 2015

본 연구의 목적은 다이이소시아네이트 화합물을 함유하는 마이크로캡슐을 제조하고 자기치유형 보호코팅재에 적용하여 공기 중 수분에 의한 자기치유 기능을 평가하는 것이다. 다이이소시아네이트 화합물의 공기 중 수분과의 반응 거동을 조사함으로써 치유 물질로서의 가능성을 확인하였다. 폴리우레탄을 캡슐막으로 하여 이소포론 다이이소시아네이트(isophorone diisocyanate, IPDI)의 마이크로캡슐화를 계면중합법에 의해 수행하였다. 마이크로캡슐의 생성여부는 FTIR 및 NMR으로 확인하였고, 마이크로캡슐의 직경 및 크기 분포, 표면 형상과 캡슐막의 두께는 광학현미경과 FE-SEM을 통하여 관찰하였다. 교반속도 및 다이올 구조 변화에 따른 마이크로캡슐의 특성 변화를 조사하였다. 자기치유형 보호코팅재를 제조하여 스크래치를 형성시킨 후 광학현미경으로 관찰한 결과, 스크래치 형성 직후 스크래치가 지나가는 자리에 위치하는 마이크로캡슐이 깨지면서 심물질이 흘러나와 스크래치를 메워주는 것을 확인하였다. 또한 CRC 보드에 마이크로캡슐을 함유한 자기치유 코팅재를 제조하여 스크래치 형성 후 상대습도 68~89%의 공기 중에 48시간 동안 방치한 후 SEM 분석 및 내투수 테스트를 진행한 결과, 스크래치가 자기치유된 것이 확인되었다.