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Effects of Aucuba japonica Extract on Oral Wound Healing  

Shim Kyung-Mi (College of Veterinary Medicine, Chonnam National University)
Kim Se-Eun (College of Veterinary Medicine, Chonnam National University)
Choi Jeong-Yun (Department of Oral Histology College of Dentistry, Chosun University)
Park Joo-Cheol (Department of Oral Histology College of Dentistry, Chosun University)
Jeong Soon-Jeong (Department of Oral Histology College of Dentistry, Chosun University)
Lee Jae-Yeong (College of Veterinary Medicine, Chonnam National University)
Bae Chun-Sik (College of Veterinary Medicine, Chonnam National University)
Park Don-Hee (School of Biological Science and Technology, Chonnam National University)
Kim Do-Man (School of Biological Science and Technology, Chonnam National University)
Jeong Moon-Jin (Department of Oral Histology College of Dentistry, Chosun University)
Kang Seong-Soo (College of Veterinary Medicine, Chonnam National University)
Publication Information
Journal of Veterinary Clinics / v.23, no.1, 2006 , pp. 55-60 More about this Journal
Abstract
Aucuba japonica has variable pharmacological effects such as hepatoprotective, choleretic, hemodynamic, antimicrobial, and anti-inflammatory activities. This study was performed to investigate the effects of Aucuba japonica extract on oral wound healing. Aucubin was extracted from Aucuba japonica, and injected on either side of buccal mucosa of male mice. Artificial full thickness wounds were made on the site with 1.5 mm biopsy punch under sterile technique. The specimens had taken on day 1, 3, and 5 with 4 mm biopsy punch. Light microscopic examination and quantitative histologic analysis were performed for reepithelization, inflammatory cell infiltration. Reepithelization of the aucubin (0.1%) group was earlier than the control group. And the number of inflammatory cells of the aucubin group was lesser than the control group. In view of the results so far achieved, the aucubin extracted from Aucuba japonica may be useful for oral wound healing and it can be applied as a topical agent on the oral wound. Further research should be performed on the mechanism of aucubin on oral wound healing and proper formulation for effective topical agents.
Keywords
aucuba japonica; aucubin; oral wound; reepithelization; mouse;
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