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A Systematic Review of Home based Pulmonary Rehabilitation in COPD Patients: Randomized Controlled Trials (만성폐쇄성폐질환자의 가정호흡재활 프로그램 효과에 대한 체계적 고찰: 무작위시험설계)

  • Ahn, Min Hee;Choi, Ja Yun;Kim, Yun Hee
    • The Korean Journal of Rehabilitation Nursing
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    • v.19 no.2
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    • pp.82-99
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    • 2016
  • Purpose: The purpose of this study was to review systematically the effects of home based pulmonary rehabilitation in chronic obstructive pulmonary disease (COPD) patients using qualitative synthesis. Methods: Studies designed randomized controlled trials were identified to extract data and to assess the quality of studies in 8 domestic and 3 foreign search engines, and hand search reference reviews. Results: A total of 9 studies met the inclusion criteria. Overall, the methodological quality of the studies ranged from average to poor. Home based pulmonary rehabilitation consisted of exercise, education, and psychosocial interventions. Several exercises such as aerobic, strength, respiratory muscle training, and flexibility were used in home based pulmonary rehabilitation for COPD patients. Upper muscle exercise and walking were the most frequently used exercises. The most common topics for education were 'knowledge of the illness' and 'drug management'. Walking distance test (WDT) and quality of life (QoL) were the most frequently measured as the dependent variables to evaluate rehabilitation outcomes, followed by pulmonary function test (PFT) and dyspnea. WDT was the most effective outcome, followed by dyspnea, QoL and PFT. Conclusion: This study informed about the details of scientific and effective home based rehabilitation programs in COPD patients for future researchers and clinicians. These findings can help expand the recognition and accessibility of home based rehabilitation in COPD patients.

A Method for Suppression of Active Metal Leaching during the Direct Synthesis of H2O2 by Using Polyelectrolyte Multilayers (고분자 전해질 다층박막을 이용한 과산화수소 직접제조 반응 중 활성금속 용출 억제 방법)

  • Chung, Young-Min
    • Korean Chemical Engineering Research
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    • v.53 no.2
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    • pp.262-268
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    • 2015
  • In this study, two types of catalysts were prepared via conventional metal supporting method and encapsulation of metal nanoparticles in the polyelectrolyte multilayers constructed on support. The resulting catalysts were applied to the direct synthesis of hydrogen peroxide, and the effect of catalyst preparation method on the catalyst life as well as hydrogen peroxide productivity was investigated. The catalytic activity was strongly dependent upon the acid strength of support regardless of the catalyst preparation methods and HBEA (SAR=25) with strong acidity was superior to other supports to promote the reaction. In the case of metal supported catalyst, while hydrogen peroxide productivity was higher than that of polyelectrolyte multilayered counterpart, the reaction performance was sharply decreased during catalyst recycling due to the metal leaching. On the other hand, construction of polyelectrolyte multilayers on support weakened the influence of acid support on the reaction medium and therefore resulted in the decrease of catalytic activity and the increase of hydrogen peroxide decomposition as well. It is noted, however, that the catalytic activity was maintained after 5 recycles, which suggests that the introduction of polyelectrolyte multilayers on the support is very effective to suppress the unfavorable metal leaching phenomenon during a reaction.

Antibacterial and remineralization effects of orthodontic bonding agents containing bioactive glass

  • Kim, You-Min;Kim, Dong-Hyun;Song, Chang Weon;Yoon, Seog-Young;Kim, Se-Yeon;Na, Hee Sam;Chung, Jin;Kim, Yong-Il;Kwon, Yong Hoon
    • The korean journal of orthodontics
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    • v.48 no.3
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    • pp.163-171
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    • 2018
  • Objective: The aim of this study was to evaluate the mechanical and biological properties of orthodontic bonding agents containing silver- or zinc-doped bioactive glass (BAG) and determine the antibacterial and remineralization effects of these agents. Methods: BAG was synthesized using the alkali-mediated solgel method. Orthodontic bonding agents containing BAG were prepared by mixing BAG with flowable resin. $Transbond^{TM}$ XT (TXT) and $Charmfil^{TM}$ Flow (CF) were used as controls. Ion release, cytotoxicity, antibacterial properties, the shear bond strength, and the adhesive remnant index were evaluated. To assess the remineralization properties of BAG, micro-computed tomography was performed after pH cycling. Results: The BAG-containing bonding agents showed no noticeable cytotoxicity and suppressed bacterial growth. When these bonding agents were used, demineralization after pH cycling began approximately 200 to $300{\mu}m$ away from the bracket. On the other hand, when CF and TXT were used, all surfaces that were not covered by the adhesive were demineralized after pH cycling. Conclusions: Our findings suggest that orthodontic bonding agents containing silver- or zinc-doped BAG have stronger antibacterial and remineralization effects compared with conventional orthodontic adhesives; thus, they are suitable for use in orthodontic practice.

Effect of Heat Treatment on Microstructure and Mechanical Properties of an Fe-6.5Mn-0.08C Medium-Manganese Steel (열처리에 따른 Fe-6.5Mn-0.08C 중망간강의 미세조직과 기계적 특성)

  • Yoon, Young-Chul;Lee, Sang-In;Hwang, Byoungchul
    • Korean Journal of Materials Research
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    • v.30 no.1
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    • pp.8-13
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    • 2020
  • Effect of heat treatment on microstructure and mechanical properties of an Fe-6.5Mn-0.08C medium-manganese steel is investigated in this study. Three kinds of medium-manganese steel specimens are fabricated by varying heat treatments of intermediate quenching (IQ), step quenching (SQ), and intercritical annealing (IA). Hardness and tensile tests are performed to examine the correlation of microstructure and mechanical properties for the Fe-6.5Mn-0.08C medium-manganese steel specimens. The IQ and SQ specimens have microstructures of martensite matrix with ferrite, whereas IA specimen exhibits microstructure of acicular ferrite matrix with martensite. The tensile test results show that the SQ specimen with martensite matrix has the highest yield strength and the lowest elongation. On the other hand, the SQ specimen has the highest hardness due to the relatively lower reduction of carbon content in martensite during intercritical annealing. According to the fractography of tensile tested specimens, the SQ specimen exhibits a dimple and quasi-cleavage fracture appearance while the IQ and IA specimens have fully ductile fracture appearance with fine-sized dimples caused by microvoid coalescence at ferrite and martensite interface.

Synthesis and Properties of Tetraaza Macrocycles Containing Two 3-Pyridylmethyl, 4-Pyridylmethyl, or Phenylmethyl Pendant Arms and Their Nickel(Ⅱ) and Copper(Ⅱ) Complexes: Effects of the Pendant Arms on the Complex Formation Reaction

  • Kang, Shin-Geol;Kim, Seong-Jin
    • Bulletin of the Korean Chemical Society
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    • v.24 no.3
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    • pp.269-273
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    • 2003
  • The synthesis and properties of 2,13-bis(3'-pyridylmethyl) $(L^3)$, 2,13-bis(4'-pyridylmethyl) $(L^4)$, and 2,13-bis(phenylmethyl) $(L^5)$ derivatives of 5,16-dimethyl-2,6,13,17-tetraazatrcyclo$[16.4.0.^{1.18}0^{7.12}]$docosane are reported. The 3- or 4-pyridylmethyl groups of $[ML^3](ClO_4)_2\;or\;[ML^4](ClO_4)_2$ (M = Ni(Ⅱ) or Cu(Ⅱ)) are not involved in coordination, and the coordination geometry (square-planar) and ligand field strength of the complexes are quite similar to those of $[ML^5](ClO_4)_2$, bearing two phenylmethyl pendant arms. However, the complex formation reactions of $L^3\;and\;L^4$ are strongly influenced by the pyridyl groups, which can interact with a proton or metal ion outside the macrocyclic ring. The macrocycle $L^5$ exhibits a high copper(Ⅱ) ion selectivity against nickel(Ⅱ) ion; the ligand readily reacts with copper(Ⅱ) ion to form $[CuL^5]^{2+}$ but does not react with hydrated nickel(Ⅱ) ion in methanol solutions. On the other hand, $L^3\;and\;L^4$ form their copper(Ⅱ) and nickel(Ⅱ) complexes under a similar condition, without showing any considerable metal ion selectivity. The ligands $L^3\;and\;L^4$ react with copper(Ⅱ) ion more rapidly than does $L^5$ at pH 6.4. At pH 5.0, however, the reaction rate of the former macrocycles is slower than that of the latter. The effects of the 3- or 4-pyridylmethyl pendant arms on the complex formation reaction of $L^3\;and\;L^4$ are discussed.

DESIGN OF A LOAD FOLLOWING CONTROLLER FOR APR+ NUCLEAR PLANTS

  • Lee, Sim-Won;Kim, Jae-Hwan;Na, Man-Gyun;Kim, Dong-Su;Yu, Keuk-Jong;Kim, Han-Gon
    • Nuclear Engineering and Technology
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    • v.44 no.4
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    • pp.369-378
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    • 2012
  • A load-following operation in APR+ nuclear plants is necessary to reduce the need to adjust the boric acid concentration and to efficiently control the control rods for flexible operation. In particular, a disproportion in the axial flux distribution, which is normally caused by a load-following operation in a reactor core, causes xenon oscillation because the absorption cross-section of xenon is extremely large and its effects in a reactor are delayed by the iodine precursor. A model predictive control (MPC) method was used to design an automatic load-following controller for the integrated thermal power level and axial shape index (ASI) control for APR+ nuclear plants. Some tracking controllers employ the current tracking command only. On the other hand, the MPC can achieve better tracking performance because it considers future commands in addition to the current tracking command. The basic concept of the MPC is to solve an optimization problem for generating finite future control inputs at the current time and to implement as the current control input only the first control input among the solutions of the finite time steps. At the next time step, the procedure to solve the optimization problem is then repeated. The support vector regression (SVR) model that is used widely for function approximation problems is used to predict the future outputs based on previous inputs and outputs. In addition, a genetic algorithm is employed to minimize the objective function of a MPC control algorithm with multiple constraints. The power level and ASI are controlled by regulating the control banks and part-strength control banks together with an automatic adjustment of the boric acid concentration. The 3-dimensional MASTER code, which models APR+ nuclear plants, is interfaced to the proposed controller to confirm the performance of the controlling reactor power level and ASI. Numerical simulations showed that the proposed controller exhibits very fast tracking responses.

Amination of Ethanol over Large Pore Zeolites (큰 기공 제올라이트에서 에탄올의 아민화반응)

  • Jeon, Hee-Young;Jeon, Seong-Hee;Lee, Cheon-Jae;Shin, Chae-Ho
    • Clean Technology
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    • v.14 no.2
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    • pp.87-94
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    • 2008
  • The catalytic properties of large pore zeolite (mordenite, beta, and Y) with 12-membered rings were comparatively evaluated in the synthesis of diethylamines from ethanol amination. The number of strong acid sites, which obviously promoted the formation of mono- and diethylamines, was decreased with the increase of Si/Al ratio of the zeolites that were used. H-beta and H-Y zeolites with multidimensional pore channels favorably formed diethylether by the dimerization of ethanol, due to their large cage volumes and low acid strength. On the other hand, H-mordenite which has one dimensional straight channel was shown to be suitable for the formation of mono- and diethylamine which are well known as the useful intermediates of fine chemicals.

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Reliability Analysis of Steel Fiber Reinforced Concrete Continuous Beams (강섬유 보강 철근콘크리트 연속보의 신뢰성 해석)

  • Yoo Han-Shin;Jang Hwa-Sup;Kwak Kae-Hwan
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.17 no.4
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    • pp.443-449
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    • 2004
  • Methods for mixing variable types of steel fibers have been developed recently to suppress outbreak of crack or to control the width of crack and improve the load resistible capacity at the same time. On the other hand, uncertainty by complex nature of destruction dynamics of steel fiber reinforced concrete(SFRC) is included. In this study, analysis of reliance considering uncertainty of SFRC beam is done. For this, intensity limit state model was proposed. Moreover, characteristic values about almost every kinds of probability variables were collected and presented according to home and foreign references. Process of improving uncertainty from the result of experiments by Bayseian updating method is also proposed on the purpose of offering better statistical characteristic values with more data in the new future. Fatigue fracture probability equation is proposed and needed statistical characteristic values were presented to analyze fatigue reliance

Effect of Liquid Isoprene Rubber on the Adhesion Property of UV Curable Acrylic Pressure-Sensitive Adhesive (액상 이소프렌 고무가 자외선 경화형 아크릴 점착제의 점착 특성에 미치는 영향)

  • Lee, Jiye;Chung, Kyungho
    • Elastomers and Composites
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    • v.49 no.3
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    • pp.210-219
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    • 2014
  • In this study, the acrylic pressure sensitive adhesive (PSA) for the optical functionality sheet was prepared by blending liquid isoprene rubber. The acrylic PSA was synthesized with butyl acrylate, acrylic acid, 2-ethylhexyl acrylate and 2-hydroxyethyl methacrylate. Toluene was used to a solvent for polymerization. Liquid isoprene rubber (LIR-50) was blended with the acrylic PSA and blend ratio was 0 ~ 50 wt%. According to the results, the adhesive transfer, which was the big problem of acrylic adhesive, was reduced with the addition of LIR-50. The secondary bonding of LIR-50 with substrate did not occurred due to absence of polar group in LIR-50. The peel strength and adhesive transfer were decreased by UV curing and the degreed of decrease depended on the amounts of photoinitiator and UV irradiation time. On the other hand holding power increased drastically by increasing amounts of photoinitiator and UV irradiation time.

Gate-Controlled Spin-Orbit Interaction Parameter in a GaSb Two-Dimensional Hole gas Structure

  • Park, Youn Ho;Koo, Hyun Cheol;Shin, Sang-Hoon;Song, Jin Dong;Kim, Hyung-Jun;Chang, Joonyeon;Han, Suk Hee;Choi, Heon-Jin
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.02a
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    • pp.382-383
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    • 2013
  • Gate-controlled spin-orbit interaction parameter is a key factor for developing spin-Field Effect Transistor (Spin-FET) in a quantum well structure because the strength of the spin-orbit interaction parameter decides the spin precession angle [1]. Many researches show the control of spin-orbit interaction parameter in n-type quantum channels, however, for the complementary logic device p-type quantum channel should be also necessary. We have calculated the spin-orbit interaction parameter and the effective mass using the Shubnikov-de Haas (SdH) oscillation measurement in a GaSb two-dimensional hole gas (2DHG) structure as shown in Fig 1. The inset illustrates the device geometry. The spin-orbit interaction parameter of $1.71{\times}10^{11}$ eVm and effective mass of 0.98 $m^0$ are obtained at T=1.8 K, respectively. Fig. 2 shows the gate dependence of the spin-orbit interaction parameter and the hole concentration at 1.8 K, which indicates the spin-orbit interaction parameter increases with the carrier concentration in p-type channel. On the order hand, opposite gate dependence was found in n-type channel [1,2]. Therefore, the combined device of p- and n-type channel spin transistor would be a good candidate for the complimentary logic device.

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