• Korean Journal of Weed Science
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• v.14 no.4
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• pp.298-313
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• 1994

Residue of herbicide napropamide [N,N-dimethyl-2-(1-napthoxy)-propionamide] and change of micro-organism were investigated in upland soil under different environmental conditions. Half-lives of degradation were 28.3 days in the sterile soil and 14.6 days in the nonsterile soil, respectively. These results suggest that microorganism remarkably affected the decomposition of napropamide. Napropamide was rapidly degraded in order of 60% > 80% ${\geq}$ 40% soil moisture content of field water-holding capacity. Numbers of bacteria and total microbes in 60% moisture content was more than those in 40% moisture content. The more the napropamide degradation was rapid in lower soil pH. The total number of microorganism increased by lapse of time after treatment of napropamide at pH 5.5. The decomposition rate of napropamide was rapid in the order of $27^{\circ}C$ > $37^{\circ}C$ > $17^{\circ}C$. At $17^{\circ}C$ of soil temperature actinomycetes in napropamide treatment plot was more than these in nontreatment plot and also at $27^{\circ}C$ and $37^{\circ}C$ bacteria in napropamide treatment plot was more than those in nontreatment plot. Napropamide degradation was more rapid and number of microorganism was more abundant at the concentration of 10ppm than at that of 20ppm. The half-life of napropamide was longer in the clay loam soil than in the silty loam soil. The half times in laboratory test than in upland field. Numbers of microbes in the experiment under all the test environmental condition was not significantly different between treatment and nontreatment of napropamide.

• Korean Journal of Clinical Pharmacy
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• v.21 no.2
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• pp.138-144
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• 2011

In order to minimize such adverse drug reactions, governments and international organs have been on the watch for them. Also in South Korea, a system has been established in order that adverse drug reactions may be reported to Korea Food and Drug Administration(KFDA). This study is to analyze drugs to cause adverse reactions, the adverse reactions and patients concerned on the authority of the data of Korea FDA, which is expected to be the preliminary data on preventable adverse reactions. This study was conducted on the 74,037 cases of adverse drug reactions reported to Korea FDA between January 2007 and June 2010. Fentanyl, iopromide and tramadol caused adverse reactions with high frequencies. Oseltamivir showed a high frequency between 2009 and 2010 due to the influence of the new influenza A. Also, OTC drugs accounted for approximately 5% of the adverse reactions. In 2009, adverse drug reactions remarkably increased (2,106 cases; 10.1%) in infants and children due to the new influenza-A(H1N1). The patients aged between 31 and 64 accounted for approximately 55% during the given period. There was no significant intergender difference. In relation to regions, the adverse reactions most frequently occurred in the gastrointestinal system and the integumentary system for three and half years. In addition to anticancer drugs and immunosuppressive drugs that are known to cause adverse reactions frequently, not a few of OTC drugs and external preparations caused such reactions. In particular, the drugs containing specific ingredients caused adverse reactions more frequently than others from 2007 until the first half of 2010. It is advisable for prescribers to acquaint themselves with such adverse reactions and to prescribe drugs other than them. They also have need to sensibly cope with adverse drug reactions just in case they have no substitute drugs. In addition, patients also need to be trained to understand possible adverse reactions in order that they can sensibly accommodate them or choose healthcare services. The results of this study are expected to be helpful to minimize adverse drug reactions.

• Investigative Magnetic Resonance Imaging
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• v.5 no.1
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• pp.57-65
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• 2001

Purpose : $T_2$-weighted half courier Echo Planar Imaging (T2HEPI) method is proposed to reduce measurement time of existing EPI by a factor of 2. In addition, high $T_2$ contrast is obtained for clinical applications. High resolution single-shot EPI images with $T_2$ contrast are obtained with $128{\times}128$ matrix size by the proposed method. Materials and methods : In order to reduce measurement time in EPI, half courier space is measured, and rest of half courier data is obtained by conjugate symmetric filling. Thus high resolution single shot EPI image with $128{\times}128$ matrix size is obtained with 64 echoes. By the arrangement of phase encoding gradients, high $T_2$ weighted images are obtained. The acquired data in k-space are shifted if there exists residual gradient field due to eddy current along phase encoding gradient, which results in a serious problem in the reconstructed image. The residual field is estimated by the correlation coefficient between the echo signal for dc and the corresponding reference data acquired during the pre-scan. Once the residual gradient field is properly estimated, it can be removed by the adjustment of initial phase encoding gradient field between $70^{\circ}$ and $180^{\circ}$ rf pulses. Results : The suggested T2EPl is implemented in a 1.0 Tela whole body MRI system. Experiments are done with the effective echo times of 72ms and 96ms with single shot acquisitions. High resolution($128{\times}128$) volunteer head images with high $T_2$ contrast are obtained in a single scan by the proposed method. Conclusion : Using the half courier technique, higher resolution EPI images are obtained with matrix size of $128{\times}128$ in a single scan. Furthermore $T_2$ contrast is controlled by the effective echo time. Since the suggested method can be implemented by software alone (pulse sequence and corresponding tuning and reconstruction algorithms) without addition of special hardware, it can be widely used in existing MRI systems.

• Genomics & Informatics
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• v.20 no.1
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• pp.9.1-9.6
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• 2022

Mendelian randomization (MR) uses genetic variation as a natural experiment to investigate the causal effects of modifiable risk factors (exposures) on outcomes. Two-sample Mendelian randomization (2SMR) is widely used to measure causal effects between exposures and outcomes via genome-wide association studies. 2SMR can increase statistical power by utilizing summary statistics from large consortia such as the UK Biobank. However, the first-order term approximation of standard error is commonly used when applying 2SMR. This approximation can underestimate the variance of causal effects in MR, which can lead to an increased false-positive rate. An alternative is to use the second-order approximation of the standard error, which can considerably correct for the deviation of the first-order approximation. In this study, we simulated MR to show the degree to which the first-order approximation underestimates the variance. We show that depending on the specific situation, the first-order approximation can underestimate the variance almost by half when compared to the true variance, whereas the second-order approximation is robust and accurate.

• International Journal of Automotive Technology
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• v.8 no.4
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• pp.521-531
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• 2007

Measurement of the vibration transmitted through rotating shafts such as half shafts in vehicles is of interest in applications such as noise transfer analysis and the study of operating deflections. Vibration signals transmitted through a rotating shaft usually include six degree-of-freedom components, thus making the measurement of vibration a challenging task. In the present work, a new measurement method is presented, one that resolves the minimum of only two one-axis accelerometer signals into all components of vibration with reasonable accuracy. The method utilizes the Dopplerized signals obtained from accelerometers attached to a rotating shaft and a Void-Kalman order tracking filter to decompose signals into orders of different vibration components. The new method proposed in the present work is verified by simulated run-up test data and applied to an experimentally obtained data set.

• Korean Journal of Clinical Pharmacy
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• v.6 no.2
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• pp.14-18
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• 1996

This study was attempted to investigate the dissolution rate and the bioavailability after oral administration of commercially available norfloxacin tablets in rabbits. The dissolution test was conducted in artificial gastric juice using basket method with for norfloxacin preparations (A, B, C and D) which were chemically equivalent. The results were as follows ; The dissolution rate was increased in the order of four different brand A>D>B>C. Area under the plasma concentration curve and peak plasma concentration were increased in the order of brand A>D>B>C. Absorption rate constant and peak time were increased in the order of brand B>A>C>D, and there was a little difference in elimination rate constant and biological half-life. The correlation of the dissolution rate and relative bioavailability showed significant linear relationship. From the results of this experiment, the bioavailability of norfloxacin tablets in rabbits may be predicted from the results of dissolution rate studies.

• Journal of the Korean Society of Clothing and Textiles
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• v.32 no.1
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• pp.35-44
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• 2008

The research is purposed to help obese children to recover their physical, spiritual inferiority complex and it give them to affirmative self formation by developing training-suit which has slender effect. In order to accomplish a research problem, this research examined the effect of wearer's outward appearance with the principle and element of design and the characteristics of obesity. In order to apply consumer's demand to developing goods, this research used 'House of quality' theory. The design ten suits(the half are made for boys) development is based on the result of 'House of quality', parents and obese children's interview, design element, slender effect. The design which is developed is evaluated by five specialists in order to prove it's quality though the 'Quad' analysis which is a subjective evaluation method.

• Journal of Korean Society of Environmental Engineers
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• v.34 no.3
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• pp.195-203
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• 2012

In this study, The effects of three different biological activated carbon (BAC) materials (each coal, coconut and wood based activated carbons) and anthracite, empty bed contact time (EBCT) and water temperature on the removal of MK, HHCB and AHTN in BAC filters were investigated. Experiments were conducted at three water temperatures (5, 15 and $25^{\circ}C$) and four EBCTs (5, 10, 15 and 20 min). The results indicated that coal based BAC retained more attached bacterial biomass on the surface of the activated carbon than the other BAC, increasing EBCT or increasing water temperature increased the synthetic musk compounds (SMCs) removal in BAC columns. The kinetic analysis suggested a first-order reaction model for MK, HHCB and AHTN removal at various water temperatures (5, 15 and $25^{\circ}C$). The pseudo-first-order biodegradation rate constants and half-lives were also calculated for MK, HHCB and AHTN removal at 5, 15 and $25^{\circ}C$. The pseudo-first-order biodegradation rate constants and half-lives of MK, HHCB and AHTN ranging from 0.0082 $min^{-1}$ to 0.4452 $min^{-1}$ and from 1.56 min to 84.51 min could be used to assist water utilities in designing and operating BAC filters for SMCs removal.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.28 no.8
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• pp.6-13
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• 2014

In this paper, a multiwavelength-switchable first-order fiber flexible filter is newly proposed, which is based on a polarization-diversity loop. The proposed filter consists of a polarization beam splitter, three half-wave plates(HWPs), and two high birefringent fibers(HBFs). The proposed filter has a good flexibility in adjusting relative angular difference between the principal axes of two HBFs by inserting an HWP between two HBFs. The first-order flat-top or narrow band transmission spectra and the zeroth-order transmission spectra, which had a channel spacing of ~0.8nm, could be obtained by controlling the three HWPs, and, in particular, each of them could also be interleaved. In addition, zeroth-order transmission spectra with a channel spacing of ~0.8nm could be flexibly converted into those with a channel spacing of ~0.4nm through the control of three HWPs, and also be interleaved. The transmission characteristics of the proposed filter was theoretically analyzed and experimentally verified.

• Journal of the Korea Institute of Building Construction
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• v.17 no.6
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• pp.577-585
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• 2017

HPC method is developing to improve the constructability and structural performance of the existing PC method. The objective of this study is to develop construction procedures and to analysis of construction period for HPC method. In order to develop construction procedures, the building construction data of the existing half-slab method was analyzed. Analyzing design drawings and specifications of nine construction cases, a prototype of half-slab method, was drawn. Applying the core technology of HPC method to the drawn prototype of half-slab method, a prototype of HPC method, was developed. The differences of both methods were 'installing PC column' and 'placing topping concrete'. To analysis the differences of both methods, seven construction cases were analyzed. According to the analysis for HPC method, cases1 and 2 had columns divided for construction shortened about 16% of a construction period. The schedule of column assembly work was analyzed to be shortened much. That is judged to be because the use of a hollow PC column leads to a decrease in the number of columns. In particular, if HPC method is applied to a building construction site using large columns, it is analyzed to shorten a construction period more than the existing Half-slab method.