• Bulletin of the Korean Chemical Society
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• v.34 no.2
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• pp.524-530
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• 2013

In this study, we describe the most expected behavior of cells on the modified surface and the correlation between the modified substrates and the response of cells. The physicochemical characteristics of substrates played an essential role in the adhesion and proliferation of cells. Glass and polymer substrates were modified using air plasma oxidation, and the surfaces were coated with self-assembled monolayer molecules of silanes. The PDMS substrates embedded with parallel micropatterns were used for evaluation of the effect of topologically modified substrate on cellular behaviour. BALB/3T3 fibroblast cells were cultured on different surfaces with distinct wettability and topology, and the growth rates and morphological change of cells were analyzed. Finally, we found the optimum conditions for the adhesion and proliferation of cells on the modified surface. This study will provide insight into the cell-surface interaction and contribute to tissue engineering applications.

• Journal of the Korean Wood Science and Technology
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• v.50 no.2
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• pp.81-92
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• 2022

To analyze the relationship between climatic factors (mean monthly temperature and total precipitation) and tree-ring growths of Pinus densiflora S. et Z. from National Parks (according to region) of the Korea, 20 trees were sampled from 13 National Parks. Only trees that were successfully cross-dated were used for dendrochronological analysis, and at least 11 trees were included. The tree-ring chronology of Mt. Bukhan (covering the shortest period of 1917 - 2016 [100 years]) was assessed, as well as that of Mt. Seorak (covering the longest period of 1687 - 2017 [331 years]). After cross-dating, each ring width series was double-standardized by first fitting a logarithmic curve and then a 50-year cubic spline. The relationships between climate and tree-ring growth were calculated with response function analysis. The results show a significant positive correlation between a given year's February-March temperature, May precipitation levels, and tree-ring growth. It indicates that a higher temperature in early spring and precipitation before cambium activity are important for radial growths of Pinus densiflora in the Korea.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.30 no.1
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• pp.30-40
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• 2008

The objectives of this study was to check up the effect of celecoxib, COX-2 inhibitor, on the pathogenesis of oral squamous cell carcinoma. After mefenamic acid, aspirin and celecoxib, COX-2 inhibitor, were inoculated to HN 22 cell line, the following results were obtained through tumor cell viability by wortmannin, growth curve of tumor cell line, apoptotic index, PGE2 synthesis, total RNA extraction, RT-PCR analysis and TEM features. 1. When wortmannin and celecoxib were given together, the survival rate of tumor cells was lowest about 47 %. So wortmannin had an effect on the decrease of survival rate of tumor cells. 2. In growth curve, the slowest growth was observed in celecoxib inoculated group. 3. The synthesis of PGE2 was decreased in all group and the obvious suppression and highest apoptotic index was observed in celecoxib inoculated group. 4. Suppression of expression of COX-2 mRNA was evident in celecoxib inoculated group. But that of COX-1,2 mRNA was observed in mefenamic acid inoculated group and aspirin inoculated group. 5. In celecoxib inoculated group, mRNA expression of AKT1 was decreased and that of PTEN & expression of caspase 3 and 9 was evidently increased. Depending on above results, when celecoxib was inoculated to oral squamous cell carcinoma cell line, an increase of mRNA expression of caspase 3,9 and PTEN is related to a decrease of mRNA expression of AKT1. Wortmannin had an effect on the decrease of survival rate of tumor cells. Celecoxib might induce apoptosis of tumor cell by suppression of AKT1 pathway and COX-2 inhibition. This results suggested that COX-2 inhibitor might be significantly effective in chemoprevention of oral squamous cell carcinoma.

• Journal of Environmental Policy
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• v.12 no.2
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• pp.59-86
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• 2013

We analyzed the correlation among the GHG (Greenhouse Gas) emission, energy consumption and economic growth for the 6 specific regions in Korea by using Panel approaches with the test of the EKC hypothesis. We also analyzed the effects of environmental regulation on GHG and economic growth. The results show that by testing of the EKC (Environmental Kuznets Curve) hypothesis model,the effects of the environmental regulation and the structure of industries on GHC emission have a significant result on the regional analysis for SOx. For the NOx and TSP, only TK region passed the turning point of the EKC among the 6 specific regions. And, for the Co, the Central, Honam and the PUKN region passed the turning point of the EKC. This is because GHG emissions by the environment regulation had a weak path effect and also regional industry structures had a weak relation with regional GHG emissions.

• Journal of the Korean Data and Information Science Society
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• v.26 no.6
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• pp.1367-1375
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• 2015

Consider the linear growth models for longitudinal data analysis. Several kind of linear growth models are selected such as time-effect and random-effect models as well as a dummy variable included model. In this work, simulation data are generated with normality assumption, and both binormal ROC curve and AUC are obtained and compared for various linear growth models. It is found that ROC curves have different shapes and AUC increase slowly, as values of the covariance increase and the time passes for random-effect models. On the other hand, AUC increases very fast as values of covariance decrease. When the covariance has positive value, we explored that the variances of random-effect models increase and the increment of AUC is smaller than that of AUC for time-effect models. And the increment of AUC for time-effect models is larger than the increment for random-effect models.

• Journal of Korea Water Resources Association
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• v.51 no.9
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• pp.747-759
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• 2018

Multivariate regional frequency analysis has advantages of regional and multivariate framework as adopting a large number of regional dataset and modeling phenomena that cannot be considered in the univariate frequency analysis. To the best of our knowledge, the multivariate regional frequency analysis has not been employed for hydrological variables in South Korea. Applicability of the multivariate regional frequency analysis should be investigated for the hydrological variable in South Korea in order to improve our capacity to model the hydrological variables. The current study focused on estimating parameters of regional copula and regional marginal models, selecting the most appropriate distribution models, and estimating regional multivariate growth curve in the multivariate regional frequency analysis. Annual maximum rainfall and duration data observed at 71 stations were used for the analysis. The results of the current study indicate that Frank and Gumbel copula models were selected as the most appropriate regional copula models for the employed regions. Several distributions, e.g. Gumbel and log-normal, were the representative regional marginal models. Based on relative root mean square error of the quantile growth curves, the multivariate regional frequency analysis provided more stable and accurate quantiles than the multivariate at-site frequency analysis, especially for long return periods. Application of regional frequency analysis in bivariate rainfall-duration analysis can provide more stable quantile estimation for hydraulic infrastructure design criteria and accurate modelling of rainfall-duration relationship.

• Advances in nano research
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• v.3 no.3
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• pp.143-168
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• 2015

Initiation of crack and its growth simulation requires accurate model of traction - separation law. Accurate modeling of traction-separation law remains always a great challenge. Atomistic simulations based prediction has great potential in arriving at accurate traction-separation law. The present paper is aimed at establishing a method to address the above problem. A method for traction-separation law prediction via utilizing atomistic simulations data has been proposed. In this direction, firstly, a simpler approach of common neighbor analysis (CNA) for the prediction of crack growth has been proposed and results have been compared with previously used approach of threshold potential energy. Next, a scheme for prediction of crack speed has been demonstrated based on the stable crack growth criteria. Also, an algorithm has been proposed that utilizes a variable relaxation time period for the computation of crack growth, accurate stress behavior, and traction-separation atomistic law. An understanding has been established for the generation of smoother traction-separation law (including the effect of free surface) from a huge amount of raw atomistic data. A new curve fit has also been proposed for predicting traction-separation data generated from the molecular dynamics simulations. The proposed traction-separation law has also been compared with the polynomial and exponential model used earlier for the prediction of traction-separation law for the bulk materials.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2006.04a
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• pp.431-436
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• 2006

The latest system of GIS has been changing from 2 dimension to 3 dimension. According to the rapid growth of the fields linked to 3D GIS, 3D GIS has variously affected the public field, the national defense field, and the industrial field. This study estimated sight distance safety of curve section considering the environmental impact based on 3D GIS. Sight distance is calculated from the relation between road which keeps the three-dimension character and driver gaze, so it needs to consider both plane and vertical ior the accurate measuring. This study made analysis of the sight distance through considering the environmental impact with driving simulation of design speed 80km/h and running speed 60-120km/h.

• Journal of the Korean Ceramic Society
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• v.31 no.10
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• pp.1099-1106
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• 1994

It is suggested that the microstructural toughening process in the initial rising portion of R-curves observed in polycrystalline alumina should be different from the grain bridging mechanism identified in the long crack regime. Microcracking in the advancing crack front seems to be a prerequisite for the development of unbroken bridging ligaments behind the crack tip. In order to test such a proposition, attempts were made to identify experimentally the presence of microcracks in the frontal zone of propagating cracks. In-situ observation is made of crack growth in a miniature double cantilever beam specimen of a average grain size of 10 ${\mu}{\textrm}{m}$ alumina. Presence of a few microcracks was identified in front of crack tip on the propagating crack plane. The R-curves were re-evaluated based on the observation.

• Journal of The Korean Astronomical Society
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• v.29 no.spc1
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• pp.19-21
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• 1996

We apply topological measures of clustering such as percolation and genus curves (PC & GC) and shape statistics to a set of scale free N-body simulations of large scale structure. Both genus and percolation curves evolve with time reflecting growth of non-Gaussianity in the N-body density field. The amplitude of the genus curve decreases with epoch due to non-linear mode coupling, the decrease being more noticeable for spectra with small scale power. Plotted against the filling factor GC shows very little evolution - a surprising result, since the percolation curve shows significant evolution for the same data. Our results indicate that both PC and GC could be used to discriminate between rival models of structure formation and the analysis of CMB maps. Using shape sensitive statistics we find that there is a strong tendency for objects in our simulations to be filament-like, the degree of filamentarity increasing with epoch.