Purpose : This study sought to determine the influence of nursing students' self-leadership, empathic ability, and depression on their interpersonal skills. Methods : This study applied a descriptive survey research design involving a self-report questionnaire. The participants were 315 nursing students in B city. Data were collected from April 27 to May 6, 2022. The data were analyzed using the percentage, mean, standard deviation, t-test, ANOVA, Scheffé test, Pearson's correlation coefficients, and multiple regression with IBM SPSS/WIN 23.0 program. Results : The participants' self-leadership score was 3.63±.65, their empathic ability score was 3.35±.40, their depression score was .84±.50, and their interpersonal skills score was 3.64±.80. Among the sub-categories, others' temperament scored the highest at 3.70±.86, followed by communication at 3.67±.86 and promoting relationships at 3.53±.86. Interpersonal skills were positively correlated with both self-leadership (r=.48, p<.001) and empathic ability (r=.33, p<.001). Self-leadership was positively correlated with empathic ability (r=.17, p<.05), but, negatively correlated with depression (r=.27, p<.001). The multiple regression analysis revealed, that the factors with the most significant effect on promoting relationships were, in descending order, self-leadership (β=.49, p<.001), empathic ability (β=.19, p<.001), and gender (β=.10, p=.033); the factors affecting others' temperament were, in descending order, self-leadership (β=.37, p<.001), empathic ability (β=.30, p<.001), severe depression (β=.14, p=.008), gender (β=.13, p=.010), and grade (β=-.13, p=.037); while the factors affecting communication were, in descending order, self-leadership (β=.41, p<.001), empathic ability (β=.23, p<.001), and gender (β=.11, p=.035). Moreover, the explanatory power of promoting relationships scored the highest at 31 %, followed by others' temperament at 27 % and communication at 26 %. Conclusion : The results of this study reveal the factors that influence the interpersonal skills of nursing students. To increase the interpersonal skills of nursing students, it is necessary to develop and apply regular curricula and programs designed to strengthen their self-leadership and empathic ability and to reduce their depression through reflecting differences between genders and grades.