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The Prognostic Factors Affecting Survival in Muscle Invasive Bladder Cancer Treated with Radiotherapy (방사선치료를 받은 근 침윤성 방광암의 예후 인자)

  • Chung Woong-Ki;Oh Bong-Ryoul;Ahn Sung Ja;Nah Byung Sik;Kwon Dong-Deuk;Park Kwangsung;Ryu Soo-Bang;Park Yang-IL
    • Radiation Oncology Journal
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    • v.20 no.2
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    • pp.130-138
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    • 2002
  • Purpose : This study analyzed the prognostic factors affecting the survival rate and evaluated the role of radiation therapy in muscle-invading bladder cancer. Materials and Methods : Twenty eight patients with bladder cancer who completed planned definitive radiotherapy in the Departments of Therapeutic Radiology and Urology, Chonnam National University Hospital between Jan. 1986 to Dec. 1998 were retrospectively analyzed. The reviews were peformed based on the patients' medical records. There were 21 males and 7 females in this study. The median of age was 72 years old ranging from 49 to 84 years. All patients were confirmed as having transitional cell carcinoma with histological grade 1 in one patient, grade 2 in 15, grade 3 in 9, and uninformed in 3. Radiation therapy was peformed using a linear accelerator with 6 or 10 MV X-rays. Radiation was delivered daily with a 1.8 or 2.0 Gy fraction size by 4 ports (anterior-posterior, both lateral, alternatively) or 3 ports (Anterior and both lateral). The median radiation dose delivered to the isocenter of the target volume was 61.24 Gy ranging from 59 to 66.6 Gy. The survival rate was calculated by the Kaplan-Meier method. Multivariate analysis was peformed on the prognostic factors affecting the survival rate. Results : The survival rate was $76\%,\;46\%,\;33\%,\;33\%$ at 1, 2, 3, 5 years, respectively, with 19 months of median survival. The potential factors of age (less than 70 years vs above 70), sex, diabetes mellitus, hypertension, hydronephrosis, 1-stage (T3a vs T3b), TUR, chemotherapy, total duration of radiotherapy, radiation dose (less than 60 Gy vs above 60 Gy), and the treatment response were investigated with uniand multivariate analysis. Un univariate analysis, the T-stage (p=0.078) and radiation dose (p=0.051) were marginally significant, and the treatment response (p=0.011) was a statistically significant factor on the survival rate. Multivariate analysis showed there were no significant prognostic factors affecting the survival rate. Conclusion : The treatment response and radiation dose are suggested as th은 statistically significant factors affecting the survival rate of muscle invasive bladder cancer. A Further prospective randomized study is needed to confirm these prognostic factors.

Analyzing Changes and Determinants of Self-rated Health during Adolescence: A Latent Growth Analysis (청소년의 주관적 건강 상태의 변화 궤적과 영향 요인: 잠재성장모형을 적용하여)

  • Choi, You-Jung;Kim, Hae-Young
    • Child Health Nursing Research
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    • v.24 no.4
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    • pp.496-505
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    • 2018
  • Purpose: The purpose of this study was to examine changes in the self-rated health of adolescents and to identify its predictors using longitudinal data from the KCYPS. Methods: A sample of 2,351 adolescents who were in the first grade of middle school in 2010 was analyzed. The study employed latent growth analysis using data from 2010 to 2016. Results: Results indicated that self-rated health of adolescents increased, following the form of a linear function. The analyses revealed that adolescent self-perception of health were conceptualized not only by their health-related behaviors, but also by personal, socioeconomic and psychological factors. Specifically, physical activity, passive leisure time activities, gender (initial: b=-.060, slope: b=.030), place of residence (initial: b=-.079), self-rated economic condition (b=.098), working status of mother (b=.016), monthly family income (b=-.001), aggression (b=.061), depression (initial: b=-.104, slope: b=.012), stress (initial: b=-.172, slope: b=.014, ego-resiliency (initial: b=.197, slope: b=-.021), and self-esteem (initial: b=.106, slope: b=-.017) had significant effects on the overall linear change of self-rated health (p<.05 for all estimators above). Conclusion: The findings of this study suggest that adolescents' self evaluation of their health is shaped by their total sense of functioning, which includes individual, health-related behavioral, socioeconomic, and psychological factors.

High-Dose-Rate Brachytherapy for Uterine Cervical Cancer : The Results of Different Fractionation Regimen (자궁경부암의 고선량률 근접치료 : 분할선량에 따른 결과 비교)

  • Yoon, Won-Sup;Kim, Tae-Hyun;Yang, Dae-Sik;Choi, Myung-Sun;Kim, Chul-Yong
    • Radiation Oncology Journal
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    • v.20 no.3
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    • pp.228-236
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    • 2002
  • Purpose : Although high-dose-rate (HDR) brachytherapy regimens have been practiced with a variety of modalities and various degrees of success, few studies on the subject have been conducted. The purpose of this study was to compare the results of local control and late complication rate according to different HDR brachytherapy fractionation regimens in uterine cervical cancer patients. Methods and Materials : From November 1992 to March 1998, 224 patients with uterine conical cancer were treated with external beam irradiation and HDR brachytherapy. In external pelvic radiation therapy, the radiation dose was $45\~54\;Gy$ (median dose 54 Gy) with daily fraction size 1.8 Gy, five times per week. In HDR brachytherapy, 122 patients (Group A) were treated with three times weekly with 3 Gy to line-A (isodose line of 2 cm radius from source) and 102 patients (Group B) underwent the HDR brachytherapy twice weekly with 4 or 4.5 Gy to line-A after external beam irradiation. Iridium-192 was used as the source of HDR brachytherapy. Late complication was assessed from grade 1 to 5 using the RTOG morbidity grading system. Results : The local control rate (LCR) at 5 years was $80\%$ in group A and $84\%$ in group B (p=0.4523). In the patients treated with radiation therapy alone, LCR at 5 years was $60.9\%$ in group A and $76.9\%$ in group B (p=0.2557). In post-operative radiation therapy patients, LCR at 5 years was $92.6\%$ In group A and $91.6\%$ in group B (p=0.8867). The incidence of late complication was $18\%$ (22 patients) and $29.4\%$ (30 patients), of bladder complication was $9.8\%$ (12 patients) and $14.7\%$ (15 patients), and of rectal complication was $9.8\%$ (12 patients) and $21.6\%$ (22 patients), in group A and B, respectively. Lower fraction sized HDR brachytherapy was associated with decrease in late complication (p=0.0405) (rectal complication, p=0.0147; bladder complication, p=0.115). The same result was observed in postoperative radiation therapy patients (p=0.0860) and radiation only treated patients (0=0.0370). Conclusion : For radiation only treated patients, a greater number of itemized studies on the proper fraction size of HDR brachytherapy, with consideration for stages and prognostic factors, are required. In postoperative radiation therapy, the fraction size of HDR brachytherapy did not have much effect on local control, yet the incidence of late complication increased with the elevation in fraction size. We suggest that HDR brachytherapy three times weekly with 3 Gy could be an alternative method of therapy.

The Relationship among Perceived Stress, Ways of Coping, and Type A/B Personality of College Students (일 전문대 학생들의 스트레스 지각과 대처방식, A/B성격 특성간의 관계)

  • Cho, Mee-Kyung;Jeong, Hyun-Sook
    • Journal of Korean Academy of Nursing Administration
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    • v.7 no.2
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    • pp.183-191
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    • 2001
  • This was designed to identify the relationship among perceived stress, ways of coping, and type A/B personality of college students. The subjects of this study were 279 from one nursing department and one non-nursing department of junior college in Daejon. and the data were collected from June 5 to 9, 2000. The instruments for this study were the Adolescent Life Change Event Questionnaire developed by Mendez, Yeaworth, York(1982) ways of coping scale developed by Lazarus and Folkman(1984), and the type A/B person-ality scale developed by Vickers(1973). The data were analyzed by utilizing SPSS/PC+ program and the results were as follows : 1. The relationship between 2, 3 grade of nursing curriculum and type A personality revealed a positive significant correlation(p=.021). 2. The subjects perceived high stress in the order of stress related to opposite sex, family, friend, self, school. 3. The subjects revealed that they have the use of stress coping in the order of aesthetic thinking, social support, problem-force, emotion-force coping. 4. There was significant difference in perceived stress according to curriculum(p=.000). 5. There was significant difference in ways of stress coping according to personality type(p=.012). 6. 1) There was positive relationship between stress related to school and problem-force coping, and between stress related to opposite sex and emotion-force coping, 2) There was positive relationship between type A personality and problem-force coping, and social support, and aesthetic thinking coping, respectively.

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A comparison of in-patients' satisfaction in hospital foodservice method (급식관리방법에 따른 환자 만족도 비교연구)

  • Kim, Jeong-Hui;Han, Min-Yeon;Kim, Ji-Hyeon;Choe, Jeong-Im;Ha, Seung-Hui
    • Journal of the Korean Dietetic Association
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    • v.2 no.1
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    • pp.10-19
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    • 1996
  • The purpose of this study were to improve in foodservice system, and to evaluate the satisfaction of patient meal. Two General Hospitals (A & B) in Ewha Womans University college of Medicine were selected for this study. The survey questionnaire consisted of general backgrounds and foodservice evaluation. We chosed factors which may influence meal satisfaction such as meal time, amount, optimal temperature, taste, quality, sanitary condition, and employee' s kindness. One-way ANOVA and Pearson' s correlation were used as statistical methods. The results can be summarized as follows 1. In meal time, for the A&B hospitals were 3.46$\pm$0.93 3.63$\pm$0.76 respectively. 2. In cold foods for the A&B hospitals were 3.23$\pm$0.89 3.52$\pm$0.78 respectively while in hot foods 3.29$\pm$1.02 3.27$\pm$0.90 respectively for A&B hospitals. 3. In taste for the A&B hospitals were 2.81$\pm$0.96 3.01$\pm$0.95 respectively. 4. In quality were 2.93$\pm$0.92 3.25$\pm$0.91 respectivly. 5. In amount were 3.38$\pm$0.95 3.36$\pm$0.98 respectively. 6. In sanitary condition for the A&B hospitals were 3.55$\pm$0.88 3.12$\pm$0.97 respectively. 7. In kindness were 3.11$\pm$0.87 3.32$\pm$0.76 respectively. 8. Quality, taste, meal time, kindness, sanitary condition, temperature, amount, age, duration, and room grade were significantly correlated to the satisfaction of patient meal in order.

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Effects of Bovine Somatotropin (bST) Administration Combined with Controlled Internal Drug Release (CIDR) on Embryo Quality and Pregnancy of Hanwoo (Korean Native Beef Cattle) during Commercial Embryo Transfer Program

  • Lee, Ho-Jun;Hwang, Seongsoo;Yoon, Jong-Taek
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.2
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    • pp.194-199
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    • 2007
  • Effects of recombinant bovine somatotropin (bST) on plasma hormonal concentration, embryo quality, and pregnancy rate were examined during the superovulation and synchronization treatment in donor and recipient cows. Hanwoos (Korean native beef cattle) were treated with controlled internal drug release (CIDR) combined with bST (CIDR+bST) or without bST (CIDR) as donor cows. The embryos recovered from donors were transferred into Holstein recipient heifers treated with bST (CIDR+bST) or without bST (CIDR) for synchronization. The correlation between IGF-I and P4 showed a positive pattern in the CIDR+bST group (r=0.44, p<0.01), but a negative pattern was shown in the CIDR group (r = -0.59, p<0.02) at day 7 of estrous cycles. Although the number of recovered, transferable, and degenerated embryos was not different, quantities of grade 1 (excellent) embryos in CIDR+bST group were significantly higher than those of the CIDR group (p<0.01). The pregnancy rate was higher in the CIDR+bST recipient group compared to CIDR group (p<0.05), when the embryos were recovered from the donors treated with CIDR. However, the pregnancy was maintained highly in both recipient groups, when the embryos were produced by CIDR+bST treated donors. It can be concluded that bST administration combined with CIDR is an effective method for superovulation and synchronization treatment to stabilize plasma hormonal levels, to obtain excellent quality of embryos, and to get higher pregnancy rate.

NIRS Calibration Equation Development and Validation for Total Nitrogen Contents Field Analysis in Fresh Rice Leaves (벼 생엽의 질소함량 현장분석을 위한 NIRS 검량식 개발 및 검증)

  • Song, Young-Eun;Lee, Deok-Ryeol;Cho, Seong-Hyun;Lee, Ki-Kwon;Jeong, Jong-Seong;Gwon, Yeong-Rip;Cho, Kyu Chae
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.58 no.3
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    • pp.301-307
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    • 2013
  • This study was evaluated high end research grade Near Infrared Reflectance Spectrophotometer (NIRS) to field grade multiple Near Infrared Reflectance Spectrophotometer (NIRS) for rapid analysis at fresh rice leaf at sight with 238 samples of fresh rice leaf during year 2012, collected Jeollabuk-do for evaluate accuracy and precision between instruments. Firstly collected and build database high end research grade NIRS using with 400 nm ~ 2500 nm during from year 2003 to year 2009, seven years collected fresh rice leaf database then trim and fit to field grade NIRS with 1200 nm ~ 2400 nm then build and create calibration, transfer calibration with special transfer algorithm. The result between instruments was 0.005% differences, rapidly analysis for chemical constituents, Total nitrogen in fresh rice leaf within 5 minutes at sight and the result equivalent with laboratory data. Nevertheless last during more than 8 years collected samples for build calibration was organic samples that make differentiate by local or yearly bases etc. This strongly suggest population evaluation technique needed and constantly update calibration and maintenance calibration to proper handling database accumulation and spread out by knowledgable control laboratory analysis and reflect calibration update such as powerful control center needed for long lasting usage of fresh rice leaf analysis with NIRS at sight. Especially the agriculture products such as rice will continuously changes that made easily find out the changes and update routinely, if not near future NIRS was worthless due to those changes. Many research related NIRS was shortly study not long term study that made not well using NIRS, so the system needed check simple and instantly using with local language supported signal methods global distance (GD) and neighbour distance (ND) algorithm. Finally the multiple popular field grades instruments should be the same results not only between research grade instruments but also between multiple field grade instruments that needed easily transfer calibration and maintenance between instruments via internet networking techniques.

Studies on the Improvement of Embryo Transfer Efficiency in Korean Cattle I. Effect of Embryo Conditions on Pregnancy Rate after Embryo Transfer (한우에서 수정란 이식의 효율 증진에 대한 연구 I. 수정란의 조건이 이식 후 수태율에 미치는 영향)

  • 김흥률;김덕임;원유석;김창근;정영채;이규승;서길웅;박창식
    • Journal of Embryo Transfer
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    • v.13 no.1
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    • pp.53-60
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    • 1998
  • This study was carried out to establish an effective system for embryo transfer techniques by analyzing several factors affecting in-vivo embryo transfer in Korean cattle. Embryos produced in-vivo were transferred into a total of 301 recipients. The results obtained in studies on the factors affecting pregnancy rate after embryo transfer by condition of embryos were as follow ; 1. The pregnancy rate of 301 recipients was 45.2% and higher with fresh embryos than with frozen embryos(63.5% : 21.4%, P<0.01). Embryos superovurated by FSH-P had slightly greater than by SUPER-OV in pragnancy rate, athough these were no difference between two treatments. 2. The pregnancy rates of transferred morulae and blastocysts showed no difference between fresh and frozen embryos(63.5% : 63~6% ; 20.0% : 25.8%). However, the pregnancy rates by quality of flesh and frozen embryos were significantly different(P<0~05). The pregnancy rates were outstandingly high in the grade A, B of fresh embryos(59.0~66.4%), and in the grade A of frozen embryos(43.6%). 3. The number of transferred embryos showed no difference in pregnancy rate, but when frozen embryos transferred, the pregnancy rate was slightly higher with two embryos than that with one embryo.

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Low Grade Pulmonary Lymphomatoid Granulomatosis with an Endobronchial Mass

  • Kim, Kyung Hoon;Park, Jinhee;Yoo, Ji Yeon;Kim, Min Jae;Kim, Il;Rhee, Chin Kook;Lee, Hea Yon
    • Tuberculosis and Respiratory Diseases
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    • v.78 no.2
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    • pp.137-141
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    • 2015
  • Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive neoplastic proliferation of B and T lymphocytes commonly involving the lungs. Epstein-Barr virus is commonly detected in lesional cells. We report a case of a 54-year-old female with underlying monoclonal gammopathy of unknown significance who presented with a 4 week history of dyspnea and cough. Computed tomography scan of the chest showed multiple lung nodules as well as endobronchial narrowing causing atelectasis at the left upper lobe. Bronchoscopic findings revealed obstruction at the lingula segment due to endobronchial mass as a rare presentation. Bronchoscopic biopsy was diagnosed with LYG grade 1. After treatment, the endobronchial mass and lung lesions were completely resolved. However, the patient eventually evolved to malignant lymphoma after 1 year.

Effect of TempCore Processing on Microstructure and Mechanical Properties of 700 MPa-Grade High-Strength Seismic Resistant Reinforced Steel Bars (700 MPa급 고강도 내진 철근의 미세조직과 기계적 특성에 미치는 템프코어 공정의 영향)

  • Shin, S.H.;Kim, S.K.;Lim, H.G.;Hwang, B.
    • Transactions of Materials Processing
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    • v.30 no.2
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    • pp.91-98
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    • 2021
  • The present study deals with the microstructure and mechanical properties of 700 MPa-grade high-strength seismic resistant reinforced steel bars fabricated by various TempCore process conditions. For the steel bars, in the surface region tempered martensite was formed by water cooling and subsequent self-tempering during TempCore process, while in the center region there was ferrite-pearlite or bainite microstructure. The steel bar fabricated by the highest water flow and the lowest equalizing temperature had the highest hardness in all regions due to the relatively fine microstructure of tempered martensite and bainite. In addition, the steel bar having finer microstructures as well as the high fraction of tempered martensite in the surface region showed the highest yield and tensile strengths. The presence of vanadium precipitates and the high fraction of ferrite contributed to the improvement of seismic resistance such as high tensile-to-yield strength ratio and high uniform elongation.