• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.889-896
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• 2015

Matrix metalloproteinase-2 (MMP2) is an endopeptidase, mainly responsible for degradation of extracellular matrix components, which plays an important role in cancer disease. A single nucleotide polymorphism (SNP) at -1306 disrupts a Sp1-type promoter site. The results from the published studies on the association between MMP2 -1306 C>T polymorphism and cancer risk are contradictory and inconclusive. In the present study, a meta-analysis was therefore performed to evaluate the strength of any association between the MMP2 -1306 C>T polymorphism and risk of cancer. We searched all eligible studies published on association between MMP2 -1306 C>T polymorphism and cancer risk in PubMed (Medline), EMBASE and Google Scholar online web databases until December 2013. Genotype distribution data were collected to calculate the pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) to examine the strength of the association. A total of 8,590 cancer cases and 9,601 controls were included from twenty nine eligible case control studies. Overall pooled analysis suggested significantly reduced risk associated with heterozygous genotype (CT vs CC: OR=0.758, 95%CI=0.637 to 0.902, p=0.002) and dominant model (TT+CT vs CC: OR=0.816, 95%CI=0.678 to 0.982, p=0.032) genetic models. However, allelic (T vs C: OR=0.882, 95%CI=0.738 to 1.055, p=0.169), homozygous (TT vs CC: OR=1.185, 95%CI=0.825 to 1.700, p=0.358) and recessive (TT vs CC+CT: OR=1.268, 95%CI=0.897 to 1.793, p=0.179) models did not show any risk. No evidence of publication bias was detected during the analysis. The results of present meta-analysis suggest that the MMP2 -1306 C>T polymorphism is significantly associated with reduced risk of cancer. However, further studies with consideration of different populations will be required to evaluate this relationship in more detail.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3117-3122
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• 2016

Background: Health-care research is a neglected discipline in Pakistan and research related to esophageal cancer (ranks 9th in Pakistani males and 5th in females) is no exception in this regard. Particularly, there are no data available to delineate the overall status of esophageal cancer epidemiological studies in Pakistan. This study describes the first ever effort to make a systematic quantification, in an attempt to provide a road-map to all stakeholders for designing appropriate epidemiological, diagnostic and therapeutic strategies. Materials and Methods: International (PubMed, ISI Web of Knowledge) and local (PakMedinet) scientific databases as well as Google search engine were searched using specified keywords to extract relevant publication. Well-defined inclusion criteria were implemented to select publications for final analyses. All data were recorded by at least 3 authors and consensus data were entered into and analyzed for descriptive statistics (such as frequencies, percentages and annual growth rates) using Microsoft Excel and SPSS software. Results: A total of 79 publications fulfilled the inclusion criteria including 20 publications for which full texts were not available. Of the 79 publications, 59 (74.6%) were original/research publications, 5 (6.3%) were case reports, 4 (5.1%) were research communications, 2 (2.5%) were review articles, 1 was (1.2%) correspondence and 8 (10.1%) were undefined categories. Only 13 (<20%) cities of Pakistan contributed towards the 79 publications. On average, only 1.9 relevant publications/year were published from 1976 (year of first publication) to the present. Alarmingly, a decline in the annual growth at -4.1% was recorded in the last six years. Conclusions: Esophageal cancer research is largely unfathomed in Pakistan. Urgent/dramatic steps are required by all concerned to address this common (and under reported) cancer of Pakistan.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.6
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• pp.27-36
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• 2015

The purpose of this study was to investigate the influence relationships among individual career orientation, preparation of old age, social networks, and the entrepreneurial intention of the potential entrepreneurs. 408 numbers of structured questionnaire were collected from the potential entrepreneurs who live in Seoul through the online Google survey method and offline face to face method. And the collected data was analyzed on frequency analysis, validity analysis, t-test, ANOVA, and regression analysis etc. using the SPSS WIN 21.0 program. The results are as follows. Firstly, innovation, entrepreneurial creativity, and autonomy orientation affect on entrepreneurial intention positively(+), but security orientation has a negative(-) effect on entrepreneurial intention in the influence relationships between individual career orientation and entrepreneurial intention. Secondly, economical and emotional preparation have positive(+) influences on entrepreneurial intention in the influence relationships between individual career orientation and entrepreneurial intention. Thirdly, the sub-variables of social networks, that is, assist and role models exert a positive(+) influence on entrepreneurial intention in the influence relationships between social networks and entrepreneurial intention. Fourthly, social networks plays a moderating role only on the relationship between security orientation and entrepreneurial intention in the analysis about the moderating effects of social networks on the influence relationships among individual career orientation, preparation of old age, and entrepreneurial intention. Fifth, a social network of relationships to help prepare the old establishment has been found to help regulate effective analysis of whether or not the results of adjustment.

• Journal of Technology Innovation
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• v.23 no.1
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• pp.1-36
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• 2015

The purpose of this research is to find individual user's preference for cloud storage service such as Daum Cloud, Naver N-Drive, GoogleDrive, Dropbox, SkyDrive and iCloud. Through literature reviewed and pilot tests, 6 attributes of cloud storage service (storage capacity, perceived cost, collaboration, accessibility, social influence and perceived security) were selected and all 6 attributes had significant effects on the preference of cloud storage service by conjoint analysis. The results shows that the user's willingness to pay is estimated 10,553 won for the free storage, 4,646 won for the function for mobile accessibility, and 2,443 won for more reliable cloud computing service provider. This study has significance to apply conjoint analysis with economic, technological, and environmental factors to cloud storage service (SaaS) and shed light on policy promotion of next generation of cloud computing ecosystem by user perception with willingness to pay on the storage service.

• Therapeutic Science for Rehabilitation
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• v.9 no.4
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• pp.95-106
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• 2020

Objective : The purpose of this study was to systematically review sex differences in episodic memory. Methods : We searched previous studies published in all electronic databases between 2010 and 2019. The key terms used in the search were 'sex differences' or 'gender differences' and 'episodic memory' or 'autobiographical memory'. 8 studies were finally extracted for analysis. Results : The 8 studies had evidence levels of II (67.5%) and III (37.5%), which are quite high. Healthy younger adults or healthy adults were recruited to examine sex differences in episodic memory. Assessment methods for episodic memory were mainly divided into cognitive tasks or standardized tests using visual or auditory stimuli. Subjects were instructed to memorize the stimuli and asked to recall them after some time. Overall females outperformed male. In particular, there were significant sex differences in verbal episodic memory. In contrast, there was no significant sex difference in visual episodic memory. Conclusion : To identify sex differences in episodic memory, a variety of test methods were used in various ways. Overall, females showed higher episodic memory than males. These findings suggest a need for cognitive intervention considering sex differences in the clinic. In the future, episodic memory tests with high ecological validity should be conducted to investigate sex differences in episodic memory.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.4
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• pp.262-272
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• 2020

A large number of studies on wave breaking have been carried out, and many experimental data have been documented. Moreover, on the basis of various experimental data set, many empirical or semi-empirical formulas based primarily on regression analysis have been proposed to quantitatively estimate wave breaking for engineering applications. However, wave breaking has an inherent variability, which imply that a linear statistical approach such as linear regression analysis might be inadequate. This study presents an alternative nonlinear method using an neural network, one of the machine learning methods, to estimate breaking wave height and breaking depth. The neural network is modeled using Tensorflow, a machine learning open source platform distributed by Google. The neural network is trained by randomly selecting the collected experimental data, and the trained neural network is evaluated using data not used for learning process. The results for wave breaking height and depth predicted by fully trained neural network are more accurate than those obtained by existing empirical formulas. These results show that neural network is an useful tool for the prediction of wave breaking.

• Journal of Internet Computing and Services
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• v.16 no.1
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• pp.83-90
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• 2015

This paper examines the rising value of social networked journalism and analyzes the case of a social news site based on the theory of networked journalism. Social networked journalism allows the public to be involved in every aspect of journalism production through crowd-sourcing and interactivity. The networking effect with the public is driving journalism to transform into a more open, more networked and more responsive venue. "wikitree" is a social networking news service on which anybody can write news and disseminate it via Facebook and Twitter. It is operated as an open sourced program which incorporates "Google Translate" to automatically convert all its content, enabling any global citizen with an Internet access to contribute news production and share either their own creative contents or generated contents from other sources. Since its inception, "wikitree global" site has been expanding its coverage rapidly with access points arising from 160 countries. Analyzing its international coverage by country and by news category as well as by the unique visit numbers via SNS, the results of the case study imply that networking with the global public can enhance news traffic to the social news site as well as to specific news items. The results also suggest that the utilization of Twitter and Facebook in social networked journalism can break the boundary between local and global public by extending news-gathering ability while growing audience's interest in the site, and engender a feasible business model for a local online journalism.

• The Journal of Korean Academy of Sensory Integration
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• v.11 no.2
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• pp.41-56
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• 2013

Objective : The purpose of this study tried to present the performed average and range through systematic review about assessment tools that measures the praxis ability of sensory integrative function for foreign and domestic normal children. Methods: With making use of Medline, PubMed, Ovid, Eric, the Library of Congress, National Science and Technology Information Center, Kiss, RISS, and the Google search engine, we searched the name of assessment tool on the basis of the framework of the theory of sensory integration. Target paper was thesis and Journal published from January 2000 to April 2011. Results: Total of 24 papers were retrieved, used assessment tools were Bruininks-Oseretsky Test of Motor Proficiency (BOTMP), Bruininks-Oseretsky Test of Motor Proficiency, Short Form (BOTMP-SF), Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2), Bruininks-Oseretsky Test of Motor Proficiency, Second Edition, Short Form (BOT-2-SF), Clinical Observations of Motor and Postural Skills (COMPS), Motor Assessment Battery for Children (MABC), Clinical Test of Sensory Interaction with Balance (CTSIB), and subtest of Sensory Integration and Praxis Test (SIPT). We presented the average and range of assessment tools applied to normal children in each country. Conclusion: A performed result in other cultural and domestic normal children which this study presented will provide a standard in comparison with performance of children with disabilities who are the actual clinical evaluation.

• Informatization Policy
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• v.25 no.3
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• pp.3-28
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• 2018

The purpose of this study is to analyze the research trends and present future research directions in the field of Cyber Physical System (CPS), a key element in the 4th Industrial Revolution, Industry 4.0, and Smart Manufacturing that are currently promoted as important innovation agenda both at home and abroad. In this study, (1) the concepts of industry 4.0, smart manufacturing and CPS are summarized; (2) analysis criteria of these fields are established; and 3) analysis results are presented and future research direction is proposed. 74 overseas and 8 domestic literature on manufacturing CPS from 2013 to 2017 are identified through 'Google Scholar Search'. Major results of the analysis are summarized as follows: (1) research on a common methodology and framework for the manufacturing CPS needs to be done based on the analysis of the existing methodologies and frameworks of various perspectives; (2) in order to improve the maturity of the manufacturing CPS, it is necessary to study actual deployment and operations of CPS, including the existing systems; (3) it is necessary to study the diagnostic methodology that can evaluate manufacturing CPS and suggest improvement strategy; and (4) as for the detailed model and tool, it is necessary to reinforce research on SCM production planning and human-machine collaboration while considering the characteristics of CPS.

• Journal of Information Management
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• v.38 no.3
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• pp.183-209
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• 2007

The representative example of the business model on internet environment, the business of the Naver, Empas and Google which provides information retrieval service is the internet portal. The portal sites provide information retrieval service which provides users information what they want to find, that is a huge social contribution. The portal site which provides a search service leads much problems. Consequently, the regulation against information retrieval is asserted powerfully in spite of the public interest. Namely, the regulation regarding the search business owner is tried. Finally, portal business owner puts the social responsibility as OSP. But, there is a doubt that portal business owner who has much problem which occurred on the portal site indirectly has responsibility directly. That is duty on portal site owner the censorship on the contents transferred. So, this thesis researches on the social critical opinion relating with a information retrieval from the legal side against the problem of the Internet.