• Ocean and Polar Research
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• v.26 no.2
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• pp.377-384
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• 2004

Annual variations of inorganic nutrients such as nitrate(+nitrite), phosphate and silicate in association with thermocline were investigated in the upper 200 m of the water column at KODES Long-term Monitoring (KOMO) station in the northeast equatorial Pacific from 1995 to 2002. Global climatic disturbances such as El Nino and La Nina, should have affected KODES area during the study period. In 1995-97 and 2000-2002, a thermocline where temperatures rapidly decrease with depth, was formed at 50-70 m water depth. Nutrient depletion, specially for nitrate and phosphate, was extended down to approximately 50 m depth, which coincided with the surface mixed layer depth. In 1998 and 1999, however a very fluctuating thermocline was observed at 20-100 m water depth. In the photic zone (up to 100 m depth), depth integration of nitrate, phosphate and silicate ranged from 2.02 to $23.14\;gN/m^2$, from 0.87 to $4.05\;gP/m^2$ and from 35.67 to $176.21\;gSi/m^2$, respectively. As a result of changes in the water column structures, nutrient concentrations also showed fluctuation parallel to the changes of thermocline in the study area.

• Journal of KIISE:Software and Applications
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• v.37 no.1
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• pp.80-84
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• 2010

Tracking hands is an essential technique for hand gesture recognition which is an efficient way in Human Computer Interaction (HCI). Recently, many researchers have focused on hands tracking using a 3D hand model and showed robust tracking results compared to using 2D hand models. In this paper, we propose a novel 3D hand tracking method based on a coupled particle filter. This provides robust and fast tracking results by estimating each part of global hand poses and local finger motions separately and then utilizing the estimated results as a prior for each other. Furthermore, in order to improve the robustness, we apply a multi-cue based method by integrating a color-based area matching method and an edge-based distance matching method. In our experiments, the proposed method showed robust tracking results for complex hand motions in a cluttered background.

• Journal of Navigation and Port Research
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• v.30 no.6 s.112
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• pp.509-515
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• 2006

As international trade has been increased, the competition of major ports is getting hard. The objective of this competition is that to get more cargoes, so port managements and operators are struggling to obtain cargoes. In addition the competition structure has classified several forms bemuse of specialization, integration and subdivision of port players. In this paper, therefore, we analyze the change of competition structure by port players' development characteristics. In the result of this study, competition structure is divided into five groups as among nations, among ports, among container terminal operation companies, among global container terminal operation companies and among container terminal operation companies operated by shipping companies. And they have showed not only competition but also co-operation partly in order to get strategic position.

• Journal of Microbiology and Biotechnology
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• v.19 no.7
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• pp.635-646
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• 2009

Rapid and accurate diagnosis of diseases is very important for appropriate treatment of patients. Recent advances in molecular-level interaction and detection technologies are upgrading the clinical diagnostics by providing new ways of diagnosis, with higher speed and accuracy. In particular, DNA microarrays can be efficiently used in clinical diagnostics which span from discovery of diseaserelevant genes to diagnosis using its biomarkers. Diagnostic DNA microarrays have been used for genotyping and determination of disease-relevant genes or agents causing diseases, mutation analysis, screening of single nucleotide polymorphisms (SNPs), detection of chromosome abnormalities, and global determination of posttranslational modification. The performance of DNA-microarray-based diagnosis is continuously improving by the integration of other tools. Thus, DNA microarrays will play a central role in clinical diagnostics and will become a gold standard method for disease diagnosis. In this paper, various applications of DNA microarrays in disease diagnosis are reviewed. Special effort was made to cover the information disclosed in the patents so that recent trends and missing applications can be revealed.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.6
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• pp.447-456
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• 2014

Until now, a disease-modifying therapy (DMT) that has an ability to slow or arrest Alzheimer's disease (AD) progression has not been developed, and all clinical trials involving AD patients enrolled by clinical assessment alone also have not been successful. Given the growing consensus that the DMT is likely to require treatment initiation well before full-blown dementia emerges, the early detection of AD will provide opportunities to successfully identify new drugs that slow the course of AD pathology. Recent advances in early detection of AD and prediction of progression of the disease using various biomarkers, including cerebrospinal fluid (CSF) $A{\beta}_{1-42}$, total tau and p-tau181 levels, and imagining biomarkers, are now being actively integrated into the designs of AD clinical trials. In terms of therapeutic mechanisms, monitoring these markers may be helpful for go/no-go decision making as well as surrogate markers for disease severity or progression. Furthermore, CSF biomarkers can be used as a tool to enrich patients for clinical trials with prospect of increasing statistical power and reducing costs in drug development. However, the standardization of technical aspects of analysis of these biomarkers is an essential prerequisite to the clinical uses. To accomplish this, global efforts are underway to standardize CSF biomarker measurements and a quality control program supported by the Alzheimer's Association. The current review summarizes therapeutic targets of developing drugs in AD pathophysiology, and provides the most recent advances in the clinical utility of CSF biomarkers and the integration of CSF biomarkers in current clinical trials.

• Journal of the Korean Society of Systems Engineering
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• v.9 no.2
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• pp.23-36
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• 2013

Plant industry is one of technology-intensive and most prosperous industries in Korea because of its recent prosperity and promising outlook in export. However, no Korean EPC company has yet been well prepared in lifting their capacity sufficient enough to get the upstream conceptual or basic design and engineering orders for sizable plant projects which are known as the more value-added. If systems engineering, a methodology which developed complex systems such as airplanes and has been justified its effectiveness in Defense and NASA projects, can be integrated with plant engineering which should be developed and applied based on the requirements of so many stakeholders, conditions, lifecycle concepts, and constraints of the projects, huge synergic effect is expected particularly in developing a specific upstream design, which is a conceptual or basic design. The notion of integration with each other between systems engineering and plant engineering can be really the crux of EPC's success in any plant projects. This paper suggests an approach showing a methodology how to dig out, analyze, evaluate, verify and implement the stakeholders' requirements into a plant design in conceptual phase using the theory and skills of systems engineering. ISO/IEC 15288 well known systems engineering standards is used. Carbon capture system is used for a case study, for it is an emerging technology in reducing emissions of carbon dioxide causing global warming from flue gas after combustion. Here systems engineering was proven to play a substantial role in enhancing the capability of designers in developing a conceptual design of whole plant or certain part of crucial plant systems.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.444-448
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• 2005

This paper presents a developing procedure of the CAN-based real-time simulator for car body control, aiming at replacing the actual W/H (Wiring Harness) and J/B(Junction Box) couple eventually. The CAN protocol, as one kind of field-bus communication, defines the lowest 2 layers of the ISO/OSI standard, namely, the physical layer(PL) and the data link layer(DLL), for which the CSMA/NBA protocol is generally adopted. For CPU, two PIC18Fxx8x's are used because of their built-in integration of CAN controller, large internal FLASH memory (48K or 64K), and their costs. To control J/B's and actuators, 2 controller boards are separately implemented, between which CAN lines communicate through CAN transceivers MCP255. A power motor for washing windshield, 1 door lock motor, and 6 blink lamps are chosen for actuators of the simulator for the first stage. For the software architecture, a polling method is used for the fast global response time despite its slow individual response time. To improve the individual response time and to escape from some eventual trapped-function loops, High/Low ports of the CPU are simply used, which increases the stability of the actuator modules. The experimental test shows generally satisfactory results in normal transmitting / receiving function and message trace function. This simulator based on CAN shows a promising usefulness of lighter, more reliable and intelligent distributed body control approach than the conventional W/H and J/B couple. Another advantage of this approach lies in the distributed control itself, which gives better performance in hard real-time computing than centralized one, and in the ability of integrating different modules through CAN.

• Journal of Institute of Control, Robotics and Systems
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• v.19 no.7
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• pp.646-652
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• 2013

EU's Galileo project is a market-based GNSS (Global Navigation Satellite System) that is under development. It is expected that Galileo will provide the positioning services based on new technologies in 2020s. Because Galileo E1 signal for OS (Open Service) shares the same center frequency with GPS L1 C/A signal, CBOC (Composite Binary Offset Carrier) modulation scheme is used in the E1 signal to guarantee interoperability between two systems. With E1 signal consisting of a data channel and a pilot channel at the same frequency band, there exist several options in designing signal acquisition for Assisted-Galileo receivers. Furthermore, compared to SNR worksheet of Assisted-GPS, some factors should be examined in Assisted-Galileo due to different correlation profile and code length of E1 signal. This paper presents SNR worksheets of Galileo E1 signals in E1-B and E1-C channel. Three implementation losses that are quite different from GPS are mainly analyzed in establishing SNR worksheets. In the worksheet, hybrid long integration of 1.5s is considered to acquire weak signal less than -150dBm. Simulation results show that the final SNR of E1-B signal with -150dBm is 19.4dB and that of E1-C signal is 25.2dB. Comparison of relative computation shows that E1-B channel is more profitable to acquire the strongest signal in weak signal environment. With information from the first satellite signal acquisition, fast acquisition of the weak signal around -155dBm can be performed with E1-C signal in the subsequent satellites.

• Journal of the Korean Association of Geographic Information Studies
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• v.11 no.3
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• pp.68-79
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• 2008

Ground vehicle borne system which is named RoSSAV(Road Safety Survey and Analysis Vehicle) developed in KICT(Korea Institute of Construction Technology) can collect road geometric data. This system therefore is able to evaluate the road safety and analyze road deficient sections using data collected along the roads. The purpose of this study is to extract road geometric data for 3D road modeling in dangerous road section and The system should be able to quickly provide more accurate data. Various sensors(circular laser scanner, GPS, INS, CCD camera and DMI) are installed in moving object and collect road environment data. Finally, We extract 3d road geometry(center, boundary), road facility and slope using integrated multi-sensor data.

• Journal of Power Electronics
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• v.13 no.5
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• pp.766-778
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• 2013

The depletion of natural resources and renewable energy sources, such as photovoltaic (PV) energy, has been highlighted for global energy solution. The PV power control unit in the PV power-generation technology requires a high step-up DC-DC converter. The conventional step-up DC-DC converter has low efficiency and limited step-up ratio. To overcome these problems, a novel high step-up DC-DC converter using an isolated switched capacitor cell is proposed. The step-up converter uses the proposed transformer and employs the switched-capacitor cell to enable integration with the boost inductor. The output of the boost converter and isolated switched-capacitor cell are connected in series to obtain high step-up with low turn-on ratio. A hardware prototype with 30 V to 40 V input voltage and 340 V output voltage is implemented to verify the performance of the proposed converter. As an extended version, another novel high step-up isolated switched-capacitor single-ended DC-DC converter integrated with a tapped-inductor (TI) boost converter is proposed. The TI boost converter and isolated-switched-capacitor outputs are connected in series to achieve high step-up. All magnetic components are integrated in a single magnetic core to lower costs. A prototype hardware with 20 V to 40 V input voltage, 340 V output voltage, and 100 W output power is implemented to verify the performance of the proposed converter.