• Title/Summary/Keyword: genetic safety

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Determination of natural periods of vibration using genetic programming

  • Joshi, Shardul G.;Londhe, Shreenivas N.;Kwatra, Naveen
    • Earthquakes and Structures
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    • v.6 no.2
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    • pp.201-216
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    • 2014
  • Many building codes use the empirical equation to determine fundamental period of vibration where in effect of length, width and the stiffness of the building is not explicitly accounted for. Also the equation, estimates the fundamental period of vibration with large safety margin beyond certain height of the building. An attempt is made to arrive at the simple empirical equations for fundamental period of vibration with adequate safety margin, using soft computing technique of Genetic Programming (GP). In the present study, GP models are developed in four categories, varying the number of input parameters in each category. Input parameters are chosen to represent mass, stiffness and geometry of the buildings directly or indirectly. Total numbers of 206 buildings are analyzed out of which, data set of 142 buildings is used to develop these models. It is observed that GP models developed under B and C category yield the same equation for fundamental period of vibration along X direction as well as along Y direction whereas the equation of fundamental period of vibration along X direction and along Y direction is of the same form for category D. The equations obtained as an output of GP models clearly indicate the influence of mass, geometry and stiffness of the building over fundamental period of vibration. These equations are then compared with the equation recommended by other researcher.

Genotoxicity Study of Glycopeptide (G-7%NANA)

  • Kim, Ha-Young;Kim, Min-Hee;Kim, Hee-Kyong;Park, Yeong-Chul
    • Toxicological Research
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    • v.34 no.3
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    • pp.259-266
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    • 2018
  • Glycomacropeptide (GMP), a whey protein of milk, has functions including differentiation and development of nervous system, and anticancer and antiviral effects. To develop new functions, N-acetylneuraminic acid (NANA) containing 7% sialic acid was separated from GMP to produce G-7%NANA. N-glycolylneuraminic acid (Neu5Gc) is another type of sialic acid separated from GMP, which has been linked to immune disorders and chronic inflammation-mediated diseases. Therefore, safety was a concern in the use of G-7%NANA in functional foods. To ensure safety, in this study, three genetic toxicity tests on G-7%NANA were conducted. In the reverse mutation test using Salmonella typhimurium TA98, TA100, TA1535, TA1537, and Escherichia coli WP2uvrA, and in the chromosome aberration test using CHO-K1 cells, no significant differences from negative control were found at all dose levels. Similarly, no dose-related differences were evident compared to negative control in the micronucleus test using ICR mice. There was no evidence of G-7%NANA-related genetic toxicity.

Study of Integrated Production-Distribution Planning Using Simulation and Genetic Algorithm in Supply Chain Network (공급사슬네트워크에서 시뮬레이션과 유전알고리즘을 이용한 통합생산분배계획에 대한 연구)

  • Lim, Seok-Jin
    • Journal of the Korea Safety Management & Science
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    • v.22 no.4
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    • pp.65-74
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    • 2020
  • Many of companies have made significant improvements for globalization and competitive business environment The supply chain management has received many attentions in the area of that business environment. The purpose of this study is to generate realistic production and distribution planning in the supply chain network. The planning model determines the best schedule using operation sequences and routing to deliver. To solve the problem a hybrid approach involving a genetic algorithm (GA) and computer simulation is proposed. This proposed approach is for: (1) selecting the best machine for each operation, (2) deciding the sequence of operation to product and route to deliver, and (3) minimizing the completion time for each order. This study developed mathematical model for production, distribution, production-distribution and proposed GA-Simulation solution procedure. The results of computational experiments for a simple example of the supply chain network are given and discussed to validate the proposed approach. It has been shown that the hybrid approach is powerful for complex production and distribution planning in the manufacturing supply chain network. The proposed approach can be used to generate realistic production and distribution planning considering stochastic natures in the actual supply chain and support decision making for companies.

Application of artificial neural network for the critical flow prediction of discharge nozzle

  • Xu, Hong;Tang, Tao;Zhang, Baorui;Liu, Yuechan
    • Nuclear Engineering and Technology
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    • v.54 no.3
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    • pp.834-841
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    • 2022
  • System thermal-hydraulic (STH) code is adopted for nuclear safety analysis. The critical flow model (CFM) is significant for the accuracy of STH simulation. To overcome the defects of current CFMs (low precision or long calculation time), a CFM based on a genetic neural network (GNN) has been developed in this work. To build a powerful model, besides the critical mass flux, the critical pressure and critical quality were also considered in this model, which was seldom considered before. Comparing with the traditional homogeneous equilibrium model (HEM) and the Moody model, the GNN model can predict the critical mass flux with a higher accuracy (approximately 80% of results are within the ±20% error limit); comparing with the Leung model and the Shannak model for critical pressure prediction, the GNN model achieved the best results (more than 80% prediction results within the ±20% error limit). For the critical quality, similar precision is achieved. The GNN-based CFM in this work is meaningful for the STH code CFM development.

Generalized Solution Procedure for Slope Stability Analysis Using Genetic Algorithm (유전자 알고리즘을 이용한 사면안정해석의 일반화 해법)

  • Shin, Eun-Chul;Patra, Chittaranjan R.;Pradhan, R.
    • Journal of the Korean Geotechnical Society
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    • v.24 no.3
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    • pp.5-11
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    • 2008
  • This paper pertains to the incorporation of a genetic algorithm methodology for determining the critical slip surface and the corresponding factor of safety of soil slopes using inclined slice method. The analysis is formulated as a constrained optimization problem to solve the nonlinear equilibrium equations and finding the factor of safety and the critical slip surface. The sensitivity of GA optimization method is presented in terms of development of failure surface. Example problem is presented to demonstrate the efficiencies of the genetic algorithm approach. The results obtained by this method are compared with other traditional optimization technique.

Prevalence of plasmid-mediated quinolone and tetracycline resistance genes in Aeromonas strains isolated from eel (Anguilla japonica) and ornamental fish

  • Gee-Wook Shin;Jun-Hwan Park;Hui-Ju Kim
    • Journal of fish pathology
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    • v.36 no.2
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    • pp.287-292
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    • 2023
  • This study investigated the genetic determinants of plasmid-mediated antibiotic resistance (PMAR) to quinolones and tetracycline in 106 Aeromonas strains isolated from eel (Anguilla japonica, 70 strains) and ornamental fish (36 strains) in Korea. Quinolones and tetracycline resistance phenotypes were found to be widely distributed throughout the both fish groups. However, the prevalence of qnr and tet genes was higher in ornamental fish strains than in eel strains (42.9% vs. 86.1% for qnr and 51.4% vs. 69.4% for tet). In addition, the profiling of the present genetic determinants revealed the dominance of qnrS, tetA, tetE and tetE+qnrS genes for eel strains but of tetA+qnrS qnrS and tetE+qnrS genes for ornamental fish strains. These results indicate that aquaculture and related industries could be a major threat to public health due to the possible spread of PMAR.

Development of Expertise-based Safety Performance Evaluation Model

  • Yoo, Wi Sung;Lee, Ung-Kyun
    • Journal of the Korea Institute of Building Construction
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    • v.13 no.2
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    • pp.159-168
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    • 2013
  • Construction projects have become increasingly complex in recent years, resulting in substantial safety hazards and frequent fall accidents. In an attempt to prevent fall accidents, various safety management systems have been developed. These systems have mainly been evaluated qualitatively and subjectively by practitioners or supervisors, and there are few tools that can be used to quantitatively evaluate the performance of safety management systems. We propose an expertise-based safety performance evaluation model (EXSPEM), which integrates a fuzzy approach-based analytic hierarchy process and a regression approach. The proposed model uses S-shaped curves to represent the degree of contribution by subjective expertise and is verified by a genetic algorithm. To illustrate its practical application, EXSPEM was applied to evaluate the safety performance of a newly developed real-time mobile detector monitoring system. It is expected that this model will be a helpful tool for systematically evaluating the application of a robust safety control and management system in a complex construction environment.

A Development of a Reliability Prediction Program Using the Field Failure (필드고장을 이용한 신뢰성예측 프로그램 개발)

  • Baek, Jae-Jin;Rhie, Kwang-Won
    • Transactions of the Korean Society of Automotive Engineers
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    • v.20 no.2
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    • pp.1-7
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    • 2012
  • A Failure data from operating condition includes various failures. Reliability evaluation by operating condition is more correct than test condition. Additional, the evaluation result by operating condition is widely used for quality assurance, forecasting amount of manufacturing at EOL. To discover valuable things from the failure data, arrangement of the failure data and information technique to handle data is needed among many failure data. This paper introduces a reliability prediction program to solve this problem based on the failure. And new technologies for parameters estimation with method of Graphic-Wizard-Parameters-Estimation and Genetic Algorithm are introduced.

Balancing and Sequencing of Mixed Model Assembly Lines Using A Genetic Algorithm (유전알고리듬을 이용한 혼합모델 조립라인의 작업할당과 투입 순서 결정)

  • 김동묵;김용주;이남석
    • Proceedings of the Safety Management and Science Conference
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    • 2005.05a
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    • pp.523-534
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    • 2005
  • This paper is concerned with the integrated problem of line balancing and model sequencing in mixed model assembly lines(MMALBS), which is important to efficient utilization of the lines. In the problem, we deal with the objective of minimizing the overall line length To apply the GAs to MMALBS problems, we suggest a GA representation which suitable for its problems, an efficient decoding technique for the objective, and genetic operators which produce feasible offsprings. Extensive experiments are carried out to analyze the performance of the proposed algorithm. The computational results show that our algorithm is promising in solution quality.

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An Efficient Algorithm for Balancing and Sequencing of Mixed Model Assembly Lines (혼합모델 조립라인의 작업할당과 투입순서 결정을 위한 효율적인 기법)

  • Kim Dong Mook;Kim Yong Ju;Lee keon Shang;Lee Nam Seok
    • Journal of the Korea Safety Management & Science
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    • v.7 no.3
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    • pp.85-96
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    • 2005
  • This paper is concerned with the integrated problem of line balancing and model sequencing in mixed model assembly lines(MMALBS), which is important to efficient utilization of the lines. In the problem, we deal with the objective of minimizing the overall line length To apply the GAs to MMALBS problems, we suggest a GA representation which suitable for its problems, an efficient decoding technique for the objective, and genetic operators which produce feasible offsprings. Extensive experiments are carried out to analyze the performance of the proposed algorithm. The computational results show that our algorithm is promising in solution quality.