Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Genotoxicity Study of Glycopeptide (G-7%NANA)

  • Kim, Ha-Young (GLP center and Department of Toxicity Assessment, Daegu Catholic University) ;
  • Kim, Min-Hee (GLP center and Department of Toxicity Assessment, Daegu Catholic University) ;
  • Kim, Hee-Kyong (Hanilbiomed Co.) ;
  • Park, Yeong-Chul (GLP center and Department of Toxicity Assessment, Daegu Catholic University)
  • Received : 2018.04.05
  • Accepted : 2018.06.12
  • Published : 2018.07.15
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Abstract

Glycomacropeptide (GMP), a whey protein of milk, has functions including differentiation and development of nervous system, and anticancer and antiviral effects. To develop new functions, N-acetylneuraminic acid (NANA) containing 7% sialic acid was separated from GMP to produce G-7%NANA. N-glycolylneuraminic acid (Neu5Gc) is another type of sialic acid separated from GMP, which has been linked to immune disorders and chronic inflammation-mediated diseases. Therefore, safety was a concern in the use of G-7%NANA in functional foods. To ensure safety, in this study, three genetic toxicity tests on G-7%NANA were conducted. In the reverse mutation test using Salmonella typhimurium TA98, TA100, TA1535, TA1537, and Escherichia coli WP2uvrA, and in the chromosome aberration test using CHO-K1 cells, no significant differences from negative control were found at all dose levels. Similarly, no dose-related differences were evident compared to negative control in the micronucleus test using ICR mice. There was no evidence of G-7%NANA-related genetic toxicity.

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