• Proceedings of the Korean Geotechical Society Conference
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• 2001.03a
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• pp.379-386
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• 2001

Piled raft foundations are usually used to reduce total and differential settlements of superstructures. In the piled raft foundations, the raft is often on its own able to provide adequate bearing capacity and only few widely spaced piles are added to the foundation to keep settlements be1ow a certain limit. In this paper, experimental studies on the load sharing ratio between piles and raft are carried out. Also, for evaluating the application of optimum design technique using a genetic algorithm, optimal locations of files are compared with the results of laboratory model tests. from tile results of laboratory model tests, there are found that the load sharing ratio between files and raft is depended on the number of piles and stiffness of raft, and the optimal locations of piles became concentrated on the middle of rafts. From these results of laboratory model tests, the optimum technique using a genetic algorithm is acknowledged to the application in the piled raft.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.370-370
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• 2000

In this paper, we design a Multi-Fuzzy model by means of HCM clustering and genetic algorithms for a nonlinear system. In order to determine structure of the proposed Multi-Fuzzy model, HCM clustering method is used. The parameters of membership function of the Multi-Fuzzy ate identified by genetic algorithms. A aggregate performance index with a weighting factor is used to achieve a sound balance between approximation and generalization abilities of the model. We use simplified inference and linear inference as inference method of the proposed Multi-Fuzzy mode] and the standard least square method for estimating consequence parameters of the Multi-Fuzzy. Finally, we use some of numerical data to evaluate the proposed Multi-Fuzzy model and discuss about the usefulness.

• Journal of Institute of Control, Robotics and Systems
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• v.4 no.1
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• pp.76-81
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• 1998

This paper presents an on-line scheme for parameter estimation of continuous-time systems, based on the model adjustment technique and the genetic algorithm technique. To deal with the initialisation and unmeasurable signal problems in on-line parameter estimation of continuous-time systems, a discrete-time model is obtained for the linear differential equation model and approximations of unmeasurable states with the observable output and its time-delayed values are obtained for the nonlinear state space model. Noisy observations may affect these approximation processes and degrade the estimation performance. A digital prefilter is therefore incorporated to avoid direct approximations of system derivatives from possible noisy observations. The parameters of both the model and the designed filter are adjusted on-line by a genetic algorithm, A set of simulation works for linear and nonlinear systems is carried out to demonstrate the effectiveness of the proposed method.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1997.11a
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• pp.267-270
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• 1997

In this paper, we proposed an optimazation method using Genetic Algorithm for nonlinear system modeling. Fuzzy Neural Network(FNNs) was used as basic model of nonlinear system. FNNs was fused of Fuzzy Inference which has linguistic property and Neural Network which has learning ability and high tolerence level. This paper, We used FNNs which was proposed by Yamakawa. The FNNs was composed Simple Inference and Error Back Propagation Algorithm. To obtain optimal model, parameter of membership function, learning rate and momentum coefficient of FNNs are tuned using genetic algorithm. And we used simplex algorithm additionaly to overcome limit of genetic algorithm. For the purpose of evaluation of proposed method, we applied proposed method to traffic choice process and waste water treatment process, and then obtained more precise model than other previous optimization methods and objective model.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.9
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• pp.1387-1399
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• 2020

Objective: The objective of this study was to estimate the genetic parameters and trends for milk, fat, and protein yields in the first three lactations of Thai dairy cattle using a 3-trait,-3-lactation random regression test-day model. Methods: Data included 168,996, 63,388, and 27,145 test-day records from the first, second, and third lactations, respectively. Records were from 19,068 cows calving from 1993 to 2013 in 124 herds. (Co) variance components were estimated by Bayesian methods. Gibbs sampling was used to obtain posterior distributions. The model included herd-year-month of testing, breed group-season of calving-month in tested milk group, linear and quadratic age at calving as fixed effects, and random regression coefficients for additive genetic and permanent environmental effects, which were defined as modified constant, linear, quadratic, cubic and quartic Legendre coefficients. Results: Average daily heritabilities ranged from 0.36 to 0.48 for milk, 0.33 to 0.44 for fat and 0.37 to 0.48 for protein yields; they were higher in the third lactation for all traits. Heritabilities of test-day milk and protein yields for selected days in milk were higher in the middle than at the beginning or end of lactation, whereas those for test-day fat yields were high at the beginning and end of lactation. Genetics correlations (305-d yield) among production yields within lactations (0.44 to 0.69) were higher than those across lactations (0.36 to 0.68). The largest genetic correlation was observed between the first and second lactation. The genetic trends of 305-d milk, fat and protein yields were 230 to 250, 25 to 29, and 30 to 35 kg per year, respectively. Conclusion: A random regression model seems to be a flexible and reliable procedure for the genetic evaluation of production yields. It can be used to perform breeding value estimation for national genetic evaluation in the Thai dairy cattle population.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.10
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• pp.1382-1387
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• 2017

Objective: During the last decade, genetic evaluation of dairy cows using longitudinal data (test day milk yield or 305-day milk yield) using random regression method has been officially adopted in several countries. The objectives of this study were to estimate covariance functions for genetic and permanent environmental effects and to obtain genetic parameters of 305-day milk yield over seven parities. Methods: Data including 60,279 total 305-day milk yield of 17,309 Iranian Holstein dairy cows in 7 parities calved between 20 to 140 months between 2004 and 2011. Residual variances were modeled by homogeneous and step functions with 7 and 10 classes. Results: The results showed that a third order polynomial for additive genetic and permanent environmental effects plus a step function with 10 classes for the residual variance was the most adequate and parsimonious model to describe the covariance structure of the data. Heritability estimates obtained by this model varied from 0.17 to 0.28. The performance of this model was better than repeatability model. Moreover, 10 classes of residual variance produce the more accurate result than 7 classes or homogeneous residual effect. Conclusion: A quadratic Legendre polynomial for additive genetic and permanent environmental effects with 10 step function residual classes are sufficient to produce a parsimonious model that explained the change in 305-day milk yield over consecutive parities of Iranian Holstein cows.

• Animal Bioscience
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• v.34 no.2
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• pp.185-191
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• 2021

Objective: The objective of this study was to estimate the genetic parameters for worm resistance (WR) and associated characteristics, using the linear-threshold animal model via Bayesian inference in single- and multiple-trait analyses. Methods: Data were collected from a herd of Santa Inês breed sheep. All information was collected with animals submitted to natural contamination conditions. All data (number of eggs per gram of feces [FEC], Famacha score [FS], body condition score [BCS], and hematocrit [HCT]) were collected on the same day. The animals were weighed individually on the day after collection (after 12-h fasting). The WR trait was defined by the multivariate cluster analysis, using the FEC, HCT, BCS, and FS of material collected from naturally infected sheep of the Santa Inês breed. The variance components and genetic parameters for the WR, FEC, HCT, BCS, and FS traits were estimated using the Bayesian inference under the linear and threshold animal model. Results: A low magnitude was obtained for repeatability of worm-related traits. The mean values estimated for heritability were of low-to-high (0.05 to 0.88) magnitude. The FEC, HCT, BCS, FS, and body weight traits showed higher heritability (although low magnitude) in the multiple-trait model due to increased information about traits. All WR characters showed a significant genetic correlation, and heritability estimates ranged from low (0.44; single-trait model) to high (0.88; multiple-trait model). Conclusion: Therefore, we suggest that FS be included as a criterion of ovine genetic selection for endoparasite resistance using the trait defined by multivariate cluster analysis, as it will provide greater genetic gains when compared to any single trait. In addition, its measurement is easy and inexpensive, exhibiting greater heritability and repeatability and a high genetic correlation with the trait of resistance to worms.

• Journal of Korea Society of Industrial Information Systems
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• v.21 no.4
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• pp.31-41
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• 2016

This paper is to evaluate the performance of a proposed hybrid genetic algorithm (pro-HGA) approach using closed-loop supply chain (CLSC) model. The proposed CLSC model is a integrated supply chain network model both with forward logistics and reverse logistics. In the proposed CLSC model, the reuse, resale and waste disposal using the returned products are taken into consideration. For implementing the proposed CLSC model, two conventional approaches and the pro-HGA are used in numerical experiment and their performances are compared with each other using various measures of performance. The experimental results show that the pro-HGA approach is more efficient in locating optimal solution than the other competing approaches.

• Journal of Genetic Medicine
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• v.20 no.2
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• pp.39-45
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• 2023

As advanced sequencing technologies continue to uncover an increasing number of variants in genes associated with human genetic diseases, there is a growing demand for systematic approaches to assess the impact of these variants on human development, health, and disease. While in silico analyses have provided valuable insights, it is essential to complement these findings with model organism studies to determine the functional consequences of genetic variants in vivo. Drosophila melanogaster is an excellent genetic model for such functional studies due to its efficient genetic technologies, high gene conservation with humans, accessibility to mutant fly resources, short life cycles, and cost-effectiveness. The traditional GAL4-UAS system, allowing precise control of gene expression through binary regulation, is frequently employed to assess the effects of monoallelic variants. Recombinase medicated cassette exchange or CRISPR-Cas9-mediated GAL4 insertion within coding introns or substitution of gene body with Kozak-Gal4 result in the loss-of-function of the target gene. This GAL4 insertion strategy also enables the expression of reference complementary DNA (cDNA) or cDNA carrying genetic variants under the control of endogenous regulatory cis elements. Furthermore, the CRISPR-Cas9-directed tissue-specific knockout and cDNA rescue system provides the flexibility to investigate candidate variants in a tissue-specific and/or developmental-timing dependent manner. In this review, we will delve into the diverse genetic techniques available in Drosophila and their applications in diagnosing and studying numerous undiagnosed diseases over the past decade.

• Proceedings of the KIEE Conference
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• 2002.07d
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• pp.2167-2170
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• 2002

In this paper, model-based tuning rules of the PID controller are proposed incorporating with genetic algorithms. Three sets of optimal PID parameters for set-point tracking are obtained based on the first-order time delay model and a genetic algorithm as a optimization tool which minimizes performance indices(IAE, ISE and ITAE). Then tuning rules are derived using the tuned parameter sets, potential rule models and a genetic algorithm. Simulation is carried out to verify the effectiveness of the proposed rules.