• 제목/요약/키워드: generalized linear model

검색결과 455건 처리시간 0.025초

Chronic Cadmium Intoxication and Renal Injury Among Workers of a Small-scale Silver Soldering Company

  • Choi, Won-Jun;Kang, Seong-Kyu;Ham, Seunghon;Chung, Wookyung;Kim, Ae Jin;Kang, Myunghee
    • Safety and Health at Work
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    • 제11권2호
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    • pp.235-240
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    • 2020
  • Background: Cadmium exposure may induce chronic intoxication with renal damage. Silver soldering may be a source of cadmium exposure. Methods: We analyzed working environment measurement data and periodic health screening data from a small-scale silver soldering company with ten workers. Concentrations of cadmium in air from working environment measurement data were obtained. Concentrations of blood and urinary cadmium, urine protein, and urine β2-microglobulin (β2M) were obtained. The generalized linear model was used to identify the association between blood and urine cadmium and urine β2M concentrations. Clinical features of chronic cadmium intoxication focused with toxicological renal effects were described. Results: The mean duration of work was 8.5 years (standard deviation [SD] = 6.9, range = 3-20 years). Cadmium concentrations in air were ranged from 0.006 to 0.015 mg/㎥. Blood cadmium concentration was elevated in all ten workers, with a highest level of 34.6 ㎍/L (mean = 21.288 ㎍/L, SD = 11.304, range = 9.641-34.630 ㎍/L). Urinary cadmium concentration was elevated in nine workers, with a highest level of 62.9 ㎍/g Cr (mean = 22.151 ㎍/g creatinine, SD = 19.889, range = 3.228-62.971 ㎍/g creatinine). Urine β2M concentration was elevated in three workers. Urinary cadmium concentration was positively associated with urine protein concentration (beta coefficient = 10.27, 95% confidence interval = [4.36, 16.18]). Other clinical parameters were compatible with renal tubular damage. Conclusion: Cadmium intoxication may occur at quite low air concentrations. Exposure limit may be needed to be lowered.

취약계층 당뇨병노인을 위한 건강멘토링프로그램의 효과 (The Effects of a Health Mentoring Program in Community-dwelling Vulnerable Elderly Individuals with Diabetes)

  • 성기월;강혜승;남지란;박미경;박지현
    • 대한간호학회지
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    • 제48권2호
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    • pp.182-194
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    • 2018
  • Purpose: This study aimed to estimate the effects of a health mentoring program on fasting blood sugar, total cholesterol, triglyceride, physical activity, self care behavior and social support changes among community-dwelling vulnerable elderly individuals with diabetes. Methods: A non-equivalent control group pre-post-test design was used. Participants were 70 community-dwelling vulnerable elderly individuals with diabetes. They were assigned to the experimental (n=30) or comparative (n=30) or control group (n=28). The experimental group participated in the health mentoring program, while the comparative group participated in health education program, the control group did not participate in any program. Data analyses involved a chi-square test, Fisher's exact test, a generalized linear model, and the Bonferroni correction, using SPSS 23.0. Results: Compared to the control group, the experimental and comparative groups showed a significant decrease in fasting blood sugar, total cholesterol, and triglyceride. Compared to the comparative and control groups, the experimental group showed significant improvement in self care behavior. However, there were no statistical differences in physical activity or social support among the three groups. Conclusion: These findings indicate that the health mentoring program is an effective intervention for community-dwelling vulnerable elderly individuals with diabetes. This program can be used as an efficient strategy for diabetes self-management within this population.

Blood Triglycerides Levels and Dietary Carbohydrate Indices in Healthy Koreans

  • Min, Hye Sook;Kang, Ji Yeon;Sung, Joohon;Kim, Mi Kyung
    • Journal of Preventive Medicine and Public Health
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    • 제49권3호
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    • pp.153-164
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    • 2016
  • Objectives: Previous studies have obtained conflicting findings regarding possible associations between indices measuring carbohydrate intake and dyslipidemia, which is an established risk factor of coronary heart disease. In the present study, we examined crosssectional associations between carbohydrate indices, including the dietary glycemic index (GI), glycemic load (GL), total amount of carbohydrates, and the percentage of energy from carbohydrates, and a range of blood lipid parameters. Methods: This study included 1530 participants (554 men and 976 women) from 246 families within the Healthy Twin Study. We analyzed the associations using a generalized linear mixed model to control for familial relationships. Results: Levels of the Apo B were inversely associated with dietary GI, GL, and the amount of carbohydrate intake for men, but these relationships were not significant when fat-adjusted values of the carbohydrate indices were used. Triglyceride levels were positively associated with dietary GI and GL in women, and this pattern was more notable in overweight participants (body mass index [BMI] ${\geq}25kg/m^2$). However, total, low-density lipoprotein and high-density lipoprotein cholesterol levels were not significantly related with carbohydrate intake overall. Conclusions: Of the blood lipid parameters we investigated, only triglyceride levels were positively related with dietary carbohydrate indices among women participants in the Healthy Twin Study, with an interactive role observed for BMI. However, these associations were not observed in men, suggesting that the association between blood lipid levels and carbohydrate intake depends on the type of lipid, specific carbohydrate indices, gender, and BMI.

다양한 모형화를 통한 자동차 보험가격 산출 (Various modeling approaches in auto insurance pricing)

  • 김명준;김영화
    • Journal of the Korean Data and Information Science Society
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    • 제20권3호
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    • pp.515-526
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    • 2009
  • 자동차 보험 산업에 있어 담보되는 위험도에 따른 적정 보험가격의 산출은 매우 중요하다. 본 논문에서는 자동차 보험 산업에서 보험가격 산출 방법이 어떻게 발전되어 왔는지에 대하여 고찰하고, 여러 통계적인 방법으로 산출한 보험가격과 실제 담보되는 위험도의 비교 분석을 통하여 보다 나은 통계적 보험가격 산출 방법을 제안하고자 한다. 그 중에서 일반선형모형을 중심으로 다루었으며, 오차항의 분포에 대한 다양한 가정을 통하여 최적의 접근 방법에 대한 논의를 하였다. 일반선형모형에 있어 오차항의 분포에 대한 적절한 가정은 모형의 최적화를 위한 중요한 가정이다. 본 연구에서는 일반적으로 널리 사용되지 않았음에도 불구하고 자동차 보험 사고 손해액과 매우 유사한 성격을 가지고 있는 트위디 분포를 오차항의 분포 가운데 하나로 적용하여 비교하였다. 실증자료 분석으로서 국내 자동차 보험사의 실제 자료를 통하여 여러 접근 방법에 대한 적정성 비교를 수행하였다.

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Prevalence and Associated Risk Factors of Toxocara vitulorum Infections in Buffalo and Cattle Calves in Three Provinces of Central Cambodia

  • Dorny, Pierre;Devleesschauwer, Brecht;Stoliaroff, Valerie;Sothy, Meas;Chea, Rortana;Chea, Bunthon;Sourloing, Hor;Samuth, Sum;Kong, Seth;Nguong, Koemseang;Sorn, San;Holl, Davun;Vercruysse, Jozef
    • Parasites, Hosts and Diseases
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    • 제53권2호
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    • pp.197-200
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    • 2015
  • The prevalence and associated risk factors of Toxocara vitulorum infection in buffalo and cattle calves was studied in 3 provinces in central Cambodia. Fecal samples were collected from 517 calves between the age of 1-15 weeks and processed for nematode egg counts by a modified McMaster method. A total of 64 calves were found to excrete T. vitulorum eggs in their feces (12.4%; 95% exact CI: 9.7-15.5). The mean fecal egg count was 2,798 EPG (SD=16,351; range=0-224,400). A multivariable generalized linear mixed model showed higher odds of T. vitulorum infection for buffalo versus cattle, for animals aged 4-8 weeks versus younger and older ones, and for animals with strongyle infection. There was no association with fecal consistency. Farmers should be aware of the potential impact of T. vitulorum, and treat their calves at the age of 2-3 weeks with anthelmintics such as benzimidazoles or pyrantel.

통근통행을 위한 통행수단으로서 자동차 선택에 개인속성 및 도시특성, 도시형태가 미치는 영향 (Impact of individual traits, urban character and urban form on selecting cars as transportation mode for work travel)

  • 이건원;정윤남;김세용
    • 한국산학기술학회논문지
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    • 제15권5호
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    • pp.3240-3250
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    • 2014
  • 본 연구는 개인들의 통행수단으로서 자동차 선택에 개인수준 및 도시특성, 도시형태의 세 가지 측면에서의 상관관계를 도출하는 것을 목적으로 한다. 본 연구에서는 자동차 이용을 감소시키는 도시특성 및 도시형태의 주요 요소로 5Ds를 중심으로 접근했다. 이러한 분석을 위해서 2005년 인구주택총조사자료 중 2%수준의 Micro Data내의 개인속성과 개인의 통행데이터 그리고 각 도시에서 제공하는 도시별 통계 데이터 등을 바탕으로 한국에 있는 도시 75개 도시와 그 거주자들을 대상으로 HGLM을 이용하여 분석하였다. 분석결과, 자동차 이용감소에 효과적인 도시특성 및 도시형태요소 분석을 위해서 개인수준의 통제는 반드시 필요하고, 5Ds는 대체로 자동차 이용 감소에 의미있는 관계를 보였으나 서구도시들에서 잘 알려진 자동차 이용 감소 요소인 Density와 Diversity는 한국의 도시에서는 상대적으로 큰 효과를 보이지 않는 사실을 도출할 수 있었다.

청소년의 학교폭력 가해행동에 영향을 미치는 요인 -다층모형 분석- (The Effects of Individual Characteristics, School Factors, and Community Factors on Adolescents School Violence Behavior -A multilevel analysis-)

  • 이지현
    • 한국아동복지학
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    • 제55호
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    • pp.143-171
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    • 2016
  • 본 연구는 청소년의 학교폭력 가해행동에 대한 청소년 개인요인, 학교요인, 지역요인의 영향을 검증하기 위해 2수준 다층모형을 적용하였고, HLM 7 프로그램으로 분석하였다. 이를 위해 서울 및 경기지역 50개 중학교의 총 1,777부 학생자료가 분석에 사용되었다. 2수준 다층모형 분석결과, 학교폭력 가해행동에 영향을 미치는 청소년 개인요인으로는 폭력에 대한 태도, 부모 애착, 아동학대 경험, 비행친구접촉으로 나타났고, 학교요인으로는 교사의 폭력적 훈육으로 나타났다. 또한 본 연구에서 지역사회 요인으로 주목한 지역무질서가 청소년의 학교폭력 가해행동에 정적으로 유의한 영향을 미치는 것으로 확인되었다. 본 연구 결과는 학교폭력 원인의 이해와 그에 따른 대책마련을 위해서는 청소년 개인, 가정, 학교 외에도 지역사회 등 청소년의 일상생활이 이루어지는 다양한 환경적 맥락을 종합적으로 고려해야 함을 제시한다. 본 연구결과를 바탕으로 학교폭력을 효과적으로 해소하기 위한 정책 및 실천 방안이 논의되었다.

Treatment Costs and Factors Associated with Glycemic Control among Patients with Diabetes in the United Arab Emirates

  • Lee, Seung-Mi;Song, Inmyung;Suh, David;Chang, Chongwon;Suh, Dong-Churl
    • Journal of Obesity & Metabolic Syndrome
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    • 제27권4호
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    • pp.238-247
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    • 2018
  • Background: We aimed to estimate the proportion of patients with diabetes who achieved target glycemic control, to estimate diabetes-related costs attributable to poor control, and to identify factors associated with them in the United Arab Emirates. Methods: This retrospective cohort study used administrative claims data handled by Abu Dhabi Health Authority (January 2010 to June 2012) to determine glycemic control and diabetes-related treatment costs. A total of 4,058 patients were matched using propensity scores to eliminate selection bias between patients with glycosylated hemoglobin (HbA1c) <7% and HbA1c ${\geq}7%$. Diabetes-related costs attributable to poor control were estimated using a recycled prediction method. Factors associated with glycemic control were investigated using logistic regression and factors associated with these costs were identified using a generalized linear model. Results: During the 1-year follow-up period, 46.6% of the patients achieved HbA1c <7%. Older age, female sex, better insurance coverage, non-use of insulin in the index diagnosis month, and non-use of antidiabetic medications during the follow-up period were significantly associated with improved glycemic control. The mean diabetes-related annual costs were $2,282 and $2,667 for patients with and without glycemic control, respectively, and the cost attributable to poor glycemic control was $172 (95% confidence interval [CI], $164-180). The diabetes-related costs were lower with mean HbA1c levels <7% (cost ratio, 0.94; 95% CI, 0.88-0.99). The costs were significantly higher in patients aged ${\geq}65$ years than those aged ${\leq}44$ years (cost ratio, 1.45; 95% CI, 1.25-1.70). Conclusion: More than 50% of patients with diabetes had poorly controlled HbA1c. Poor glycemic control may increase diabetes-related costs.

치면열구전색 전후의 어린이 소변 내 Bisphenol-A의 농도 변화 (Changes in bisphenol A concentrations in urine according to sealant filling in children)

  • 신아라;김지혜;전은숙;정윤숙;송근배;최연희
    • Journal of Korean Academy of Oral Health
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    • 제41권4호
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    • pp.231-236
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    • 2017
  • Objectives: The objectives of this study were to investigate the changes in bisphenol A (BPA) concentrations in urine from before to after sealant filling and the relationship between BPA and the number of teeth with sealed surfaces. Methods: Thirty-one children aged 6 and 7 years from three elementary schools in Daegu city who did not have any sealant and resin filling were selected as subjects. Urine samples were collected before and after sealant filling until 24 hours, with informed consent from their caregivers. The BPA concentration in all the collected urine samples was analyzed at Seegene Medical. Statistical analysis was performed using the Friedman test, Scheirer-Ray-Hope test, and the repeated-measures generalized linear mixed model of SPSS version 22.0. Results: The BPA concentrations increased from $3.49-{\mu}g/g$ creatinine before to $4.91-{\mu}g/g$ creatinine 2-3 hours later and to $4.15-{\mu}g/g$ creatinine after 24 hours. The more teeth with sealed surfaces, the higher the BPA concentration in children, but the difference was not statistically significant (P>0.05). Conclusions: The BPA concentrations were highest at 2-3 hours after sealant filling and decreased at 24 hours. Exposure to the sealant appears to have a meaningful correlation with the concentration of BPA in the urine of children.

한국판 청소년용 음식중독도구의 타당도와 신뢰도 (Validity and Reliability of a Korean Version of Yale Food Addiction Scale for Children (YFAS-C))

  • 김정호;송지현;김란;장미영;홍현주;김현지;신성희
    • 대한간호학회지
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    • 제49권1호
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    • pp.59-68
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    • 2019
  • Purpose: This study evaluated the psychometric properties of the Korean version of Yale Food Addiction Scale for Children (YFAS-C). Methods: Participants were 419 young adolescent students (11~15 years old). The content validity of the expert group was calculated as the content validity index (CVI) after the translation and reverse translation process of the 25 items of the YFAS-C. The multitrait-multimethod matrix (MTMM) method was used to verify the construct validity; the generalized linear model (GLM) was used to evaluate the concurrent and incremental validity. Reliability was calculated as Kuder-Richardson-20 (KR-20) and Spearman-Brown coefficients. Results: The CVI of the 25 items was greater than the item-level CVI .80 and the scale-level CVI .90. The Korean version of YFAS-C had verified convergent validity in emotional eating and external eating and discriminant validity in restrained eating. In addition, it had verified concurrent validity in emotional eating and external eating. Finally the incremental validity of the Korean version of YFAS-C was statistically significant on BMI. Reliability was KR-20 ${\alpha}=.69$ and the Spearman-Brown coefficient was .64. Conclusion: The Korean version of YFAS-C is a valid and reliable scale for measuring the severity of food addiction; it can be a useful scale for preventing obesity by predicting food addiction early.