Safety and Health at Work

Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency (산업안전보건연구원)
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Chronic Cadmium Intoxication and Renal Injury Among Workers of a Small-scale Silver Soldering Company

  • Choi, Won-Jun (Department of Occupational and Environmental Medicine, Gachon University College of Medicine, Gil Medical Center) ;
  • Kang, Seong-Kyu (Department of Occupational and Environmental Medicine, Gachon University College of Medicine, Gil Medical Center) ;
  • Ham, Seunghon (Department of Occupational and Environmental Medicine, Gachon University College of Medicine, Gil Medical Center) ;
  • Chung, Wookyung (Division of Nephrology, Department of Internal Medicine, Gachon University College of Medicine, Gil Medical Center) ;
  • Kim, Ae Jin (Division of Nephrology, Department of Internal Medicine, Gachon University College of Medicine, Gil Medical Center) ;
  • Kang, Myunghee (Department of Pathology, Gachon University, Gil Medical Center)
  • Received : 2019.08.27
  • Accepted : 2020.03.26
  • Published : 2020.06.30
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Abstract

Background: Cadmium exposure may induce chronic intoxication with renal damage. Silver soldering may be a source of cadmium exposure. Methods: We analyzed working environment measurement data and periodic health screening data from a small-scale silver soldering company with ten workers. Concentrations of cadmium in air from working environment measurement data were obtained. Concentrations of blood and urinary cadmium, urine protein, and urine β2-microglobulin (β2M) were obtained. The generalized linear model was used to identify the association between blood and urine cadmium and urine β2M concentrations. Clinical features of chronic cadmium intoxication focused with toxicological renal effects were described. Results: The mean duration of work was 8.5 years (standard deviation [SD] = 6.9, range = 3-20 years). Cadmium concentrations in air were ranged from 0.006 to 0.015 mg/㎥. Blood cadmium concentration was elevated in all ten workers, with a highest level of 34.6 ㎍/L (mean = 21.288 ㎍/L, SD = 11.304, range = 9.641-34.630 ㎍/L). Urinary cadmium concentration was elevated in nine workers, with a highest level of 62.9 ㎍/g Cr (mean = 22.151 ㎍/g creatinine, SD = 19.889, range = 3.228-62.971 ㎍/g creatinine). Urine β2M concentration was elevated in three workers. Urinary cadmium concentration was positively associated with urine protein concentration (beta coefficient = 10.27, 95% confidence interval = [4.36, 16.18]). Other clinical parameters were compatible with renal tubular damage. Conclusion: Cadmium intoxication may occur at quite low air concentrations. Exposure limit may be needed to be lowered.

Keywords

References

  1. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for cadmium. Atlanta (GA): U.S. Department of Health and Human Services, Public Health Service (US); 2012.
  2. Kim EA, Lee HE, Kang SK. Occupational burden of cancer in Korea. Saf Health Work 2010;1:61-8. https://doi.org/10.5491/SHAW.2010.1.1.61
  3. Yang H, Shu Y. Cadmium transporters in the kidney and cadmium-induced nephrotoxicity. Int J Mol Sci 2015;16:1484-94. https://doi.org/10.3390/ijms16011484
  4. Thevenod F. Nephrotoxicity and the proximal tubule. Insights from cadmium. Nephron Physiol 2003;93:87-93. https://doi.org/10.1159/000070241
  5. Rani A, Kumar A, Lal A, Pant M. Cellular mechanisms of cadmium-induced toxicity: a review. Int J Environ Health Res 2014;24:378-99. https://doi.org/10.1080/09603123.2013.835032
  6. Prozialeck WC, Edwards JR. Mechanisms of cadmium-induced proximal tubule injury: new insights with implications for biomonitoring and therapeutic interventions. J Pharmacol Exp Ther 2012;343:2-12. https://doi.org/10.1124/jpet.110.166769
  7. Kang SK, Hong JP, Kim KW, Jang JY, Chung HK, Chung KC. Assessment of occupational exposure to cadmium in Korea. Kor J Occup Environ Med 1994;6:252-8. https://doi.org/10.35371/kjoem.1994.6.2.252
  8. Weman K. 16 - soldering and brazing. Welding processes handbook. 2nd ed. Philadelphia (USA): Woodhead Publishing; 2012. p. 167-74.
  9. Smith NJ, Topping MD, Stewart JD, Fletcher JG. Occupational cadmium exposure in jig solderers. Br J Ind Med 1986;43:663-6.
  10. Perrin B, Green S, Morgan WD. Longitudinal measurements of the cadmium burden of 'jig solderers' using IVNAA. Appl Radiat Isot 1998;49:701-2. https://doi.org/10.1016/S0969-8043(97)00206-6
  11. Lee MY, Yang JS, Kang SK. External quality assessment scheme for biological monitoring of occupational exposure to toxic chemicals. Saf Health Work 2011;2:229-35. https://doi.org/10.5491/SHAW.2011.2.3.229
  12. Liu YZ, Huang JX, Luo CM, Xu BH, Zhang CJ. Effects of cadmium on cadmium smelter workers. Scand J Work Environ Health 1985;11:29-32.
  13. Elinder CG, Edling C, Lindberg E, Kagedal B, Vesterberg O. Beta 2-Microglobulinuria among workers previously exposed to cadmium: followup and dose-response analyses. Am J Ind Med 1985;8:553-64. https://doi.org/10.1002/ajim.4700080607
  14. U.S. Department of Labor. Title 29, code of federal regulation, Part 1910.1000-1910.1200; 1998.
  15. [Internet]Hours worked. OECD. 2018 [cited 2020 jan 20]. Available from: https://www.oecd-ilibrary.org/content/data/47be1c78-en.
  16. Elinder CG, Lind B, Kjellstrom T, Linnman L, Friberg L. Cadmium in kidney cortex, liver, and pancreas from Swedish autopsies. Estimation of biological half time in kidney cortex, considering calorie intake and smoking habits. Arch Environ Health 1976;31:292-302. https://doi.org/10.1080/00039896.1976.10667239
  17. Horiguchi H, Oguma E, Sasaki S, Miyamoto K, Ikeda Y, Machida M, Kayama F. Dietary exposure to cadmium at close to the current provisional tolerable weekly intake does not affect renal function among female Japanese farmers. Environ Res 2004;95:20-31. https://doi.org/10.1016/S0013-9351(03)00142-7
  18. Waalkes MP, Goering PL. Metallothionein and other cadmium-binding proteins: recent developments. Chem Res Toxicol 1990;3:281-8. https://doi.org/10.1021/tx00016a001
  19. Nordberg GF. Historical perspectives on cadmium toxicology. Toxicol Appl Pharmacol 2009;238:192-200. https://doi.org/10.1016/j.taap.2009.03.015
  20. Klaassen CD, Liu J, Diwan BA. Metallothionein protection of cadmium toxicity. Toxicol Appl Pharmacol 2009;238:215-20. https://doi.org/10.1016/j.taap.2009.03.026
  21. He L, Wang B, Hay EB, Nebert DW. Discovery of ZIP transporters that participate in cadmium damage to testis and kidney. Toxicol Appl Pharmacol 2009;238:250-7. https://doi.org/10.1016/j.taap.2009.02.017
  22. Bridges CC, Zalups RK. Molecular and ionic mimicry and the transport of toxic metals. Toxicol Appl Pharmacol 2005;204:274-308. https://doi.org/10.1016/j.taap.2004.09.007
  23. Prozialeck WC, Edwards JR. Cell adhesion molecules in chemically-induced renal injury. Pharmacol Ther 2007;114:74-93. https://doi.org/10.1016/j.pharmthera.2007.01.001
  24. Thevenod F. Cadmium and cellular signaling cascades: to be or not to be? Toxicol Appl Pharmacol 2009;238:221-39. https://doi.org/10.1016/j.taap.2009.01.013
  25. Gobe G, Crane D. Mitochondria, reactive oxygen species and cadmium toxicity in the kidney. Toxicol Lett 2010;198:49-55. https://doi.org/10.1016/j.toxlet.2010.04.013
  26. Liu J, Qu W, Kadiiska MB. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 2009;238:209-14. https://doi.org/10.1016/j.taap.2009.01.029
  27. Kang SK, Yang JS, Kim KW, Jang JY, Chung HK. Assessment of cadmium in blood and urine of occupationally exposed workers and renal dysfunction by cumulative exposure estimate. Kor J Occup Environ Med 1995;7:101-10. https://doi.org/10.35371/kjoem.1995.7.1.101
  28. Kang SK, Yang JS, Kim DS. Assessment of health effect in wokers exposed to cadmium. Incheon (Korea). Occupational Safety and Health Research Institute; 1999.
  29. Thun MJ, Elinder CG, Friberg L. Scientific basis for an occupational standard for cadmium. Am J Ind Med 1991;20:629-42. https://doi.org/10.1002/ajim.4700200506
  30. Chettle DR, Ellis KJ. Further scientific issues in determining an occupational standard for cadmium. Am J Ind Med 1992;22:117-24. https://doi.org/10.1002/ajim.4700220111
  31. Roels HA, Van Assche FJ, Oversteyns M, De Groof M, Lauwerys RR, Lison D. Reversibility of microproteinuria in cadmium workers with incipient tubular dysfunction after reduction of exposure. Am J Ind Med 1997;31:645-52. https://doi.org/10.1002/(SICI)1097-0274(199705)31:5<645::AID-AJIM21>3.0.CO;2-Y
  32. Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V. Regulation of uric acid metabolism and excretion. Int J Cardiol 2016;213:8-14. https://doi.org/10.1016/j.ijcard.2015.08.109

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