• BMB Reports
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• v.49 no.2
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• pp.81-92
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• 2016

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe the mechanisms by which various IIS components regulate aging in C. elegans and D. melanogaster. We also cover systemic and tissue-specific effects of the IIS components on the regulation of lifespan. We further discuss IIS-mediated physiological processes other than aging and their effects on human disease models focusing on C. elegans studies. As both C. elegans and D. melanogaster have been essential for key findings regarding the effects of IIS on organismal aging in general, these invertebrate models will continue to serve as workhorses to help our understanding of mammalian aging.

• Proceedings of the Society of Korea Industrial and System Engineering Conference
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• 2002.05a
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• pp.195-202
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• 2002

The primary objective of Supply Chain Management (SCM) is to optimize the cash, material and information flow for satisfying customer demands through coordinating the relationship between Supply Chain components such as suppliers, manufacturers, and inventories, etc. By Supply Chain Planning (SCP), operation tasks or goals, should be done in specific due date, are ordered to each SC component for achieving such objective. However, the achievement for operation tasks or goals is affected by uncertainties in SC. In general, reliability theory Is explained as the probability that a product or system will perform its specified function under prescribed conditions without failure for a specified period of time. Therefore, the reliability of SC can be defined as the probability that SC will satisfy customer demands until the specific due date. In this paper, a basic framework to evaluate reliability is respectively proposed as supply chain components, and then a overall framework to estimate the reliability for SC is also proposed.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.31B no.1
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• pp.72-80
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• 1994

In this paper, a new variable block-size transform coding algorithm using information of segmentation is proposed. In general variable block-size transform coding algorithms, the information which is used to form variable blocks is thrown away, but in the proposed algorithm, the information of segmentation which is composed of texture and contour information is maintained for efficient coding. That is, the number of blocks can be reduced by contour information, a DC component of block can be predicted by texture information, and the region compensation, which reduces mean difference between regions, using texture and contour information can diminish the magnitude of AC components. The result is that the proposed algorithm has improved highly the coding efficiency of DC and AC components.

• Journal of applied mathematics & informatics
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• v.26 no.1_2
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• pp.355-364
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• 2008

Under pathological stress stimuli, dynamics of a biological system can be changed by alteration of several components such as functional proteins, ultimately leading to disease state. These dynamics in disease state can be modeled using differential equations in which kinetic or system parameters can be obtained from experimental data. One of the most effective ways to restore a particular disease state of biology system (i.e., cell, organ and organism) into the normal state makes optimization of the altered components usually represented by system parameters in the differential equations. There has been no such approach as far as we know. Here we show this approach with a cardiac hypertrophy model in which we obtain the existence of the optimal parameters and construct an optimal system which can be used to find the optimal parameters.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.864-865
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• 2011

Battery Disconnecting System (BDS) is the important equipment in electric vehicle system. Therefore, most of electric vehicle companies, i.e. Hyundai Motors, Renault Motors, General Motors, want to have the reliability of 15 years - 150, 000 miles. Recently, reliability prediction through Siemens Norm SN 29500 is considered without testing. In this paper, we will introduce the standard and various input parameters. Also the case study will be shown for BDS. Prediction model is constructed by listing all the components of BDS. It calculates the $\pi$ factors for each components using the conversion equation in the standard and converts the reference failure rates to the expected operating failure rates. According to the result, the parts which will be improved are EV-Relays.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.1
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• pp.14-21
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• 1995

General Mechanical Structures have various and complex vibration transmission paths. In order to identify the mechanism of vibration transmission. The correct estimation of exciation forces and the exact modeling of transmission paths are required. In this paper, vector synthesis technique is employed to identify the characteristics of vibration input and it's transmission to body structure for the mounting system of a compressor in a refrigerator. Vibration reduction efficiency of each transmission path is evaluated by comparing individual vector components obtained before and after the paths from experimental research. The degree of effect is used to estimate the contribution of vibration input components to total output. And this paper presents a new technique based on simulation studies using vector synthesis dragram, by which the effects of change of the magnitude and phase of transmission paths can be predicted.

• Journal of the Korean Society of Clothing and Textiles
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• v.2 no.1
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• pp.151-155
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• 1978

General components and detergency of commercial shampoos have been investigated and the results are summerized in the following. Shampoos were analyzed for surfactants and additives by KS method and surfactants were confirmed by T.L.C. Considerable differences in amounts of non volatiles and surfactants were found. Three of them contain either lanoline or sterols as additives and in the three. propylene glycol was found in their liquid part. It was shown that predominant sufactant was anionic and in all, except one. a little ampholytic surfactant was detected. But, contrary to forecast, in only one a little of non ionic surfactant was detected. Detergency of shampoos was examined using artificially soiled wool muslin. Considerable difference was found, and all shampoos showed higher detergency than a synthetic powder type detergent for textiles. There were no significant correlation between detergency and amount of surfactants or suspending power of detergents.

• Wind and Structures
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• v.11 no.2
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• pp.137-152
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• 2008

This paper discusses engineering aspects of the rear-flank downdraft that was recorded near Lubbock, Texas on 4 June 2002, and produced a gust wind speed nearly equal to the design value (50-year return period) for the region. The general characteristics of the storm, and the decomposition of the time histories into deterministic 'running mean' and random turbulence components are discussed. The fluctuating wind speeds generated by the event can be represented as a dominant low-frequency 'running mean' with superimposed random turbulence of higher frequencies. Spectral and correlation characteristics of the residual turbulence are found to be similar to those of high-frequency turbulence in boundary-layer winds. However, the low-frequency components in the running-mean wind speeds are spatially homogeneous, in contrast to the low-frequency turbulence found in synoptic boundary-layer winds. With respect to transmission line design, this results in significantly higher 'span reduction factors'.

• YAKHAK HOEJI
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• v.14 no.1_2
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• pp.21-27
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• 1970

Isoimperatorin and Oxypeucedanin isolated from root of Angelica Koreana Max. (Umbelliferae) that is used as "Kang-Whal" a botanical drug, in Korea, Show following general pharmacologic activities. The treatment with Oxypeucedanin on the exercised duodenum of the rabbit increased the motility of it while isoimperatorin shows little effects. But on the exercised heart of the frogs, both components depressed its contractility. Whereas Oxypeucedanin depressed both blood pressure of the carotied artery and respiration of the rabbit, Isoimperatorin tends to increase blood pressure, respiration and the tonus of the muscle of the earth worm. Oxypeucedanin did not affect the tonus of the muscles of the earth worm, but depressed the uterus contraction of the rabbit, which was, on the contrary, increased by Isoimperatorin.

• Journal of the Ergonomics Society of Korea
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• v.22 no.3
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• pp.45-56
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• 2003

This study was conducted to develop user interface design guidelines for those who design education software products (web sites or CD-ROM titles). To establish this guideline scheme, international standards, commercial design guidelines, and research papers were surveyed. Especially, ISO 9241 was referred as a basic model of a guideline scheme. First, the research group developed draft guidelines. After that, education software developers, designers, and a user group reviewed the draft and the draft was revised with their commentations. Five components were selected as a primary class of guideline scheme: general principle, dialogue design, user guidance, visual interface, and information presentation. Each component was divided several components as a secondary class. Finally, 45 items were selected as user interface design guidelines for the education software design.