• 한국환경복원기술학회지
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• 제12권1호
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• pp.101-110
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• 2009

The vascular plants in the Mt. Hoemun were listed 541 taxa composed of 113 families, 354 genera, 473 species, 1 subspecies, 64 varieties and 3 forms. Divided into 541 taxa; woody plants were 151 taxa (27.9%) and herbaceous plants were 390 taxa (72.1%). Based on the list of rare plants by the Korea Forest Service, 10 taxa were recorded in the studied areas; Lilium distichum (Preservation priority order: No. 159), Lilium callosum (No. 191), Tricyrtis dilatata (No. 97), Iris ensata var. sponianea (No. 197), Gastrodia elata (No.9), Aristolochia contorta (No. 151), Paeonia obovata (No. 30: Legal protection species), Prunus yedoensis (No. 110 : Planted species), Viola albida (No. 202), Schpolia japonica (No. 208). Based on the list of Korean endemic plants, 15 taxa were recorded; Cephalotaxus koreana, Lilium amabile, Salix purpurea var. japonica, Pseudostellaria multiflora, Aconitum pseudolaeve var. erectum, Filipendula glaberrima, Weigela subsessilis, etc. Based on the list of approved for delivering overseas of plants, 10 taxa were recorded; Carex okamotoi, Lilium distichum, Clematis trichotoma, Vaccinium oldhami, Paulownia coreana, Asperula lasiantha; etc. Specific plant species by floral region were total 4S taxa (8.3% of all 541 taxa of vascular plants); Gastrodia elata, Paeonia obovata in class V, Carex arenicola, Corydalis grandicalyx in class IV, 5 taxa (Spiraea salicifolia, Schpolia japonica, Asperula lasiantha, etc.) in class III, 7 taxa (Lilium distichum, Iris ensata var. spontanea, Caryopteris incana, etc.) in class II and 28 taxa (Camptosorus sibiricus, Orixa japonica, Lonicera praeflorens, etc.) in class I. The naturalized plants in the surveyed sites were 13 families, 38 genera, 43 species, 2 varieties, 45 taxa (Phleum pratense, Medicago sativa, Sonchus asper, etc.) and naturalization rate was 8.3% of all 541 taxa of vascular plants. Ambrosia artemisiifolia var. elatior an ecosystem disturbing wild plants have been increasing. Therefore, the counter plants for continuous control and conservation are needed on the ecosystem of Mt. Hoemun.

• Archives of Pharmacal Research
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• 제22권4호
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• pp.404-409
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• 1999

The inhibitory effects of the constituents of Gastrodia elata Bl. (GE) on glutamate-induced apoptosis in human neuronal cells were investigated using IMR32 human neuroblastoma cells. Glutamate (GLU) induced DNA fragmentation, a hallmark of apoptosis, in a dose-dependent manner. GLU also induced a slow and sustained increase in intracellular $Ca^{2+}$ concentration. Treatment with EGTA, an extracellular $Ca^{2+}$ chelator, in a nominal $Ca^{2+}$ -free buffer solution abolished the GLU-induced intracellular $Ca^{2+}$ increase, indicating that GLU stimulated Ca2+ influx pathway in the IMR32 cells. BAPTA, an intracellualr $Ca^{2+}$ chelator, significantly inhibited the GLU-induced apoptosis assessed by the flow cytometry measuring hypodiploid DNA content indicative of apoptosis, implying that intracellular $Ca^{2+}$ rise may mediate the apoptotic action of GLU. Vanillin (VAN) and p-hydroxybenzaldehyde(p-HB), known constituents of GE, significantly inhibited both intracellular $Ca^{2+}$ rise and apoptosis induced by GLU. These results suggest that the apoptosis-inhibitory actions of the constituents of GE may account, at least in part, for the basis of their antiepileptic activities. These results further suggest that intracelluarl $Ca^{2+}$ signaling pathway may be a molecular target of the constituents of GE.

• 동의신경정신과학회지
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• 제33권3호
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• pp.277-285
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• 2022

Objectives: Gastrodia elata (GE) has been used to treat cognition impairment, including Alzheimer's disease (AD) in Korea. The purpose of this study was to investigate the effects of GE water extracts (GEE) on the lipopolysaccharide (LPS)-induced AD model in mice. (Aβ). Methods: We classified six groups as follow; group 1: control (CON), group 2: LPS (0.5 mg/kg/day, four times), group 3: 4 mg/kg donepezil (DP), group 4: 100 mg/kg GEE+LPS, group 5: 200 mg/kg GEE+LPS, group 6: 500 mg/kg GEE+LPS. Results: We found that GEE has an effect that inhibits decrease of discrimination index in object recognition test, as well as spontaneous alteration in the Y-maze test by LPS. Treatment with LPS increased amlyloid-β (Aβ) concentration, and decreased brain-derived neurotrophic factor (BDNF) in cerebral cortex of mice. However, GEE significantly protected against LPS-induced Aβ and BDNF changes. Our findings also showed that the inflammatory cytokines [tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β)] mRNA and protein were up-regulated by the LPS injection. But GEE significantly suppressed LPS-induced inflammatory cytokines increase in a dose-dependent manner. Conclusions: This study suggests that the GEE may be an effective AD therapeutic agent, in treating neurodegenerative diseases including AD.

• 대한본초학회지
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• 제30권6호
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• pp.69-75
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• 2015

Objectives : This study was designed to investigate effects of the combination with Korean Red Ginseng (Panax ginseng C.A. Meyer), Gastrodia Rhizoma (Gastrodia elata Blume) and Polygoni Multiflori Radix (Polygonum multiflorum Thunberg) on metabolic disorders including cholesterol and erectile dysfunction in hyperlipidemia rats.Methods : Animals were divided into six groups; Control with normal diet, high fat/cholesterol-diet (HFCD), fluvastatin, Korean Red Ginseng treated (KRG), and the combination treated (Korean Red Ginseng, Gastrodia Rhizoma and Polygoni Multiflori Radix; 1:1:1 for KGP1 and 2:1:1 for KGP2). The experimental groups initially received HFCD for 10 weeks and then treated orally with fluvastatin, KRG, KGP1 and KGP2 during the final 6 weeks. Erectile function was determined by the measurements of intracavernosal pressure (ICP) and maximal arterial pressure (MAP) after electrical stimulation of the cavernosal nerve.Results : KGP2 decreased the level of total cholesterol and LDL cholesterol in the sera of HFCD rats without no changes of body weights. KRG, KGP1 and KGP2 decreased the level of C-reactive protein (CRP) levels except of fluvastatin, synthetic HMG-CoA reductase inhibitor. KRG, KGP1 and KGP2 significantly increased the ICP, ICP/MAP ratio, area under the curve (AUC) compared with those of normal rat. Morphometric analyses showed that KRG, KGP1 and KGP2 increased the volume of smooth muscle and the regular arrangement of collagen fibers in corpus cavernosum of HFCD rats. The penile expression of eNOS was increased by KRG, KGP1 and KGP2.Conclusions : Based on these results, we suggest that the combination with Korean Red Ginseng, Gastrodia Rhizoma and Polygoni Multiflori may improve hyperlipidemia through regulating the lipid profiles and erectile dysfunction in rats.

• 생명과학회지
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• 제16권7호
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• pp.1214-1218
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• 2006

페놀성 화합물들의 병용투여가 rat의 진정효과에 미치는 영향을 조사하였다. 천마성분으로서 positive GABAergic neuromodulation을 보이는 4-hydroxy-3-methoxybenzaldehyde와 강력한 항산화물질인 2,3-dihydroxlrbenzaldehyde를 동량 투여한 결과, pentyleneterazole에 의해 유발된 사망률이 유의하게 감소되었으며 pentobarbital에 의해 유도된 수면시간은 유의하게 연장되었으나 항불안효과와 근육이완효과는 나타나지 않았다. 이러한 결과로 보아 항경련효과를 가진 화합물과 항산화 효과를 가진 화합물을 병용투여 함으로서 경련이나 불면 등의 신경증상을 효과적으로 억제할 수 있을 것으로 사료된다.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2007년도 춘계학술발표회
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• pp.187-188
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• 2007

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVI)
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• pp.123-123
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• 2005

• 생약학회지
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• 제17권1호
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• pp.19-22
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• 1986

As a continuation of the previous work, a second group of sixty solvent fractions prepared from twenty plant species were screened for their inhibitory effects on adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)- or collagen-induced rat platelet aggregation. The results suggested that five plant species including Angelica koreana, Cassia obtusifolia, Gastrodia elata, Paeonia lactiflora and Salvia miltiorrhiza are potential sources of inhibitors of platelet aggregation.

• Natural Product Sciences
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• 제9권2호
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• pp.87-90
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• 2003

The purpose of this study was to find the effect of 36 traditional medicinal plant species on hepatoprotective activity screening. For this study, carbon tetrachloride $(CCl_{4})$ intoxificated rats were used. Test extracts were made with the traditional medicinal plants refluxed in 95% MeOH and orally administered to the rats. Sixteen species, such as Mentha arvensis, Sophora japonica, Benincasa hispida, Lonicera japonica (Lonicerae Flos), Agaricus blazei, Epimedium koreanum, Aralia continentalis, Lithospermum erythrorhizon, Cimicifuga foetida, Gastrodia elata, Sanguisorba officinalis, Cephalonoplos segetum, Bupleurum falcatum, Alisma plantago-aquatica var. orientale, Lonicera japonica (Lonicerae Folium) and Sinomenium acutum showed protective effect against increased serum alanine aminotransferase (ALT) and/or serum asparteate aminotransferase (AST) activities.

• 한국환경생태학회지
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• 제15권4호
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• pp.319-329
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• 2002

경상북도 구룡산과 청옥산 지역에서 확인된 식물종은 96과 268속 349종 51변종 5품종으로 총 405종류가 확인되었다. 본 조사지역은 식물구계학상 중부아구에 속한다. 희귀 및 멸종위기종으로 6종, 즉 관중, 꽃창포, 천마, 도깨비부채. 꼬리진달래 및 토현삼이 확인되었다.