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http://dx.doi.org/10.5352/JLS.2006.16.7.1214

Sedative Effects of Combined Administration of 4-Hydroxy-3-methoxybenzaldehyde, a Component of Gastrodia elata, and 2,3-Dihydroxybenzaldehyde in Rats  

Lee, Dong-Ung (Department of Biotechnology Dongguk University)
Choi, Hyung-Chul (Department of Pharmacology College of Medicine, Yeungnam University)
Lee, Kwang-Youn (Department of Pharmacology College of Medicine, Yeungnam University)
Lee, Soo-Kwan (Department of Pediatrics, College of Medicine, Yeungnam University)
Kim, Jung-Ae (College of Pharmacy, Yeungnam University)
Yong, Chul-Soon (College of Pharmacy, Yeungnam University)
Kim, Jin-Sook (College of Pharmacy, Yeungnam University)
Huh, Geun (College of Pharmacy, Yeungnam University)
Shin, Son-Moon (Department of Pediatrics, School of Medicine, Sungkyunkwan University)
Koo, Byung-Soo (Department of Oriental Neuropsychiatry, Dongguk University)
Ha, Jeoung-Hee (Department of Pharmacology, School of Medicine, Kyungpook National University)
Publication Information
Journal of Life Science / v.16, no.7, 2006 , pp. 1214-1218 More about this Journal
Abstract
The present study was performed to investigate the sedative effects of the combined administration of phenolic compounds. 4-hydroxy-3-methoxybenzaldehyde, a component of Gastrodia elnta, showing positive GABAergic neuromodulation was administered intraperitoneally together with an identical dose of 2,3-dihydroxybenzaldehyde, a potent antioxidant, to the rats and then evaluated for its effects on the convulsion, the hypnosis, the inxiety and the muscle relaxation. Combined administration of both compounds significantly reduced the pentyleneterazole-induced lethality. In addition, this mixture significantly enhanced the pentobarbital-induced sleeping time. Contrary to the anticonvulsive and sedative effects, the combined administration did not exhibit anxiolytic or muscle relaxant activities. These results indicated that the combined treatment of 2,3-dihydroxybenzaldehtyde and 4-hydroxy-3-methoxybenzaldehyde with different effects leads to the anticonvulsion and/or sedation
Keywords
Gastrodia elata; sedatives; phenolic compound; combined administration;
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