Beneficial effect of Combination with Korean Red Ginseng, Gastrodia Rhizoma and Polygoni Multiflori on Cholesterol and Erectile Dysfunction in Hyperlipidemia rats |
Lee, Yun Jung
(College of Oriental Medicine, Wonkwang University)
Kho, Min Chul (College of Oriental Medicine, Wonkwang University) Tan, Rui (College of Oriental Medicine, Wonkwang University) Lee, Jae Yun (College of Oriental Medicine, Wonkwang University) Hwang, Jin Seok (College of Oriental Medicine, Wonkwang University) Cha, Jeong Dan (Institute of JinAn Red Ginseng Korea) Choi, Kyung Min (Institute of JinAn Red Ginseng Korea) Kang, Dae Gill (College of Oriental Medicine, Wonkwang University) |
1 | Qin R, Li X, Tao L, Li Y, Sun J, Kang X, Chen J. Protection by tetrahydroxystillbene glucoside against nerotoxicity induced by MPP+: the involvement of PI3K/Akt pathway activation. Toxicol Lett. 2011 ; 202 : 1-7. DOI |
2 | Lee YJ, Choi DH, Kim EJ, Kim HY, Kwon TO, Kang DG, Lee HS. Hypotensive, hypolipidemic, and vascular protective effects of Morus alba L. in rats fed an atherogenic diet. Am J Chin Med. 2011 ; 39 : 39-52. DOI |
3 | Park SH, Jang MJ, Hong JH, Rhee SJ, Choi KH, Park MR. Effects of mulberry leaf extract feeding on lipid status of rats fed high cholesterol diets. J Korean Soc Food Sci Nutr. 2007 ; 36 : 43-50. DOI |
4 | Duprez DA, Somasundaram PE, Sigurdsson G, Hoke L, Florea N, Cohn JN. Relationship between Creactive protein and arterial stiffness in an asymptomatic population. J Hum Hypertens. 2005 ; 19 : 515-9. DOI |
5 | Hommels MJ, van der Ven AJAM, Kroon AA, Kessels AGH, Van Dieijen-Visser MP, Van Engelshoven JAM, Bruggeman CA, De Leeuw PW. C-reactive protein, atherosclerosis and kidney function in hypertensive patients. J Hum Hypertens. 2005 ; 19 : 521-6. DOI |
6 | Kim JH, Klyachkin ML, Svendsen E, Davies MG, Hagen PO. Experimental hypercholesterolemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction. J Urol. 1994 ; 151 : 198-205. DOI |
7 | Lee YJ, Kim HY, Yoon JJ, Lee SM, Kho JH, Lee HS, Choi KM, Kang DG. Combination with Korean Red Ginseng and Gastrodia Rhizoma Enhances Vascular Protective Effects in Hyperlipidemic Rats. Korean J Orient Med Pre. 2012 ; 20 : 1-11. |
8 | Ahn TY, Azadzoi KM, Saenz de Tejada I. Effects of oxidatively modified low density lipoprotein on corpus cavernisum smooth muscle tone. Int J Impot Res. 1995 ; 4 : 52-5. |
9 | De May JG, Vanhoutte PM. Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J Physiol. 1981 ; 316 : 347-55. DOI |
10 | Kreuzer J, Viedt C, Brandes RP, Seeger F, Rosenkranz AS, Sauer H, Babich A, Nürnberg B, Kather H, Krieger-Brauer HI. Platelet-derived growth factor activates production of reactive oxygen species by NAD(P)H oxidase in smooth muscle cells through Gi1,2. FASEB J. 2003 ; 17 : 38-40. DOI |
11 | Krauss RM. Triglycerides and atherogenic lipoproteins: rationale for lipid management. Am J Med. 1998 ; 105 : 58S-62S. DOI |
12 | Janes PJ, Leith CA, Pederson RA. Meal-frequency effects on plasma hormone concentrations and cholesterol synthesis in human. Am J Clin Nutr. 1993 ; 57 : 868-74. DOI |
13 | Lusis AJ. Genetic factors effecting blood lopoproteins. J Lipid Res. 1988 ; 29 : 397-429. |
14 | Kwon KR, Park WP, Kang WM, Jeon EY, Jang JH. Identification and analysis of differentially expressed genes in mountain cultivated ginseng and mountain wild ginseng. J Acupunct Meridian Stud. 2011 ; 4 : 123-8. DOI |
15 | Azadzoi KM, Saenz de Tajade I. Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. J Urol Res. 1991 ; 146 : 238-40. DOI |
16 | Hong MH, Lim HK, Park JE, Jun NJ, Lee YJ. Cho MJ, Kim SM. The Antihypertensive and Vasodilating Effects of Adventitious Root Extracts of Wild Ginseng. J Korean Soc Appl Biol Chem. 2008 ; 51 : 102-7. DOI |
17 | Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med. 1992 ; 326 : 90-4. DOI |
18 | Juenemann KP, Aufenanger J, Konrad T, Pill J, Berle B, Persson-Juenemann C. The effect of impaired lipid metabolism on the smooth muscle cells of rabbits. Urol Res. 1991 ; 19 : 24-8. |
19 | Lee EJ, Kim HS, Kim BC, Hwang SW, Hwang SY. The Effect of Herbal Formula KH-305 on Erectile Dysfunction in Hyperlipidemic Rat. J Korean Soc Food Sci Nutr. 2007 ; 36 : 548-53. DOI |
20 | Podlasek CA, Zelner DJ, Bervig TR, Gonzalez CM, McKenna KE, McVary KT. Characterization and localization of nitric oxide synthase isoforms in the BB/WOR diabetic rat. J Urol. 2001 ; 166 : 746-55. DOI |
21 | Kim SD, Kim YJ, Huh JS, Kim SW, Sohn DW. Improvement of erectile function by Korean red ginseng (Panax ginseng) in a male rat model of metabolic syndrome. Asian J Androl. 2013 ; 15 : 395-9. DOI |
22 | Li N, Chen Z, Mao X, Yu J, Zhao R. Effects of lipid regulation using raw and processed radix polygoni multiflori in rats fed a high-fat diet. Evid Based Complement Alternat Med. 2012 ; 2012 : 329171. |
23 | Lee YJ, Hwang SM, Kang DG, Kim JS, Lee HS. Effect of Gastrodia elata on tumor necrosis factoralpha-induced matrix metalloproteinase activity in endothelial cells. J Nat Med. 2009 ; 63 : 463-7. DOI |
24 | Mizuno M, Yamada J, Terai H, Kozukue N, Lee YS, Tsuchide H. Differences in immunomodulating effects between wild and cultured Panax ginseng. Biochem Biophys Res Commun. 1994 ; 200 : 1672-8. DOI |
25 | Liu CX, Xiao PG. Recent advances on ginseng research in China. J Ethnopharmacol. 1992 ; 36 : 27-38. DOI |
26 | Liu J, Mori A. Antioxidant and free radical scavenging activities of Gastrodia elata Bl. and Uncaria rhynchophylla (Miq.) Jacks. Neuropharmacology. 1992 ; 31 : 1287-98. DOI |
27 | Hwang SM, Lee YJ, Kang DG, Lee HS. Antiinflammatory effect of Gastrodia elata rhizome in human umbilical vein endothelial cells. Am J Chin Med. 2009 ; 37 : 395-406. DOI |
28 | Wang W, Cao CY, Wang DQ, Zhao DZ. Effect of prepared polygonum multiflorum on striatum extracellular acetylcholine and choline in rat of intracerebral perfusion with sodium azide. Zhongguo Zhong Yao Za Zhi. 2006 ; 31 : 751-3. |
29 | Pankey EA, Lasker GF, Gur S, Hellstrom WJ, Kadowitz PJ. Analysis of Erectile Responses to Imatinib in the Rat. Urology. 2013 ; 253 : 17-24. |
30 | Na MK, Park JY, An RB, Lee SM, Kim YH, Lee JP, Seong RS, Lee KS, Bae KH. Quality evaluation of Polygoni multiflori Radix. J Pharmacogn. 2000 ; 31 : 335-9. |
31 | Lv L, Shao X, Wang L, Huang D, Ho CT, Sang S. Stilben glucoside from polygonum multiflorum thunb.: a novel natual inhibitor of advanced glycation end product formation by trapping of methylglyoxal. J Agric Food Chem. 2010 ; 58 : 2239-45. DOI |