• Cross-Cultural Studies
• /
• v.43
• /
• pp.327-354
• /
• 2016

Rimbaud's prose poem, Barbare in Illuminations, is known for its abstruseness with regard to forms, themes, metaphors. This paper first analyzes the poem's grammatical structure to make sense of such an inscrutable piece of work, then discusses its autotextuality in order to decipher its meaning by comparison with Rimbaud's other works. Autotextuality, a method of literary interpretation of Rimbaud's prose poem presented by Steve Murphy, refers to the intertextuality between the author's works. Despite some previous researches focusing on the intertextuality of Barbare, previous authors have failed not only to find its meaning but also to determine its significance. The abstruseness of Rimbaud's Barbare is sometimes considered an example of the meaningless of Rimbaud's work. However, examining the textual structure and the autotextuality builds meaning, rather than rendering the work meaningless. Barbare which consists entirely of noun phrases and metaphors means destruction, fusion and the pure power of regeneration in the original context of Rimbaud's work. This poem is Rimbaud's answer to Baudelaire's poetic question, Any of where out of World, and presents a strange scenery that uses 'the eternal female voice' to reach the Vulcan in the North Pole. Interpretation of Barbare could provide a methodology for reading the difficult Illuminations. The kind of analyses used are, for example, analysis of the text, analysis of verbal indicators, autotextuality, and an understanding of the joy and the solitude in the silence of the poem. Understanding Barbare may provide a method of interpreting the abstruseness of Illuminations. Through this approach, we can connect and combine every fragment of the Illuminations, so that we can reconstruct the story and the adventure contained therein.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.8
• /
• pp.649-656
• /
• 2019

Flux cored arc welding (FCAW), which is used widely in many fields, such as shipyards, bridge structures, construction machinery, and plant industry, is an alternative to shielded metal arc welding (SMAW). FCAW is used largely in the welding of carbon and alloy steel because it can be welded in all poses and obtain excellent quality in the field under a range of working conditions. In this study, the mechanical properties of welded parts were analyzed after different welding of SS400 and SM490A using FCAW. The following conclusions were drawn. The tensile test results satisfied the KS standard tensile strength in the range of 400~510 N/mm2 in all welding positions. The bending test confirmed that most of the specimens did not show surface breakage or other defects during bending and exhibited sufficient toughness, even after plastic deformation. The hardness test results were lower than the standard value of 350 Hv of KS B 0893. Similar to the hardness test, were greater than the KS reference value. The macro test revealed no internal flaws, non-metallic inclusions, bubbles or impurities on the entire cross section of the weld, and there were no concerns regarding lamination.

• Korean Journal of Heritage: History & Science
• /
• v.54 no.3
• /
• pp.204-227
• /
• 2021

This paper proposed the validity and necessity of establishing the Jungwon Historical and Cultural Area by reviewing the historical characteristics of the name Jungwon and its temporal and spatial range. We also explored ways to utilize the Jungwon historical and cultural Area under the Special Act on the Maintenance of Historical and Cultural Areas. Jungwon, which means the center of the country, has strategic value as a key area connecting the Korean Peninsula to the north and south through the Geripryeong and Jukryeong. It also includes Chungju, which connects the Namhan and Bukhan Rivers . From the Mahan period, the areas of Cheongju and Jincheon, the Miho Stream basin to the west, and Chungju to the east were closely connected to each other. Afterwards, Baekje, Koguryo, and Silla engaged in a fierce battle to occupy the Jungwon area. Jungwon culture was born through the negotiation and fusion of the cultures of the three kingdoms. In particular, Silla continued to value the Jungwon area, demonstrated by the installation of Seowongyeong in Cheongju and Bukwongyeong in Wonju, centering on the Jungwongyeong. Since we have a historical view with a focus on ancient kingdoms, we have overlooked the full value of the history and culture of Jungwon. We need to recognize the importance of Jungwon area and think about how to utilize it. Therefore, we suggested in this paper that there be more public information services on the cultural heritage of Jungwon, the historical heritage experience, and the education programs for local residents. The development and operation of Jungwon's history, culture, and tourism contents, as well as the various academic research papers should be used to reveal the identity of the Jungwon historical and cultural area.

• Journal of Ginseng Research
• /
• v.45 no.2
• /
• pp.295-304
• /
• 2021

Background: Acute promyelocytic leukemia (APL) is a hematopoietic malignancy driven by promyelocytic leukemia-retinoic acid receptor A (PML-RARA) fusion gene. The therapeutic drugs currently used to treat APL have adverse effects. 20(S)-ginsenoside Rh2 (GRh2) is an anticancer medicine with high effectiveness and low toxicity. However, the underlying anticancer mechanisms of GRh2-induced PML-RARA degradation and apoptosis in human APL cell line (NB4 cells) remain unclear. Methods: Apoptosis-related indicators and PML-RARA expression were determined to investigate the effect of GRh2 on NB4 cells. Z-VAD-FMK, LY294002, and C 87, as inhibitors of caspase, and the phosphatidylinositol 3-kinase (PI3K) and tumor necrosis factor-α (TNF-α) pathways were used to clarify the relationship between GRh2-induced apoptosis and PML-RARA degradation. Results: GRh2 dose- and time-dependently decreased NB4 cell viability. GRh2-induced apoptosis, cell cycle arrest, and caspase3, caspase8, and caspase9 activation in NB4 cells after a 12-hour treatment. GRh2-induced apoptosis in NB4 cells was accompanied by massive production of reactive oxygen species, mitochondrial damage and upregulated Bax/Bcl-2 expression. GRh2 also induced PML/PML-RARA degradation, PML nuclear bodies formation, and activation of the downstream p53 pathway in NB4 cells. Z-VAD-FMK inhibited caspase activation and significantly reversed GRh2-induced apoptosis and PML-RARA degradation. GRh2 also upregulated TNF-α expression and inhibited Akt phosphorylation. LY294002, an inhibitor of the PI3K pathway, enhanced the antitumor effects of GRh2, and C 87, an inhibitor of the TNF-α pathway, reversed NB4 cell viability, and GRh2-mediated apoptosis in a caspase-8-dependent manner. Conclusion: GRh2 induced caspase-dependent PML-RARA degradation and apoptosis in NB4 cells via the Akt/Bax/caspase9 and TNF-α/caspase8 pathways.

• Journal of Periodontal and Implant Science
• /
• v.51 no.3
• /
• pp.213-223
• /
• 2021

Purpose: The atmospheric pressure plasma jet (APPJ) has been introduced as an effective disinfection method for titanium surfaces due to their massive radical generation at low temperatures. Helium (He) has been widely applied as a discharge gas in APPJ due to its bactericidal effects and was proven to be effective in our previous study. This study aimed to evaluate the safety and effects of He-APPJ application at both the cell and tissue levels. Methods: Cellular-level responses were examined using human gingival fibroblasts and osteoblasts (MC3T3-E1 cells). He-APPJ was administered to the cells in the experimental group, while the control group received only He-gas treatment. Immediate cell responses and recovery after He-APPJ treatment were examined in both cell groups. The effect of He-APPJ on osteogenic differentiation was evaluated via an alkaline phosphatase activity assay. In vivo, He-APPJ treatment was administered to rat calvarial bone and the adjacent periosteum, and samples were harvested for histological examination. Results: He-APPJ treatment for 5 minutes induced irreversible effects in both human gingival fibroblasts and osteoblasts in vitro. Immediate cell detachment of human gingival fibroblasts and osteoblasts was shown regardless of treatment time. However, the detached areas in the groups treated for 1 or 3 minutes were completely repopulated within 7 days. Alkaline phosphatase activity was not influenced by 1 or 3 minutes of plasma treatment, but was significantly lower in the 5 minute-treated group (P=0.002). In vivo, He-APPJ treatment was administered to rat calvaria and periosteum for 1 or 3 minutes. No pathogenic changes occurred at 7 days after He-APPJ treatment in the He-APPJ-treated group compared to the control group (He gas only). Conclusions: Direct He-APPJ treatment for up to 3 minutes showed no harmful effects at either the cell or tissue level.

• Journal of the Korea Convergence Society
• /
• v.12 no.8
• /
• pp.301-308
• /
• 2021

In this study, the antioxidant and anti-inflammatory, anti-obesity properties, of Sargassum macrocarpum extracts were identified to assess the availability of Sargassum macrocarpum extracts as cosmetics and foods. To measure antioxidant activity, we conducted TPC, TFC, DPPH, ABTS, NO, FRAP. For polyphenols, 30.81±1.12 mg/g was shown. Flavonoids showed 25.72±0.94 mg/g. The DPPH experiment showed an antioxidant function of 6.746 mg ascorbic acid/g extract, the ABTS experiment showed an antioxidant function of 15.59 mg ascorbic acid/g extract, and the NO experiment showed an antioxidant function of 6.781 mg ascorbic acid/g extract. In FRAP, 1 mg of the Sargassum macrocarpum extract showed a reduction of 4.573±0.097 ㎍ of ascorbic acid. In cytotoxicity experiments, Sargassum macrocarpum extracts showed a cell survival rate of more than 80% at all concentrations, and an inflammatory inhibition of 25.95±0.85%, and an lipid accumulation inhibition of 29.75±2.35%. These results indicate that Sargassum macrocarpum extract is available as an anti-inflammatory cosmetic and anti-obesity inner beauty material. In future studies, it is necessary to study how pure substances containing Sargassum macrocarpum extract affect antioxidants, anti-inflammatory and anti-obesity

• The Korea Journal of Herbology
• /
• v.33 no.2
• /
• pp.59-67
• /
• 2018

Objective : Plantago asiatica L. has been used for many years in Korea, China, and Japan for the treatment of many diseases such as anti-inflammatory, anti-asthma and diuretic. But the anti-obesity effect of Plantaginis asiaticae Folium has not been studied yet. Thus, this study aimed to demonstrate the anti-obesity efficacy of Plantaginis asiaticae Folium water extract (PAF) in high fat diet-induced obesity animal model. Method : Male, five-weeks old C57BL/6 mice were divided into 5 groups; ND (normal diet + 0.9% saline), HFD (high-fat diet + 0.9% saline), PC (high-fat diet + Garcinia cambogia 500 mg/kg), PAF 100, 300 (high-fat diet + PAF 100, 300 mg/kg. Treatments were performed daily for 6 weeks per os. We evaluated the changes of body weight, white adipose tissues weight, hepatic and fecal lipids level, pancreatic lipase activity and lipid profiles in plasma. Result : Body weights, adipose tissue weights and FER were significantly lower in mice fed the high-fat diet with PAF treatment than in mice fed the high-fat diet alone. In plasma, TG, TC, LDL-C, ATS and ALT levels significantly decreased in PAF groups compared with HFD group. Also, hepatic triglyceride (TG) levels decreased and fecal TG increased in PAF groups compared to HFD group. In addition, the activity of pancreatic lipase was decreased in the PAF groups compared to that of HFD group. Conclusion: These results suggest PAF extract is effective in preventing and improvement obesity, so it might be a potential and safe material for anti-obesity agent of weight control or functional supplements.

• BMB Reports
• /
• v.56 no.4
• /
• pp.234-239
• /
• 2023

Thioredoxin-like protein 1 (TXNL1), one of the thioredoxin superfamily known as redox-regulator, plays an essential in maintaining cell survival via various antioxidant and anti-apoptotic mechanisms. It is well known that relationship between ischemia and oxidative stress, however, the role of TXNL1 protein in ischemic damage has not been fully investigated. In the present study, we aimed to determine the protective role of TXNL1 against on ischemic injury in vitro and in vivo using cell permeable Tat-TXNL1 fusion protein. Transduced Tat-TXNL1 inhibited ROS production and cell death in H₂O₂-exposed hippocampal neuronal (HT-22) cells and modulated MAPKs and Akt activation, and pro-apoptotic protein expression levels in the cells. In an ischemia animal model, Tat-TXNL1 markedly decreased hippocampal neuronal cell death and the activation of astrocytes and microglia. These findings indicate that cell permeable Tat-TXNL1 protects against oxidative stress in vitro and in vivo ischemic animal model. Therefore, we suggest Tat-TXNL1 can be a potential therapeutic protein for ischemic injury.

• Journal of Korea Entertainment Industry Association
• /
• v.13 no.8
• /
• pp.189-198
• /
• 2019

This study aims to make meaning of the reactions of the Korean people through the text mining of comments on videos of the December 2018 MMA performance of intro on YouTube. For this, comments on 15 YouTube videos were collected over the past 10 months. With the collected data, a total of 5,135 comments were analyzed through crawling using the Python and BeautifulSoup programs, data was refined over a total of 3 sessions, and a final total of 5,080 comments were used as analysis material. A mining technique was used for data analysis and the process of refinement, analysis, and visualization was achieved using the Textom program. Research results showed that keyword analysis showed the keywords of 'performance', 'Korea', 'video', 'top', 'cool', 'dance', 'idol', 'legend', 'love', and 'gratitude' in that order and keywords such as 'patriotism' and 'Olympics' also appeared frequently. N-gram analysis showed that comments with contexts such as 'a top performance that will remain a legend among Korean idol performances', and 'an idol performance that displayed the traditional culture of Korea' were in higher ranks. Based on such keyword analysis results, topic modeling was applied and 5 top keywords were extracted from a total of 5 topics. Analysis results of topic contents and distribution showed that topics in the comments of this performance's videos largely consisted of the 3 reactions of 'high praise regarding the stage performance', 'affection towards the fusion and artistic sublimation of Korean traditional dance', and 'gratitude towards the uploading of cool dance videos'

• Journal of Service Research and Studies
• /
• v.13 no.4
• /
• pp.113-130
• /
• 2023

This study is a single case study of the application of service design in a regional emergency medical centre of a senior general hospital, focusing on the experiences of patients and medical staff. It aims to measure and improve the experience of healthcare services using service design techniques and to verify their effectiveness. A qualitative case study centred on ethnography and design workshops was conducted to collect in-depth experience data from patients and medical staff. The study identified key experiential differences between patients and healthcare workers, with a particular focus on the challenges faced in emergency medical services. The qualitative data collected through patient and healthcare worker interviews and design thinking workshops were analysed and incorporated into the design in order to understand the complex dynamics of the regional emergency medical centre environment. The results of the study highlighted the need to improve communication, manage patient flow, and improve the environment in three main aspects of the current state of design reflecting the needs of patients and medical staff. By analysing the differences in the specific needs of the two groups of patients and medical staff, a design-led implementation process can be applied to improve the services of the regional emergency medical centre. This study highlights the role and importance of design in healthcare and provides an efficient way to bridge the gap between theoretical research and practical design implementation. This will contribute to creating a faster, more effective, and more satisfying healthcare experience. It is hoped that this will be a new opportunity to see service design as a key to a new innovation process for the satisfaction of both patients and medical staff.