• 경영과정보연구
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• 제30권4호
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• pp.475-509
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• 2011

본 연구는 우리나라 195개의 기업을 대상으로 세계적으로 관심의 대상이 되고 있는 노동시장의 유연성 전략 즉 수량적 유연성과 기능적 유연성이 조직의 결과변수인 생산성, 노사협력성, 고용안정 등에 어떠한 영향을 주는가를 기업 단위로 분석하였다. 또한 노동시장 유연성(수량적 유연성 및 기능적 유연성)과 노사협력성 및 고용안정간의 관계에서 노조 힘의 조절역할에 대해서도 분석하였다. 결과는 수량적 유연성은 생산성, 노사협력성, 고용안정 등과 유의한 관계를 보여주지 않았으나 기능적 유연성은 생산성, 노사협력성, 고용안정 등에 상당한 정의관계를 보여 주었다. 이러한 결과는 기업의 노동시장 전략에서 기능적 유연성의 중요성을 다시 확인할 수 있다. 서구에서는 기능적 유연성의 중요성을 지속적으로 주장하고 수량적 유연성의 문제점을 지적하고 있다. 그러나 본 연구에서는 기능적 유연성의 긍정적 측면은 확인이 되었으나 수량적 유연성의 부정적 관계가 확인될 수 없었다는 점에서 이들 관계는 앞으로 좀 더 연구가 지속되어야 하는 과제도 남겼다. 노동시장 유연성과 노사협력 및 고용안정과의 관계에서 노조 힘의 조절역할에 대한 분석결과는 수량적 유연성과 노사협력성 관계에서만 노조 힘의 상호작용 효과가 확인되었다. 이러한 결과는 노조의 기회주의적 행동에 대한 가능성을 엿볼 수 있다. 이러한 결과에 대한 논의를 할 것이다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회A
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• pp.446-450
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• 2007

It is strongly expected that inkjet printing method will be play and important role on printable electronics such as 3D integration of embedded ceramic devices(capacitor, resistor, inductor and electrode or circuit), Si-TFT and organic TFT including display C/F, RFID, FPCB, and etc. A inkjet printing method had been center of attention to strengthen the competitiveness of flat panel display on market and to open the new world of manufacturing process of printable electronics. We will survey the industrial tendency of printable electronics and flat panel display including some examples of inkjet printing and present the considerable points of inkjet printing method and some role of materials for successful inkjet printing.

• Journal of Information Technology Applications and Management
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• 제17권2호
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• pp.91-109
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• 2010

The success of new product is a key factor for getting competitive advantages. Marketing research has been investigating marketing capability, manufacturing technical capability, cross-functional integration, market knowledge competence, and competitive environment as the key success factors of new product advantage. Recently, the role of IT capability in enhancing new product advantage is assumed in the literature. However, the empirical studies on the role of IT capability are lacking. The purpose of this study is to identify the effects of IT capability on new product competitive advantages and the relationship between IT capability and the key success factors for new product advantage. Conducting an empirical field study, the IT capability is shown to have a direct effect on new product competitive advantages, and to be also the key success factor to make up for marketing capability and manufacturing technical capability. This study develops a conceptual model on the role of IT capability in enhancing new product competitive advantages by integrating marketing research and IS research.

• Journal of Plant Biotechnology
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• 제48권4호
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• pp.207-222
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• 2021

Coffee is the most frequently consumed functional beverage world wide. The average daily coffee consumption is increasing. This crop, which plays an important role in the global economy is under great threat from climate change. To with stand the current climate change, farmers have to learn crop cultivation techniques, strategies to protect crops from diseases, and understand which type of seed varieties to use to avoid crop loss. The present review briefly discusses the coffee cultivation techniques, impact of climate changes on coffee production, processing techniques of coffee, and the importance of coffee in our society, including its chemical composition and prevention against, major diseases. Furthermore, the importance and role of advanced nanotechnology along with molecular approaches for coffee crop improvement and facing challenges are explained.

• 한국산학기술학회논문지
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• 제4권4호
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• pp.357-360
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• 2003

작약의 methanol 추출물은 혈소판 활성 실험에서 혈소판 응집에 대해 강한 억제를 보였다. 활성성분은 chromatography방법을 사용하여 정제하였고 NMR과 기존의 Data로 분석하였다. Compound 1b는 benzoyloxypaeoniflorin과 동일한 구조임을 확인하였으며. compound 2e는 작약의 주성분인 paeoniflorin과 동일한 화학구조를 가졌으며 , compound 3a의 분석결과 구조적 유사성은 있으나 동일한 구조식은 확인 할 수 없었지만 collagen에서 응집억제활성이 90％이상의 뛰어난 활성을 나타내어 benzoyloxypaeoniflorin과 유사하게 benzoyl 기가 다른 작용기로 치환되었거나 Rl group이 다른 작용기로 치환된 형태로 추측하였다. Paeoniflorin이 collagen보다 thrombin에서 강한 억제를 보이는 것은 Ca/sup 2＋/ chelate를 형성함으로 인해 calcium 대사산물이 파괴된 것으로 추측했다. Compound 3a는 paeoniflorin의 benzoyl 기에 있는 OH기나 paeoniflorin의 glycoside 5-carbon위치의 OH기 대신에 다른 작용기가 대사산물로의 역할을 수행했을 것으로 추정했다.

• 미생물학회지
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• 제46권3호
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• pp.229-232
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• 2010

에놀라아제는 대부분의 생명체에서 에너지 대사에 중추적인 기능을 하는 해당과정에 관여하는 효소이며, Escherichia coli에서 RNA 가공 및 분해에 중심적인 역할을 하는 RNase E와 PNPase, Helicase와 함께 RNA 분해 복합체를 형성한다고 알려져 있다. E. coli에서 에놀라아제의 mRNA는 RNase E의 동족체인 RNase G에 의해 잘려서 분해되어 조절 된다고 알려져있다. 산소가 없는 환경에서 과발현되는 것으로 알려진 에놀라아제의 발현에 있어서 RNase G의 역할을 알아보기 위하여, 연구를 수행한 결과, 미세호기성 조건에서는 에놀라아제와 RNase G의 발현양 사이에는 상관관계가 밝혀내었다. 이러한 연구결과는 미세호기성 조건에서는 RNase G 이외에 에놀라아제의 조절에 기여하는 다른 기작이 있을 수 있다는 것을 시사한다.

• Journal of Korean Neurosurgical Society
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• 제66권6호
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• pp.642-651
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• 2023

Objective : Endothelial colony-forming cells (ECFCs) have been reported to play an important role in the pathogenesis of moyamoya disease (MMD). We have previously observed stagnant growth in MMD ECFCs with functional impairment of tubule formation. We aimed to verify the key regulators and related signaling pathways involved in the functional defects of MMD ECFCs. Methods : ECFCs were cultured from peripheral blood mononuclear cells of healthy volunteers (normal) and MMD patients. Low-density lipoproteins uptake, flow cytometry, high content screening, senescence-associated β-galactosidase, immunofluorescence, cell cycle, tubule formation, microarray, real-time quantitative polymerase chain reaction, small interfering RNA transfection, and western blot analyses were performed. Results : The acquisition of cells that can be cultured for a long time with the characteristics of late ECFCs was significantly lower in the MMD patients than the normal. Importantly, the MMD ECFCs showed decreased cellular proliferation with G1 cell cycle arrest and cellular senescence compared to the normal ECFCs. A pathway enrichment analysis demonstrated that the cell cycle pathway was the major enriched pathway, which is consistent with the results of the functional analysis of ECFCs. Among the genes associated with the cell cycle, cyclin-dependent kinase inhibitor 2A (CDKN2A) showed the highest expression in MMD ECFCs. Knockdown of CDKN2A in MMD ECFCs enhanced proliferation by reducing G1 cell cycle arrest and inhibiting senescence through the regulation of CDK4 and phospho retinoblastoma protein. Conclusion : Our study suggests that CDKN2A plays an important role in the growth retardation of MMD ECFCs by inducing cell cycle arrest and senescence.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 추계학술대회
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• pp.21-21
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• 2018

Natural product substances have historically served as the most significant also be prepared by source of new leads for pharmaceutical development. They can chemical synthesis(both semisynthesis and total synthesis) and have played a important role in the field of organic chemistry by providing synthetic targets. Rcently, they have also been extended for commercial purpose to refer to medicinal products, health functional foods, dietary supplements and cosmetics from natural sources. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. However, with the advent of robotics, bioinformatics, high throughput screening(HTS), molecular biology-biotechnology, combinatorial chemistry, in silico(molecular modeling) and other methodologies, the pharmaceutical industry has largely moved away from plant derived natural products as a source for leads and prospective drug candidates. The strategy for natural prduct industry is now changing from drug approaches to health foods by identifying effective natural products as preparations. In Korea, a lot of development of natural product based drugs have been done, but very few on health functional foods. The concept of natural product based health foods is not active components as lead compounds but standardized extracts or preparation mixed with other medicinal plants. The representative material has been recently known to be a standardized ginseng extract "Ginsana G 115" developed by Swiss Pharmaton company. The purpose of this presentation is to underline how natural products research continues to make significant contributions in the domain of discovery and development of new health functional foods. It is proposed to present the development of high value added health food or health functional foods through scientific investigation on efficacy and standardization of new materials form natural products.

• Molecules and Cells
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• 제28권6호
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• pp.553-558
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• 2009

In the periphery, a galectin-1 receptor, CD7, plays crucial roles in galectin-1-mediated apoptosis of activated T-cells as well as progression of T-lymphoma. Previously, we demonstrated that $NF-{\kappa}B$ downregulated CD7 gene expression through the p38 MAPK pathway in developing immature thymocytes. However, its regulatory pathway is not well understood in functional mature T-cells. Here, we show that CD7 expression was downregulated by Twist2 in Jurkat cells, a human acute T-cell lymphoma cell line, and in EL4 cells, a mature murine T-cell lymphoma cell line. Furthermore, ectopic expression of Twist2 in Jurkat cells reduced galectin-1-induced apoptosis. While full-length Twist2 decreased CD7 promoter activity, a C-terminal deletion form of Twist2 reversed its inhibition, suggesting an important role of the C-terminus in CD7 regulation. In addition, CD7 expression was enhanced by histone deacetylase inhibitors such as trichostatin A and sodium butyrate, which indicates that Twist2 might be one of candidate factors involved in histone deacetylation. Based on these results, we conclude that upregulation of Twist2 increases the resistance to galectin-1-mediated-apoptosis, which may have significant implications for the progression of some T-cells into tumors such as Sezary cells.

• Journal of Plant Biotechnology
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• 제37권2호
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• pp.115-124
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• 2010

As the completion of genome sequencing, large collection of expression data and the great efforts in annotating plant genomes, the next challenge is to systematically assign functions to all predicted genes in the genome. Functional genome analysis of plants has entered the high-throughput stage. The generations and collections of mutants at the genome-wide level form technological platform of functional genomics. However, to identify the exact function of unknown genes it is necessary to understand each gene's role in the complex orchestration of all gene activities in the plant cell. Gene function analysis therefore necessitates the analysis of temporal and spatial gene expression patterns. The most conclusive information about changes in gene expression levels can be gained from analysis of the varying qualitative and quantitative changes of messenger RNAs, proteins and metabolites. New technologies have been developed to allow fast and highly parallel measurements of these constituents of the cell that make up gene activity. We have reviewed currently employed technologies to identify unknown functions of predicted genes including map-based cloning, insertional mutagenesis, reverse genetics, chemical mutagenesis, microarray analysis, FOX-hunting system, gene silencing mutagenesis, proteomics and chemical genomics. Recent improvements in technologies for functional genomics enable whole-genome functional analysis, and thus open new avenues for studies of the regulations and functions of unknown genes in plants.