• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3629-3633
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• 2014

Background: Glioblastoma (GBM) is an immunosuppressive tumor whose median survival time is only 12-15 months, and patients with GBM have a uniformly poor prognosis. It is known that heredity contributes to formation of glioma, but there are few genetic studies concerning GBM. Materials and Methods: We genotyped six tagging SNPs (tSNP) in Han Chinese GBM and control patients. We used Microsoft Excel and SPSS 16.0 statistical package for statistical analysis and SNP Stats to test for associations between certain tSNPs and risk of GBM in five different models. ORs and 95%CIs were calculated for unconditional logistic-regression analysis with adjustment for age and gender. The SHEsis software platform was applied for analysis of linkage disequilibrium, haplotype construction, and genetic associations at polymorphism loci. Results: We found rs891835 in CCDC26 to be associated with GBM susceptibility at a level of p=0.009. The following genotypes of rs891835 were found to be associated with GBM risk in four different models of gene action: i) genotype GT (OR=2.26; 95%CI, 1.29-3.97; p=0.019) or GG (OR=1.33; 95%CI, 0.23-7.81; p=0.019) in the codominant model; ii) genotypes GT and GG (OR=2.18; 95%CI, 1.26-3.78; p=0.0061) in the dominant model; iii) GT (OR=2.24; 95%CI, 1.28-3.92; p=0.0053) in the overdominant model; iv) the allele G of rs891835 (OR=1.85; 95%CI, 1.14-3.00; p=0.015) in the additive model. In addition, "CG" and "CGGAG" were found by haplotype analysis to be associated with increased GBM risk. In contrast, genotype GG of CCDC26 rs6470745 was associated with decreased GBM risk (OR=0.34; 95%CI, 0.12-1.01; p=0.029) in the recessive model. Conclusions: Our results, combined with those from previous studies, suggest a potential genetic contribution of CCDC26 to GBM progression among Han Chinese.

• 한국유기농업학회지
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• 제20권1호
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• pp.91-99
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• 2012

This study was conducted to develop a functional feed additive for pig with spent $Lycium$ $chinense$ Mill fruit. We investigated the optimum conditions for the extraction of polyphenol from spent $Lycium$ $chinense$ Mill using methanol. Methanol concentration as a solvent for extraction, extraction time and the volume of solvent per a gram of solid (ground spent Lyceum chinense Mill) were selected as parameters. Three levels of parameters were configured according to Box Behnken experiment design, a fractional factorial design, and total 15 trials were employed. Total polyphenol concentration from each trial was used as response from experiment system and effects of parameters on total polyphenol extraction efficiency were determined using response surface model. As a result, all terms in analysis of variance, regression ($p$ = 0.001), linear ($p$ = 0.002), square ($p$ = 0.017) and interaction ($p$ = 0.047) was significant and adjusted determination coefficient ($R^2$) was 94.7%. Total polyphenol extraction efficiency was elevated along increased methanol content and decreased solvent to solid ratio. However extraction time did not affect the efficiency. This study provides a primary information for the optimum extraction conditions to maximize total polyphenol recovery from spent Lycium chinens Mill fruit and this result could be applied to re-use of argo-industrial by-products and to develop of functional feed additives in organic farming.

• 대한간호학회지
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• 제45권5호
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• pp.733-741
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• 2015

Purpose: This study was a descriptive survey research to identify the impact of bowel function, anxiety and depression on quality of life in patients with rectal cancer who had a sphincter-preserving resection. Methods: Participants were 100 patients who had rectal cancer surgery at W hospital in Korea. Bowel function, anxiety & depression, and quality of life were measured using the BFI (Bowel Function Instrument), HADS (Hospital Anxiety-Depression Scale) and the FACT-C (Functional Assessment of Cancer Therapy-Colorectal). Results: The mean scores were $39.81{\pm}5.16$ for bowel function, $6.15{\pm}3.25$ for anxiety, $7.24{\pm}3.13$ for depression, and $72.50{\pm}13.27$ for quality of life. There were significant negative correlations between quality of life and anxiety (r= -.59, p <.001) and between quality of life and depression (r= -.53, p <.001). But the correlation between quality of life and bowel function was significantly positive (r=.22, p =.025). The influence of the independent variables on the total quality of life was examined using multiple regression analysis. Anxiety (${\beta}$= -.38, p =.002), bowel function (${\beta}$= -.25, p =.028) and occupation (${\beta}$=.16, p =.048) were identified as factors affecting quality of life. The explanation power of this regression model was 44% and it was statistically significant (F=16.53, p <.001). Conclusion: The results of this study indicate that in order to improve the bowel function of patients after sphincter-preserving resection for rectal cancer, effective nursing interventions should be developed. As psychological problem such as anxiety and depression can relate to quality of life for these patients, nurses should work on improving the situation by providing continuous emotional nursing.

• 환경영향평가
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• 제20권5호
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• pp.729-745
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• 2011

The purpose of this paper is to estimate the external diseconomies of an unwelcomed facility on the nearby houses. The facility and the area studied are Dangin-Ri power plant in Mapo-Gu, Seoul and the residential district surrounding it respectively. The nearby housing prices have been changed according to the time and circumstances of the public announcements about the reconstruction or removal plans of the plant. These price changes are regarded as the capitalized values of the external diseconomies due to the plant. This study is based on the hedonic price theory in order to estimate the diseconomies in monetary value. The tools for the estimation are four models of multiple regression with the transaction price as the dependant variable and various housing characteristics including the external effects of the plant as the independent variables. The sample analyzed is 833 house transactions for the past 5 years in the research area. The facts found are as follows; First, the most suitable functional form for the estimation is confirmed to be the linear model. Second, there are significant differences in influence on the housing values among the independent variables, that is, locational characteristics, physical features, and environmental changes with time. Third, the external diseconomy is estimated as \80,137,807 in case that the plant would be reconstructed in the underground of the present site, whereon a substitutional public park would be constructed and as \59,142,248 in case that the plant would move away.

• 한국식생활문화학회지
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• 제25권6호
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• pp.810-819
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• 2010

The objective of this study was to produce muffins with added dukeum ramie leaf powder and to compare them to a control. We used two different optimal composition ratios to produce muffins. The physical and sensory characters were varied by changing the ratio of dukeum ramie leaf powder, butter, and sugar to identify a critical value using response surface regression analysis. The ranges for the added dukeum ramie leaf powder, sugar, and butter were 15-35, 60-100, and 60-100 g, respectively. Muffins with added dukeum ramie leaves had comparable mineral and antioxidant vitamin compositions to those of dried ramie leaves. Muffins with added dukeum ramie leaf powder satisfied the suitability of the model, showing a p-value within 5% of significance level (p<0.05) for every aspect Volume and height differed without any association to ingredients. Lightness increased when less dukeum ramie leaf powder was added with more butter and sugar, redness increased when more dukeum ramie leaf powder and sugar were added with 70-80 g of butter, whereas yellowness increased when less dukeum ramie powder was added. Texture and toughness increased when less dukeum ramie leaf powder was added. The degree of gumminess and chewiness depended hugely on the amount of sugar. Cohesiveness, decreased with more dukeum ramie leaf powder and butter, whereas hardness increased with a medium range of ingredients. Sensory character increased with less dukeum ramie powder, and overall quality increased with more butter and sugar, but depended on the amount of added dukeum ramie power. The critical values from the sensory characteristics showed that 27 g of dukeum ramie powder, 72 g of sugar, and 86 g of butter was optimum.

• 한국콘텐츠학회논문지
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• 제11권8호
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• pp.187-197
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• 2011

연구는 기존 연구들이 단일한 개념으로 인식하고 있던 혁신성향 개념을 인지적 혁신성향과 감각적 혁신성향으로 구분하고 두 유형의 혁신 성향의 정도에 따라 신제품에 대한 소비자의 지각된 위험의 민감성이 다름을 보였다. 이러한 지각된 위험의 유형과 수준의 차이는 각각의 혁신 성향이 소비자의 신제품 구매의도에 있어 서로 다른 영향력이 있음을 보여 줌으로써 혁신성향이 소비자의 신제품 구매의도에 미치는 경로가 이중경로임을 제시하였다. 217명을 대상으로 회귀분석과 공변량 구조 분석을 통하여 실증 분석을 수행한 결과 감각적 혁신성향 보다 인지적 혁신성향이 높을수록 사회적 위험보다 기능적 위험을 더 많이 지각하는 반면 감각적 혁신성향이 높을수록 기능적 위험보다는 사회적 위험을 더 지각하는 것으로 나타났다. 즉, 신제품 구매에 따른 기능적 위험 지각과 사회적 위험 지각이 소비자의 혁신성향의 유형에 따라 다르게 나타남을 제시하였다. 기존 연구에서는 소비자의 혁신성향 개념을 하나의 구성 개념으로 파악하여 신제품 구매의도에 대한 영향 관계를 파악하였으나 본 연구는 감각적 혁신성향과 인지적 혁신성향으로 소비자의 혁신성향을 구분하고 신제품 구매의도와의 관계를 파악하였으며 각각의 혁신성향이 신제품에 대해 인지하는 지각 위험의 경로를 달리함을 밝혔다.

• 감성과학
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• 제14권1호
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• pp.17-26
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• 2011

최근 고령 인구의 증가와 건강에 대한 관심으로 운동과 재활이 가능한 기능성 운동기기의 제품 개발을 통해 다양한 삶의 질 향상을 위한 헬스케어 서비스의 고부가가치화가 가속화되고 있다. 본 연구는 기능성 자전거 디자인개발을 위하여 디자인프로세스에 의하여 디자인과 3차의 실험을 진행하였다. 1차 실험은 구조적 측면, 심미적 측면, 기능적 측면, 사용적 측면의 4가지 항목을 조사하였다. 2차 실험에서는 모델링된 10개의 샘플에 대해 10개의 유니버설디자인 항목을 적용하여 전체적으로 평가점수가 고른 분포를 나타내고 있는 샘플(F)을 선정하였다. 3차 실험에서는 1/4 크기의 모형을 제작하여 사용자 서비스 측면의 평가를 진행하였다. 설문항목은 헬스케어 전문가와 협의를 통해 기능성 자전거의 서비스 평가항목 60개의 PPP(product performance program)를 실험하였다. 실험결과, 심미성 요소는 통일성, 비례, 전형성의 항목이 관련 있는 것을 알 수 있었다. 10개 항목(설문 문항 55개)에서는 육체적인 부담의 최소화, 간단하고 직관적인 사용의 항목이 높게 조사되었으며 반대로 정보전달의 배려와 사고와 오작동 방지의 설문 문항이 낮게 나타났다. 앞으로 위의 실험 결과를 좀 더 정확한 측정을 위해 실제 모형이 제작되면 헬스케어 전문가, 디자이너 그리고 고령자를 포함하여 다시 한 번 평가를 진행할 예정이다.

• 성인간호학회지
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• 제28권3호
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• pp.302-313
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• 2016

Purpose: The objective of this study was to identify factors related to self-care adherence in symptomatic patients with heart failure (HF). Methods: Using a cross-sectional design, a convenience sample 209 outpatient clinic patients were recruited at two medical centers. Between October 2011 and August 2012, data were collected using the structured questionnaire. Factors related to self-care adherence were examined using hierarchical multiple regression. Results: Mean age of participants was 67.71 years and a half of them (53.6%) were female. They showed relatively low self-care adherence with mean scores of $61.88{\pm}12.92$. Lower self-care adherence was reported in asking for low sodium items, weighing oneself, checking for ankle edema, and exercising for 30 minutes. The overall model significantly explained 23.9% of variance in self-care adherence. Among the predictors, education, New York Heart Association functional classification, and social support were statistically significant in influencing self-care adherence. The variable of negative emotional status such as anxiety and depression were not found to be significant. Conclusion: These findings demonstrate that social support could help self-care adherence among symptomatic patients with HF. Thus, programs targeting self-care adherence in this population should consider the strategies improving social support.

• 한국조경학회지
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• 제29권5호
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• pp.28-36
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• 2001

The purpose of this study is to research the influence of soundscape in the preference of landscape. Specifically, standards type of communication are applied to the landscape such as positive scenery and negative scenery. The spatial image was analyzed by the variables of Kaplan\`s information process model. The level of visual preferences was measured by a type of acoustic information and visual information in the landscape, and this data was analyzed by multiple regression. The results of this study can be summarized as follows; The value of landscape preference was maximum value in Type I and minimum value in Type II from all fluent of coherence, mystery, and legibility to, except complexity, and it was not different from preference. These results clearly show the influence of sounds effecting decision of landscape preference. It was different by the type of acoustic information and visual information in landscape. The results of ANOVA among types of acoustic information were differences of mean between positive sound, no sound and negative sound from coherence, mystery, and legibility to, except complexity. These variables may be the major factors which must be considered in planning and designing as the functional basis for quantitative analysis.

• 대한의생명과학회지
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• 제19권3호
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• pp.261-265
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• 2013

The corpus luteum is a transient endocrine gland essential for regulation of the ovarian cycle as well as for establishing and maintaining pregnancy. Prostaglandin $F_{2{\alpha}}$ (PGF) initiates functional and structural regression of the corpus luteum and therefore is an important regulator of the estrous cycle. It is a matter of debate whether the endothelial cells of the bovine corpus luteum express PGFR, the cognate receptor for PGF. Therefore, the aim of this study was to assess the expression of PGFR in bovine endothelial cells. Endothelial cells were isolated from the bovine corpus luteum of the mid-luteal stage using magnetic beads and cultured in vitro. We demonstrate that this isolation procedure generates a pure culture of endothelial cells as confirmed by synthesis of Factor VIII and lack of expression of $3{\beta}$-hydroxysteroid dehydrogenase. By RT-PCR, Western blot and immunofluorescence analyses, we further show that the cultured endothelial cells produced PGFR. This model system can be utilized to provide an experimental system to investigate the role of PGF on endothelial cells during the reproductive cycle.