• Journal of Korean Neurosurgical Society
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• 제64권3호
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• pp.329-339
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• 2021

It has been recognised for over a century that the events of gastrulation are fundamental in determining, not only the development of the neuraxis but the organisation of the entire primitive embryo. Until recently our understanding of gastrulation was based on detailed histological analysis in animal models and relatively rare human tissue preparations from aborted fetuses. Such studies resulted in a model of gastrulation that neurosurgeons have subsequently used as a means of trying to explain some of the congenital anomalies of caudal spinal cord and vertebral development that present in paediatric neurosurgical practice. Recent advances in developmental biology, in particular cellular biology and molecular genetics have offered new insights into very early development. Understanding the processes that underlie cellular interactions, gene expression and activation/inhibition of signalling pathways has changed the way embryologists view gastrulation and this has led to a shift in emphasis from the 'descriptive and morphological' to the 'mechanistic and functional'. Unfortunately, thus far it has proved difficult to translate this improved knowledge of normal development, typically derived from non-human models, into an understanding of the mechanisms underlying human malformations such as the spinal dysraphisms and anomalies of caudal development. A paediatric neurosurgeons perspective of current concepts in gastrulation is presented along with a critical review of the current hypotheses of human malformations that have been attributed to disorders of this stage of embryogenesis.

• 중환자간호학회지
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• 제12권2호
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• pp.61-72
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• 2019

Purpose : The aim of this study was to explore the attributes, antecedents, and consequences of patient-centered care (PCC) for older adults with multimorbidity in acute care hospitals. Methods : The concept analysis performed by Walker and Avant was used to analyze PCC. Fifteen studies from the literature related to PCC appear in systematic literature reviews in the fields of theology, medicine, psychology, and nursing. Results : PCC in acute care hospitals was defined according to the five attributes of 'maintaining patient autonomy', 'empowering self-care', 'individualized and relationship-based care', 'shared decision-making', and 'creating a homelike environment'. Antecedents of PCC were found to be a respect for patients' preferences, qualifications of the nursing staff, care coordination and integration, and organizational support. Consequences of effective PCC were a functional status; health-related quality of life; satisfaction with care, mortality, and medical costs from the perspective of the patient and family; and quality of care and therapeutic relationships from nurses' viewpoints. Conclusion : PCC as defined by the results of this study will contribute to the foundation of institutionalization and the creation of a safe and healthy acute care hospital culture focused on patients' preferences and values.

• 생물정신의학
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• 제28권2호
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• pp.36-49
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• 2021

Suicide is a leading cause of death worldwide, especially among adolescents and young adults. Considering this fact, it is imperative that we understand the neural mechanisms underlying suicidal thoughts and behaviors in youth from a neurodevelopmental perspective. In this review, we focused on the magnetic resonance imaging studies that examined the neural correlates of suicidal ideations (SI) or attempts (SA) in youth. We reviewed twenty-three cross-sectional studies reporting the structural and functional alterations in association with SI or SA among adolescents and young adults with various mental disorders. The previous literature suggests that the dorsolateral prefrontal cortex, anterior cingulate cortex, and ventral frontolimbic circuit, may play an important role in the pathophysiology of suicidal behavior in youth through altered top-down control over emotion and impulsivity. Future studies with a longitudinal design and using multimodal imaging techniques may be of help to identify novel therapeutic targets specific for youth with suicidal thoughts and behaviors.

• 식품과학과 산업
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• 제50권3호
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• pp.39-50
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• 2017

In order to secure competitiveness of the home meal replacement (HMR) industry from a long-term perspective, development of packaging and processing technologies must be achieved. The development of technology that can secure freshness, nutrition, and taste but secures the shelf life is the key to the future growth of HMR. The future of HMR can be considered in terms of nutrition, environment and safety. From the nutritional point of view, it is expected that development of healthy HMR such as low-salt, low-sugar, low-fat, and high fiber and premium HMR with functional ingredient enhanced, and personalized HMR for silver, infant and patients will be done. And it is expected that development of HMR utilizing environmentally friendly food or local food, development of energy reduction and environmentally friendly disinfection technology, development of environmentally friendly packaging material, and providing information on HMR preparation using QR code and RFID from the environmental and safe point of view.

• 생태와환경
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• 제53권4호
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• pp.436-444
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• 2020

대기 중 미세먼지가 환경과 인간의 공중 보건에 악영향을 미치고 있다는 사실은 점점 명확해지고 있다. 미세먼지가 식물의 잎에 침착, 흡수되므로 식물이 미세먼지를 제거하는 바이오필터로 활용하기 위한 연구들이 활발히 진행되고 있다. 또한, 식물에 흡수된 미세먼지는 식물에 다양한 생리적, 형태적 영향을 미치게 된다. 본 연구는 식물과 미세먼지간의 상호작용에 대해 국내외에서 수행되어온 연구들의 방법과 결과를 특히 생태적 관점에서 종합 정리하였다.

• Journal of Microbiology and Biotechnology
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• 제31권6호
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• pp.765-774
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• 2021

Although research on the osteal signaling pathway has progressed, understanding of gut microbial-dependent signaling pathways for metabolic and immune bone homeostasis remains elusive. In recent years, the study of gut microbiota has shed light on our understanding of bone homeostasis. Here, we review microbiota-mediated gut-bone crosstalk via bone morphogenetic protein/SMADs, Wnt and OPG/receptor activator of nuclear factor-kappa B ligand signaling pathways in direct (translocation) and indirect (metabolite) manners. The mechanisms underlying gut microbiota involvement in these signaling pathways are relevant in immune responses, secretion of hormones, fate of osteoblasts and osteoclasts and absorption of calcium. Collectively, we propose a signaling network for maintaining a dynamic homeostasis between the skeletal system and the gut ecosystem. Additionally, the role of gut microbial improvement by dietary intervention in osteal signaling pathways has also been elucidated. This review provides unique resources from the gut microbial perspective for the discovery of new strategies for further improving treatment of bone diseases by increasing the abundance of targeted gut microbiota.

• International Journal of Computer Science & Network Security
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• 제21권2호
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• pp.21-39
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• 2021

The acceptance of smartphone applications in the learning field is one of the most significant challenges for higher education institutions in Saudi Arabia. These institutions serve large and varied sectors of society and have a tremendous impact on the knowledge gained by student segments at various ages. M-learning is of great importance because it provides access to learning through a wide range of mobile networks and allows students to learn at any time and in any place. There is a lack of quality requirements for M-learning applications in Saudi societies partly because of mandates for high levels of privacy and gender segregation in education (Garg, 2013; Sarrab et al., 2014). According to the Saudi Arabian education ministry policy, gender segregation in education reflects the country's religious and traditional values (Ministry of Education, 2013, No. 155). The opportunity of many applications would help the Saudi target audience more easily accept M-learning applications and expand their knowledge while maintaining government policy related to religious values and gender segregation in the educational environment. In addition, students can share information through the online framework without breaking religious restrictions. This study uses a quantitative perspective to focus on defining the technical aspects and learning requirements for distributing knowledge among students within the digital environment. Additionally, the framework of the unified theory of acceptance and use of technology (UTAUT) is used to modify new constructs, called application quality requirements, that consist of quality requirements for systems, information, and interfaces.

• 한국정보시스템학회지:정보시스템연구
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• 제30권4호
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• pp.43-69
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• 2021

Purpose Although companies occupied the network market take the advantageous position first and can be successful in securing users over a certain size, it is important to satisfy the customers' demand and prevent the outflow of users toward a new alternative SNS. What is more, there are frequent changes in the flow of users toward new SNSs. Despite these dynamic market circumstances, there is a lack of research to explain the switching behaviors of SNS users. Design/methodology/approach The objective of this study is to explain and verify a specified migration theory(Push-Pull-Mooring model) focused on SNS fatigue in the psychological point of view, as well as reviewing previous studies on functional and technical characteristics of SNSs themselves. Moreover, this study tried to highlight factors affecting users actual SNS switch rather than their switching intention. Findings According to the statistical analysis, the most influenced pull factor to switch SNS was the alternative attractiveness. On the other hand, undesired relationship burden, service innovation and important mooring factors to prevent users' SNS switch. This study has a significant contribution to the theory, which analyzed users' actual SNS switch, and examined SNS users' psychological factors(SNS fatigue), reviewing the characteristics of existing services. To secure more users and to keep them, companies providing social network service need to develop differentiated strategies by analyzing psychological characteristics of various users.

• 한국컴퓨터정보학회논문지
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• 제27권9호
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• pp.217-224
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• 2022

본 연구는 D&M 모델과 ECM모델을 기반으로 소비자가 대중교통 모바일 결제 앱을 지속적으로 사용하는 데 영향을 미치는 연구 모델을 구축하였다. 온라인 설문조사를 통해 중국 베이징지역에서 264개의 유효한 설문지를 획득하여 Smartpls3.0으로 분석하였다. 연구 결과는, 지각된 정보의 질, 지각된 시스템의 질, 그리고 지각된 인터페이스 설계의 질은 지각된 유용성과 만족을 통하여 소비자 지속적 사용의도에 유의한 긍정적 영향을 미치는 것으로 나타났다. 지각된 기능의 질은 단지 지각된 유용성만을 통해 지속적 사용의도에 긍정적인 영향을 미치는 것이다.

• 식품보건융합연구
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• 제9권2호
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• pp.1-6
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• 2023

As oil palm trees are an important economic source in many countries, particularly in Southeast Asia and Africa, the study of Ganoderma boninense is crucial for the sustainability of the oil palm industry. This study aims to understand the biology and ecology of the fungus, its pathogenesis, and the impact it has on oil palm trees. This knowledge can be used to develop management strategies to mitigate the damage caused by the fungus, such as the use of resistant varieties, chemical and biological control methods, and cultural practices. This study is to ensure the long-term productivity and sustainability of the oil palm industry. The main method of recent academic studies on this pathogen is molecular biology, with a focus on genetic analysis and functional genomics. Researchers have used techniques such as PCR, DNA sequencing, and transcriptomics to identify genes and pathways involved in pathogenesis and better understand the fungus's interactions with its host plant. Other methods used in recent studies include biochemical analysis, microscopy, and phytohormonal assays to investigate the biochemistry and physiology of the interaction between G. boninense and oil palm. This study is intended to provide implications from a new perspective by organizing and integrating studies on Ganoderma boninense.